{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:54:13Z","timestamp":1771480453049,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1007\/s10067-013-2334-z","type":"journal-article","created":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T19:42:56Z","timestamp":1374522176000},"page":"1743-1749","source":"Crossref","is-referenced-by-count":29,"title":["Profile of inflammatory mediators in tonsils of patients with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome"],"prefix":"10.1007","volume":"32","author":[{"given":"Patricia M.","family":"Valenzuela","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Araya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio I.","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximena","family":"Maul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constanza","family":"Beltr\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Talesnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,7,23]]},"reference":[{"key":"2334_CR1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0022-3476(87)80285-8","volume":"110","author":"GS Marshall","year":"1987","unstructured":"Marshall GS, Edwards KM, Butler J, Lawton AR (1987) Syndrome of periodic fever, pharyngitis and aphthous stomatitis. J Pediatr 110:43\u201346","journal-title":"J Pediatr"},{"key":"2334_CR2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/BOR.0b013e32833cc9cb","volume":"22","author":"R Caorsi","year":"2010","unstructured":"Caorsi R, Pelagatti MA, Federici S, Finetti M, Martini A, Gattorno M (2010) Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome. Curr Opin Rheumatol 22:579\u2013584","journal-title":"Curr Opin Rheumatol"},{"key":"2334_CR3","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0022-3476(99)70335-5","volume":"135","author":"S Padeh","year":"1999","unstructured":"Padeh S, Brezniak N, Zemer D, Pras E, Livneh A, Langevitz P et al (1999) Periodic fever, aphthous stomatitis, pharyngitis and adenopathy syndrome: clinical characteristics and outcome. J Pediatr 135:98\u2013101","journal-title":"J Pediatr"},{"key":"2334_CR4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0022-3476(99)70321-5","volume":"135","author":"KT Thomas","year":"1999","unstructured":"Thomas KT, Feder HM, Lawton AR, Edwards KM (1999) Periodic fever syndrome in children. J Pediatr 135:15\u201321","journal-title":"J Pediatr"},{"issue":"Suppl 1","key":"2334_CR5","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1007\/s10875-008-9178-3","volume":"28","author":"M Gattorno","year":"2008","unstructured":"Gattorno M, Federici S, Pelagatti MA, Caorsi R, Brisca G, Malattia C et al (2008) Diagnosis and management of autoinflammatory diseases in childhood. J Clin Immunol 28(Suppl 1):S73\u2013S83","journal-title":"J Clin Immunol"},{"key":"2334_CR6","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1651-2227.2009.01554.x","volume":"99","author":"HM Feder","year":"2010","unstructured":"Feder HM, Salazar JC (2010) A clinical review of 105 patients with PFAPA (a periodic fever syndrome). Acta Paediatr 99:178\u2013184","journal-title":"Acta Paediatr"},{"key":"2334_CR7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s100670050086","volume":"18","author":"WI Lee","year":"1999","unstructured":"Lee WI, Yang MH, Lee KF, Chen LC, Lin SJ, Yeh KW et al (1999) PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis, adenitis). Clin Rheumatol 18:207\u2013213","journal-title":"Clin Rheumatol"},{"key":"2334_CR8","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1136\/adc.2005.084731","volume":"91","author":"D Tasher","year":"2006","unstructured":"Tasher D, Somekh E, Dalal I (2006) PFAPA syndrome: new clinical aspects disclosed. Arch Dis Child 91:981\u2013984","journal-title":"Arch Dis Child"},{"key":"2334_CR9","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1111\/j.1651-2227.2007.00499.x","volume":"96","author":"J Forsvoll","year":"2007","unstructured":"Forsvoll J, Oymar K (2007) C-reactive protein in the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome. Acta Paediatr 96:1670\u20131673","journal-title":"Acta Paediatr"},{"key":"2334_CR10","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s10067-009-1222-z","volume":"28","author":"PM Valenzuela","year":"2009","unstructured":"Valenzuela PM, Majerson D, Tapia JL, Talesnik E (2009) Syndrome of periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) in siblings. Clin Rheumatol 28:1235\u20131237","journal-title":"Clin Rheumatol"},{"issue":"3","key":"2334_CR11","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/INF.0b013e31818c8ea5","volume":"28","author":"IC Sampio","year":"2009","unstructured":"Sampio IC, Rodrigo MJ, Monteiro J (2009) Two siblings with periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. Pediatr Infect Dis J 28(3):254\u2013255","journal-title":"Pediatr Infect Dis J"},{"issue":"12","key":"2334_CR12","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s00431-011-1479-5","volume":"170","author":"P Ant\u00f3n-Martin","year":"2011","unstructured":"Ant\u00f3n-Martin P, Ortiz R, Guill\u00e9n S, Allende LM, Cuesta MT, L\u00f3pez MF et al (2011) PFAPA syndrome in siblings. Is there a genetic background? Eur J Pediatr 170(12):1563\u20131568","journal-title":"Eur J Pediatr"},{"issue":"1","key":"2334_CR13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jpeds.2010.09.054","volume":"158","author":"M Adachi","year":"2011","unstructured":"Adachi M, Watanabe A, Nishiyama A, Oyazato Y, Kamioka I, Murase M et al (2011) Familial cases of periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis syndrome. J Pediatr 158(1):155\u2013159","journal-title":"J Pediatr"},{"key":"2334_CR14","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1093\/rheumatology\/keq187","volume":"49","author":"M Cochard","year":"2010","unstructured":"Cochard M, Clet J, Le L, Pillet P, Onrubia X, Gu\u00e9ron T et al (2010) PFAPA syndrome is not a sporadic disease. Rheumatology 49:1984\u20131987","journal-title":"Rheumatology"},{"issue":"2","key":"2334_CR15","first-page":"90","volume":"17","author":"S Stojanov","year":"2006","unstructured":"Stojanov S, Hoffmann F, K\u00e9ry A, Renner ED, Hartl D, Lohse P et al (2006) Cytokine profile in PFAPA syndrome suggests continuous inflammation and reduced anti-inflammatory response. Eur Cytokine Netw 17(2):90\u201397","journal-title":"Eur Cytokine Netw"},{"key":"2334_CR16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1471-2431-10-65","volume":"10","author":"KL Brown","year":"2010","unstructured":"Brown KL, Wekell P, Osla V, Sundqvist M, S\u00e4vman K, Fasth A et al (2010) Profile of blood cells and inflammatory mediators in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. BMC Pediatr 10:65. doi: 10.1186\/1471-2431-10-65","journal-title":"BMC Pediatr"},{"key":"2334_CR17","first-page":"939","volume":"110","author":"H Michiko","year":"2006","unstructured":"Michiko H, Shoki O, Hiroyuki M (2006) Analysis of perturbation of cytokine networks upon and around a febrile episode in a PFAPA syndrome patient. J Jpn Pediatr Soc 110:939\u2013944","journal-title":"J Jpn Pediatr Soc"},{"key":"2334_CR18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jpeds.2007.03.015","volume":"151","author":"M Renko","year":"2007","unstructured":"Renko M, Salo E, Putto-Laurila A, Saxen H, Mattila PS, Luotonen J et al (2007) A randomized, controlled trial of tonsillectomy in periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome. J Pediatr 151:289\u2013292","journal-title":"J Pediatr"},{"issue":"2","key":"2334_CR19","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jpeds.2009.02.038","volume":"155","author":"W Garavello","year":"2009","unstructured":"Garavello W, Romagnoli M, Gaini RM (2009) Effectiveness of adentonsillectomy in PFAPA syndrome: a randomized study. J Pediatr 155(2):250\u2013253","journal-title":"J Pediatr"},{"key":"2334_CR20","doi-asserted-by":"crossref","unstructured":"Burton MJ, Pollard AJ, Ramsden JD (2010) Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA). Cochrane database of systematic reviews. Issue 9. Art. No.:CD008669. doi: 10.1002\/14651858.CD008669","DOI":"10.1002\/14651858.CD008669"},{"issue":"2","key":"2334_CR21","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1001\/archoto.2007.7","volume":"134","author":"G Licameli","year":"2008","unstructured":"Licameli G, Jeffrey J, Luz J, Jones D, Kenna M (2008) Effect of adenotonsillectomy in PFAPA syndrome. Arch Otolaryngol Head Neck Surg 134(2):136\u2013140","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"1","key":"2334_CR22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1001\/archoto.2007.15","volume":"134","author":"KK Wong","year":"2008","unstructured":"Wong KK, Finlay JC, Moxham JP (2008) Role of tonsillectomy in PFAPA syndrome. Arch Otolaryngol Head Neck Surg 134(1):16\u201319","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"2334_CR23","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.rdc.2007.07.009","volume":"33","author":"S Padeh","year":"2007","unstructured":"Padeh S, Berkun Y (2007) Auto-inflammatory fever syndromes. Rheum Dis Clin N Am 33:585\u2013623","journal-title":"Rheum Dis Clin N Am"},{"key":"2334_CR24","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.pcl.2005.02.007","volume":"52","author":"S Long","year":"2005","unstructured":"Long S (2005) Distinguishing among prolonged, recurrent, and periodic fever syndromes: approach of a pediatric infectious diseases subspecialist. Pediatr Clin N Am 52:811\u2013835","journal-title":"Pediatr Clin N Am"},{"issue":"17","key":"2334_CR25","doi-asserted-by":"crossref","first-page":"7148","DOI":"10.1073\/pnas.1103681108","volume":"108","author":"S Stojanov","year":"2011","unstructured":"Stojanov S, Lapidus S, Chitkara P, Feder H, Salazar JC, Fleisher TA et al (2011) Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a disorder of innate immunity and Th1 activation responsive to IL-1 blockade. PNAS 108(17):7148\u20137153","journal-title":"PNAS"},{"key":"2334_CR26","first-page":"358","volume":"10","author":"S Padeh","year":"2008","unstructured":"Padeh S, Stoffman N, Berkun Y (2008) Periodic fever accompanied by aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA syndrome) in adults. IMAJ 10:358\u2013360","journal-title":"IMAJ"},{"issue":"6","key":"2334_CR27","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/archoto.2009.56","volume":"135","author":"L Pignataro","year":"2009","unstructured":"Pignataro L, Torretta S, Pietrogrande MC, Dellepiane R, Pavesi P, Bossi A, Drago L, Capaccio P (2009) Outcome of tonsillectomy in selected patients with PFAPA syndrome. Arch Otolaryngol Head Neck Surg 135(6):548\u2013555","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"2334_CR28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00403-007-0794-1","volume":"300","author":"A Akman","year":"2008","unstructured":"Akman A, Ekinci NC, Kacaroglu H, Yavuzer U, Alposy E, Yegin O (2008) Relationship between periodontal findings and specific polymorphisms of interleukin 1-alpha and interleukin-1beta in Turkish patients with Be\u00e7het's disease. Arch Dermatol Res 300:19\u201326","journal-title":"Arch Dermatol Res"},{"key":"2334_CR29","unstructured":"Kolly L, Busso N, von Scheven-Gete A, Bagnoud N, MSc, Moix I et al. (2012) Periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis syndrome is linked to dysregulated monocyte IL-1\u03b2 production. http:\/\/dx.doi.org\/ 10.1016\/j.jaci.2012.07.043"},{"key":"2334_CR30","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1126\/science.1201475","volume":"332","author":"D Wu","year":"2011","unstructured":"Wu D, Molofsky AB, Liang H-E, Ricardo-Gonzalez RR, Jouihan HA et al (2011) Eosinophils sustain alternatively activated macrophages associated with glucose homeostasis. Science 332:243\u2013347","journal-title":"Science"},{"key":"2334_CR31","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.4049\/jimmunol.172.4.2059","volume":"172","author":"L Chen","year":"2004","unstructured":"Chen L, Grabowski KA, Jun-ping X, Coleman J, Huang Z et al (2004) IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophils. J Immunol 172:2059\u20132066","journal-title":"J Immunol"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-013-2334-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-013-2334-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-013-2334-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T05:44:23Z","timestamp":1715751863000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-013-2334-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,23]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["2334"],"URL":"https:\/\/doi.org\/10.1007\/s10067-013-2334-z","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,23]]}}}