{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:39:00Z","timestamp":1791117540495,"version":"4.1.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T00:00:00Z","timestamp":1399939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s10067-014-2665-4","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T06:10:07Z","timestamp":1399875007000},"page":"1263-1271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Osteopontin circulating levels correlate with renal involvement in systemic lupus erythematosus and are lower in ACE inhibitor-treated patients"],"prefix":"10.1007","volume":"33","author":[{"given":"Marco","family":"Quaglia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Chiocchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Cena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Musetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Monti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nausicaa","family":"Clemente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Dianzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Magnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Stratta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,5,13]]},"reference":[{"issue":"2","key":"2665_CR1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.tcb.2005.12.005","volume":"16","author":"H Rangaswami","year":"2006","unstructured":"Rangaswami H, Bulbule A, Kundu GC (2006) Osteopontin: role in cell signaling and cancer progression. Trends Cell Biol 16(2):79\u201387","journal-title":"Trends Cell Biol"},{"issue":"3\u20134","key":"2665_CR2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12079-009-0068-0","volume":"3","author":"SA Lund","year":"2009","unstructured":"Lund SA, Giachelli CM, Scatena M (2009) The role of osteopontin in inflammatory processes. J Cell Commun Signal 3(3\u20134):311\u2013322","journal-title":"J Cell Commun Signal"},{"issue":"5","key":"2665_CR3","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1091\/mbc.5.5.565","volume":"5","author":"DR Senger","year":"1994","unstructured":"Senger DR, Perruzzi CA, Papadopoulos-Sergiou A, Van de Water L (1994) Adhesive properties of osteopontin: regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain. Mol Biol Cell 5(5):565\u2013574","journal-title":"Mol Biol Cell"},{"issue":"4","key":"2665_CR4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1050-1738(00)00055-4","volume":"10","author":"Y Yokasaki","year":"2000","unstructured":"Yokasaki Y, Sheppard D (2000) Mapping of the cryptic integrin-binding site in osteopontin suggests a new mechanism by which thrombin can regulate inflammation and tissue repair. Trends Cardiovasc Med 10(4):155\u2013159","journal-title":"Trends Cardiovasc Med"},{"issue":"5","key":"2665_CR5","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1074\/jbc.M112.362954","volume":"288","author":"Y Yamaguchi","year":"2013","unstructured":"Yamaguchi Y, Shao Z, Sharif S, Du XY et al (2013) Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage. J Biol Chem 288(5):3097\u20133111","journal-title":"J Biol Chem"},{"issue":"8","key":"2665_CR6","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1161\/ATVBAHA.111.230011","volume":"31","author":"JS Shao","year":"2011","unstructured":"Shao JS, Sierra OL, Cohen R, Mecham RP et al (2011) Vascular calcification and aortic fibrosis: a bifunctional role for osteopontin in diabetic arteriosclerosis. Arterioscler Thromb Vasc Biol 31(8):1821\u20131833","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"2665_CR7","doi-asserted-by":"crossref","first-page":"650","DOI":"10.4012\/dmj.23.650","volume":"23","author":"Y Hamada","year":"2004","unstructured":"Hamada Y, Yuki K, Okazaki M, Fujitani W et al (2004) Osteopontin-derived peptide SVVYGLR induces angiogenesis in vivo. Dent Mater J 23(4):650\u2013655","journal-title":"Dent Mater J"},{"key":"2665_CR8","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/jlb.60.4.540","volume":"60","author":"SW Krause","year":"1996","unstructured":"Krause SW, Rehli M, Kreutz M, Schwarzfischer L et al (1996) Differential screening identifies genetic markers of monocyte to macrophage maturation. J Leukoc Biol 60:540\u2013545","journal-title":"J Leukoc Biol"},{"key":"2665_CR9","doi-asserted-by":"crossref","first-page":"17101","DOI":"10.1073\/pnas.0508666102","volume":"102","author":"ML Shinohara","year":"2005","unstructured":"Shinohara ML, Jansson M, Hwang ES, Werneck MB et al (2005) T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc Natl Acad Sci U S A 102:17101\u201317106","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2665_CR10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1128\/CDLI.12.1.206-212.2005","volume":"12","author":"K Kawamura","year":"2005","unstructured":"Kawamura K, Iyonaga K, Ichiyasu H, Nagano J et al (2005) Differentiation, maturation, and survival of dendritic cells by osteopontin regulation. Clin Diagn Lab Immunol 12:206\u2013212","journal-title":"Clin Diagn Lab Immunol"},{"key":"2665_CR11","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1073\/pnas.0914902107","volume":"107","author":"A Triantafyllopoulou","year":"2010","unstructured":"Triantafyllopoulou A, Franzke CW, Seshan SV, Perino G et al (2010) Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages. Proc Natl Acad Sci U S A 107:3012\u20133017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2665_CR12","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1681\/ASN.2007040486","volume":"19","author":"J Lorenzen","year":"2008","unstructured":"Lorenzen J, Shah R, Biser A, Staicu S et al (2008) The role of osteopontin in the development of albuminuria. J Am Soc Nephrol 19(5):884\u2013890","journal-title":"J Am Soc Nephrol"},{"key":"2665_CR13","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1172\/JCI12980","volume":"107","author":"DT Denhardt","year":"2001","unstructured":"Denhardt DT, Noda M, O\u2019Regan AW et al (2001) Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling and cell survival. J Clin Invest 107:1055\u20131061","journal-title":"J Clin Invest"},{"key":"2665_CR14","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/ATVBAHA.107.144824","volume":"27","author":"M Scatena","year":"2007","unstructured":"Scatena M, Liaw L, Giachelli CM (2007) Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease. Arterioscler Thromb Vasc Biol 27:2302\u20132309","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2665_CR15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0021-9150(03)00298-3","volume":"170","author":"R Ohmori","year":"2003","unstructured":"Ohmori R, Momiyama Y, Taniguchi H et al (2003) Plasma osteopontin levels are associated with the presence and extent of coronary artery disease. Atherosclerosis 170:333\u2013337","journal-title":"Atherosclerosis"},{"issue":"2","key":"2665_CR16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1055\/s-0030-1251504","volume":"36","author":"K Kingel","year":"2010","unstructured":"Kingel K, Kandolf R (2010) Osteopontin: a biomarker to predict the outcome of inflammatory heart disease. Semin Thromb Hemost 36(2):195\u2013202","journal-title":"Semin Thromb Hemost"},{"key":"2665_CR17","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-3083.2007.01908.x","volume":"65","author":"J Agnholt","year":"2007","unstructured":"Agnholt J, Kelsen J, Schack L et al (2007) Osteopontin, a protein with cytokine like properties, is associated with inflammation in Crohn\u2019s disease. Scand J Immunol 65:453\u2013460","journal-title":"Scand J Immunol"},{"issue":"4","key":"2665_CR18","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1182\/blood-2003-05-1748","volume":"103","author":"A Chiocchetti","year":"2004","unstructured":"Chiocchetti A, Indelicato M, Bensi T et al (2004) High levels of osteopontin associated with polymorphisms in its gene are a risk factor for development of autoimmunity\/lymphoproliferation. Blood 103(4):1376\u20131382","journal-title":"Blood"},{"issue":"2","key":"2665_CR19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/art.20808","volume":"52","author":"S D\u2019alfonso","year":"2005","unstructured":"D\u2019alfonso S, Barizzone N, Giordano M et al (2005) Two single-nucleotide polymorphisms in the 5\u2032 and 3\u2032 ends of the osteopontin gene contribute to susceptibility to systemic lupus erythematosus. Arthirtis Rheumatol 52(2):539\u2013547","journal-title":"Arthirtis Rheumatol"},{"key":"2665_CR20","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/rheumatology\/keh558","volume":"44","author":"CK Wong","year":"2005","unstructured":"Wong CK, Lit LCW, Tam SL et al (2005) Elevation of plasma osteopontin concentration is correlated with disease activity in patients with systemic lupus erythematosus. Rheumatology 44:602\u2013606","journal-title":"Rheumatology"},{"key":"2665_CR21","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1084\/jem.172.4.1177","volume":"172","author":"R Patarca","year":"1990","unstructured":"Patarca R, Wei FY, Singh P, Morasso MI et al (1990) Dysregulated expression of the T cell cytokine Eta-1 in CD4-8- lymphocytes during the development of murine autoimmune disease. J Exp Med 172:1177\u20131183","journal-title":"J Exp Med"},{"issue":"3","key":"2665_CR22","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1681\/ASN.V103444","volume":"10","author":"KL Hudkins","year":"1999","unstructured":"Hudkins KL, Giachelli CM, Cui Y, Couser WG et al (1999) Osteopontin expression in fetal and mature human kidney. J Am Soc Nephrol 10(3):444\u2013457","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"2665_CR23","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1159\/000319490","volume":"32","author":"C Zhou","year":"2010","unstructured":"Zhou C, Wu J, Torres L, Hicks JM et al (2010) Blockade of osteopontin inhibits glomerular fibrosis in a model of anti-glomerular basement membrane glomerulonephritis. Am J Nephrol 32(4):324\u2013331","journal-title":"Am J Nephrol"},{"issue":"4","key":"2665_CR24","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1365-2362.2010.02271.x","volume":"40","author":"J Lorenzen","year":"2010","unstructured":"Lorenzen J, Kr\u00e4mer R, Kliem V et al (2010) Circulating levels of osteopontin are closely related to glomerular filtration rate and cardiovascular risk markers in patients with chronic kidney disease. Eur J Clin Investig 40(4):294\u2013300","journal-title":"Eur J Clin Investig"},{"issue":"5","key":"2665_CR25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1507\/endocrj.51.499","volume":"51","author":"H Yamaguchi","year":"2004","unstructured":"Yamaguchi H, Igarashi M, Hirata A et al (2004) Progression of diabetic nephropathy enhances the plasma osteopontin level in type 2 diabetic patients. Endocr J 51(5):499\u2013504","journal-title":"Endocr J"},{"key":"2665_CR26","first-page":"9","volume":"29","author":"X Yan","year":"2010","unstructured":"Yan X, Sano M, Lu L et al (2010) Plasma concentrations of osteopontin, but not thrombin-cleaved osteopontin, are associated with the presence and severity of nephropathy and coronary artery disease in patients with type 2 diabetes mellitus. Cardiovasc Diabetol 29:9\u201370","journal-title":"Cardiovasc Diabetol"},{"key":"2665_CR27","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1136\/ard.2009.113621","volume":"69","author":"J Lorenzen","year":"2010","unstructured":"Lorenzen J, Svjetlana L, Kr\u00e4mer R et al (2010) Osteopontin in antineutrophil cytoplasmic autoantibody-associated vasculitis: relation to disease activity, organ manifestation and immunosuppressive therapy. Ann Rheum Dis 69:1169\u20131171","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"2665_CR28","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1053\/ajkd.2000.9790","volume":"36","author":"H Okada","year":"2000","unstructured":"Okada H, Moriwaki K, Konishi K et al (2000) Tubular osteopontin expression in human glomerulonephritis and renal vasculitis. Am J Kidney Dis 36(3):498\u2013506","journal-title":"Am J Kidney Dis"},{"issue":"12","key":"2665_CR29","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1681\/ASN.2012040390","volume":"23","author":"P Ruggenenti","year":"2012","unstructured":"Ruggenenti P, Cravedi P, Remuzzi G (2012) Mechanisms and treatment of CKD. J Am Soc Nephrol 23(12):1917\u20131928","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"2665_CR30","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1046\/j.1523-1755.2001.00032.x","volume":"60","author":"Y Xie","year":"2001","unstructured":"Xie Y, Sakatsume M, Nishi S et al (2001) Expression, roles, receptors, and regulation of osteopontin in the kidney. Kidney Int 60(5):1645\u20131657","journal-title":"Kidney Int"},{"key":"2665_CR31","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/path.1856","volume":"207","author":"AB Kramer","year":"2005","unstructured":"Kramer AB, Ricardo SD, Kelly DJ et al (2005) Modulation of osteopontin in proteinuria-induced renal interstitial fibrosis. J Pathol 207:483\u2013492","journal-title":"J Pathol"},{"issue":"9","key":"2665_CR32","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/art.1780400928","volume":"40","author":"MC Hochberg","year":"1997","unstructured":"Hochberg MC, for the Diagnostic and Therapeutic Criteria Committee of the American College of Rheumatology (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40(9):1725","journal-title":"Arthritis Rheum"},{"key":"2665_CR33","unstructured":"National Kidney Foundation (2011) http:\/\/www.kidney.org\/professionals\/kdoqi\/guidelines.cfm . Accessed 29 Jun 2011"},{"issue":"11","key":"2665_CR34","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1002\/acr.20572","volume":"63","author":"J Romero-Diaz","year":"2011","unstructured":"Romero-Diaz J, Isenberg D, Ramsey-Goldman R (2011) Measures of adult systemic lupus erythematosus: updated version of British Isles Lupus Assessment Group (BILAG 2004), European Consensus Lupus Activity Measurements (ECLAM), Systemic Lupus Activity Measure, Revised (SLAM-R), Systemic Lupus Activity Questionnaire for Population Studies (SLAQ), Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K), and Systemic Lupus International Collaborating Clinics\/American College of Rheumatology Damage Index (SDI). Arthritis Care Res (Hoboken) 63(11):S37\u2013S46","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"2","key":"2665_CR35","first-page":"373","volume":"27","author":"DD Gladman","year":"2000","unstructured":"Gladman DD, Goldsmith CH, Urowitz MB, Bacon P et al (2000) The Systemic Lupus International Collaborating Clinics\/American College of Rheumatology (SLICC\/ACR) Damage Index for Systemic Lupus Erythematosus International Comparison. J Rheumatol 27(2):373\u2013376","journal-title":"J Rheumatol"},{"issue":"7","key":"2665_CR36","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/ki.2009.518","volume":"77","author":"SB Nicholas","year":"2010","unstructured":"Nicholas SB, Liu J, Kim J et al (2010) Critical role for osteopontin in diabetic nephropathy. Kidney Int 77(7):588\u2013600","journal-title":"Kidney Int"},{"issue":"2","key":"2665_CR37","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cyto.2010.03.020","volume":"51","author":"LF Congote","year":"2010","unstructured":"Congote LF, Sadyakassova G, Dobocan MC et al (2010) Erythropoietin-dependent endothelial proteins: potential use against erythropoietin resistance. Cytokine 51(2):113\u2013118","journal-title":"Cytokine"},{"issue":"1","key":"2665_CR38","doi-asserted-by":"crossref","first-page":"R18","DOI":"10.1186\/ar4150","volume":"15","author":"OJ Rullo","year":"2013","unstructured":"Rullo OJ, Woo JM, Parsa MF, Hoftman AD et al (2013) Plasma levels of osteopontin identify patients at risk for organ damage in systemic lupus erythematosus. Arthritis Res Ther 15(1):R18","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"2665_CR39","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/0003319708314250","volume":"60","author":"M Koshikawa","year":"2009","unstructured":"Koshikawa M, Aizawa K, Kasai H et al (2009) Elevated osteopontin levels in patients with peripheral arterial disease. Angiology 60(1):42\u201345","journal-title":"Angiology"},{"issue":"3","key":"2665_CR40","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2165\/11589400-000000000-00000","volume":"11","author":"E Cangiano","year":"2011","unstructured":"Cangiano E, Marchesini J, Campo G et al (2011) ACE inhibition modulates endothelial apoptosis and renewal via endothelial progenitor cells in patients with acute coronary syndromes. Am J Cardiovasc Drugs 11(3):189\u2013198","journal-title":"Am J Cardiovasc Drugs"},{"issue":"3","key":"2665_CR41","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1254\/jphs.FP0050056","volume":"98","author":"T Kusuyama","year":"2005","unstructured":"Kusuyama T, Yoshiyama M, Omura T et al (2005) Angiotensin blockade inhibits osteopontin expression in non-infarcted myocardium after myocardial infarction. J Pharmacol Sci 98(3):283\u2013289","journal-title":"J Pharmacol Sci"},{"issue":"2","key":"2665_CR42","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3109\/10641963.2010.496521","volume":"33","author":"F Nemati","year":"2011","unstructured":"Nemati F, Rahbar-Roshandel N, Hosseini F et al (2011) Anti-inflammatory effects of anti-hypertensive agents: influence on interleukin-1\u03b2 secretion by peripheral blood polymorphonuclear leukocytes from patients with essential hypertension. Clin Exp Hypertens 33(2):66\u201376","journal-title":"Clin Exp Hypertens"},{"issue":"4","key":"2665_CR43","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1046\/j.1523-1755.2000.00309.x","volume":"58","author":"XQ Yu","year":"2000","unstructured":"Yu XQ, Wu LL, Huang XR et al (2000) Osteopontin expression in progressive renal injury in remnant kidney: role of angiotensin II. Kidney Int 58(4):1469\u20131480","journal-title":"Kidney Int"},{"issue":"2","key":"2665_CR44","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1046\/j.1523-1755.2003.00751.x","volume":"63","author":"C Li","year":"2003","unstructured":"Li C, Yang CW, Park CW et al (2003) Long-term treatment with Ramipril attenuates renal osteopontin expression in diabetic rats. Kidney Int 63(2):454\u2013463","journal-title":"Kidney Int"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-014-2665-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-014-2665-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-014-2665-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T12:13:13Z","timestamp":1648987993000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-014-2665-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,13]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["2665"],"URL":"https:\/\/doi.org\/10.1007\/s10067-014-2665-4","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,13]]}}}