{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:46:32Z","timestamp":1789389992562,"version":"build-2803163510"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:00:00Z","timestamp":1431561600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s10067-015-2966-2","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T15:55:25Z","timestamp":1431532525000},"page":"1857-1863","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Possible association of proinflammatory cytokines including IL1\u03b2 and TNF\u03b1 with enhanced Th17 cell differentiation in patients with Behcet\u2019s disease"],"prefix":"10.1007","volume":"35","author":[{"given":"Jun","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Takai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naruyoshi","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagisa","family":"Arimitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sueshige","family":"Wakisaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,5,14]]},"reference":[{"key":"2966_CR1","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1056\/NEJM199910213411707","volume":"341","author":"T Sakane","year":"1999","unstructured":"Sakane T, Takeno M, Suzuki N, Inaba G (1999) Beh\u00e7et\u2019s disease. N Engl J Med 341:1284\u20131291","journal-title":"N Engl J Med"},{"key":"2966_CR2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2249.2004.02688.x","volume":"139","author":"H Nagafuchi","year":"2005","unstructured":"Nagafuchi H, Takeno M, Yoshikawa H, Kurokawa MS, Nara K, Takada E, Masuda C, Mizoguchi M, Suzuki N (2005) Excessive expression of Txk, a member of the Tec family of tyrosine kinases, contributes to excessive Th1 cytokine production by T lymphocytes in patients with Behcet\u2019s disease. Clin Exp Immunol 139:363\u2013370","journal-title":"Clin Exp Immunol"},{"key":"2966_CR3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2249.2005.02695.x","volume":"139","author":"Y Imamura","year":"2005","unstructured":"Imamura Y, Kurokawa MS, Yoshikawa H, Nara K, Takada E, Masuda C, Tsukikawa S, Ozaki S, Matsuda T, Suzuki N (2005) Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet\u2019s disease. Clin Exp Immunol 139:371\u2013378","journal-title":"Clin Exp Immunol"},{"key":"2966_CR4","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.4049\/jimmunol.177.9.6415","volume":"177","author":"M Melikoglu","year":"2006","unstructured":"Melikoglu M, Uysal S, Krueger JG, Kaplan G, Gogus F, Yazici H, Oliver S (2006) Characterization of the divergent wound-healing responses occurring in the pathergy reaction and normal healthy volunteers. J Immunol 177:6415\u20136421","journal-title":"J Immunol"},{"key":"2966_CR5","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1002\/art.20334","volume":"50","author":"M Ben Ahmed","year":"2004","unstructured":"Ben Ahmed M, Houman H, Miled M, Dellagi K, Louzir H (2004) Involvement of chemokines and Th1 cytokines in the pathogenesis of mucocutaneous lesions of Beh\u00e7et\u2019s disease. Arthritis Rheum 50:2291\u20132295","journal-title":"Arthritis Rheum"},{"key":"2966_CR6","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s00296-007-0367-9","volume":"27","author":"A Kulaber","year":"2007","unstructured":"Kulaber A, Tugal-Tutkun I, Yent\u00fcr SP, Akman-Demir G, Kaneko F, G\u00fcl A, Saruhan-Direskeneli G (2007) Pro-inflammatory cellular immune response in Beh\u00e7et\u2019s disease. Rheumatol Int 27:1113\u20131118","journal-title":"Rheumatol Int"},{"key":"2966_CR7","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s12016-007-8064-8","volume":"35","author":"M Melikoglu","year":"2008","unstructured":"Melikoglu M, Kural-Seyahi E, Tascilar K, Yazici H (2008) The unique features of vasculitis in Beh\u00e7et\u2019s syndrome. Clin Rev Allergy Immunol 35:40\u201346. doi: 10.1007\/s12016-007-8064-8","journal-title":"Clin Rev Allergy Immunol"},{"key":"2966_CR8","doi-asserted-by":"publisher","first-page":"3058","DOI":"10.1167\/iovs.07-1390","volume":"49","author":"W Chi","year":"2008","unstructured":"Chi W, Zhu X, Yang P, Liu X, Lin X, Zhou H, Huang X, Kijlstra A (2008) Upregulated IL-23 and IL-17 in Beh\u00e7et patients with active uveitis. Invest Ophthalmol Vis Sci 49:3058\u20133064. doi: 10.1167\/iovs.07-1390","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2966_CR9","doi-asserted-by":"crossref","first-page":"CR227","DOI":"10.12659\/MSM.881720","volume":"17","author":"K Hamzaoui","year":"2011","unstructured":"Hamzaoui K, Bouali E, Ghorbel I, Khanfir M, Houman H, Hamzaoui A (2011) Expression of Th-17 and ROR\u03b3t mRNA in Beh\u00e7et\u2019s disease. Med Sci Monit 17:CR227\u2013CR234","journal-title":"Med Sci Monit"},{"key":"2966_CR10","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.jaci.2011.05.029","volume":"128","author":"G Geri","year":"2011","unstructured":"Geri G, Terrier B, Rosenzwajg M, Wechsler B, Touzot M, Seilhean D, Tran TA, Bodaghi B, Musset L, Soumelis V, Klatzmann D, Cacoub P, Saadoun D (2011) Critical role of IL-21 in modulating T(H)17 and regulatory T cells in Beh\u00e7et disease. J Allergy Clin Immunol 128:655\u2013664. doi: 10.1016\/j.jaci.2011.05.029","journal-title":"J Allergy Clin Immunol"},{"key":"2966_CR11","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.jneuroim.2011.01.012","volume":"233","author":"K Hamzaoui","year":"2011","unstructured":"Hamzaoui K, Borhani Haghighi A, Ghorbel IB, Houman H (2011) RORC and Foxp3 axis in cerebrospinal fluid of patients with neuro-Beh\u00e7et\u2019s disease. J Neuroimmunol 233:249\u2013253. doi: 10.1016\/j.jneuroim.2011.01.012","journal-title":"J Neuroimmunol"},{"key":"2966_CR12","first-page":"880","volume":"16","author":"W Chi","year":"2010","unstructured":"Chi W, Yang P, Zhu X, Wang Y, Chen L, Huang X, Liu X (2010) Production of interleukin-17 in Behcet\u2019s disease is inhibited by cyclosporin A. Mol Vis 16:880\u2013886","journal-title":"Mol Vis"},{"key":"2966_CR13","first-page":"S32","volume":"31","author":"SY Na","year":"2013","unstructured":"Na SY, Park MJ, Park S, Lee ES (2013) Up-regulation of Th17 and related cytokines in Beh\u00e7et\u2019s disease corresponding to disease activity. Clin Exp Rheumatol 31:S32\u2013S40","journal-title":"Clin Exp Rheumatol"},{"key":"2966_CR14","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/j.1365-2249.2011.04543.x","volume":"168","author":"J Shimizu","year":"2012","unstructured":"Shimizu J, Takai K, Fujiwara N, Arimitsu N, Ueda Y, Wakisaka S, Yoshikawa H, Kaneko F, Suzuki T, Suzuki N (2012) Excessive CD4+ T cells co-expressing interleukin-17 and interferon-\u03b3 in patients with Beh\u00e7et\u2019s disease. Clin Exp Immunol 168:68\u201374. doi: 10.1111\/j.1365-2249.2011.04543.x","journal-title":"Clin Exp Immunol"},{"key":"2966_CR15","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/ng.625","volume":"42","author":"EF Remmers","year":"2010","unstructured":"Remmers EF, Cosan F, Kirino Y, Ombrello MJ, Abaci N, Satorius C, Le JM, Yang B, Korman BD, Cakiris A, Aglar O, Emrence Z, Azakli H, Ustek D, Tugal-Tutkun I, Akman-Demir G, Chen W, Amos CI, Dizon MB, Kose AA, Azizlerli G, Erer B, Brand OJ, Kaklamani VG, Kaklamanis P, Ben-Chetrit E, Stanford M, Fortune F, Ghabra M, Ollier WE, Cho YH, Bang D, O'Shea J, Wallace GR, Gadina M, Kastner DL, G\u00fcl A (2010) Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Beh\u00e7et\u2019s disease. Nat Genet 42:698\u2013702. doi: 10.1038\/ng.625","journal-title":"Nat Genet"},{"key":"2966_CR16","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/ng.624","volume":"42","author":"N Mizuki","year":"2010","unstructured":"Mizuki N, Meguro A, Ota M, Ohno S, Shiota T, Kawagoe T, Ito N, Kera J, Okada E, Yatsu K, Song YW, Lee EB, Kitaichi N, Namba K, Horie Y, Takeno M, Sugita S, Mochizuki M, Bahram S, Ishigatsubo Y, Inoko H (2010) Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Beh\u00e7et\u2019s disease susceptibility loci. Nat Genet 42:703\u2013706. doi: 10.1038\/ng.624","journal-title":"Nat Genet"},{"key":"2966_CR17","first-page":"1078","volume":"335","author":"International Study Group for Beh\u00e7et\u2019s Disease","year":"1990","unstructured":"International Study Group for Beh\u00e7et\u2019s Disease (1990) Criteria for diagnosis of Beh\u00e7et\u2019s disease. Lancet 335:1078\u20131080","journal-title":"Lancet"},{"key":"2966_CR18","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/nature06764","volume":"452","author":"JD Milner","year":"2008","unstructured":"Milner JD, Brenchley JM, Laurence A, Freeman AF, Hill BJ, Elias KM, Kanno Y, Spalding C, Elloumi HZ, Paulson ML, Davis J, Hsu A, Asher AI, O'Shea J, Holland SM, Paul WE, Douek DC (2008) Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome. Nature 452:773\u2013776. doi: 10.1038\/nature06764","journal-title":"Nature"},{"key":"2966_CR19","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nri3707","volume":"14","author":"SL Gaffen","year":"2014","unstructured":"Gaffen SL, Jain R, Garg AV, Cua DJ (2014) The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol 14:585\u2013600. doi: 10.1038\/nri3707","journal-title":"Nat Rev Immunol"},{"key":"2966_CR20","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1159\/000363502","volume":"164","author":"L Cosmi","year":"2014","unstructured":"Cosmi L, Liotta F, Maggi E, Romagnani S, Annunziato F (2014) Th17 and non-classic Th1 cells in chronic inflammatory disorders: two sides of the same coin. Int Arch Allergy Immunol 164:171\u2013177. doi: 10.1159\/000363502","journal-title":"Int Arch Allergy Immunol"},{"key":"2966_CR21","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1002\/art.22866","volume":"56","author":"Z Chen","year":"2007","unstructured":"Chen Z, Tato CM, Muul L, Laurence A, O'Shea JJ (2007) Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum 56:2936\u20132946","journal-title":"Arthritis Rheum"},{"key":"2966_CR22","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/nature10957","volume":"484","author":"CE Zielinski","year":"2012","unstructured":"Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F (2012) Pathogen-induced human TH17 cells produce IFN-\u03b3 or IL-10 and are regulated by IL-1\u03b2. Nature 484:514\u2013518. doi: 10.1038\/nature10957","journal-title":"Nature"},{"key":"2966_CR23","first-page":"S35","volume":"30","author":"J Shimizu","year":"2012","unstructured":"Shimizu J, Izumi T, Arimitsu N, Fujiwara N, Ueda Y, Wakisaka S, Yoshikawa H, Kaneko F, Suzuki T, Takai K, Suzuki N (2012) Skewed TGF\u03b2\/Smad signalling pathway in T cells in patients with Beh\u00e7et\u2019s disease. Clin Exp Rheumatol 30:S35\u2013S39","journal-title":"Clin Exp Rheumatol"},{"key":"2966_CR24","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1172\/JCI25308","volume":"116","author":"Y Chen","year":"2006","unstructured":"Chen Y, Langrish CL, McKenzie B, Joyce-Shaikh B, Stumhofer JS, McClanahan T, Blumenschein W, Churakovsa T, Low J, Presta L, Hunter CA, Kastelein RA, Cua DJ (2006) Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest 116:1317\u20131326","journal-title":"J Clin Invest"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-015-2966-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-015-2966-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-015-2966-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T08:57:41Z","timestamp":1559120261000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-015-2966-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,14]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["2966"],"URL":"https:\/\/doi.org\/10.1007\/s10067-015-2966-2","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,14]]}}}