{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:54:57Z","timestamp":1783004097149,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2015,6,7]],"date-time":"2015-06-07T00:00:00Z","timestamp":1433635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1007\/s10067-015-2987-x","type":"journal-article","created":{"date-parts":[[2015,6,6]],"date-time":"2015-06-06T04:59:39Z","timestamp":1433566779000},"page":"1211-1216","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Azathioprine during pregnancy in systemic lupus erythematosus patients is not associated with poor fetal outcome"],"prefix":"10.1007","volume":"34","author":[{"given":"Miguel \u00c1ngel","family":"Saavedra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulises","family":"\u00c1ngeles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Javier","family":"Jara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,7]]},"reference":[{"key":"2987_CR1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.rdc.2007.01.002","volume":"33","author":"ME Clowse","year":"2007","unstructured":"Clowse ME (2007) Lupus activity in pregnancy. Rheum Dis Clin N Am 33:237\u2013252","journal-title":"Rheum Dis Clin N Am"},{"key":"2987_CR2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/ar1957","volume":"8","author":"M Ostensen","year":"2006","unstructured":"Ostensen M, Khamashta M, Lockshin M, Parke A, Brucato A, Carp H et al (2006) Anti-inflammatory and immunosuppressive drugs and reproduction. Arthritis Res Ther 8:209","journal-title":"Arthritis Res Ther"},{"key":"2987_CR3","doi-asserted-by":"crossref","unstructured":"Saavedra Salinas M\u00c1, Barrera Cruz A, Cabral Casta\u00f1eda AR, Jara Quezada LJ, Arce-Salinas CA, \u00c1lvarez Nemegyei J et al (2015) Clinical practice guidelines for the attention of pregnant women with autoimmune rheumatic diseases of the Mexican College of Rheumatology. Part II. Reumatol Clin. doi: 10.1016\/j.reuma.2014.12.004","DOI":"10.1016\/j.reuma.2014.12.004"},{"key":"2987_CR4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/tera.10043","volume":"65","author":"JE Polifka","year":"2002","unstructured":"Polifka JE, Friedman JM (2002) Teratogen update: azathioprine and 6-mercaptopurine. Teratology 65:240\u2013246","journal-title":"Teratology"},{"key":"2987_CR5","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1046\/j.1365-2036.2003.01537.x","volume":"17","author":"B N\u00f8rgard","year":"2003","unstructured":"N\u00f8rgard B, Pedersen L, Fonager K, Rasmussen SN, S\u00f8rensen HT (2003) Azathioprine, mercaptopurine and birth outcome: a population-based cohort study. Aliment Pharmacol Ther 17:827\u2013834","journal-title":"Aliment Pharmacol Ther"},{"key":"2987_CR6","doi-asserted-by":"crossref","unstructured":"Mozaffari S, Abdolghaffari A, Nikfar S, Abdollahi M (2014) Pregnancy outcomes in women with inflammatory bowel disease following exposure to thiopurines and antitumor necrosis factor drugs: A systematic review with meta-analysis. Hum Exp Toxicol 34:445\u2013459","DOI":"10.1177\/0960327114550882"},{"key":"2987_CR7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/bdra.20583","volume":"85","author":"BJ Cleary","year":"2009","unstructured":"Cleary BJ, K\u00e4ll\u00e9n B (2009) Early pregnancy azathioprine use and pregnancy outcomes. Birth Defects Res A Clin Mol Teratol 85:647\u2013654","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"2987_CR8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-2036.2006.03162.x","volume":"25","author":"V Langagerdaard","year":"2007","unstructured":"Langagerdaard V, Pedersen L, Gislum M, N\u00f8rgard B, S\u00f8rensen HT (2007) Birth outcome in women treated with azathioprine or mercaptopurine during pregnancy: a Danish nationwide cohort study. Aliment Pharmacol Ther 25:73\u201378","journal-title":"Aliment Pharmacol Ther"},{"key":"2987_CR9","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/bdra.20399","volume":"79","author":"LH Goldstein","year":"2007","unstructured":"Goldstein LH, Dolinsky G, Greenberg R, Schaefer C, Cohen-Kerem R, Diav-Citrin O et al (2007) Pregnancy outcome of women exposed to azathioprine during pregnancy. Birth Defects Research A Clin Mol Teratol 79:696\u2013701","journal-title":"Birth Defects Research A Clin Mol Teratol"},{"key":"2987_CR10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/ibd.22948","volume":"19","author":"M Akbari","year":"2013","unstructured":"Akbari M, Shah S, Velayos FS, Mahadevan U, Cheifetz AS (2013) Systematic review and meta-analysis on the effects of thiopurines on birth outcomes from female and male patients with inflammatory bowel disease. Inflamm Bowel Dis 19:15\u201322","journal-title":"Inflamm Bowel Dis"},{"key":"2987_CR11","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/096120339600500205","volume":"5","author":"JO Martinez-Rueda","year":"1996","unstructured":"Martinez-Rueda JO, Arce-Salinas CA, Kraus A, Alcocer-Varela J, Alarcon-Segovia D (1996) Factors associated with fetal losses in severe systemic lupus erythematosus. Lupus 5:113\u2013119","journal-title":"Lupus"},{"key":"2987_CR12","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/art.1780400928","volume":"40","author":"MC Hochberg","year":"1997","unstructured":"Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725","journal-title":"Arthritis Rheum"},{"key":"2987_CR13","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1177\/0961203314552116","volume":"24","author":"M Saavedra","year":"2015","unstructured":"Saavedra M, S\u00e1nchez A, Morales S, Navarro-Zarza J, Angeles U, Jara L (2015) Primigravida is associated with flare in women with systemic lupus erythematosus. Lupus 24:180\u2013185","journal-title":"Lupus"},{"key":"2987_CR14","unstructured":"Available from: http:\/\/www.who.int\/classifications\/icd\/en\/ . Accessed 14 April 2014"},{"key":"2987_CR15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s12026-014-8577-1","volume":"60","author":"LJ Jara","year":"2014","unstructured":"Jara LJ, Medina G, Cruz-Dominguez P, Navarro C, Vera-Lastra O, Saavedra MA (2014) Risk factors of systemic lupus erythematosus flares during pregnancy. Immunol Res 60:184\u2013192","journal-title":"Immunol Res"},{"key":"2987_CR16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1053\/j.ackd.2013.01.011","volume":"20","author":"S Hou","year":"2013","unstructured":"Hou S (2013) Pregnancy in renal transplant recipients. Adv Chronic Kidney Dis 20:253\u2013259","journal-title":"Adv Chronic Kidney Dis"},{"key":"2987_CR17","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1177\/0961203312456893","volume":"21","author":"K Bramham","year":"2012","unstructured":"Bramham K, Soh MC, Nelson-Piercy C (2012) Pregnancy and renal outcomes in lupus nephritis: an update and guide to management. Lupus 21:1271\u20131283","journal-title":"Lupus"},{"key":"2987_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/01443615.2012.716106","volume":"33","author":"JR Hutson","year":"2013","unstructured":"Hutson JR, Matlow JN, Moretti ME, Koren G (2013) The fetal safety of thiopurines for the treatment of inflammatory bowel disease in pregnancy. J Obstet Gynaecol 33:1\u20138","journal-title":"J Obstet Gynaecol"},{"key":"2987_CR19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1600-0897.1992.tb00778.x","volume":"28","author":"M Ostensen","year":"1992","unstructured":"Ostensen M (1992) Treatment with immunosuppressive and disease modifying drugs during pregnancy and lactation. Am J Reprod Immunol 28:148\u2013152","journal-title":"Am J Reprod Immunol"},{"key":"2987_CR20","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/art.1780180106","volume":"18","author":"E Ginzler","year":"1975","unstructured":"Ginzler E, Sharon E, Diamond H, Kaplan D (1975) Long-term maintenance therapy with azathioprine in systemic lupus erythematosus. Arthritis Rheum 18:27\u201334","journal-title":"Arthritis Rheum"},{"key":"2987_CR21","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/ibd.21154","volume":"16","author":"JP Gisbert","year":"2010","unstructured":"Gisbert JP (2010) Safety of immunomodulators and biologics for the treatment of inflammatory bowel disease during pregnancy and breast-feeding. Inflamm Bowel Dis 16:881\u2013895","journal-title":"Inflamm Bowel Dis"},{"issue":"Suppl","key":"2987_CR22","first-page":"S597","volume":"66","author":"S Panchal","year":"2014","unstructured":"Panchal S, Flint J, van de Venne M, Piper M, Hurrel A, Cunningham J et al (2014) A systematic analysis of the safety of prescribing anti-rheumatic immunosuppressive and biologic drugs in pregnant women. Arthritis Rheum 66(Suppl):S597","journal-title":"Arthritis Rheum"},{"key":"2987_CR23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/rheumatology\/35.2.133","volume":"35","author":"G Ruiz-Irastorza","year":"1996","unstructured":"Ruiz-Irastorza G, Lima F, Alves J, Khamashta MA, Simpson J, Hughes GR et al (1996) Increased rate of lupus flare during pregnancy and the puerperium: a prospective study of 78 pregnancies. Br J Rheumatol 35:133\u2013138","journal-title":"Br J Rheumatol"},{"key":"2987_CR24","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/art.20864","volume":"52","author":"ME Clowse","year":"2005","unstructured":"Clowse ME, Magder LS, Witter F, Petri M (2005) The impact of increased lupus activity on obstetric outcomes. Arthritis Rheum 52:514\u2013521","journal-title":"Arthritis Rheum"},{"key":"2987_CR25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ogc.2012.11.008","volume":"40","author":"JM Alexander","year":"2013","unstructured":"Alexander JM, Wilson KL (2013) Hypertensive emergencies of pregnancy. Obstet Gynecol Clin N Am 40:89\u2013101","journal-title":"Obstet Gynecol Clin N Am"},{"key":"2987_CR26","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/acr.21888","volume":"65","author":"W Marder","year":"2013","unstructured":"Marder W, Ganser MA, Romero V, Hyzy MA, Gordon C, McCune WJ et al (2013) In utero azathioprine exposure and increased utilization of special educational services in children born to mothers with systemic lupus erythematosus. Arthritis Care Res (Hoboken) 65:759\u2013766","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2987_CR27","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s10067-012-1941-4","volume":"31","author":"MA Saavedra","year":"2012","unstructured":"Saavedra MA, Cruz-Reyes C, Vera-Lastra O, Romero GT, Cruz-Cruz P, Arias-Flores R et al (2012) Impact of previous lupus nephritis on maternal and fetal outcomes during pregnancy. Clin Rheumatol 31:813\u2013819","journal-title":"Clin Rheumatol"},{"key":"2987_CR28","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1093\/rheumatology\/kes425","volume":"52","author":"R Fischer-Betz","year":"2013","unstructured":"Fischer-Betz R, Specker C, Brinks R, Aringer M, Schneider M (2013) Low risk of renal flares and negative outcomes in women with lupus nephritis conceiving after switching from mycophenolate mofetil to azathioprine. Rheumatology (Oxford) 52:1070\u20131076","journal-title":"Rheumatology (Oxford)"},{"key":"2987_CR29","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1002\/acr.22364","volume":"66","author":"H Al Maimouni","year":"2014","unstructured":"Al Maimouni H, Gladman DD, Iba\u00f1ez D, Urowitz MB (2014) Switching treatment between mycophenolate mofetil and azathioprine in lupus patients: indications and outcomes. Arthritis Care Res (Hoboken) 66:1905\u20131909","journal-title":"Arthritis Care Res (Hoboken)"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-015-2987-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-015-2987-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-015-2987-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T08:57:42Z","timestamp":1559120262000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-015-2987-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,7]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["2987"],"URL":"https:\/\/doi.org\/10.1007\/s10067-015-2987-x","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,7]]}}}