{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:28:33Z","timestamp":1790378913269,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:00:00Z","timestamp":1497916800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s10067-017-3734-2","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T02:24:18Z","timestamp":1497925458000},"page":"2377-2381","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["In psoriatic arthritis Dkk-1 and PTH are lower than in rheumatoid arthritis and healthy controls"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9187-232X","authenticated-orcid":false,"given":"Angelo","family":"Fassio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Idolazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ombretta","family":"Viapiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Benini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Vantaggiato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bertoldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Rossini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Gatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,20]]},"reference":[{"key":"3734_CR1","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1016\/j.cellsig.2013.04.002","volume":"25","author":"C Miao","year":"2013","unstructured":"Miao C, Yang Y, He X et al (2013) Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling. Cell Signal 25:2069\u20132078. doi:\n10.1016\/j.cellsig.2013.04.002","journal-title":"Cell Signal"},{"key":"3734_CR2","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1093\/rheumatology\/keh553","volume":"44","author":"M Sen","year":"2005","unstructured":"Sen M (2005) Wnt signalling in rheumatoid arthritis. Rheumatol Oxf Engl 44:708\u2013713. doi:\n10.1093\/rheumatology\/keh553","journal-title":"Rheumatol Oxf Engl"},{"key":"3734_CR3","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/nyas.12968","volume":"1364","author":"W Xie","year":"2016","unstructured":"Xie W, Zhou L, Li S et al (2016) Wnt\/\u03b2-catenin signaling plays a key role in the development of spondyloarthritis. Ann N Y Acad Sci 1364:25\u201331. doi:\n10.1111\/nyas.12968","journal-title":"Ann N Y Acad Sci"},{"key":"3734_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00223-013-9749-z","volume":"93","author":"M Rossini","year":"2013","unstructured":"Rossini M, Gatti D, Adami S (2013) Involvement of WNT\/\u03b2-catenin signaling in the treatment of osteoporosis. Calcif Tissue Int 93:121\u2013132. doi:\n10.1007\/s00223-013-9749-z","journal-title":"Calcif Tissue Int"},{"key":"3734_CR5","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.devcel.2005.02.017","volume":"8","author":"DA Glass","year":"2005","unstructured":"Glass DA, Bialek P, Ahn JD et al (2005) Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 8:751\u2013764. doi:\n10.1016\/j.devcel.2005.02.017","journal-title":"Dev Cell"},{"key":"3734_CR6","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1242\/jcs.02883","volume":"119","author":"GJ Spencer","year":"2006","unstructured":"Spencer GJ, Utting JC, Etheridge SL et al (2006) Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro. J Cell Sci 119:1283\u20131296. doi:\n10.1242\/jcs.02883","journal-title":"J Cell Sci"},{"key":"3734_CR7","first-page":"77","volume":"33","author":"M Rossini","year":"2015","unstructured":"Rossini M, Viapiana O, Adami S et al (2015) In patients with rheumatoid arthritis, Dickkopf-1 serum levels are correlated with parathyroid hormone, bone erosions and bone mineral density. Clin Exp Rheumatol 33:77\u201383","journal-title":"Clin Exp Rheumatol"},{"key":"3734_CR8","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.semarthrit.2011.01.006","volume":"41","author":"D Daoussis","year":"2011","unstructured":"Daoussis D, Andonopoulos AP (2011) The emerging role of Dickkopf-1 in bone biology: is it the main switch controlling bone and joint remodeling? Semin Arthritis Rheum 41:170\u2013177. doi:\n10.1016\/j.semarthrit.2011.01.006","journal-title":"Semin Arthritis Rheum"},{"key":"3734_CR9","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/art.1780260210","volume":"26","author":"S Carette","year":"1983","unstructured":"Carette S, Graham D, Little H et al (1983) The natural disease course of ankylosing spondylitis. Arthritis Rheum 26:186\u2013190","journal-title":"Arthritis Rheum"},{"key":"3734_CR10","doi-asserted-by":"publisher","unstructured":"Rossini M, Viapiana O, Idolazzi L et al (2015) Higher level of Dickkopf-1 is associated with low bone mineral density and higher prevalence of vertebral fractures in patients with ankylosing spondylitis. Calcif Tissue Int. doi:\n10.1007\/s00223-015-0093-3","DOI":"10.1007\/s00223-015-0093-3"},{"key":"3734_CR11","doi-asserted-by":"publisher","first-page":"3257","DOI":"10.1002\/art.24888","volume":"60","author":"H Appel","year":"2009","unstructured":"Appel H, Ruiz-Heiland G, Listing J et al (2009) Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis. Arthritis Rheum 60:3257\u20133262. doi:\n10.1002\/art.24888","journal-title":"Arthritis Rheum"},{"key":"3734_CR12","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/art.27231","volume":"62","author":"D Daoussis","year":"2010","unstructured":"Daoussis D, Liossis S-NC, Solomou EE et al (2010) Evidence that Dkk-1 is dysfunctional in ankylosing spondylitis. Arthritis Rheum 62:150\u2013158. doi:\n10.1002\/art.27231","journal-title":"Arthritis Rheum"},{"key":"3734_CR13","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1210\/jc.2010-2552","volume":"96","author":"D Gatti","year":"2011","unstructured":"Gatti D, Viapiana O, Idolazzi L et al (2011) The waning of teriparatide effect on bone formation markers in postmenopausal osteoporosis is associated with increasing serum levels of DKK1. J Clin Endocrinol Metab 96:1555\u20131559. doi:\n10.1210\/jc.2010-2552","journal-title":"J Clin Endocrinol Metab"},{"key":"3734_CR14","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1007\/s00223-012-9665-7","volume":"92","author":"O Viapiana","year":"2013","unstructured":"Viapiana O, Fracassi E, Troplini S et al (2013) Sclerostin and DKK1 in primary hyperparathyroidism. Calcif Tissue Int 92:324\u2013329. doi:\n10.1007\/s00223-012-9665-7","journal-title":"Calcif Tissue Int"},{"key":"3734_CR15","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s40257-013-0032-x","volume":"14","author":"W-H Boehncke","year":"2013","unstructured":"Boehncke W-H, Menter A (2013) Burden of disease: psoriasis and psoriatic arthritis. Am J Clin Dermatol 14:377\u2013388. doi:\n10.1007\/s40257-013-0032-x","journal-title":"Am J Clin Dermatol"},{"key":"3734_CR16","doi-asserted-by":"publisher","unstructured":"Gladman DD, Antoni C, Mease P, et al (2005) Psoriatic arthritis: epidemiology, clinical features, course, and outcome. Ann Rheum Dis 64 Suppl 2:ii14-17. doi: \n10.1136\/ard.2004.032482","DOI":"10.1136\/ard.2004.032482"},{"key":"3734_CR17","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1136\/annrheumdis-2011-200216","volume":"71","author":"GR Heiland","year":"2012","unstructured":"Heiland GR, Appel H, Poddubnyy D et al (2012) High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis. Ann Rheum Dis 71:572\u2013574. doi:\n10.1136\/annrheumdis-2011-200216","journal-title":"Ann Rheum Dis"},{"key":"3734_CR18","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1002\/art.21972","volume":"54","author":"W Taylor","year":"2006","unstructured":"Taylor W, Gladman D, Helliwell P et al (2006) Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum 54:2665\u20132673. doi:\n10.1002\/art.21972","journal-title":"Arthritis Rheum"},{"key":"3734_CR19","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ et al (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62:2569\u20132581. doi:\n10.1002\/art.27584","journal-title":"Arthritis Rheum"},{"key":"3734_CR20","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1136\/annrheumdis-2015-207507","volume":"75","author":"MM Schoels","year":"2016","unstructured":"Schoels MM, Aletaha D, Alasti F, Smolen JS (2016) Disease activity in psoriatic arthritis (PsA): defining remission and treatment success using the DAPSA score. Ann Rheum Dis 75:811\u2013818. doi:\n10.1136\/annrheumdis-2015-207507","journal-title":"Ann Rheum Dis"},{"key":"3734_CR21","unstructured":"Wells G, Boers M, Tugwell P, MDA Working Group (2006) Low disease activity state in rheumatoid arthritis: concepts and derivation of minimal disease activity. Clin Exp Rheumatol 24:S-52-59."},{"key":"3734_CR22","doi-asserted-by":"publisher","first-page":"R164","DOI":"10.1186\/ar3123","volume":"12","author":"N Dalbeth","year":"2010","unstructured":"Dalbeth N, Pool B, Smith T et al (2010) Circulating mediators of bone remodeling in psoriatic arthritis: implications for disordered osteoclastogenesis and bone erosion. Arthritis Res Ther 12:R164. doi:\n10.1186\/ar3123","journal-title":"Arthritis Res Ther"},{"key":"3734_CR23","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1007\/s00198-015-3069-2","volume":"26","author":"Z Petho","year":"2015","unstructured":"Petho Z, Kulcsar-Jakab E, Kalina E et al (2015) Vitamin D status in men with psoriatic arthritis: a case-control study. Osteoporos Int J Establ Result Coop Eur Found Osteoporos Natl Osteoporos Found USA 26:1965\u20131970. doi:\n10.1007\/s00198-015-3069-2","journal-title":"Osteoporos Int J Establ Result Coop Eur Found Osteoporos Natl Osteoporos Found USA"},{"key":"3734_CR24","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nm1538","volume":"13","author":"D Diarra","year":"2007","unstructured":"Diarra D, Stolina M, Polzer K et al (2007) Dickkopf-1 is a master regulator of joint remodeling. Nat Med 13:156\u2013163. doi:\n10.1038\/nm1538","journal-title":"Nat Med"},{"key":"3734_CR25","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1002\/art.27496","volume":"62","author":"G Kr\u00f6nke","year":"2010","unstructured":"Kr\u00f6nke G, Uderhardt S, Kim K-A et al (2010) R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway. Arthritis Rheum 62:2303\u20132312. doi:\n10.1002\/art.27496","journal-title":"Arthritis Rheum"},{"key":"3734_CR26","doi-asserted-by":"publisher","unstructured":"Zou Y-C, Yang X-W, Yuan S-G et al (2016) Downregulation of dickkopf-1 enhances the proliferation and osteogenic potential of fibroblasts isolated from ankylosing spondylitis patients via the Wnt\/\u03b2-catenin signaling pathway in vitro. Connect Tissue Res:1\u201312. doi:\n10.3109\/03008207.2015.1127916","DOI":"10.3109\/03008207.2015.1127916"},{"key":"3734_CR27","doi-asserted-by":"publisher","unstructured":"Chen B, Cheng G, Wang H, Feng Y (2016) Increased risk of vertebral fracture in patients with rheumatoid arthritis. Medicine (Baltimore). doi:\n10.1097\/MD.0000000000005262","DOI":"10.1097\/MD.0000000000005262"},{"key":"3734_CR28","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.semarthrit.2016.05.005","volume":"46","author":"S Chandran","year":"2016","unstructured":"Chandran S, Aldei A, Johnson SR et al (2016) Prevalence and risk factors of low bone mineral density in psoriatic arthritis: a systematic review. Semin Arthritis Rheum 46:174\u2013182. doi:\n10.1016\/j.semarthrit.2016.05.005","journal-title":"Semin Arthritis Rheum"},{"key":"3734_CR29","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1136\/annrheumdis-2016-210441","volume":"76","author":"A Ogdie","year":"2017","unstructured":"Ogdie A, Harter L, Shin D et al (2017) The risk of fracture among patients with psoriatic arthritis and psoriasis: a population-based study. Ann Rheum Dis 76:882\u2013885. doi:\n10.1136\/annrheumdis-2016-210441","journal-title":"Ann Rheum Dis"},{"key":"3734_CR30","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.blre.2013.08.002","volume":"27","author":"F Zhou","year":"2013","unstructured":"Zhou F, Meng S, Song H, Claret FX (2013) Dickkopf-1 is a key regulator of myeloma bone disease: opportunities and challenges for therapeutic intervention. Blood Rev 27:261\u2013267. doi:\n10.1016\/j.blre.2013.08.002","journal-title":"Blood Rev"},{"key":"3734_CR31","doi-asserted-by":"publisher","first-page":"311","DOI":"10.5306\/wjco.v2.i8.311","volume":"2","author":"S Fatima","year":"2011","unstructured":"Fatima S, Lee NP, Luk JM (2011) Dickkopfs and Wnt\/\u03b2-catenin signalling in liver cancer. World J Clin Oncol 2:311\u2013325. doi:\n10.5306\/wjco.v2.i8.311","journal-title":"World J Clin Oncol"},{"key":"3734_CR32","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1186\/1471-2407-14-649","volume":"14","author":"TD Rachner","year":"2014","unstructured":"Rachner TD, Thiele S, G\u00f6bel A et al (2014) High serum levels of Dickkopf-1 are associated with a poor prognosis in prostate cancer patients. BMC Cancer 14:649. doi:\n10.1186\/1471-2407-14-649","journal-title":"BMC Cancer"},{"key":"3734_CR33","doi-asserted-by":"publisher","first-page":"8271","DOI":"10.3748\/wjg.v22.i37.8271","volume":"22","author":"S Hees Van","year":"2016","unstructured":"Van Hees S, Michielsen P, Vanwolleghem T (2016) Circulating predictive and diagnostic biomarkers for hepatitis B virus-associated hepatocellular carcinoma. World J Gastroenterol 22:8271\u20138282. doi:\n10.3748\/wjg.v22.i37.8271","journal-title":"World J Gastroenterol"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-017-3734-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-017-3734-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-017-3734-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T06:23:35Z","timestamp":1505197415000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-017-3734-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,20]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["3734"],"URL":"https:\/\/doi.org\/10.1007\/s10067-017-3734-2","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,20]]}}}