{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:41:33Z","timestamp":1791722493266,"version":"4.3.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T00:00:00Z","timestamp":1446854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s10067-015-3109-5","type":"journal-article","created":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T04:47:21Z","timestamp":1446871641000},"page":"2251-2258","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["IL-37 inhibits the production of pro-inflammatory cytokines in MSU crystal-induced inflammatory response"],"prefix":"10.1007","volume":"35","author":[{"given":"Mei","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wantai","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Qing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenguang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingcai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingguo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,7]]},"reference":[{"key":"3109_CR1","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1172\/JCI29404","volume":"116","author":"F Martinon","year":"2006","unstructured":"Martinon F, Glimcher LH (2006) Gout: new insights into an old disease. J Clin Invest 116:2073\u20132075","journal-title":"J Clin Invest"},{"key":"3109_CR2","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.3949\/ccjm.75.Suppl_5.S9","volume":"75","author":"AL Weaver","year":"2008","unstructured":"Weaver AL (2008) Epidemiology of gout. Cleve Clin J Med 75:S9\u2013S12","journal-title":"Cleve Clin J Med"},{"key":"3109_CR3","first-page":"1859","volume":"35","author":"Z Miao","year":"2008","unstructured":"Miao Z, Li C, Chen Y, Zhao S, Wang Y, Wang Z et al (2008) Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China. J Rheumatol 35:1859\u20131864","journal-title":"J Rheumatol"},{"key":"3109_CR4","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1136\/ard.2007.076232","volume":"67","author":"L Annemans","year":"2008","unstructured":"Annemans L, Spaepen E, Gaskin M, Bonnemaire M, Malier V, Gilbert T et al (2008) Gout in the UK and Germany: prevalence, comorbidities and management in general practice 2000\u20132005. Ann Rheum Dis 67:960\u2013966","journal-title":"Ann Rheum Dis"},{"key":"3109_CR5","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/BOR.0b013e3282f33f87","volume":"20","author":"A Taniguchi","year":"2008","unstructured":"Taniguchi A, Kammatani N (2008) Control of renal uric acid excretion and gout. Curr Opin Rheumatol 20:192\u2013197","journal-title":"Curr Opin Rheumatol"},{"key":"3109_CR6","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nature01991","volume":"425","author":"Y Shi","year":"2003","unstructured":"Shi Y, Evans JE, Rock KL (2003) Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425:516\u2013521","journal-title":"Nature"},{"key":"3109_CR7","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s11926-011-0162-1","volume":"13","author":"F Ghaemi-Oskouie","year":"2011","unstructured":"Ghaemi-Oskouie F, Shi Y (2011) The role of uric acid as an endogenous danger signal in immunity and inflammation. Curr Rheumatol Rep 13:160\u2013166","journal-title":"Curr Rheumatol Rep"},{"key":"3109_CR8","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/ar1908","volume":"8","author":"BN Cronstein","year":"2006","unstructured":"Cronstein BN, Terkeltaub R (2006) The inflammatory process of gout and its treatment. Arthritis Res Ther 8:S1\u2013S3","journal-title":"Arthritis Res Ther"},{"key":"3109_CR9","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/art.1780360912","volume":"36","author":"E Ortiz-Bravo","year":"1993","unstructured":"Ortiz-Bravo E, Sieck MS, Schumacher HR Jr (1993) Changes in the proteins coating monosodium urate crystals during active and subsiding inflammation. Immunogold studies of synovial fluid from patients with gout and of fluid obtained using the rat subcutaneous air pouch model. Arthritis Rheum 36:1274\u20131285","journal-title":"Arthritis Rheum"},{"key":"3109_CR10","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/art.1780390718","volume":"39","author":"F Liot\u00e9","year":"1996","unstructured":"Liot\u00e9 F, Prudhommeaux F, Schiltz C, Champy R, Herbelin A, Ortiz-Bravo E et al (1996) Inhibition and prevention of monosodium urate monohydrate crystal-induced acute inflammation in vivo by transforming growth factor beta1. Arthritis Rheum 39:1192\u20131198","journal-title":"Arthritis Rheum"},{"key":"3109_CR11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/art.1780360118","volume":"36","author":"GF Falasca","year":"1993","unstructured":"Falasca GF, Ramachandrula A, Kelley KA, O\u2019Connor CR, Reginato AJ (1993) Superoxide anion production and phagocytosis of crystals by cultured endothelial cells. Arthritis Rheum 36:105\u2013116","journal-title":"Arthritis Rheum"},{"issue":"10","key":"3109_CR12","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.4049\/jimmunol.138.10.3213","volume":"138","author":"FS Giovine Di","year":"1987","unstructured":"Di Giovine FS, Malawista SE, Nuki G, Duff GW (1987) Interleukin 1 (IL-1) as a mediator of crystal arthritis: stimulation of T cell and synovial fi broblast mitogenesis by urate crystalinduced IL-1. J Immunol 138(10):3213\u20133218","journal-title":"J Immunol"},{"key":"3109_CR13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1172\/JCI113921","volume":"83","author":"PA Guerne","year":"1989","unstructured":"Guerne PA, Zuraw BL, Vaughan JH, Carson DA, Lotz M (1989) Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. J Clin Invest 83:585\u2013592","journal-title":"J Clin Invest"},{"key":"3109_CR14","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1002\/anr.1780321114","volume":"32","author":"PA Guerne","year":"1989","unstructured":"Guerne PA, Terkeltaub R, Zuraw B, Lotz M (1989) Inflammatory microcrystals stimulate interleukin-6 production and secretion by human monocytes and synoviocytes. Arthritis Rheum 32:1443\u20131452","journal-title":"Arthritis Rheum"},{"key":"3109_CR15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1084\/jem.169.1.291","volume":"169","author":"R Fava","year":"1989","unstructured":"Fava R, Olsen N, Keski-Oja J, Moses H, Pincus T (1989) Active and latent forms of transforming growth factor beta activity in synovial effusions. J Exp Med 169:291\u2013296","journal-title":"J Exp Med"},{"key":"3109_CR16","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1136\/ard.2010.145821","volume":"70","author":"YH Chen","year":"2011","unstructured":"Chen YH, Hsieh SC, Chen WY, Li KJ, Wu CH, Wu PC et al (2011) Spontaneous resolution of acute gouty arthritis is associated with rapid induction of the anti-inflammatory factors TGF\u03b21, IL-10 and soluble TNF receptors and the intracellular cytokine negative regulators CIS and SOCS3. Ann Rheum Dis 70:1655\u20131663","journal-title":"Ann Rheum Dis"},{"key":"3109_CR17","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1136\/annrheumdis-2011-200711","volume":"71","author":"S Anna","year":"2012","unstructured":"Anna S, Francesca O, Roberta R, Frallonardo P, Dayer JM, Punzi L (2012) Cytokine levels in human synovial fluid during the different stages of acute gout: role of transforming growth factor \u03b21 in the resolution phase. Ann Rheum Dis 71:621\u2013624","journal-title":"Ann Rheum Dis"},{"key":"3109_CR18","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ni.1944","volume":"11","author":"MF Nold","year":"2010","unstructured":"Nold MF, Nold-Petry CA, Zepp JA, Palmer BE, Bufler P, Dinarello CA (2010) IL-37 is a fundamental inhibitor of innate immunity. Nat Immunol 11:1014\u20131022","journal-title":"Nat Immunol"},{"key":"3109_CR19","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1182\/blood-2010-07-273417","volume":"117","author":"CA Dinarello","year":"2011","unstructured":"Dinarello CA (2011) Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117:3720\u20133732","journal-title":"Blood"},{"key":"3109_CR20","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1684\/ecn.2011.0288","volume":"22","author":"D Boraschi","year":"2011","unstructured":"Boraschi D, Lucchesi D, Hainzl S, Leitner M, Maier E, Mangelberger D et al (2011) IL-37: a new anti-inflammatory cytokine of the IL-1 family. Eur Cytokine Netw 22:127\u2013147","journal-title":"Eur Cytokine Netw"},{"key":"3109_CR21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/cyto.2002.0873","volume":"18","author":"S Kumar","year":"2002","unstructured":"Kumar S, Hanning CR, Brigham-Burke MR, Rieman DJ, Lehr R, Khandekar S et al (2002) Interleukin-1F7B (IL-1H4\/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production. Cytokine 18:61\u201371","journal-title":"Cytokine"},{"key":"3109_CR22","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.4049\/jimmunol.180.8.5477","volume":"180","author":"S Sharma","year":"2008","unstructured":"Sharma S, Kulk N, Nold MF, Graf R, Kim SH, Reinhardt D et al (2008) The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines. J Immunol 180:5477\u20135482","journal-title":"J Immunol"},{"key":"3109_CR23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1042\/BJ20040217","volume":"381","author":"P Bufler","year":"2004","unstructured":"Bufler P, Gamboni-Robertson F, Azam T, Kim SH, Dinarello CA (2004) Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide. Biochem J 381:503\u2013510","journal-title":"Biochem J"},{"issue":"40","key":"3109_CR24","doi-asserted-by":"crossref","first-page":"16711","DOI":"10.1073\/pnas.1111982108","volume":"108","author":"EN McNamee","year":"2011","unstructured":"McNamee EN, Masterson JC, Jedlicka P, McManus M, Grenz A, Collins CB et al (2011) Interleukin 37 expression protects mice from colitis. PNAS 108(40):16711\u201316716","journal-title":"PNAS"},{"key":"3109_CR25","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1038\/ncomms5711","volume":"5","author":"DB Ballak","year":"2014","unstructured":"Ballak DB, van Diepen JA, Moschen AR, Jansen HJ, Hijmans A, Groenhof GJ et al (2014) IL-37 protects against obesity-induced inflammation and insulin resistance. Nat Commun 5:4711","journal-title":"Nat Commun"},{"issue":"11","key":"3109_CR26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004462","volume":"10","author":"S Moretti","year":"2014","unstructured":"Moretti S, Bozza S, Oikonomou V, Renga G, Casagrande A, Lannitti RG et al (2014) IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis. Plos Pathog 10(11), e1004462","journal-title":"Plos Pathog"},{"key":"3109_CR27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1479-5876-12-69","volume":"12","author":"L Ye","year":"2014","unstructured":"Ye L, Ji L, Wen Z, Zhou Y, Hu D, Li Y et al (2014) IL-37 inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells of patients with systemic lupus erythematosus: its correlation with disease activity. J Transl Med 12:69","journal-title":"J Transl Med"},{"key":"3109_CR28","volume":"9","author":"PW Zhao","year":"2014","unstructured":"Zhao PW, Jiang WG, Wang L (2014) Plasma levels of IL-37 and correlation with TNF-a, IL-17A, and disease activity during DMARD treatment of rheumatoid arthritis. PLoS One 9, e95346","journal-title":"PLoS One"},{"key":"3109_CR29","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1186\/ar2930","volume":"12","author":"A Scanu","year":"2010","unstructured":"Scanu A, Oliviero F, Gruaz L, Sfriso P, Pozzuoli A, Frezzato F et al (2010) High-density lipoproteins down-regulate CCL2 production in human fibroblast like synoviocytes stimulated by urate crystals. Arthritis Res Ther 12:R23","journal-title":"Arthritis Res Ther"},{"key":"3109_CR30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","volume":"440","author":"F Martinon","year":"2006","unstructured":"Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440:237\u2013241","journal-title":"Nature"},{"key":"3109_CR31","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1002\/art.20317","volume":"50","author":"DR Yagnik","year":"2004","unstructured":"Yagnik DR, Evans BJ, Florey O, Mason JC, Landis RC, Haskard DO (2004) Macrophage release of transforming growth factor beta1 during resolution of monosodium urate monohydrate crystal-induced inflammation. Arthritis Rheum 50:2273\u20132280","journal-title":"Arthritis Rheum"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-015-3109-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-015-3109-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-015-3109-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T09:03:20Z","timestamp":1718183000000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-015-3109-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,7]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["3109"],"URL":"https:\/\/doi.org\/10.1007\/s10067-015-3109-5","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,7]]}}}