{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:16:30Z","timestamp":1779214590392,"version":"3.51.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T00:00:00Z","timestamp":1467158400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Medical University of Lodz, Jagiellonian University in Krakow","award":["No 503\/8-000-01\/503-81-002, No POIG.01.01.02-00-06"],"award-info":[{"award-number":["No 503\/8-000-01\/503-81-002, No POIG.01.01.02-00-06"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s10067-016-3340-8","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T18:56:19Z","timestamp":1467226579000},"page":"1993-2001","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Nailfold capillaroscopy assessment of microcirculation abnormalities and endothelial dysfunction in children with primary or secondary Raynaud syndrome"],"prefix":"10.1007","volume":"35","author":[{"given":"Joanna","family":"Latuskiewicz-Potemska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonina","family":"Chmura-Skirlinska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryszard J.","family":"Gurbiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elzbieta","family":"Smolewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,6,29]]},"reference":[{"key":"3340_CR1","first-page":"395","volume":"5","author":"B Gryglewska","year":"2010","unstructured":"Gryglewska B (2010) The role of microcirculation in hypertension and its assessment based on skin microvasculature function testing (in Polish). Arterial Hypertens 5:395\u2013410","journal-title":"Arterial Hypertens"},{"key":"3340_CR2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1191\/1358863x05vm639ra","volume":"10","author":"JC Cooke","year":"2005","unstructured":"Cooke JC, Marshall JM (2005) Mechanisms of Raynaud\u2019s disease. Vasc Med 10:293\u2013307","journal-title":"Vasc Med"},{"key":"3340_CR3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/rheumatology\/keh552","volume":"44","author":"AL Herrick","year":"2005","unstructured":"Herrick AL (2005) Pathogenesis of Raynaud\u2019s phenomenon. Rheumatology 44:587\u2013596","journal-title":"Rheumatology"},{"key":"3340_CR4","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.jaad.2008.06.004","volume":"59","author":"R Bakst","year":"2008","unstructured":"Bakst R, Merola JF, Franks AG Jr, Sanchez M et al (2008) Raynaud\u2019s phenomenon: pathogenesis and management. J Am Acad Dermatol 59:633\u2013653","journal-title":"J Am Acad Dermatol"},{"key":"3340_CR5","series-title":"Chapter 1","first-page":"5","volume-title":"Endothelin in the microvasculature in basic science part 1","author":"M Barton","year":"2005","unstructured":"Barton M (2005) Endothelin in the microvasculature in basic science part 1, Chapter 1. Elsevier Science, USA, pp 5\u201312"},{"key":"3340_CR6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cardiores.2007.06.004","volume":"76","author":"F B\u04e7hm","year":"2007","unstructured":"B\u04e7hm F, Pernow J (2007) The importance of endotelin-1 for vascular dysfunction in cardiovascular disease. Cardiovasc Res 76:8\u201318","journal-title":"Cardiovasc Res"},{"key":"3340_CR7","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1002\/art.11060","volume":"48","author":"S Rajagopalan","year":"2003","unstructured":"Rajagopalan S, Pfenninger D, Kehrer C et al (2003) Increased asymmmetric dimethylarginine and endothelin1 levels in secondary Raynaud\u2019s phenomenon. Arthritis Rheum 48:1992\u20132000","journal-title":"Arthritis Rheum"},{"key":"3340_CR8","first-page":"436","volume":"25","author":"I Gazi","year":"2006","unstructured":"Gazi I, Jagroop IA, Mikhailidis DP (2006) Endothelin-1, platelets and Raynaud\u2019s phenomenon. Int Angiol 25:436","journal-title":"Int Angiol"},{"key":"3340_CR9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s005990070018","volume":"30","author":"G Brevetti","year":"2000","unstructured":"Brevetti G, De Caterina M, Martone VD et al (2000) Measurement of soluble adhesion molecules in primary Raynaud\u2019s phenomenon secondary to connective tissue diseases. Int J Clin Lab Res 30:75\u201381","journal-title":"Int J Clin Lab Res"},{"key":"3340_CR10","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1093\/rheumatology\/34.11.1048","volume":"34","author":"CP Denton","year":"1995","unstructured":"Denton CP, Bickerstaff MC, Shiwen X et al (1995) Serial circulating adhesion molecule levels reflect disease severity in Systemic Sclerosis. Br J Rheumatol 34:1048\u20131054","journal-title":"Br J Rheumatol"},{"key":"3340_CR11","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.1007\/s00018-013-1425-y","volume":"70","author":"SK Sedimbi","year":"2013","unstructured":"Sedimbi SK, H\u00e4ggl\u04e7f T, Karlsson MCI (2013) IL-18 in inflammatory and autoimmune disease. Cell Mol Life Sci 70:4795\u2013808","journal-title":"Cell Mol Life Sci"},{"key":"3340_CR12","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1189\/jlb.0602313","volume":"73","author":"JA Gracie","year":"2003","unstructured":"Gracie JA, Robertson SE, McInnes JB (2003) Interleukin 18. J Leukoc Biol 73:213\u2013224","journal-title":"J Leukoc Biol"},{"key":"3340_CR13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/01.moh.0000141926.95319.42","volume":"11","author":"P Reddy","year":"2004","unstructured":"Reddy P (2004) Interleukin-18: recent advances. Curr Opin Hematol 11:405\u2013410","journal-title":"Curr Opin Hematol"},{"key":"3340_CR14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.niox.2004.04.005","volume":"10","author":"M-M Cals-Grierson","year":"2004","unstructured":"Cals-Grierson M-M, Ormerod AD (2004) Nitric Oxide function in the skin. Nitric Oxide 10:179\u2013193","journal-title":"Nitric Oxide"},{"key":"3340_CR15","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/rheumatology\/kei276","volume":"45","author":"A Dooley","year":"2006","unstructured":"Dooley A, Gao B, Bradley N et al (2006) Abnormal nitric oxide metabolism in systemic sclerosis: increased levels of nitrated proteins and asymmetric dimethylarginine. Rheumatology 45:676\u2013684","journal-title":"Rheumatology"},{"key":"3340_CR16","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/S0140-6736(99)04095-7","volume":"354","author":"AT Tucker","year":"1999","unstructured":"Tucker AT, Pearson RM, Cooke ED, Benjamin N (1999) Effect of nitric-oxide-generating system on microcirculatory blood flow in skin of patients with severe Raynaud\u2019s syndrome: a randomized trial. Lancet 354:1670\u20131675","journal-title":"Lancet"},{"key":"3340_CR17","first-page":"485","volume":"10","author":"EC LeRoy","year":"1992","unstructured":"LeRoy EC, Medsger TA Jr (1992) Raynaud\u2019s phenomenon: a proposal for classification. Clin Exp Rheumatol 10:485\u2013488","journal-title":"Clin Exp Rheumatol"},{"key":"3340_CR18","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1525-1470.2006.00278.x","volume":"23","author":"S Pavlov-Dolijanovi\u0107","year":"2006","unstructured":"Pavlov-Dolijanovi\u0107 S, Damjanov N, Ostoji\u0107 P et al (2006) The prognostic value of nailfold capiillary changes for the development connective tissue disease in children and adolescents with primary Raynaud phenomenon: a follow-up study of 250 patients. Pediatr Dermatol 23:437\u2013442","journal-title":"Pediatr Dermatol"},{"key":"3340_CR19","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/art.1780240907","volume":"24","author":"HR Maricq","year":"1981","unstructured":"Maricq HR (1981) Wide-field capillary microscopy. Arthritis Rheum 24:1159\u20131165","journal-title":"Arthritis Rheum"},{"key":"3340_CR20","first-page":"77","volume-title":"Clinical capillaroscopy","author":"A Bollinger","year":"1990","unstructured":"Bollinger A, Fagrell B (1990) Clinical capillaroscopy. Hogrefe\u2009+\u2009Huber Publishers, Toronto-S tuttgart, pp 77\u201392"},{"key":"3340_CR21","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1586\/eci.11.35","volume":"7","author":"M Cutolo","year":"2011","unstructured":"Cutolo M, Sulli A, Smith V (2011) Evaluating microangiopathy in systemic sclerosis: what have we learnt and what is left to discover? Expert Rev Clin Immunol 7:395\u2013397","journal-title":"Expert Rev Clin Immunol"},{"key":"3340_CR22","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s00296-009-1019-z","volume":"29","author":"SN Lambova","year":"2009","unstructured":"Lambova SN, M\u03cbller-Ladner U (2009) The role of capillaroscopy in differentiation of primary and secondary Raynaud\u2019s phenomenon in rheumatic diseases: a review of the literature and two case reports. Rheumatol Int 29:1263\u20131271","journal-title":"Rheumatol Int"},{"key":"3340_CR23","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00296-012-2434-0","volume":"33","author":"SN Lambova","year":"2013","unstructured":"Lambova SN, M\u03cbller-Ladner U (2013) Capillaroscopic pattern in systemic lupus erythematosus and undifferentiated connective tissue disease: what we still have to learn? Rheumatol Int 33:689\u2013695","journal-title":"Rheumatol Int"},{"key":"3340_CR24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10067-009-1288-7","volume":"29","author":"HS Kim","year":"2010","unstructured":"Kim HS, Park MK, Kim HY, Park SH (2010) Capillary dimension measured by computer-based digitalized image correlated with plasma endothelin-1 levels in patients with systemic sclerosis. Clin Rheumatol 29:247\u2013254","journal-title":"Clin Rheumatol"},{"key":"3340_CR25","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/03009740802366050","volume":"38","author":"A Kuryliszyn\u2013Moskal","year":"2009","unstructured":"Kuryliszyn\u2013Moskal A, Ciolkiewicz M, Klimiuk PA, Sierakowski S (2009) Clinical significance of nailfold capillaroscopy in systemic lupus erythematosus: correlation with endothelial cell activation markers and disease activity. Scand J Rheumatol 38:38\u201345","journal-title":"Scand J Rheumatol"},{"key":"3340_CR26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5603\/FHC.2011.0015","volume":"49","author":"A Kuryliszyn-Moskal","year":"2011","unstructured":"Kuryliszyn-Moskal A, Dubicki A, Zarzycki W et al (2011) Microvascular abnormalities in capillaroscopy correlate with higher serum IL-18 and E-selectin levels in patients with type 1 diabetes complicated by microangiopathy. Folia Histochem Cytobiol 49:104\u2013110","journal-title":"Folia Histochem Cytobiol"},{"key":"3340_CR27","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2169\/internalmedicine.33.579","volume":"33","author":"K Yamane","year":"1994","unstructured":"Yamane K (1994) Endothelin and collagen vascular disease: a review with special reference to Raynaud\u2019s phenomenon and systemic sclerosis. Intern Med 33:579\u2013582","journal-title":"Intern Med"},{"key":"3340_CR28","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1042\/cs0960577","volume":"96","author":"CM Edwards","year":"1999","unstructured":"Edwards CM, Marshall JM, Pugh M (1999) Cardiovascular responses evoked by mild cool stimuli in primary Raynaud\u2019s disease: the role of endothelin. Clin Sci 96:577\u2013588","journal-title":"Clin Sci"},{"key":"3340_CR29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/mvre.1996.0055","volume":"52","author":"J D\u04e7rffler-Melly","year":"1996","unstructured":"D\u04e7rffler-Melly J, L\u03cbschier TF, Wenk M et al (1996) Endothelin-1 and cold provocation in health, primary Raynaud\u2019s phenomenon, and progressive systemic sclerosis. Microvasc Res 52:193\u2013197","journal-title":"Microvasc Res"},{"key":"3340_CR30","first-page":"1325","volume":"20","author":"A Blann","year":"1993","unstructured":"Blann A, Illingworth K, Jayson M (1993) Mechanism of endothelial cell damage in systemic sclerosis and Raynaud\u2019s phenomenon. J Rheumatol 20:1325\u20131330","journal-title":"J Rheumatol"},{"key":"3340_CR31","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/art.1780380206","volume":"38","author":"M Gruschwitz","year":"1995","unstructured":"Gruschwitz M, Hornstein O, Driesch P (1995) Correlation of soluble adhesion molecules in the peripheral blood of scleroderma patients with their in situ expression and with disease activity? Arthritis Rheum 38:184\u2013189","journal-title":"Arthritis Rheum"},{"key":"3340_CR32","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1002\/art.22705","volume":"56","author":"MA Amin","year":"2007","unstructured":"Amin MA, Mansfield PJ, Pakozdi A (2007) IL-18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways. Arthritis Rheum 56:1787\u20131797","journal-title":"Arthritis Rheum"},{"key":"3340_CR33","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1749-6632.2009.04742.x","volume":"1173","author":"F Favilli","year":"2009","unstructured":"Favilli F, Anzilotte C, Martinelli L (2009) IL-18 activity in systemic lupus erythematosus. Contemporary challenges in autoimmunity. Ann NY Acad Sci 1173:301\u2013309","journal-title":"Ann NY Acad Sci"},{"key":"3340_CR34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/1358836X0000500304","volume":"5","author":"LI Romero","year":"2000","unstructured":"Romero LI, Zhang DN, Cooke JP et al (2000) Differential expression of nitric oxide by dermal microvascular endothelial cells from patients with scleroderma. Vasc Med 5:147\u2013158","journal-title":"Vasc Med"},{"key":"3340_CR35","first-page":"314","volume":"25","author":"T Yamamoto","year":"1998","unstructured":"Yamamoto T, Katayama I, Nishioka K (1998) Nitric oxide production and inducible nitric oxide synthase expression in systemic sclerosis. J Rheumatol 25:314\u2013317","journal-title":"J Rheumatol"},{"key":"3340_CR36","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/rheumatology\/37.10.1123","volume":"37","author":"T Yamamoto","year":"1998","unstructured":"Yamamoto T, Sawada Y, Katayama I, Nishioka K (1998) Increased production of nitric oxide stimulated by interleukine-1\u03b2 in peripheral blood mononuclear cells in patients with systemic sclerosis. Br J Rheumatol 37:1123\u20131125","journal-title":"Br J Rheumatol"},{"key":"3340_CR37","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/1529-0131(200005)43:5<1085::AID-ANR19>3.0.CO;2-7","volume":"43","author":"G Neumann Andersen","year":"2000","unstructured":"Neumann Andersen G, Caidahl K, Kazzam E et al (2000) Correlation between increased nitric oxide production and markers of endothelial activation in systemic sclerosis. Arthritis Rheum 43:1085\u20131093","journal-title":"Arthritis Rheum"},{"key":"3340_CR38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0009-8981(03)00324-3","volume":"336","author":"JW Choi","year":"2003","unstructured":"Choi JW (2003) Nitric oxide productions increased in patients with rheumatoid arthritis but does not correlate with laboratory parameters of disease activity. Clin Chim Acta 336:83\u201387","journal-title":"Clin Chim Acta"},{"key":"3340_CR39","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00296-007-0321-x","volume":"27","author":"BE Bica","year":"2007","unstructured":"Bica BE, Gomes NM, Fernandes PD et al (2007) Nitric oxide levels and the severity of juvenile idiopathic arthritis. Rheumatol Int 27:819\u2013825","journal-title":"Rheumatol Int"},{"key":"3340_CR40","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1002\/art.1780401013","volume":"40","author":"HM Belmont","year":"1997","unstructured":"Belmont HM, Levartovsky D, Goel A et al (1997) Increased nitric oxide production accompanied by the up-regulation of inducible nitric oxide synthase in vascular endothelium from patients with systemic lupus erythematosus. Arthritis Rheum 40:1810\u20131816","journal-title":"Arthritis Rheum"},{"issue":"Suppl","key":"3340_CR41","first-page":"1469","volume":"41","author":"BM Kahaleh","year":"1998","unstructured":"Kahaleh BM, Fan P (1998) Down regulation of nitric oxide synthase gene in microvascular endothelial cells from lesional scleroderma: assessment by quantitative RT-PCR and possible role for cytotoxic T cells. Arthritis Rheum 41(Suppl):1469","journal-title":"Arthritis Rheum"},{"key":"3340_CR42","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/rheumatology\/40.10.1089","volume":"40","author":"Y Allanore","year":"2001","unstructured":"Allanore Y, Borderie D, Hilliquin P et al (2001) Low levels of nitric oxide (NO) in systemic sclerosis: inducible NO synthase production is decreased in cultured peripheral blood monocyte\/macrophage cells. Rheumatology 40:1089\u20131996","journal-title":"Rheumatology"},{"key":"3340_CR43","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.vph.2014.09.003","volume":"63","author":"D Kundu","year":"2014","unstructured":"Kundu D, Abraham D, Black CM et al (2014) Reduced levels of S-nitrosothiols in plasma of patients with systemic sclerosis and Raynaud\u2019s Phenomenon. Vasc Pharmacol 63:178\u2013181","journal-title":"Vasc Pharmacol"},{"key":"3340_CR44","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/rheumatology\/41.8.843","volume":"41","author":"M Matucci-Cerinic","year":"2002","unstructured":"Matucci-Cerinic M, Kahaleh MB (2002) Beauty and the Beast. The nitric oxide paradox in systemic sclerosis. Rheumatology 41:843\u2013847","journal-title":"Rheumatology"},{"key":"3340_CR45","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1475-097X.1993.tb00327.x","volume":"13","author":"I Ringqvist","year":"1993","unstructured":"Ringqvist I, Hedner T, Leppert J et al (1993) Effects of cold pressor test on circulating atrial natriuretic peptide 99\u2013126 (ANP) in patients with Raynaud\u2019s phenomenon and influence of treatment with magnesium sulphate and nifedipine. Clin Physiol 13:271\u2013280","journal-title":"Clin Physiol"},{"key":"3340_CR46","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1093\/rheumatology\/ket421","volume":"53","author":"AL Herrick","year":"2014","unstructured":"Herrick AL, Murray AK, Ruck A et al (2014) A double-blind, randomized, placebo-controlled crossover trial of the \u03b12C-adrenoceptor antagonist ORM-12741 for prevention of cold-induced vasospasm in patients with systemic sclerosis. Rheumatology (Oxford) 53:948\u2013952","journal-title":"Rheumatology (Oxford)"},{"key":"3340_CR47","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/acr.21622","volume":"64","author":"A Fava","year":"2012","unstructured":"Fava A, Wung PK, Wigley FM et al (2012) Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud\u2019s phenomenon. Arthritis Care Res (Hoboken) 64:925\u2013929","journal-title":"Arthritis Care Res (Hoboken)"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-016-3340-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-016-3340-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-016-3340-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T11:34:55Z","timestamp":1656761695000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-016-3340-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,29]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["3340"],"URL":"https:\/\/doi.org\/10.1007\/s10067-016-3340-8","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,29]]}}}