{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:23:49Z","timestamp":1791062629046,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T00:00:00Z","timestamp":1332979200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1007\/s10067-012-1972-x","type":"journal-article","created":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T01:42:51Z","timestamp":1332898971000},"page":"1059-1064","source":"Crossref","is-referenced-by-count":35,"title":["Increased serum levels of soluble CD163 in patients with scleroderma"],"prefix":"10.1007","volume":"31","author":[{"given":"Kazuhiro","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihide","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Yoshizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Kuwatsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihoko","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoi","family":"Takenaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,3,29]]},"reference":[{"key":"1972_CR1","doi-asserted-by":"crossref","first-page":"10514","DOI":"10.1016\/S0021-9258(19)86738-8","volume":"254","author":"AS Douvas","year":"1979","unstructured":"Douvas AS, Achten M, Tan EM (1979) Identification of a nuclear protein (Scl-70) as a unique target of human antinuclear antibodies in scleroderma. J Biol Chem 254:10514\u201310522","journal-title":"J Biol Chem"},{"key":"1972_CR2","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1073\/pnas.77.3.1627","volume":"77","author":"Y Moroi","year":"1980","unstructured":"Moroi Y, Peebles C, Fritzler MJ, Steigerwald J, Tan EM (1980) Autoantibody to centromere (kinetochore) in scleroderma sera. Proc Natl Acad Sci USA 77:1627\u20131631","journal-title":"Proc Natl Acad Sci USA"},{"key":"1972_CR3","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1172\/JCI116343","volume":"91","author":"M Kuwana","year":"1993","unstructured":"Kuwana M, Kaburaki J, Mimori T, Tojo T, Homma M (1993) Autoantibody reactive with three classes of RNA polymerases in sera from patients with systemic sclerosis. J Clin Invest 91:1399\u20131404","journal-title":"J Clin Invest"},{"key":"1972_CR4","first-page":"1477","volume":"21","author":"AL Herrick","year":"1994","unstructured":"Herrick AL, Rieley F, Schofield D, Hollis S, Braganza JM, Jayson MI (1994) Micronutrient antioxidant status in patients with primary Raynaud's phenomenon and systemic sclerosis. J Rheumatol 21:1477\u20131483","journal-title":"J Rheumatol"},{"key":"1972_CR5","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1002\/1529-0131(200111)44:11<2653::AID-ART445>3.0.CO;2-1","volume":"44","author":"P Sambo","year":"2001","unstructured":"Sambo P, Baroni SS, Luchetti M, Paroncini P, Dusi S, Orlandini G, Gabrielli A (2001) Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway. Arthritis Rheum 44:2653\u20132664","journal-title":"Arthritis Rheum"},{"key":"1972_CR6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000246083","volume":"194","author":"I Emerit","year":"1997","unstructured":"Emerit I, Filipe P, Meunier P, Auclair C, Freitas J, Deroussent A, Gouyette A, Fernandes A (1997) Clastogenic activity in the plasma of scleroderma patients: a biomarker of oxidative stress. Dermatology 194:140\u2013146","journal-title":"Dermatology"},{"key":"1972_CR7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0190-9622(93)70014-K","volume":"28","author":"DF Murrell","year":"1993","unstructured":"Murrell DF (1993) A radical proposal for the pathogenesis of scleroderma. J Am Acad Dermatol 28:78\u201385","journal-title":"J Am Acad Dermatol"},{"key":"1972_CR8","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1093\/rheumatology\/kel012","volume":"45","author":"F Ogawa","year":"2006","unstructured":"Ogawa F, Shimizu K, Muroi E, Hara T, Hasegawa M, Takehara K, Sato S (2006) Serum levels of 8-isoprostane, a marker of oxidative stress, are elevated in patients with systemic sclerosis. Rheumatology (Oxford) 45:815\u2013818","journal-title":"Rheumatology (Oxford)"},{"key":"1972_CR9","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1002\/eji.1830230940","volume":"23","author":"SK Law","year":"1993","unstructured":"Law SK, Micklem KJ, Shaw JM, Zhang XP, Dong Y, Willis AC, Mason DY (1993) A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily. Eur J Immunol 23:2320\u20132325","journal-title":"Eur J Immunol"},{"key":"1972_CR10","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1006\/cyto.2000.0720","volume":"12","author":"TH Sulahian","year":"2000","unstructured":"Sulahian TH, Hogger P, Wahner AE, Wardwell K, Goulding NJ, Sorg C, Droste A, Stehling M, Wallace PK, Morganelli PM, Guyre PM (2000) Human monocytes express CD163, which is upregulated by IL-10 and identical to p155. Cytokine 12:1312\u20131321","journal-title":"Cytokine"},{"key":"1972_CR11","doi-asserted-by":"crossref","first-page":"51561","DOI":"10.1074\/jbc.M409629200","volume":"279","author":"M Madsen","year":"2004","unstructured":"Madsen M, Moller HJ, Nielsen MJ, Jacobsen C, Graversen JH, van den Berg T, Moestrup SK (2004) Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region. J Biol Chem 279:51561\u201351567","journal-title":"J Biol Chem"},{"key":"1972_CR12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1161\/CIRCRESAHA.107.149435","volume":"101","author":"AP Levy","year":"2007","unstructured":"Levy AP, Purushothaman KR, Levy NS, Purushothaman M, Strauss M, Asleh R, Marsh S, Cohen O, Moestrup SK, Moller HJ, Zias EA, Benhayon D, Fuster V, Moreno PR (2007) Downregulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2\u20132 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability. Circ Res 101:106\u2013110","journal-title":"Circ Res"},{"key":"1972_CR13","first-page":"202","volume":"15","author":"EC LeRoy","year":"1988","unstructured":"LeRoy EC, Black C, Fleischmajer R, Jablonska S, Krieg T, Medsger TA Jr, Rowell N, Wollheim F (1988) Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 15:202\u2013205","journal-title":"J Rheumatol"},{"key":"1972_CR14","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJM197502132920706","volume":"292","author":"A Bohan","year":"1975","unstructured":"Bohan A, Peter JB (1975) Polymyositis and dermatomyositis (first of two parts). N Engl J Med 292:344\u2013347","journal-title":"N Engl J Med"},{"key":"1972_CR15","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/art.1780310207","volume":"31","author":"VD Steen","year":"1988","unstructured":"Steen VD, Powell DL, Medsger TA Jr (1988) Clinical correlations and prognosis based on serum autoantibodies in patients with systemic sclerosis. Arthritis Rheum 31:196\u2013203","journal-title":"Arthritis Rheum"},{"key":"1972_CR16","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/art.1780370313","volume":"37","author":"S Sato","year":"1994","unstructured":"Sato S, Ihn H, Kikuchi K, Takehara K (1994) Antihistone antibodies in systemic sclerosis. Association with pulmonary fibrosis. Arthritis Rheum 37:391\u2013394","journal-title":"Arthritis Rheum"},{"key":"1972_CR17","first-page":"281","volume":"25","author":"K Shimizu","year":"2007","unstructured":"Shimizu K, Ogawa F, Muroi E, Hara T, Komura K, Bae SJ, Sato S (2007) Increased serum levels of nitrotyrosine, a marker for peroxynitrite production, in systemic sclerosis. Clin Exp Rheumatol 25:281\u2013286","journal-title":"Clin Exp Rheumatol"},{"key":"1972_CR18","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/rheumatology\/40.4.406","volume":"40","author":"C Nishijima","year":"2001","unstructured":"Nishijima C, Sato S, Hasegawa M, Nagaoka T, Hirata A, Komatsu K, Takehara K (2001) Renal vascular damage in Japanese patients with systemic sclerosis. Rheumatology (Oxford) 40:406\u2013409","journal-title":"Rheumatology (Oxford)"},{"key":"1972_CR19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jneuroim.2007.04.016","volume":"187","author":"BO Fabriek","year":"2007","unstructured":"Fabriek BO, Moller HJ, Vloet RP, van Winsen LM, Hanemaaijer R, Teunissen CE, Uitdehaag BM, van den Berg TK, Dijkstra CD (2007) Proteolytic shedding of the macrophage scavenger receptor CD163 in multiple sclerosis. J Neuroimmunol 187:179\u2013186","journal-title":"J Neuroimmunol"},{"key":"1972_CR20","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jhep.2007.05.014","volume":"47","author":"HJ Moller","year":"2007","unstructured":"Moller HJ, Gronbaek H, Schiodt FV, Holland-Fischer P, Schilsky M, Munoz S, Hassanein T, Lee WM (2007) Soluble CD163 from activated macrophages predicts mortality in acute liver failure. J Hepatol 47:671\u2013676","journal-title":"J Hepatol"},{"key":"1972_CR21","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1002\/art.20174","volume":"50","author":"D Baeten","year":"2004","unstructured":"Baeten D, Moller HJ, Delanghe J, Veys EM, Moestrup SK, De Keyser F (2004) Association of CD163+ macrophages and local production of soluble CD163 with decreased lymphocyte activation in spondylarthropathy synovitis. Arthritis Rheum 50:1611\u20131623","journal-title":"Arthritis Rheum"},{"key":"1972_CR22","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/art.30213","volume":"63","author":"DJ Todd","year":"2011","unstructured":"Todd DJ, Knowlton N, Amato M, Frank MB, Schur PH, Izmailova ES, Roubenoff R, Shadick NA, Weinblatt ME, Centola M, Lee DM (2011) Erroneous augmentation of multiplex assay measurements in patients with rheumatoid arthritis due to heterophilic binding by serum rheumatoid factor. Arthritis Rheum 63:894\u2013903","journal-title":"Arthritis Rheum"},{"key":"1972_CR23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jim.2009.06.003","volume":"347","author":"AN Hoofnagle","year":"2009","unstructured":"Hoofnagle AN, Wener MH (2009) The fundamental flaws of immunoassays and potential solutions using tandem mass spectrometry. J Immunol Methods 347:3\u201311","journal-title":"J Immunol Methods"},{"key":"1972_CR24","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.clim.2005.07.009","volume":"117","author":"H Zhuang","year":"2005","unstructured":"Zhuang H, Narain S, Sobel E, Lee PY, Nacionales DC, Kelly KM, Richards HB, Segal M, Stewart C, Satoh M, Reeves WH (2005) Association of anti-nucleoprotein autoantibodies with upregulation of type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus. Clin Immunol 117:238\u2013250","journal-title":"Clin Immunol"},{"key":"1972_CR25","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/rheumatology\/37.12.1307","volume":"37","author":"S Ligier","year":"1998","unstructured":"Ligier S, Fortin PR, Newkirk MM (1998) A new antibody in rheumatoid arthritis targeting glycated IgG: IgM anti-IgG-AGE. Br J Rheumatol 37:1307\u20131314","journal-title":"Br J Rheumatol"},{"key":"1972_CR26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/096120339700600213","volume":"6","author":"L Casciola-Rosen","year":"1997","unstructured":"Casciola-Rosen L, Rosen A (1997) Ultraviolet light-induced keratinocyte apoptosis: a potential mechanism for the induction of skin lesions and autoantibody production in LE. Lupus 6:175\u2013180","journal-title":"Lupus"},{"key":"1972_CR27","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1084\/jem.185.1.71","volume":"185","author":"L Casciola-Rosen","year":"1997","unstructured":"Casciola-Rosen L, Wigley F, Rosen A (1997) Scleroderma autoantigens are uniquely fragmented by metal-catalyzed oxidation reactions: implications for pathogenesis. J Exp Med 185:71\u201379","journal-title":"J Exp Med"},{"key":"1972_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-197401000-00001","volume":"53","author":"PJ Cannon","year":"1974","unstructured":"Cannon PJ, Hassar M, Case DB, Casarella WJ, Sommers SC, LeRoy EC (1974) The relationship of hypertension and renal failure in scleroderma (progressive systemic sclerosis) to structural and functional abnormalities of the renal cortical circulation. Medicine (Baltimore) 53:1\u201346","journal-title":"Medicine (Baltimore)"},{"key":"1972_CR29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0165-6147(00)88968-3","volume":"16","author":"AR Butler","year":"1995","unstructured":"Butler AR, Flitney FW, Williams DL (1995) NO, nitrosonium ions, nitroxide ions, nitrosothiols and iron-nitrosyls in biology: a chemist's perspective. Trends Pharmacol Sci 16:18\u201322","journal-title":"Trends Pharmacol Sci"},{"key":"1972_CR30","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0008-6363(96)00109-5","volume":"32","author":"M Suematsu","year":"1996","unstructured":"Suematsu M, Wakabayashi Y, Ishimura Y (1996) Gaseous monoxides: a new class of microvascular regulator in the liver. Cardiovasc Res 32:679\u2013686","journal-title":"Cardiovasc Res"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-012-1972-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-012-1972-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-012-1972-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T04:29:17Z","timestamp":1641616157000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-012-1972-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,29]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["1972"],"URL":"https:\/\/doi.org\/10.1007\/s10067-012-1972-x","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,29]]}}}