{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:07:17Z","timestamp":1790687237473,"version":"4.1.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T00:00:00Z","timestamp":1565913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T00:00:00Z","timestamp":1565913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Bircher-Bener Grant for Preventative Medicine from Sackler Faculty of Medicine, Tel Aviv University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurogenetics"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s10048-019-00586-1","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T03:49:17Z","timestamp":1565927357000},"page":"187-195","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["VPS53 gene is associated with a new phenotype of complicated hereditary spastic paraparesis"],"prefix":"10.1007","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5315-3738","authenticated-orcid":false,"given":"Moran","family":"Hausman-Kedem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shay","family":"Ben-Shachar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shay","family":"Menascu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Geva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liora","family":"Sagie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviva","family":"Fattal-Valevski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,16]]},"reference":[{"issue":"1","key":"586_CR1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1136\/jnnp.72.1.43","volume":"72","author":"P McMonagle","year":"2002","unstructured":"McMonagle P, Webb S, Hutchinson M (2002) The prevalence of \u201cpure\u201d autosomal dominant hereditary spastic paraparesis in the island of Ireland. J Neurol Neurosurg Psychiatry 72(1):43\u201346","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"6","key":"586_CR2","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s10545-007-0745-1","volume":"30","author":"F Sedel","year":"2007","unstructured":"Sedel F, Fontaine B, Saudubray JM, Lyon-Caen O (2007) Hereditary spastic paraparesis in adults associated with inborn errors of metabolism: a diagnostic approach. J Inherit Metab Dis 30(6):855\u2013864","journal-title":"J Inherit Metab Dis"},{"key":"586_CR3","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1136\/jnnp.44.10.871","volume":"44","author":"AE Harding","year":"1981","unstructured":"Harding AE (1981) Hereditary \u201cpure\u201d spastic paraplegia: a clinical and genetic study of 22 families. J Neurol Neurosurg Psychiatry 44:871\u2013883","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"586_CR4","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1136\/jnnp.69.2.150","volume":"69","author":"CJ McDermott","year":"2000","unstructured":"McDermott CJ, White K, Bushby K, Shaw PJ (2000) Hereditary spastic paraparesis: a review of new developments. J Neurol Neurosurg Psychiatry 69:150\u2013160","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"586_CR5","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1097\/WCO.0b013e3282f190ba","volume":"20","author":"C Depienne","year":"2007","unstructured":"Depienne C, Stevanin G, Brice A, Durr A (2007) Hereditary spastic paraplegias: an update. Curr Opin Neurol 20:674\u2013680","journal-title":"Curr Opin Neurol"},{"issue":"4","key":"586_CR6","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1111\/j.1469-8749.1991.tb14881.x","volume":"33","author":"RE Appleton","year":"1991","unstructured":"Appleton RE, Farrell K, Dunn HG (1991) \u2018Pure\u2019 and \u2018complicated\u2019 forms of hereditary spastic paraplegia presenting in childhood. Dev Med Child Neurol 33(4):304\u2013312","journal-title":"Dev Med Child Neurol"},{"issue":"8334","key":"586_CR7","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/S0140-6736(83)92879-9","volume":"1","author":"AE Harding","year":"1983","unstructured":"Harding AE (1983) Classification of the hereditary ataxias and paraplegias. Lancet 1(8334):1151\u20131155","journal-title":"Lancet"},{"key":"586_CR8","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.3389\/fneur.2018.01117","volume":"9","author":"FF da Gra\u00e7a","year":"2019","unstructured":"da Gra\u00e7a FF, de Rezende TJR, Vasconcellos LFR, Pedroso JL, Barsottini OGP, Fran\u00e7a MC Jr (2019) Neuroimaging in hereditary spastic paraplegias: current use and future perspectives. Front Neurol 9:1117","journal-title":"Front Neurol"},{"key":"586_CR9","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.expneurol.2014.06.011","volume":"61C","author":"T Lo Giudice","year":"2014","unstructured":"Lo Giudice T, Lombardi F, Santorelli FM, Kawarai T, Orlacchio A (2014) Hereditary spastic paraplegia: clinical- genetic characteristics and evolving molecular mechanisms. Exp Neurol 61C:518\u2013539","journal-title":"Exp Neurol"},{"issue":"6","key":"586_CR10","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s00439-015-1536-7","volume":"134","author":"C Tesson","year":"2015","unstructured":"Tesson C, Koht J, Stevanin G (2015) Delving into the complexity of hereditary spastic paraplegias: how unexpected phenotypes and inheritance modes are revolutionizing their nosology. Hum Genet 134(6):511\u2013538","journal-title":"Hum Genet"},{"key":"586_CR11","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.jns.2017.06.019","volume":"379","author":"PVS Souza","year":"2017","unstructured":"Souza PVS, Bortholin T, Dias RB, Chieia MAT, Burlin S, Naylor FGM et al (2017) New genetic causes for complex hereditary spastic paraplegia. J Neurol Sci 379:283\u2013292","journal-title":"J Neurol Sci"},{"key":"586_CR12","doi-asserted-by":"publisher","first-page":"981","DOI":"10.3389\/fneur.2018.00981","volume":"9","author":"A D\u2019Amore","year":"2018","unstructured":"D\u2019Amore A, Tessa A, Casali C, Dotti MT, Filla A, Silvestri G et al (2018) Next generation molecular diagnosis of hereditary spastic paraplegias: an Italian cross-sectional study. Front Neurol 9:981","journal-title":"Front Neurol"},{"key":"586_CR13","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ejhg.2015.200","volume":"24","author":"DS Lynch","year":"2016","unstructured":"Lynch DS, Koutsis G, Tucci A, Panas M, Baklou M, Breza M et al (2016) Hereditary spastic paraplegia in Greece: characterization of a previously unexplored population using next-generation sequencing. Eur J Hum Genet 24:857\u2013863 10.1038","journal-title":"Eur J Hum Genet"},{"issue":"7","key":"586_CR14","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s00109-018-1655-4","volume":"96","author":"C Lu","year":"2018","unstructured":"Lu C, Li LX, Dong HL, Wei Q, Liu ZJ, Ni W et al (2018 Jul) Targeted next-generation sequencing improves diagnosis of hereditary spastic paraplegia in Chinese patients. J Mol Med (Berl) 96(7):701\u2013712","journal-title":"J Mol Med (Berl)"},{"issue":"Pt 7","key":"586_CR15","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1093\/brain\/aww111","volume":"139","author":"E Kara","year":"2016","unstructured":"Kara E, Tucci A, Manzoni C, Lynch DS, Elpidorou M, Bettencourt C, Chelban V, Manole A, Hamed SA, Haridy NA, Federoff M, Preza E, Hughes D, Pittman A, Jaunmuktane Z, Brandner S, Xiromerisiou G, Wiethoff S, Schottlaender L, Proukakis C, Morris H, Warner T, Bhatia KP, Korlipara LVP, Singleton AB, Hardy J, Wood NW, Lewis PA, Houlden H (2016) Genetic and phenotypic characterization of complex hereditary spastic paraplegia. Brain 139(Pt 7):1904\u20131918","journal-title":"Brain"},{"key":"586_CR16","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jns.2017.10.010","volume":"383","author":"D Burguez","year":"2017","unstructured":"Burguez D, Polese-Bonatto M, Scudeiro LAJ, Bj\u00f6rkhem I, Sch\u00f6ls L, Jardim LB, Matte U, Saraiva-Pereira ML, Siebert M, Saute JAM (2017) Clinical and molecular characterization of hereditary spastic paraplegias: a next-generation sequencing panel approach. J Neurol Sci 383:18\u201325","journal-title":"J Neurol Sci"},{"key":"586_CR17","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1002\/ana.24611","volume":"79","author":"R Sch\u00fcle","year":"2016","unstructured":"Sch\u00fcle R, Wiethoff S, Martus P, Karle KN, Otto S, Klebe S, Klimpe S, Gallenm\u00fcller C, Kurzwelly D, Henkel D, Rimmele F, Stolze H, Kohl Z, Kassubek J, Klockgether T, Vielhaber S, Kamm C, Klopstock T, Bauer P, Z\u00fcchner S, Liepelt-Scarfone I, Sch\u00f6ls L (2016) Hereditary spastic paraplegia: clinicogenetic lessons from 608 patients. Ann Neurol 79:646\u2013658","journal-title":"Ann Neurol"},{"key":"586_CR18","doi-asserted-by":"crossref","first-page":"11.10.1","DOI":"10.1002\/0471250953.bi1110s43","volume":"43","author":"GA Van der Auwera","year":"2013","unstructured":"Van der Auwera GA, Carneiro MO, Hartl C, Poplin R, Del Angel G, Levy-Moonshine A, Jordan T, Shakir K, Roazen D, Thibault J, Banks E, Garimella KV, Altshuler D, Gabriel S, DePristo MA (2013) From FastQ data to high confidence variant calls: the genome analysis toolkit best practices pipeline. Curr Protoc Bioinformatics 43:11.10.1\u201311.1033","journal-title":"Curr Protoc Bioinformatics"},{"issue":"7571","key":"586_CR19","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature15393","volume":"526","author":"A Auton","year":"2015","unstructured":"1000 Genomes Project Consortium, Auton A, Brooks LD, Durbin RM, Garrison EP, Kang HM, Abecasis GR et al (2015) A global reference for human genetic variation. Nature. 526(7571):68\u201374","journal-title":"Nature."},{"key":"586_CR20","doi-asserted-by":"publisher","unstructured":"Lek M, Karczewski KJ, Minikel EV, Samocha KE, Banks E et al (2016) Analysis of protein-coding genetic variation in 60,706 humans. Nature. 536(7616):285\u2013291. https:\/\/doi.org\/10.1038\/nature19057","DOI":"10.1038\/nature19057"},{"issue":"1","key":"586_CR21","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/s41467-017-00141-2","volume":"8","author":"Z Ren","year":"2017","unstructured":"Ren Z, La Carpia F, Halvorsen M, Wang Q, McSweeney KM et al (2017) Annotating pathogenic non-coding variants in genic regions. Nat Commun 8(1):236","journal-title":"Nat Commun"},{"issue":"5","key":"586_CR22","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","volume":"17","author":"S Richards","year":"2015","unstructured":"Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J et al (2015) Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med 17(5):405\u2013424","journal-title":"Genet Med"},{"key":"586_CR23","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1136\/jmedgenet-2013-101823","volume":"51","author":"M Feinstein","year":"2014","unstructured":"Feinstein M, Flusser H, Lerman-Sagie T, Ben-Zeev B, Lev D, Agamy O, Cohen I, Kadir R, Sivan S, Leshinsky-Silver E, Markus B, Birk OS (2014) VPS53 mutations cause progressive cerebello-cerebral atrophy type 2 (PCCA2). J Med Genet 51:303\u2013308","journal-title":"J Med Genet"},{"issue":"8","key":"586_CR24","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.8.e96","volume":"40","author":"B Ben-Zeev","year":"2003","unstructured":"Ben-Zeev B, Hoffman C, Lev D, Watemberg N, Malinger G, Brand N, Lerman-Sagie T (2003) Progressive cerebellocerebral atrophy: a new syndrome with microcephaly, mental retardation, and spastic quadriplegia. J Med Genet 40(8):e96","journal-title":"J Med Genet"},{"issue":"4","key":"586_CR25","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.ajhg.2010.09.007","volume":"87","author":"O Agamy","year":"2010","unstructured":"Agamy O, Ben Zeev B, Lev D, Marcus B, Fine D, Su D, Narkis G, Ofir R, Hoffmann C, Leshinsky-Silver E, Flusser H, Sivan S, S\u00f6ll D, Lerman-Sagie T, Birk OS (2010) Mutations disrupting selenocysteine formation cause progressive cerebello-cerebral atrophy. Am J Hum Genet 87(4):538\u2013544","journal-title":"Am J Hum Genet"},{"issue":"5","key":"586_CR26","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1136\/thoraxjnl-2011-200301","volume":"67","author":"MR Knowles","year":"2012","unstructured":"Knowles MR, Leigh MW, Carson JL, Davis SD, Dell SD, Ferkol TW et al (2012) Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure. Thorax 67(5):433\u2013441","journal-title":"Thorax"},{"issue":"3","key":"586_CR27","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.tcb.2010.11.003","volume":"21","author":"JS Bonifacino","year":"2011","unstructured":"Bonifacino JS, Hierro A (2011 Mar) Transport according to GARP: receiving retrograde cargo at the trans-Golgi network. Trends Cell Biol 21(3):159\u2013167","journal-title":"Trends Cell Biol"},{"issue":"5","key":"586_CR28","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/ncb3129","volume":"17","author":"C Schindler","year":"2015","unstructured":"Schindler C, Chen Y, Pu J, Guo X, Bonifacino JS (2015) EARP, a multisubunit tethering complex involved in endocytic recycling. Nat Cell Biol 17(5):639\u2013650","journal-title":"Nat Cell Biol"},{"key":"586_CR29","doi-asserted-by":"publisher","first-page":"5251","DOI":"10.1128\/MCB.00495-09","volume":"29","author":"FJ P\u00e9rez-Victoria","year":"2009","unstructured":"P\u00e9rez-Victoria FJ, Bonifacino JS (2009) Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-Golgi network. Mol Cell Biol 29:5251\u20135263","journal-title":"Mol Cell Biol"},{"key":"586_CR30","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.08712","volume":"4","author":"F Fr\u00f6hlich","year":"2015","unstructured":"Fr\u00f6hlich F, Petit C, Kory N, Christiano R, Hannibal-Bach HK, Graham M, Liu X, Ejsing CS, Farese RV Jr, Walther TC (2015) The GARP complex is required for cellular sphingolipid homeostasis. eLife 4:e08712","journal-title":"eLife"},{"key":"586_CR31","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1016\/j.celrep.2017.06.012","volume":"19","author":"J Wei","year":"2017","unstructured":"Wei J, Zhang Y-Y, Luo J, Wang J-Q, Zhou Y-X, Miao H-H et al (2017) The GARP complex is involved in intracellular cholesterol transport via targeting NPC2 to lysosomes. Cell Rep 19:2823\u20132835","journal-title":"Cell Rep"},{"key":"586_CR32","doi-asserted-by":"publisher","first-page":"14176","DOI":"10.1073\/pnas.1009419107","volume":"107","author":"N Vasan","year":"2010","unstructured":"Vasan N, Hutagalung A, Novick P, Reinisch K (2010) Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated retrograde protein (GARP) complex to a family of tethering complexes. Proc Natl Acad Sci U S A 107:14176\u201314181","journal-title":"Proc Natl Acad Sci U S A"},{"key":"586_CR33","doi-asserted-by":"publisher","first-page":"s16","DOI":"10.1016\/0303-8467(92)90010-Z","volume":"94s","author":"RP Bruyn","year":"1992","unstructured":"Bruyn RP (1992) The neuropathology of hereditary spastic paraparesis. Clin Neurol Neurosurg 94s:s16\u2013s18","journal-title":"Clin Neurol Neurosurg"},{"issue":"6170","key":"586_CR34","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1126\/science.1247363","volume":"343","author":"G Novarino","year":"2014","unstructured":"Novarino G, Fenstermaker AG, Zaki MS, Hofree M, Silhavy JL, Heiberg AD, Abdellateef M, Rosti B, Scott E, Mansour L, Masri A, Kayserili H, al-Aama JY, Abdel-Salam GMH, Karminejad A, Kara M, Kara B, Bozorgmehri B, Ben-Omran T, Mojahedi F, Mahmoud IGED, Bouslam N, Bouhouche A, Benomar A, Hanein S, Raymond L, Forlani S, Mascaro M, Selim L, Shehata N, al-Allawi N, Bindu PS, Azam M, Gunel M, Caglayan A, Bilguvar K, Tolun A, Issa MY, Schroth J, Spencer EG, Rosti RO, Akizu N, Vaux KK, Johansen A, Koh AA, Megahed H, Durr A, Brice A, Stevanin G, Gabriel SB, Ideker T, Gleeson JG (2014) Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Science. 343(6170):506\u2013511","journal-title":"Science."},{"issue":"12","key":"586_CR35","doi-asserted-by":"publisher","first-page":"5249","DOI":"10.1172\/JCI77598","volume":"124","author":"J Chang","year":"2014","unstructured":"Chang J, Lee S, Blackstone C (2014) Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation. J Clin Invest 124(12):5249\u20135262","journal-title":"J Clin Invest"},{"issue":"1","key":"586_CR36","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.ajhg.2013.05.006","volume":"93","author":"A Boukhris","year":"2013","unstructured":"Boukhris A, Schule R, Loureiro JL, Louren\u00e7o CM, Mundwiller E, Gonzalez MA, Charles P, Gauthier J, Rekik I, Acosta Lebrigio RF, Gaussen M, Speziani F, Ferbert A, Feki I, Caballero-Oteyza A, Dionne-Laporte A, Amri M, Noreau A, Forlani S, Cruz VT, Mochel F, Coutinho P, Dion P, Mhiri C, Schols L, Pouget J, Darios F, Rouleau GA, Marques W Jr, Brice A, Durr A, Zuchner S, Stevanin G (2013 Jul 11) Alteration of ganglioside biosynthesis responsible for complex hereditary spastic paraplegia. Am J Hum Genet 93(1):118\u2013123","journal-title":"Am J Hum Genet"},{"key":"586_CR37","doi-asserted-by":"publisher","first-page":"356","DOI":"10.3389\/fnmol.2017.00356","volume":"10","author":"JC Dodge","year":"2017","unstructured":"Dodge JC (2017) Lipid involvement in neurodegenerative diseases of the motor system: insights from lysosomal storage diseases. Front Mol Neurosci 10:356","journal-title":"Front Mol Neurosci"},{"issue":"2","key":"586_CR38","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/tra.12028","volume":"14","author":"J Hirst","year":"2013","unstructured":"Hirst J, Irving C, Borner GH (2013) Adaptor protein complexes AP-4 and AP-5: new players in endosomal trafficking and progressive spastic paraplegia. Traffic. 14(2):153\u2013164","journal-title":"Traffic."},{"key":"586_CR39","doi-asserted-by":"publisher","first-page":"12860","DOI":"10.1073\/pnas.1004756107","volume":"107","author":"FJ Perez-Victoria","year":"2010","unstructured":"Perez-Victoria FJ, Abascal-Palacios G, Tasc\u00f3n I, Kajava A, Magad\u00e1n JG, Pioro EP et al (2010) Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex. Proc Natl Acad Sci U S A 107:12860\u201312865","journal-title":"Proc Natl Acad Sci U S A"},{"key":"586_CR40","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s00438-013-0741-0","volume":"288","author":"JM Moser","year":"2013","unstructured":"Moser JM, Bigini P, Schmitt-John T (2013) The wobbler mouse, an ALS animal model. Mol Gen Genomics 288:207\u2013229","journal-title":"Mol Gen Genomics"},{"key":"586_CR41","first-page":"1723","volume":"139","author":"P Denora","year":"2016","unstructured":"Denora P, Smets K, Zolfanelli K, Ceuterick-de Groote C, Casali C, Deconinck T et al (2016) Motor neuron degeneration in spastic paraplegia 11 mimics amyotrophic lateral sclerosis lesions. Brain. 139:1723\u20131734","journal-title":"Brain."}],"container-title":["neurogenetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10048-019-00586-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10048-019-00586-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10048-019-00586-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T04:41:21Z","timestamp":1695098481000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10048-019-00586-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,16]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["586"],"URL":"https:\/\/doi.org\/10.1007\/s10048-019-00586-1","relation":{},"ISSN":["1364-6745","1364-6753"],"issn-type":[{"value":"1364-6745","type":"print"},{"value":"1364-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,16]]},"assertion":[{"value":"30 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All study protocols were reviewed and approved by the Institutional Review Board at the Tel Aviv Sourasky Medical Center.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}}]}}