{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T23:46:13Z","timestamp":1768779973777,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurogenetics"],"DOI":"10.1007\/s10048-024-00772-w","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T14:02:21Z","timestamp":1720447341000},"page":"367-375","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["TREK-1 channel as a therapeutic target for dexmedetomidine-mediated neuroprotection in cerebral ischemia"],"prefix":"10.1007","volume":"25","author":[{"given":"Yang","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"XiaoDan","family":"Teng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"772_CR1","first-page":"25","volume":"9","author":"X Zeng","year":"2022","unstructured":"Zeng X, Zhang YD, Ma RY, Chen YJ, Xiang XM, Hou DY et al (2022) Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1\/RIP3-exosome axis. Mil Med Res 9:25","journal-title":"Mil Med Res"},{"key":"772_CR2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.bbi.2020.12.009","volume":"92","author":"M Franke","year":"2021","unstructured":"Franke M, Bieber M, Kraft P, Weber ANR, Stoll G, Schuhmann MK (2021) The NLRP3 inflammasome drives inflammation in ischemia\/reperfusion injury after transient middle cerebral artery occlusion in mice. Brain Behav Immun 92:223\u2013233","journal-title":"Brain Behav Immun"},{"key":"772_CR3","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.jare.2021.01.016","volume":"33","author":"B Pan","year":"2021","unstructured":"Pan B, Sun J, Liu Z, Wang L, Huo H, Zhao Y et al (2021) Longxuetongluo Capsule protects against cerebral ischemia\/reperfusion injury through endoplasmic reticulum stress and MAPK-mediated mechanisms. J Adv Res 33:215\u2013225","journal-title":"J Adv Res"},{"key":"772_CR4","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/s12276-022-00734-y","volume":"54","author":"Q Xia","year":"2022","unstructured":"Xia Q, Zhan G, Mao M, Zhao Y, Li X (2022) TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury. Exp Mol Med 54:180\u2013193","journal-title":"Exp Mol Med"},{"key":"772_CR5","doi-asserted-by":"publisher","first-page":"116921","DOI":"10.1016\/j.lfs.2019.116921","volume":"236","author":"P Li","year":"2019","unstructured":"Li P, Zhang Y, Liu H (2019) The role of Wnt\/\u03b2-catenin pathway in the protection process by dexmedetomidine against cerebral ischemia\/reperfusion injury in rats. Life Sci 236:116921","journal-title":"Life Sci"},{"key":"772_CR6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s41419-019-1416-5","volume":"10","author":"YB Sun","year":"2019","unstructured":"Sun YB, Zhao H, Mu DL, Zhang W, Cui J, Wu L et al (2019) Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis. Cell Death Dis 10:167","journal-title":"Cell Death Dis"},{"key":"772_CR7","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.bpa.2020.10.002","volume":"35","author":"SR Tasbihgou","year":"2021","unstructured":"Tasbihgou SR, Barends CRM, Absalom AR (2021) The role of dexmedetomidine in neurosurgery. Best Pract Res Clin Anaesthesiol 35:221\u2013229","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"772_CR8","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.bbi.2020.10.008","volume":"91","author":"B Mei","year":"2021","unstructured":"Mei B, Li J, Zuo Z (2021) Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central \u03b12A adrenoceptor. Brain Behav Immun 91:296\u2013314","journal-title":"Brain Behav Immun"},{"key":"772_CR9","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1056\/NEJMoa2024922","volume":"384","author":"CG Hughes","year":"2021","unstructured":"Hughes CG, Mailloux PT, Devlin JW, Swan JT, Sanders RD, Anzueto A et al (2021) Dexmedetomidine or propofol for Sedation in mechanically ventilated adults with Sepsis. N Engl J Med 384:1424\u20131436","journal-title":"N Engl J Med"},{"key":"772_CR10","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1056\/NEJMoa1904710","volume":"380","author":"Y Shehabi","year":"2019","unstructured":"Shehabi Y, Howe BD, Bellomo R, Arabi YM, Bailey M, Bass FE et al (2019) Early Sedation with Dexmedetomidine in critically ill patients. N Engl J Med 380:2506\u20132517","journal-title":"N Engl J Med"},{"key":"772_CR11","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1017\/S0265021508004493","volume":"25","author":"K Kida","year":"2008","unstructured":"Kida K, Ohtani N, Shoji K, Yasui Y, Masaki E (2008) Postoperative pain status after intraoperative systemic dexmedetomidine and epidural neostigmine in patients undergoing lower abdominal surgery. Eur J Anaesthesiol 25:869\u2013875","journal-title":"Eur J Anaesthesiol"},{"key":"772_CR12","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.bja.2021.01.033","volume":"126","author":"JR Lee","year":"2021","unstructured":"Lee JR, Joseph B, Hofacer RD, Upton B, Lee SY, Ewing L et al (2021) Effect of dexmedetomidine on sevoflurane-induced neurodegeneration in neonatal rats. Br J Anaesth 126:1009\u20131021","journal-title":"Br J Anaesth"},{"key":"772_CR13","doi-asserted-by":"publisher","first-page":"7006","DOI":"10.1111\/ejn.15474","volume":"54","author":"K Unchiti","year":"2021","unstructured":"Unchiti K, Leurcharusmee P, Samerchua A, Pipanmekaporn T, Chattipakorn N, Chattipakorn SC (2021) The potential role of dexmedetomidine on neuroprotection and its possible mechanisms: evidence from in vitro and in vivo studies. Eur J Neurosci 54:7006\u20137047","journal-title":"Eur J Neurosci"},{"key":"772_CR14","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s00134-021-06356-8","volume":"47","author":"Y Shehabi","year":"2021","unstructured":"Shehabi Y, Serpa Neto A, Howe BD, Bellomo R, Arabi YM, Bailey M et al (2021) Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial. Intensive Care Med 47:455\u2013466","journal-title":"Intensive Care Med"},{"key":"772_CR15","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/j.tips.2022.09.007","volume":"43","author":"N Persson","year":"2022","unstructured":"Persson N, Uusalo P, Nedergaard M, Lohela TJ, Lilius TO (2022) Could dexmedetomidine be repurposed as a glymphatic enhancer? Trends Pharmacol Sci 43:1030\u20131040","journal-title":"Trends Pharmacol Sci"},{"key":"772_CR16","doi-asserted-by":"publisher","first-page":"108332","DOI":"10.1016\/j.intimp.2021.108332","volume":"101","author":"M Tian","year":"2021","unstructured":"Tian M, Wang W, Wang K, Jin P, Lenahan C, Wang Y et al (2021) Dexmedetomidine alleviates cognitive impairment by reducing blood-brain barrier interruption and neuroinflammation via regulating Th1\/Th2\/Th17 polarization in an experimental sepsis model of mice. Int Immunopharmacol 101:108332","journal-title":"Int Immunopharmacol"},{"key":"772_CR17","doi-asserted-by":"publisher","first-page":"116553","DOI":"10.1016\/j.lfs.2019.116553","volume":"235","author":"L Chen","year":"2019","unstructured":"Chen L, Cao J, Cao D, Wang M, Xiang H, Yang Y et al (2019) Protective effect of dexmedetomidine against diabetic hyperglycemia-exacerbated cerebral ischemia\/reperfusion injury: an in vivo and in vitro study. Life Sci 235:116553","journal-title":"Life Sci"},{"key":"772_CR18","doi-asserted-by":"publisher","first-page":"9556","DOI":"10.18632\/aging.102404","volume":"11","author":"M Zhai","year":"2019","unstructured":"Zhai M, Liu C, Li Y, Zhang P, Yu Z, Zhu H et al (2019) Dexmedetomidine inhibits neuronal apoptosis by inducing Sigma-1 receptor signaling in cerebral ischemia-reperfusion injury. Aging 11:9556\u20139568","journal-title":"Aging"},{"key":"772_CR19","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1186\/s12871-021-01423-5","volume":"21","author":"W Liu","year":"2021","unstructured":"Liu W, Shao C, Zang C, Sun J, Xu M, Wang Y (2021) Protective effects of dexmedetomidine on cerebral ischemia\/reperfusion injury via the microRNA-214\/ROCK1\/NF-\u03baB axis. BMC Anesthesiol 21:203","journal-title":"BMC Anesthesiol"},{"key":"772_CR20","doi-asserted-by":"publisher","first-page":"7834","DOI":"10.1002\/jcb.28058","volume":"120","author":"YQ Wang","year":"2019","unstructured":"Wang YQ, Tang YF, Yang MK, Huang XZ (2019) Dexmedetomidine alleviates cerebral ischemia-reperfusion injury in rats via inhibition of hypoxia-inducible factor-1\u03b1. J Cell Biochem 120:7834\u20137844","journal-title":"J Cell Biochem"},{"key":"772_CR21","doi-asserted-by":"crossref","unstructured":"Yu W, Lyu J, Jia L, Sheng M, Yu H, Du H (2020) Dexmedetomidine Ameliorates Hippocampus Injury and Cognitive Dysfunction Induced by Hepatic Ischemia\/Reperfusion by Activating SIRT3-Mediated Mitophagy and Inhibiting Activation of the NLRP3 Inflammasome in Young Rats. Oxid Med Cell Longev. ; 2020: 7385458","DOI":"10.1155\/2020\/7385458"},{"key":"772_CR22","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/bja\/aet338","volume":"113","author":"L Tong","year":"2014","unstructured":"Tong L, Cai M, Huang Y, Zhang H, Su B, Li Z et al (2014) Activation of K(2)P channel-TREK1 mediates the neuroprotection induced by sevoflurane preconditioning. Br J Anaesth 113:157\u2013167","journal-title":"Br J Anaesth"},{"key":"772_CR23","doi-asserted-by":"crossref","unstructured":"Fan J, Du J, Zhang Z, Shi W, Hu B, Hu J et al (2022) The Protective effects of Hydrogen Sulfide New Donor Methyl S-(4-Fluorobenzyl)-N-(3,4,5-Trimethoxybenzoyl)-l-Cysteinate on the ischemic stroke. Molecules ; 27","DOI":"10.3390\/molecules27051554"},{"key":"772_CR24","doi-asserted-by":"crossref","unstructured":"Sawicka M, Szymczak RK (2022) Paradoxical embolism to the central nervous system in a young Polish woman on a trek in the Himalayas. J Travel Med ; 29","DOI":"10.1093\/jtm\/taab110"},{"key":"772_CR25","doi-asserted-by":"publisher","first-page":"2684","DOI":"10.1038\/sj.emboj.7600234","volume":"23","author":"C Heurteaux","year":"2004","unstructured":"Heurteaux C, Guy N, Laigle C, Blondeau N, Duprat F, Mazzuca M et al (2004) TREK-1, a K\u2009+\u2009channel involved in neuroprotection and general anesthesia. EMBO J 23:2684\u20132695","journal-title":"EMBO J"},{"key":"772_CR26","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00011-021-01515-5","volume":"71","author":"N Wang","year":"2022","unstructured":"Wang N, Nie H, Zhang Y, Han H, Wang S, Liu W et al (2022) Dexmedetomidine exerts cerebral protective effects against cerebral ischemic injury by promoting the polarization of M2 microglia via the Nrf2\/HO-1\/NLRP3 pathway. Inflamm Res 71:93\u2013106","journal-title":"Inflamm Res"},{"key":"772_CR27","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1007\/s12035-020-02223-7","volume":"58","author":"H Lv","year":"2021","unstructured":"Lv H, Li Y, Cheng Q, Chen J, Chen W (2021) Neuroprotective effects against cerebral ischemic Injury exerted by Dexmedetomidine via the HDAC5\/NPAS4\/MDM2\/PSD-95 Axis. Mol Neurobiol 58:1990\u20132004","journal-title":"Mol Neurobiol"},{"key":"772_CR28","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1001\/jama.2017.2088","volume":"317","author":"Y Kawazoe","year":"2017","unstructured":"Kawazoe Y, Miyamoto K, Morimoto T, Yamamoto T, Fuke A, Hashimoto A et al (2017) Effect of Dexmedetomidine on Mortality and Ventilator-Free days in patients requiring mechanical ventilation with Sepsis: a Randomized Clinical Trial. JAMA 317:1321\u20131328","journal-title":"JAMA"},{"key":"772_CR29","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.bja.2018.04.046","volume":"121","author":"X Duan","year":"2018","unstructured":"Duan X, Coburn M, Rossaint R, Sanders RD, Waesberghe JV, Kowark A (2018) Efficacy of perioperative dexmedetomidine on postoperative delirium: systematic review and meta-analysis with trial sequential analysis of randomised controlled trials. Br J Anaesth 121:384\u2013397","journal-title":"Br J Anaesth"},{"key":"772_CR30","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1093\/bja\/aev226","volume":"115","author":"M Mahmoud","year":"2015","unstructured":"Mahmoud M, Mason KP (2015) Dexmedetomidine: review, update, and future considerations of paediatric perioperative and periprocedural applications and limitations. Br J Anaesth 115:171\u2013182","journal-title":"Br J Anaesth"},{"key":"772_CR31","doi-asserted-by":"publisher","first-page":"2209735","DOI":"10.1080\/07853890.2023.2209735","volume":"55","author":"Q Guo","year":"2023","unstructured":"Guo Q, Ma M, Yu H, Han Y, Zhang D (2023) Dexmedetomidine enables copper homeostasis in cerebral ischemia\/reperfusion via ferredoxin 1. Ann Med 55:2209735","journal-title":"Ann Med"},{"key":"772_CR32","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s10735-023-10120-1","volume":"54","author":"J Li","year":"2023","unstructured":"Li J, Wang K, Liu M, He J, Zhang H, Liu H (2023) Dexmedetomidine alleviates cerebral ischemia-reperfusion injury via inhibiting autophagy through PI3K\/Akt\/mTOR pathway. J Mol Histol 54:173\u2013181","journal-title":"J Mol Histol"},{"key":"772_CR33","first-page":"164","volume":"29","author":"J Lyu","year":"2023","unstructured":"Lyu J, Zhou Y, Zhang M, Tang L, Bao X, Sun Z et al (2023) Neuroprotective effect of Dexmedetomidine on Cerebral Ischemia-Reperfusion Injury in rats. Altern Ther Health Med 29:164\u2013169","journal-title":"Altern Ther Health Med"}],"container-title":["Neurogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10048-024-00772-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10048-024-00772-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10048-024-00772-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T11:05:00Z","timestamp":1730718300000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10048-024-00772-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,8]]},"references-count":33,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["772"],"URL":"https:\/\/doi.org\/10.1007\/s10048-024-00772-w","relation":{},"ISSN":["1364-6753"],"issn-type":[{"value":"1364-6753","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,8]]},"assertion":[{"value":"13 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures were performed in accordance with the regulations of the Ethical Committee for Research on Laboratory Animals, as assessed and approved by the Medical Ethics Committee of Harbin Medical University (Harbin, China), which complies with guidelines from the National In-stitutes of Health (USA).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}