{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:51:18Z","timestamp":1790790678824,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T00:00:00Z","timestamp":1447459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T00:00:00Z","timestamp":1447459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01 HL070831"],"award-info":[{"award-number":["P01 HL070831"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s10067-015-3117-5","type":"journal-article","created":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T04:22:59Z","timestamp":1447474979000},"page":"1425-1431","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The role of the unfolded protein response in axial spondyloarthritis"],"prefix":"10.1007","volume":"35","author":[{"given":"Judith A.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,11,14]]},"reference":[{"key":"3117_CR1","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1002\/art.1780401015","volume":"40","author":"MA Brown","year":"1997","unstructured":"Brown MA, Kennedy LG, MacGregor AJ, Darke C, Duncan E et al (1997) Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment. Arthritis Rheum 40:1823\u20131828","journal-title":"Arthritis Rheum"},{"key":"3117_CR2","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s10067-014-2662-7","volume":"33","author":"JD Reveille","year":"2014","unstructured":"Reveille JD (2014) An update on the contribution of the MHC to AS susceptibility. Clin Rheumatol 33:749\u2013757","journal-title":"Clin Rheumatol"},{"key":"3117_CR3","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/nrrheum.2012.41","volume":"8","author":"JD Reveille","year":"2012","unstructured":"Reveille JD (2012) Genetics of spondyloarthritis\u2014beyond the MHC. Nat Rev Rheumatol 8:296\u2013304","journal-title":"Nat Rev Rheumatol"},{"key":"3117_CR4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.molimm.2013.06.013","volume":"57","author":"PC Robinson","year":"2014","unstructured":"Robinson PC, Brown MA (2014) Genetics of ankylosing spondylitis. Mol Immunol 57:2\u201311","journal-title":"Mol Immunol"},{"key":"3117_CR5","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/0092-8674(90)90512-D","volume":"63","author":"RE Hammer","year":"1990","unstructured":"Hammer RE, Maika SD, Richardson JA, Tang JP, Taurog JD (1990) Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders. Cell 63:1099\u20131112","journal-title":"Cell"},{"key":"3117_CR6","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1146\/annurev-immunol-032414-112110","volume":"33","author":"P Bowness","year":"2015","unstructured":"Bowness P (2015) Hla-B27. Annu Rev Immunol 33:29\u201348","journal-title":"Annu Rev Immunol"},{"key":"3117_CR7","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1002\/eji.1830270205","volume":"27","author":"MT Fiorillo","year":"1997","unstructured":"Fiorillo MT, Meadows L, D\u2019Amato M, Shabanowitz J, Hunt DF et al (1997) Susceptibility to ankylosing spondylitis correlates with the C-terminal residue of peptides presented by various HLA-B27 subtypes. Eur J Immunol 27:368\u2013373","journal-title":"Eur J Immunol"},{"key":"3117_CR8","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0167-5699(90)90051-A","volume":"11","author":"R Benjamin","year":"1990","unstructured":"Benjamin R, Parham P (1990) Guilt by association: HLA-B27 and ankylosing spondylitis. Immunol Today 11:137\u2013142","journal-title":"Immunol Today"},{"key":"3117_CR9","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1084\/jem.20031690","volume":"199","author":"M Hulsmeyer","year":"2004","unstructured":"Hulsmeyer M, Fiorillo MT, Bettosini F, Sorrentino R, Saenger W et al (2004) Dual, HLA-B27 subtype-dependent conformation of a self-peptide. J Exp Med 199:271\u2013281","journal-title":"J Exp Med"},{"key":"3117_CR10","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.jmb.2011.11.021","volume":"415","author":"D Narzi","year":"2012","unstructured":"Narzi D, Becker CM, Fiorillo MT, Uchanska-Ziegler B, Ziegler A et al (2012) Dynamical characterization of two differentially disease associated MHC class I proteins in complex with viral and self-peptides. J Mol Biol 415:429\u2013442","journal-title":"J Mol Biol"},{"key":"3117_CR11","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1074\/jbc.M508528200","volume":"281","author":"C Ruckert","year":"2006","unstructured":"Ruckert C, Fiorillo MT, Loll B, Moretti R, Biesiadka J et al (2006) Conformational dimorphism of self-peptides and molecular mimicry in a disease-associated HLA-B27 subtype. J Biol Chem 281:2306\u20132316","journal-title":"J Biol Chem"},{"key":"3117_CR12","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.4049\/jimmunol.170.2.1099","volume":"170","author":"E May","year":"2003","unstructured":"May E, Dorris ML, Satumtira N, Iqbal I, Rehman MI et al (2003) CD8 alpha beta T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats. J Immunol 170:1099\u20131105","journal-title":"J Immunol"},{"key":"3117_CR13","doi-asserted-by":"publisher","first-page":"8895","DOI":"10.1074\/jbc.M311757200","volume":"279","author":"AN Antoniou","year":"2004","unstructured":"Antoniou AN, Ford S, Taurog JD, Butcher GW, Powis SJ (2004) Formation of HLA-B27 homodimers and their relationship to assembly kinetics. J Biol Chem 279:8895\u20138902","journal-title":"J Biol Chem"},{"key":"3117_CR14","doi-asserted-by":"publisher","first-page":"23459","DOI":"10.1074\/jbc.M110336200","volume":"277","author":"NS Dangoria","year":"2002","unstructured":"Dangoria NS, DeLay ML, Kingsbury DJ, Mear JP, Uchanska-Ziegler B et al (2002) HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum. J Biol Chem 277:23459\u201323468","journal-title":"J Biol Chem"},{"key":"3117_CR15","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/art.23164","volume":"58","author":"B Galocha","year":"2008","unstructured":"Galocha B, de Castro JA (2008) Folding of HLA-B27 subtypes is determined by the global effect of polymorphic residues and shows incomplete correspondence to ankylosing spondylitis. Arthritis Rheum 58:401\u2013412","journal-title":"Arthritis Rheum"},{"key":"3117_CR16","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.3899\/jrheum.100889","volume":"37","author":"JD Taurog","year":"2010","unstructured":"Taurog JD (2010) The role of HLA-B27 in spondyloarthritis. J Rheumatol 37:2606\u20132616","journal-title":"J Rheumatol"},{"key":"3117_CR17","doi-asserted-by":"publisher","first-page":"5110","DOI":"10.4049\/jimmunol.172.8.5110","volume":"172","author":"TM Tran","year":"2004","unstructured":"Tran TM, Satumtira N, Dorris ML, May E, Wang A et al (2004) HLA-B27 in transgenic rats forms disulfide-linked heavy chain oligomers and multimers that bind to the chaperone BiP. J Immunol 172:5110\u20135119","journal-title":"J Immunol"},{"key":"3117_CR18","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.4049\/jimmunol.163.12.6665","volume":"163","author":"JP Mear","year":"1999","unstructured":"Mear JP, Schreiber KL, Munz C, Zhu X, Stevanovic S et al (1999) Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies. J Immunol 163:6665\u20136670","journal-title":"J Immunol"},{"key":"3117_CR19","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1002\/art.38644","volume":"66","author":"C Jeanty","year":"2014","unstructured":"Jeanty C, Sourisce A, Noteuil A, Jah N, Wielgosik A et al (2014) HLA-B27 Subtype oligomerization and intracellular accumulation patterns correlate with predisposition to spondyloarthritis. Arthritis Rheumatol 66:2113\u20132123","journal-title":"Arthritis Rheumatol"},{"key":"3117_CR20","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1146\/annurev.biochem.73.011303.074134","volume":"74","author":"M Schroder","year":"2005","unstructured":"Schroder M, Kaufman RJ (2005) The mammalian unfolded protein response. Annu Rev Biochem 74:739\u2013789","journal-title":"Annu Rev Biochem"},{"key":"3117_CR21","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nrm2199","volume":"8","author":"D Ron","year":"2007","unstructured":"Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8:519\u2013529","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3117_CR22","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1146\/annurev-immunol-032414-112116","volume":"33","author":"SE Bettigole","year":"2015","unstructured":"Bettigole SE, Glimcher LH (2015) Endoplasmic reticulum stress in immunity. Annu Rev Immunol 33:107\u2013138","journal-title":"Annu Rev Immunol"},{"key":"3117_CR23","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1146\/annurev-pathol-012513-104649","volume":"10","author":"SA Oakes","year":"2015","unstructured":"Oakes SA, Papa FR (2015) The role of endoplasmic reticulum stress in human pathology. Annu Rev Pathol 10:173\u2013194","journal-title":"Annu Rev Pathol"},{"key":"3117_CR24","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.semcdb.2007.09.003","volume":"18","author":"JD Malhotra","year":"2007","unstructured":"Malhotra JD, Kaufman RJ (2007) The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol 18:716\u2013731","journal-title":"Semin Cell Dev Biol"},{"key":"3117_CR25","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1126\/science.287.5453.664","volume":"287","author":"F Urano","year":"2000","unstructured":"Urano F, Wang X, Bertolotti A, Zhang Y, Chung P et al (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287:664\u2013666","journal-title":"Science"},{"key":"3117_CR26","doi-asserted-by":"publisher","first-page":"e45078","DOI":"10.1371\/journal.pone.0045078","volume":"7","author":"AB Tam","year":"2012","unstructured":"Tam AB, Mercado EL, Hoffmann A, Niwa M (2012) ER stress activates NF-kappaB by integrating functions of basal IKK activity, IRE1 and PERK. PLoS One 7:e45078","journal-title":"PLoS One"},{"key":"3117_CR27","doi-asserted-by":"publisher","first-page":"10161","DOI":"10.1128\/MCB.24.23.10161-10168.2004","volume":"24","author":"J Deng","year":"2004","unstructured":"Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ et al (2004) Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol 24:10161\u201310168","journal-title":"Mol Cell Biol"},{"key":"3117_CR28","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/ni.1857","volume":"11","author":"F Martinon","year":"2010","unstructured":"Martinon F, Chen X, Lee AH, Glimcher LH (2010) TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol 11:411\u2013418","journal-title":"Nat Immunol"},{"key":"3117_CR29","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.4049\/jimmunol.0903052","volume":"185","author":"L Zeng","year":"2010","unstructured":"Zeng L, Liu YP, Sha H, Chen H, Qi L et al (2010) XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages. J Immunol 185:2324\u20132330","journal-title":"J Immunol"},{"key":"3117_CR30","doi-asserted-by":"publisher","first-page":"17698","DOI":"10.1073\/pnas.1011736107","volume":"107","author":"JC Goodall","year":"2010","unstructured":"Goodall JC, Wu C, Zhang Y, McNeill L, Ellis L et al (2010) Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc Natl Acad Sci U S A 107:17698\u201317703","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3117_CR31","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1002\/eji.200737882","volume":"38","author":"JA Smith","year":"2008","unstructured":"Smith JA, Turner MJ, DeLay ML, Klenk EI, Sowders DP et al (2008) Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1. Eur J Immunol 38:1194\u20131203","journal-title":"Eur J Immunol"},{"key":"3117_CR32","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1002\/art.24763","volume":"60","author":"ML DeLay","year":"2009","unstructured":"DeLay ML, Turner MJ, Klenk EI, Smith JA, Sowders DP et al (2009) HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats. Arthritis Rheum 60:2633\u20132643","journal-title":"Arthritis Rheum"},{"key":"3117_CR33","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1097\/BOR.0000000000000069","volume":"26","author":"N Yeremenko","year":"2014","unstructured":"Yeremenko N, Paramarta JE, Baeten D (2014) The interleukin-23\/interleukin-17 immune axis as a promising new target in the treatment of spondyloarthritis. Curr Opin Rheumatol 26:361\u2013370","journal-title":"Curr Opin Rheumatol"},{"key":"3117_CR34","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nm.2817","volume":"18","author":"JP Sherlock","year":"2012","unstructured":"Sherlock JP, Joyce-Shaikh B, Turner SP, Chao CC, Sathe M et al (2012) IL-23 induces spondyloarthropathy by acting on ROR-gammat\u2009+\u2009CD3\u2009+\u2009CD4-CD8- entheseal resident T cells. Nat Med 18:1069\u20131076","journal-title":"Nat Med"},{"key":"3117_CR35","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.1002\/art.38809","volume":"66","author":"DB Guiliano","year":"2014","unstructured":"Guiliano DB, Fussell H, Lenart I, Tsao E, Nesbeth D et al (2014) Endoplasmic reticulum degradation-enhancing alpha-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation. Arthritis Rheumatol 66:2976\u20132988","journal-title":"Arthritis Rheumatol"},{"key":"3117_CR36","doi-asserted-by":"publisher","first-page":"398483","DOI":"10.1155\/2015\/398483","volume":"2015","author":"P Lapaquette","year":"2015","unstructured":"Lapaquette P, Guzzo J, Bretillon L, Bringer MA (2015) Cellular and molecular connections between autophagy and inflammation. Mediators Inflamm 2015:398483","journal-title":"Mediators Inflamm"},{"key":"3117_CR37","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1007\/s00018-012-1173-4","volume":"70","author":"S Deegan","year":"2013","unstructured":"Deegan S, Saveljeva S, Gorman AM, Samali A (2013) Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress. Cell Mol Life Sci 70:2425\u20132441","journal-title":"Cell Mol Life Sci"},{"key":"3117_CR38","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.4049\/jimmunol.175.4.2438","volume":"175","author":"MJ Turner","year":"2005","unstructured":"Turner MJ, Sowders DP, DeLay ML, Mohapatra R, Bai S et al (2005) HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response. J Immunol 175:2438\u20132448","journal-title":"J Immunol"},{"key":"3117_CR39","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1002\/art.21740","volume":"54","author":"TM Tran","year":"2006","unstructured":"Tran TM, Dorris ML, Satumtira N, Richardson JA, Hammer RE et al (2006) Additional human beta2-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats. Arthritis Rheum 54:1317\u20131327","journal-title":"Arthritis Rheum"},{"key":"3117_CR40","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/art.22295","volume":"56","author":"MJ Turner","year":"2007","unstructured":"Turner MJ, Delay ML, Bai S, Klenk E, Colbert RA (2007) HLA-B27 up-regulation causes accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: Implications for the pathogenesis of spondylarthritis-like disease. Arthritis Rheum 56:215\u2013223","journal-title":"Arthritis Rheum"},{"key":"3117_CR41","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1002\/art.38638","volume":"66","author":"H Benham","year":"2014","unstructured":"Benham H, Rehaume LM, Hasnain SZ, Velasco J, Baillet AC et al (2014) Interleukin-23 mediates the intestinal response to microbial beta-1,3-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis Rheumatol 66:1755\u20131767","journal-title":"Arthritis Rheumatol"},{"key":"3117_CR42","first-page":"2159","volume":"29","author":"J Gu","year":"2002","unstructured":"Gu J, Rihl M, Marker-Hermann E, Baeten D, Kuipers JG et al (2002) Clues to pathogenesis of spondyloarthropathy derived from synovial fluid mononuclear cell gene expression profiles. J Rheumatol 29:2159\u20132164","journal-title":"J Rheumatol"},{"key":"3117_CR43","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1080\/03009740802213310","volume":"37","author":"W Dong","year":"2008","unstructured":"Dong W, Zhang Y, Yan M, Liu H, Chen Z et al (2008) Upregulation of 78-kDa glucose-regulated protein in macrophages in peripheral joints of active ankylosing spondylitis. Scand J Rheumatol 37:427\u2013434","journal-title":"Scand J Rheumatol"},{"key":"3117_CR44","doi-asserted-by":"publisher","first-page":"574","DOI":"10.3899\/jrheum.101257","volume":"39","author":"Y Feng","year":"2012","unstructured":"Feng Y, Ding J, Fan CM, Zhu P (2012) Interferon-gamma contributes to HLA-B27-associated unfolded protein response in spondyloarthropathies. J Rheumatol 39:574\u2013582","journal-title":"J Rheumatol"},{"key":"3117_CR45","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/annrheumdis-2013-204170","volume":"73","author":"B Neerinckx","year":"2014","unstructured":"Neerinckx B, Carter S, Lories RJ (2014) No evidence for a critical role of the unfolded protein response in synovium and blood of patients with ankylosing spondylitis. Ann Rheum Dis 73:629\u2013630","journal-title":"Ann Rheum Dis"},{"key":"3117_CR46","doi-asserted-by":"publisher","first-page":"3807","DOI":"10.1002\/art.30593","volume":"63","author":"L Zeng","year":"2011","unstructured":"Zeng L, Lindstrom MJ, Smith JA (2011) Ankylosing spondylitis macrophage production of higher levels of interleukin-23 in response to lipopolysaccharide without induction of a significant unfolded protein response. Arthritis Rheum 63:3807\u20133817","journal-title":"Arthritis Rheum"},{"key":"3117_CR47","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1136\/annrheumdis-2012-202925","volume":"73","author":"F Ciccia","year":"2014","unstructured":"Ciccia F, Accardo-Palumbo A, Rizzo A, Guggino G, Raimondo S et al (2014) Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation. Ann Rheum Dis 73:1566\u20131574","journal-title":"Ann Rheum Dis"},{"key":"3117_CR48","doi-asserted-by":"publisher","first-page":"211ra156","DOI":"10.1126\/scitranslmed.3006534","volume":"5","author":"F Engin","year":"2013","unstructured":"Engin F, Yermalovich A, Nguyen T, Hummasti S, Fu W et al (2013) Restoration of the unfolded protein response in pancreatic beta cells protects mice against type 1 diabetes. Sci Transl Med 5:211ra156","journal-title":"Sci Transl Med"},{"key":"3117_CR49","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1002\/art.38001","volume":"65","author":"G Layh-Schmitt","year":"2013","unstructured":"Layh-Schmitt G, Yang EY, Kwon G, Colbert RA (2013) HLA-B27 alters the response to tumor necrosis factor alpha and promotes osteoclastogenesis in bone marrow monocytes from HLA-B27-transgenic rats. Arthritis Rheum 65:2123\u20132131","journal-title":"Arthritis Rheum"},{"key":"3117_CR50","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1517\/14728222.2015.1053869","volume":"19","author":"A Rivas","year":"2015","unstructured":"Rivas A, Vidal RL, Hetz C (2015) Targeting the unfolded protein response for disease intervention. Expert Opin Ther Targets 19:1203\u20131218","journal-title":"Expert Opin Ther Targets"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-015-3117-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-015-3117-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-015-3117-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-015-3117-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T21:24:30Z","timestamp":1692134670000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-015-3117-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,14]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["3117"],"URL":"https:\/\/doi.org\/10.1007\/s10067-015-3117-5","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,14]]},"assertion":[{"value":"1 November 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"This study has been funded by the Rheumatology Research Foundation, NIH\/NHLBI P01 HL070831.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}}]}}