{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:45:31Z","timestamp":1792626331009,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T00:00:00Z","timestamp":1415750400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s10067-014-2809-6","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T16:36:37Z","timestamp":1415982997000},"page":"1263-1270","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hyaluronic acid and glucosamine sulfate for adult Kashin-Beck disease: a cluster-randomized, placebo-controlled study"],"prefix":"10.1007","volume":"35","author":[{"given":"Chuan-tao","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-fang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-ling","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,12]]},"reference":[{"key":"2809_CR1","first-page":"343","volume":"89","author":"L Sokoloff","year":"1989","unstructured":"Sokoloff L (1989) The history of Kashin-Beck disease. N Y State J Med 89:343\u2013351","journal-title":"N Y State J Med"},{"key":"2809_CR2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s002640000177","volume":"25","author":"M Hinsenkamp","year":"2001","unstructured":"Hinsenkamp M (2001) Kashin-Beck disease. Int Orthop 25:133\u2013133","journal-title":"Int Orthop"},{"key":"2809_CR3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0889-857X(21)00824-3","volume":"13","author":"L Sokoloff","year":"1989","unstructured":"Sokoloff L (1989) Kashin-Beck disease. Rheum Dis Clin North Am 13:101\u2013104","journal-title":"Rheum Dis Clin North Am"},{"key":"2809_CR4","unstructured":"Chinese Health Statistical Digest (2010) http:\/\/www.chinacdc.cn\/tjsj\/gjwstjsj\/201206\/ W020120608368277572334.pdf. (in Chinese)"},{"key":"2809_CR5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1385\/BTER:77:3:193","volume":"77","author":"X Peng","year":"2000","unstructured":"Peng X, Lingxia Z, Schrauzer GN, Xiong G (2000) Selenium, boron, and germanium deficiency in the etiology of Kashin-Beck disease. Biol Trace Elem Res 77:193\u2013197","journal-title":"Biol Trace Elem Res"},{"key":"2809_CR6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s002640100248","volume":"25","author":"G Xiong","year":"2001","unstructured":"Xiong G (2001) Diagnostic, clinical and radiological characteristics of Kashin-Beck disease in Shaanxi Province, PR China. Int Orthop 25:147\u2013150","journal-title":"Int Orthop"},{"key":"2809_CR7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s002640050139","volume":"21","author":"F Mathieu","year":"1997","unstructured":"Mathieu F, Begaux F, Lan ZY, Suetens C, Hinsenkamp (1997) Clinical manifestations of Kashin-Beck disease in Nyemo valley, Tibet. Int Orthop 21:151\u2013156","journal-title":"Int Orthop"},{"key":"2809_CR8","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s002640000192","volume":"25","author":"F Mathieu","year":"2001","unstructured":"Mathieu F, Begaux F, Suetens C, De Maertelaer V, Hinsenkamp M (2001) Anthropometry and clinical features of Kashin-Beck disease in central Tibet. Int Orthop 25:138\u2013141","journal-title":"Int Orthop"},{"key":"2809_CR9","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s00264-010-1062-0","volume":"35","author":"R Luo","year":"2011","unstructured":"Luo R, Liu G, Liu W, Pei F, Zhou Z, Li J et al (2011) Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck Disease (KBD) patients. Int 0rthop 35:1409\u20131414","journal-title":"Int 0rthop"},{"key":"2809_CR10","first-page":"591","volume":"23","author":"XG Cao","year":"2004","unstructured":"Cao XG, Lu XY, Xu GY, Zhang BD, Liu Q, Jiao SQ (2004) Clinical observation of therapeutic effect of three of medicine on Kashin-Beck disease. Chin J Endemiol 23:591\u2013592 (in Chinese)","journal-title":"Chin J Endemiol"},{"key":"2809_CR11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/RHU.0b013e31823e3a3b","volume":"18","author":"W Liu","year":"2012","unstructured":"Liu W, Liu G, Pei F, Liu Y, Zhou Z, Li J et al (2012) Kashin-Beck Disease in Sichuan, China: report of a pilot open therapeutic trial JCR. J Clin Rheumatol 18:8\u201314","journal-title":"J Clin Rheumatol"},{"key":"2809_CR12","first-page":"371","volume":"15","author":"ZM Tu","year":"2009","unstructured":"Tu ZM, Yang LG, Zhou JF, Gao DL, Dong S, Xie JJ et al (2009) Comparison of treatment results of arthroscopic knee debridement alone with a combination of arthroscopic debridement and drilling decompression in knee Kaschin-Beck disease. Chin J Endo 15:371\u2013374 (in chinese)","journal-title":"Chin J Endo"},{"key":"2809_CR13","first-page":"459","volume":"4","author":"LG Yang","year":"2009","unstructured":"Yang LG, Tu ZM, Zhou JF, Gao DL, Dong S, Ren JL et al (2009) Surgical treatment on the adult Kaschin-Beck disease. Chin J Joint Surg 4:459\u2013462 (in Chinese)","journal-title":"Chin J Joint Surg"},{"key":"2809_CR14","doi-asserted-by":"crossref","unstructured":"Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G (2006) Viscosupplementation for the treatment of osteoarthritis of the knee (Review). Cochrane Database Syst Rev","DOI":"10.1002\/14651858.CD005321.pub2"},{"key":"2809_CR15","doi-asserted-by":"crossref","first-page":"538","DOI":"10.2106\/00004623-200403000-00012","volume":"86","author":"CT Wang","year":"2004","unstructured":"Wang CT, Lin J, Chang CJ, Lin YT, Hou SM (2004) Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. A meta-analysis of randomized controlled trials. JBJS 86:538\u2013545","journal-title":"JBJS"},{"key":"2809_CR16","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.joca.2010.09.014","volume":"19","author":"RR Bannuru","year":"2011","unstructured":"Bannuru RR, Natov NS, Dasi UR, Schmid CH, McAlindon TE (2011) Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis: meta-analysis. Osteoarthritis Cartilage 19:611\u2013619","journal-title":"Osteoarthritis Cartilage"},{"key":"2809_CR17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4137\/CMAMD.S12743","volume":"6","author":"LE Miller","year":"2013","unstructured":"Miller LE, Block JE (2013) US-approved intra-articular hyaluronic acid injections are safe and effective in patients with knee osteoarthritis: systematic review and meta-analysis of randomized, saline-controlled trials. Clin Med Insights Arthritis Musculoskelet Disord 6:57\u201363","journal-title":"Clin Med Insights Arthritis Musculoskelet Disord"},{"key":"2809_CR18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0140-6736(00)03610-2","volume":"357","author":"JY Reginster","year":"2001","unstructured":"Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere et al (2001) Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. The Lancet 357:251\u2013256","journal-title":"The Lancet"},{"key":"2809_CR19","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1001\/jama.283.11.1469","volume":"283","author":"TE McAlindon","year":"2000","unstructured":"McAlindon TE, LaValley MP, Gulin JP, Felson DT (2000) Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. Jama 283:1469\u20131475","journal-title":"Jama"},{"key":"2809_CR20","first-page":"18","volume":"3","author":"CS Chen","year":"1991","unstructured":"Chen CS, Liang ST (1991) An analysis of striking decrease of Kashin-Beck disease prevalence in Yongshou County, Shaanxi Province. Endemic Dis Bull 3:18\u201318 (in Chinese)","journal-title":"Endemic Dis Bull"},{"key":"2809_CR21","unstructured":"Diagnostic criteria of Kashin-Beck disease. http:\/\/www.moh.gov.cn\/zwgkzt\/s9500\/201212\/ 34063.shtml. (in Chinese)"},{"key":"2809_CR22","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.joca.2008.06.011","volume":"17","author":"K Zhou","year":"2009","unstructured":"Zhou K, Liu G, Wu T, Du L (2009) Selenium for preventing Kashin-Beck osteoarthropathy in children: a meta-analysis. Osteoarthritis Cartilage 17:144\u2013151","journal-title":"Osteoarthritis Cartilage"},{"key":"2809_CR23","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.joca.2012.02.012","volume":"20","author":"Y Jirong","year":"2012","unstructured":"Jirong Y, Huiyun P, Zhongzhe Y, Birong D, Weimin L, Ming Y et al (2012) Sodium selenite for treatment of Kashin-Beck disease in children: a systematic review of randomised controlled trial. Osteoarthritis Cartilage 20:605\u2013613","journal-title":"Osteoarthritis Cartilage"},{"key":"2809_CR24","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.joca.2012.03.013","volume":"20","author":"J Yue","year":"2012","unstructured":"Yue J, Yang M, Yi S, Dong B, Li W, Yang Z et al (2012) Chondroitin sulfate and\/or glucosamine hydrochloride for Kashin-Beck disease: a cluster-randomized, placebo-controlled study. Osteoarthritis Cartilage 20:622\u2013629","journal-title":"Osteoarthritis Cartilage"},{"key":"2809_CR25","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s10067-012-1979-3","volume":"31","author":"X Tang","year":"2012","unstructured":"Tang X, Pei FX, Zhou ZK, Liu G, Shen B, Kang PD et al (2012) A randomized, single-blind comparison of the efficacy and tolerability of hyaluronate acid and meloxicam in adult patients with Kashin-Beck disease of the knee. Clin Rheumatol 31:1079\u20131086","journal-title":"Clin Rheumatol"},{"key":"2809_CR26","first-page":"588","volume":"23","author":"P Xu","year":"2004","unstructured":"Xu P, Guo X, Jin WZ, Yao JF, Wang JH, Zhang FQ et al (2004) Curative effects of intra-articular injections of sodium hyaluronate to treat Kaschin-Beck disease. Chin J Endemiol 23:588\u2013590 (in Chinese)","journal-title":"Chin J Endemiol"},{"key":"2809_CR27","first-page":"185","volume":"26","author":"YX Yu","year":"2011","unstructured":"Yu YX, Guo DW, Huang LQ, Xue RH, Wang ZL (2011) Intra-articular sodium hyaluronate injection for treating knee osteoarthritis. Chin J Endemiol 26:185\u2013187 (in Chinese)","journal-title":"Chin J Endemiol"},{"key":"2809_CR28","first-page":"56","volume":"26","author":"LJ Liu","year":"2011","unstructured":"Liu LJ, Zhang XH, Wei DH, Wang HY, Xu SL, Zha XSZ et al (2011) The serum cytokine levels and efficacy of therapeutic trajectory for Kashin Beck disease in Tibet. J Tibet Univ 26:56\u201359 (in Chinese)","journal-title":"J Tibet Univ"},{"key":"2809_CR29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s002640000206","volume":"25","author":"F Mathieu","year":"2001","unstructured":"Mathieu F, Suetens C, Begaux F, De Maertelaer V, Hinsenkamp M (2001) Effects of physical therapy on patients with Kashin-Beck disease in Tibet. Int Orthop 25:191\u2013193","journal-title":"Int Orthop"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-014-2809-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-014-2809-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-014-2809-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T08:09:46Z","timestamp":1650614986000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-014-2809-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,12]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["2809"],"URL":"https:\/\/doi.org\/10.1007\/s10067-014-2809-6","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,12]]}}}