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Healthy control MRI data were obtained from a previously approved study (Ethics Committee approval no. 2020\/787), and retrospective analysis of patient clinical, genetic, laboratory, and neuroimaging data was covered by Ethics Committee approval no. 2021\/162. Genetic analyses were performed as part of routine clinical diagnostic evaluation. All genetic analyses and neuroimaging scans of the patients reported here were performed as part of routine clinical diagnostic procedures, and written informed consent for the publication of anonymised clinical, imaging, and genetic data was obtained from the participants. 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