{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:50:43Z","timestamp":1769601043236,"version":"3.49.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T00:00:00Z","timestamp":1191283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1007\/s10067-007-0747-2","type":"journal-article","created":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T13:00:37Z","timestamp":1191243637000},"page":"565-572","source":"Crossref","is-referenced-by-count":15,"title":["Does low-dose and short-term glucocorticoids treatment increase the risk of osteoporosis in rheumatoid arthritis female patients?"],"prefix":"10.1007","volume":"27","author":[{"given":"Izabela","family":"Korczowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Olewicz-Gawlik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Trefler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Hrycaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Krzysztof \u0141\u0105cki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,10,2]]},"reference":[{"key":"747_CR1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/03009749409095198","volume":"23","author":"T Pincus","year":"1994","unstructured":"Pincus T (1994) Rheumatoid arthritis: a medical emergency? Scand J Rheumatol 23:21\u201330","journal-title":"Scand J Rheumatol"},{"key":"747_CR2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/art.1780370408","volume":"4","author":"F Wolfe","year":"1994","unstructured":"Wolfe F, Mitchell DM, Sibley JT, Fries JF, Bloch DA, Williams CA, Spitz PW, Haga M, Kleinhexel SM, Cathey MA (1994) The mortality of rheumatoid arthritis. Arthritis Rheum 4:481\u2013494","journal-title":"Arthritis Rheum"},{"key":"747_CR3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/ard.53.7.480-a","volume":"53","author":"JK \u0141\u0105cki","year":"1994","unstructured":"\u0141\u0105cki JK, Sobieska M, Leszczynski P, Wiktorowicz K (1994) Microheterogenity of alpha 1-acid glycoprotein in rheumatoid arthritis patients treated with methotrexate. Ann Rheum Dis 53:480","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"747_CR4","first-page":"193","volume":"23","author":"H Hamalainen","year":"2005","unstructured":"Hamalainen H, Kautiainen H, Kaarela K, Kotaniemi A (2005) The development of bone mineral density and the occurrence of osteoporosis from 15 to 20\u00a0years of disease onset in patients with rheumatoid arthritis. Clin Exp Rheumatol. 23(2):193\u2013198","journal-title":"Clin Exp Rheumatol."},{"key":"747_CR5","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/0002-9343(93)90218-E","volume":"94","author":"G Anon","year":"1993","unstructured":"Anon G (1993) Consensus development conference: diagnosis, prophilaxis, and treatment of osteoporosis. Am J Med 94:646\u2013650","journal-title":"Am J Med"},{"key":"747_CR6","unstructured":"Parfit AM (1983) The physiological and clinical significance of bone histomorphometric data. In: Recker R (ed) Bone histomorphometry, technics and interpretation. CRC Press, Boca Raton, pp 143\u2013223"},{"key":"747_CR7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1749-6632.1990.tb00178.x","volume":"587","author":"T Fujita","year":"1990","unstructured":"Fujita T, Matsui T, Nakao Y, Shiozawa S, Imai Y (1990) Cytokines and osteoporosis. Ann NY Acad Sci 587:371\u2013375","journal-title":"Ann NY Acad Sci"},{"key":"747_CR8","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1210\/edrv-7-4-379","volume":"7","author":"EF Eriksen","year":"1986","unstructured":"Eriksen EF (1986) Normal and pathological remodelling of human trabecular bone: three dimensional reconstruction of the remodelling sequence in normal and in metabolic bone disease. Endocrine Rev 7:379\u2013408","journal-title":"Endocrine Rev"},{"key":"747_CR9","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1002\/art.1780361105","volume":"36","author":"GM Hall","year":"1993","unstructured":"Hall GM, Spector TD, Griffin AJ, Jawad AS, Hall ML, Doyle DV (1993) The effect of rheumatoid arthritis and steroides therapy on bone density in postmenopausal women. Arthritis Rheum 36:1510\u20131516","journal-title":"Arthritis Rheum"},{"key":"747_CR10","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/clinchem\/45.8.1359","volume":"45","author":"NB Watts","year":"1999","unstructured":"Watts NB (1999) Clinical utility of biochemical markers of bone remodeling. Clin Chem 45:1359\u20131368","journal-title":"Clin Chem"},{"issue":"12","key":"747_CR11","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1002\/1529-0131(200112)44:12<2790::AID-ART466>3.0.CO;2-X","volume":"44","author":"KJ Armour","year":"2001","unstructured":"Armour KJ, Armour KE, van\u2019t Hof RJ, Reid DM, Wei XQ, Liew FY, Ralston SH (2001) Activation of the inducible nitric oxide synthase pathway to inflammation-induced osteoporosis by supressing bone formation and causing osteoblast apoptosis. Arthritis Rheum 44(12):2790\u20132796","journal-title":"Arthritis Rheum"},{"key":"747_CR12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF02030244","volume":"9","author":"H Rico","year":"1990","unstructured":"Rico H, Herandez ER, Gomez-Castresana F, Yague M, Cabranes JA, Valor R (1990) Osteopenia in rheumatoid arthritis: a biochemical, hormonal and histmorphometric study. Clin Rheumatol 9:63","journal-title":"Clin Rheumatol"},{"issue":"Suppl 3","key":"747_CR13","doi-asserted-by":"crossref","first-page":"S217","DOI":"10.1007\/BF03194376","volume":"7","author":"Y Suzuki","year":"1997","unstructured":"Suzuki Y, Mizushima Y (1997) Osteoporosis and rheumatoid arthritis. Osteoporosis Int 7(Suppl 3):S217\u201322","journal-title":"Osteoporosis Int"},{"issue":"2","key":"747_CR14","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10067-004-0989-1","volume":"24","author":"GS Habib","year":"2005","unstructured":"Habib GS, Haj S (2005) Bone mineral density in patients with early rheumatoid arthritis treated with corticosteroids. Clin Rheumatol 24(2):129\u2013133","journal-title":"Clin Rheumatol"},{"issue":"1","key":"747_CR15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00296-004-0496-3","volume":"26","author":"F Tascioglu","year":"2005","unstructured":"Tascioglu F, Colak O, Armagan O, Alatas O, Oner C (2005) The treatment of osteoporosis in patients with rheumatoid arthritis receiving glucocorticoids: a comparison of alendronate and intranasal salmon calcitonin. Rheumatol Int 26(1):21\u201329","journal-title":"Rheumatol Int"},{"issue":"3","key":"747_CR16","first-page":"508","volume":"33","author":"JF Roldan","year":"2006","unstructured":"Roldan JF, Del Rincon I, Escalante A (2006) Loss of cortical bone from the metacarpal diaphysis in patients with rheumatoid arthritis: independent effects of systemic inflammation and glucocorticoids. J Rheumatol 33(3):508\u2013516","journal-title":"J Rheumatol"},{"key":"747_CR17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF02030755","volume":"3","author":"OS Als","year":"1984","unstructured":"Als OS, Christiansen C, Hellesen C (1984) Prevelance of decreased bone mass in rheumatoid arthritis. Relation to anti-inflammatory treatment. Clin Rheumatol 3:201\u2013208","journal-title":"Clin Rheumatol"},{"key":"747_CR18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3109\/03009749309099266","volume":"22","author":"H Kroger","year":"1993","unstructured":"Kroger H, Penttila IM, Alhava EM (1993) Low serum vitamin D metabolites in women with rheumatoid arthritis. Scand J Rheumatol 22:172","journal-title":"Scand J Rheumatol"},{"key":"747_CR19","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1172\/JCI112234","volume":"76","author":"P Charles","year":"1985","unstructured":"Charles P, Poser JW, Mosekilde L, Jensen FT (1985) Estimation of bone turnover evaluated by 47 calcium kinetics: efficiency of serum bone gamma-carboxyglutamic acid containing protein, serum alkaline phosphatase and urinary hydroxyproline excertion. J Clin Invest 76:2254\u20132258","journal-title":"J Clin Invest"},{"key":"747_CR20","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1172\/JCI117595","volume":"94","author":"MB Goldring","year":"1994","unstructured":"Goldring MB, Birkhead JR, Suen LF, Yamin R, Mizuno S, G\u0142owacki J, Abiser JL, Apperley JF (1994) Interleukin-1 \u03b2-modulated gene expression in immortalized human chondrocytes. J Clin Invest 94:2307\u20132316","journal-title":"J Clin Invest"},{"key":"747_CR21","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0006-291X(86)80454-5","volume":"134","author":"J Bocquet","year":"1986","unstructured":"Bocquet J, Daireaux M, Langris M, Jouis V, Pujol JP, Beliard R, Loyau G (1986) Effect of a interleukin-1 like factor (mononuclear cell factor) on proteoglycan synthesis in cultured human articular chondrocytes. Biochem Biophys Res Commun 134:539\u2013549","journal-title":"Biochem Biophys Res Commun"},{"key":"747_CR22","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1172\/JCI113823","volume":"82","author":"MB Goldring","year":"1988","unstructured":"Goldring MB, Birkhead JR, Sandell LJ, Kimura T, Krane SM (1988) Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes. J Clin Invest 82:2026\u20132037","journal-title":"J Clin Invest"},{"key":"747_CR23","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.4049\/jimmunol.145.10.3297","volume":"145","author":"Y Ishimi","year":"1990","unstructured":"Ishimi Y, Miyaura C, Jin CH, Akashu T, Abe E, Nakamura Y, Yamaguchi A, Yoshiki S, Matsuda T, Hirano T, Kishimoto T, Suda T (1990) IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 145:3297\u20133303","journal-title":"J Immunol"},{"key":"747_CR24","first-page":"102","volume":"24","author":"SD Gertzbein","year":"1976","unstructured":"Gertzbein SD, Lance EM (1976) The stimulation of lymphocytes by chondrocytes in mixed cultures. Clin Exp Immunol 24:102\u2013109","journal-title":"Clin Exp Immunol"},{"key":"747_CR25","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/jbmr.5650050912","volume":"5","author":"SH Ralston","year":"1990","unstructured":"Ralston SH, Russell RG, Gowen M (1990) Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women. J Bone Miner Res 5:983\u2013988","journal-title":"J Bone Miner Res"},{"key":"747_CR26","doi-asserted-by":"crossref","first-page":"87S","DOI":"10.1016\/8756-3282(95)00185-G","volume":"17","author":"T Suda","year":"1995","unstructured":"Suda T, Udagawa N, Nakamura I, Miyaura C, Takahashi N (1995) Modulation of osteoclast differentiation by local factors. Bone 17:87S\u201391S","journal-title":"Bone"},{"key":"747_CR27","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2165\/00063030-200013060-00006","volume":"13","author":"JK \u0141\u0105cki","year":"2000","unstructured":"\u0141\u0105cki JK (2000) Management of the patients with severe refractory rheumatoid arthritis: are the never treatment options worth considering. BioDrugs 13:425\u2013435","journal-title":"BioDrugs"},{"key":"747_CR28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF01630483","volume":"44","author":"JK \u0141\u0105cki","year":"1995","unstructured":"\u0141\u0105cki JK, Klama K, Mackiewicz SH, Mackiewicz U, Muller W (1995) Circulating interleukin-10 and intrleukin-6 serum levels in rheumatoid arthritis patients treated with methotrexate or gold salts. Preliminary report. Inflamm Res 44:24\u201326","journal-title":"Inflamm Res"},{"key":"747_CR29","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/rheumatology\/38.9.841","volume":"38","author":"P Oelzner","year":"1999","unstructured":"Oelzner P, Franke S, Muller A, Hein G, Stein G (1999) Relationship between soluble markers of immune activation and bone turnover in postmenopausal woman with rheumatoid arthritis. Rheumatology Oxford 38:841\u2013847","journal-title":"Rheumatology Oxford"},{"key":"747_CR30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/rheumatology\/30.2.86","volume":"30","author":"RC Butler","year":"1991","unstructured":"Butler RC, Davie MW, Worsfold M, Sharp CA (1991) Bone mineral content in patients with rheumatoid arthritis: relationship to low dose steroid therapy. Br J Rheumatol 30:86\u201390","journal-title":"Br J Rheumatol"},{"key":"747_CR31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1365-2796.1993.tb00738.x","volume":"234","author":"T Olbright","year":"1993","unstructured":"Olbright T, Benker G (1993) Glucocorticosteroid induced osteoporosis: pathogenesis, prevention and treatment with special regard to the rheumatic diseases. J Int Med 234:237","journal-title":"J Int Med"},{"key":"747_CR32","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0049-0172(00)80011-6","volume":"4","author":"DJ Adachi","year":"2000","unstructured":"Adachi DJ, Olszynski W, Hanley DA, Hodsman AB, Kendler DL, Siminoski KG, Brown J, Cowden EA, Goltzman D, Ioannidis G, Josse RG, Ste-Marie LG, Tenenhouse AM, Davison KS, Blocka KLN, Pollock P, Sibley J (2000) Management of corticosteroid-induced osteoporosis. Sem Arthr Rheum 4:228\u2013251","journal-title":"Sem Arthr Rheum"},{"issue":"6","key":"747_CR33","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/S8756-3282(02)00737-8","volume":"30","author":"F McLaughlin","year":"2002","unstructured":"McLaughlin F, Mackintosh J, Hayes BP, McLaren A, Uings IJ, Salmon P, Humphreys J, Meldrum E, Farrow SN (2002) Glucocorticoid-induced osteopenia in the mouse as assessed by histomorphometry, microcomputed tomography, and biochemical markers. Bone 30(6):924\u2013930","journal-title":"Bone"},{"issue":"Suppl 1","key":"747_CR34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s003930070036","volume":"59","author":"R Westhovens","year":"2000","unstructured":"Westhovens R, Dequeker J (2000) Rheumatoid arthritis and osteoporosis. Z Rheumatol 59(Suppl 1):33\u201338","journal-title":"Z Rheumatol"},{"key":"747_CR35","first-page":"153","volume":"64","author":"B Cortet","year":"1997","unstructured":"Cortet B, Flipo RM, Pigny P, Duquesnoy B, Racadot A, Boersma A, Delcambre B (1997) How useful are bone turnover markers in rheumatoid arthritis? Rev-Rhum 64:153\u2013159","journal-title":"Rev-Rhum"},{"key":"747_CR36","first-page":"1282","volume":"25","author":"A Gough","year":"1998","unstructured":"Gough A, Sambrook P, Devlin J, Huissoon A, Njeh C, Nguyen T, Emery P (1998) Osteoclastic activation is the principial mechanism leading to secondary osteoporosis in rheumatoid arthritis. J Rheumatol 25:1282\u20131289","journal-title":"J Rheumatol"},{"key":"747_CR37","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1136\/ard.54.11.886","volume":"54","author":"M Hakala","year":"1995","unstructured":"Hakala M, Aman S, Luukkainen R, Risteli L, Kauppi M, Nieminen P, Risteli J (1995) Application of markers of collagen metabolism in serum and synovial fluid for assessment of disease process in patients with rheumatoid arthritis. Ann Rheum Dis 54:886\u2013890","journal-title":"Ann Rheum Dis"},{"key":"747_CR38","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/ard.52.5.338","volume":"52","author":"H Kroger","year":"1993","unstructured":"Kroger H, Risteli J, Risteli L, Penttila I, Alhava E (1993) Serum osteocalcin and carboxyterminal propeptide of type I procollagen in rheumatoid arthritis. Ann Rheum Dis 52:338","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"747_CR39","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s11926-002-0068-z","volume":"4","author":"KG Saag","year":"2002","unstructured":"Saag KG (2002) Glucocorticoid use in rheumatoid arthritis. Curr Rheumatol Rep 4(3):218\u201325","journal-title":"Curr Rheumatol Rep"},{"key":"747_CR40","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/rheumatology\/33.9.816","volume":"33","author":"G Kollerup","year":"1994","unstructured":"Kollerup G, Hansen M, Horslev-Peterson K (1994) Urinary hydroxypyridinium cross-links of collagen in rheumatoid arthritis. Relation to disease activity and effects of methylprednisolone. Br J Rheumatol 33:816\u2013820","journal-title":"Br J Rheumatol"},{"key":"747_CR41","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1749-6632.2002.tb04205.x","volume":"966","author":"JW Bijlsma","year":"2002","unstructured":"Bijlsma JW, Van Everdingen AA, Huisman M, De Nijs RN, Jacobs JW (2002) Glucocorticoids in rheumatoid arthritis: effects on erosions and bone. Ann N Y Acad Sci 966:82\u201390","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"747_CR42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-136-1-200201010-00006","volume":"136","author":"AA Everdingen van","year":"2002","unstructured":"van Everdingen AA, Jacobs JW, Siewertsz Van Reesema DR, Bijlsma JW (2002) Low-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficiacy, disease-modifying properties, and side effects: a randomized, double-blind, placebo-controlled clinical trial. Ann Intern Med 136(1):1\u201312","journal-title":"Ann Intern Med"},{"key":"747_CR43","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/rheumatology\/38.1.6","volume":"38","author":"RF Laan","year":"1999","unstructured":"Laan RF, Jansen TL, van Riel PL (1999) Glucocorticosteroides in the management of rheumatoid arthristis. Rheumatology 38:6","journal-title":"Rheumatology"},{"key":"747_CR44","first-page":"145","volume":"21","author":"AA Everdingen van","year":"2003","unstructured":"van Everdingen AA, Siewertsz Van Reesema DR, Jacobs JW, Bijlsma JW (2003) Low dose glucocorticoids in early rheumatoid arthritis: discordant effects on bone mineral density and fractures? Clin Exp Rheumatol 21:145\u2013147","journal-title":"Clin Exp Rheumatol"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-007-0747-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-007-0747-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-007-0747-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T08:48:39Z","timestamp":1684054119000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-007-0747-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,2]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["747"],"URL":"https:\/\/doi.org\/10.1007\/s10067-007-0747-2","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,2]]}}}