{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T03:36:11Z","timestamp":1774064171673,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["Project for Conceptual Development for the institution of the Ministry of Health Czech Republic - Institute of Rheumatology (number 023728),"],"award-info":[{"award-number":["Project for Conceptual Development for the institution of the Ministry of Health Czech Republic - Institute of Rheumatology (number 023728),"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007543","name":"Grantov\u00e1 Agentura, Univerzita Karlova","doi-asserted-by":"publisher","award":["GAUK number 214615"],"award-info":[{"award-number":["GAUK number 214615"]}],"id":[{"id":"10.13039\/100007543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Charles University, Faculty of Physical Education and Sports","award":["SVV for FTVS 2017 - number 260466"],"award-info":[{"award-number":["SVV for FTVS 2017 - number 260466"]}]},{"name":"Charles University, Faculty of Physical education and Sport","award":["Programme of the institutional support for the development of science at Charles University Progress, No. Q41 Biological aspects of the investigation of human movement"],"award-info":[{"award-number":["Programme of the institutional support for the development of science at Charles University Progress, No. Q41 Biological aspects of the investigation of human movement"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s10067-017-3802-7","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T16:43:12Z","timestamp":1504111392000},"page":"173-179","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Changes of patient-reported outcomes and protein fingerprint biomarkers after exercise therapy for axial spondyloarthritis"],"prefix":"10.1007","volume":"38","author":[{"given":"Marketa","family":"Husakova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Sofie","family":"Siebuhr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"Pavelka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Spiritovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Christine","family":"Bay-Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Levitova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,8,30]]},"reference":[{"key":"3802_CR1","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/art.1780270401","volume":"27","author":"S Linden van der","year":"1984","unstructured":"van der Linden S, Valkenburg HA, Cats A (1984) Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum 27:361\u2013368","journal-title":"Arthritis Rheum"},{"key":"3802_CR2","doi-asserted-by":"publisher","first-page":"ii1","DOI":"10.1136\/ard.2008.104018","volume":"68","author":"J Sieper","year":"2009","unstructured":"Sieper J, Rudwaleit M, Baraliakos X et al (2009) The Assessment of SpondyloArthritis international Society (ASAS) handbook: a guide to assess spondyloarthritis. Ann Rheum Dis 68:ii1\u2013ii44. \n                    https:\/\/doi.org\/10.1136\/ard.2008.104018","journal-title":"Ann Rheum Dis"},{"key":"3802_CR3","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1136\/ard.2010.145995","volume":"70","author":"D Poddubnyy","year":"2011","unstructured":"Poddubnyy D, Rudwaleit M, Haibel H et al (2011) Rates and predictors of radiographic sacroiliitis progression over 2 years in patients with axial spondyloarthritis. Ann Rheum Dis 70:1369\u20131374. \n                    https:\/\/doi.org\/10.1136\/ard.2010.145995","journal-title":"Ann Rheum Dis"},{"key":"3802_CR4","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/acr.22908","volume":"69","author":"C Fern\u00e1ndez-Carballido","year":"2017","unstructured":"Fern\u00e1ndez-Carballido C, Navarro-Comp\u00e1n V, Castillo-Gallego C et al (2017) Disease activity as a major determinant of quality of life and physical function in patients with early axial spondyloarthritis. Arthritis Care Res (Hoboken) 69:150\u2013155. \n                    https:\/\/doi.org\/10.1002\/acr.22908","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"3802_CR5","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.3899\/jrheum.150463","volume":"42","author":"M Bedaiwi","year":"2015","unstructured":"Bedaiwi M, Sari I, Thavaneswaran A et al (2015) Fatigue in ankylosing spondylitis and nonradiographic axial spondyloarthritis: analysis from a longitudinal observation cohort. J Rheumatol 42:2354\u20132360. \n                    https:\/\/doi.org\/10.3899\/jrheum.150463","journal-title":"J Rheumatol"},{"key":"3802_CR6","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1002\/art.24483","volume":"60","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, Haibel H, Baraliakos X et al (2009) The early disease stage in axial spondylarthritis: results from the German spondyloarthritis inception cohort. Arthritis Rheum 60:717\u2013727. \n                    https:\/\/doi.org\/10.1002\/art.24483","journal-title":"Arthritis Rheum"},{"key":"3802_CR7","doi-asserted-by":"publisher","unstructured":"van der Heijde D, Ramiro S, Landew\u00e9 R, et al (2017) 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis. doi: \n                    https:\/\/doi.org\/10.1136\/annrheumdis-2016-210770","DOI":"10.1136\/annrheumdis-2016-210770"},{"key":"3802_CR8","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.semarthrit.2015.08.003","volume":"45","author":"JR Millner","year":"2016","unstructured":"Millner JR, Barron JS, Beinke KM et al (2016) Exercise for ankylosing spondylitis: an evidence-based consensus statement. Semin Arthritis Rheum 45:411\u2013427. \n                    https:\/\/doi.org\/10.1016\/j.semarthrit.2015.08.003","journal-title":"Semin Arthritis Rheum"},{"key":"3802_CR9","unstructured":"Karapolat H1, Akkoc Y, Sari I, Eyigor S, Akar S, Kirazli Y, Akkoc N (2008) Comparison of group-based exercise versus home-based exercise in patients with ankylosing spondylitis: effects on Bath Ankylosing Spondylitis Indices, quality of life and depression. Clin Rheumatol 27(6):695-700"},{"key":"3802_CR10","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/s13075-016-1180-1","volume":"18","author":"A Levitova","year":"2016","unstructured":"Levitova A, Hulejova H, Spiritovic M et al (2016) Clinical improvement and reduction in serum calprotectin levels after an intensive exercise programme for patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis. Arthritis Res Ther 18:275. \n                    https:\/\/doi.org\/10.1186\/s13075-016-1180-1","journal-title":"Arthritis Res Ther"},{"key":"3802_CR11","doi-asserted-by":"publisher","first-page":"3565","DOI":"10.1007\/s00296-011-2237-8","volume":"32","author":"AC Bay-Jensen","year":"2012","unstructured":"Bay-Jensen AC, Leeming DJ, Kleyer A et al (2012) Ankylosing spondylitis is characterized by an increased turnover of several different metalloproteinase-derived collagen species: a cross-sectional study. Rheumatol Int 32:3565\u20133572. \n                    https:\/\/doi.org\/10.1007\/s00296-011-2237-8","journal-title":"Rheumatol Int"},{"key":"3802_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0054504","volume":"8","author":"AC Bay-Jensen","year":"2013","unstructured":"Bay-Jensen AC, Wichuk S, Byrjalsen I et al (2013) Circulating protein fragments of cartilage and connective tissue degradation are diagnostic and prognostic markers of rheumatoid arthritis and ankylosing spondylitis. PLoS One 8:1\u20137. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0054504","journal-title":"PLoS One"},{"key":"3802_CR13","doi-asserted-by":"publisher","first-page":"197","DOI":"10.2217\/bmm.15.119","volume":"10","author":"AS Siebuhr","year":"2016","unstructured":"Siebuhr AS, Bay-Jensen AC, Karsdal MA et al (2016) CRP and a biomarker of type I collagen degradation, C1M, can differentiate anti-inflammatory treatment response in ankylosing spondylitis. Biomark Med 10:197\u2013208. \n                    https:\/\/doi.org\/10.2217\/bmm.15.119","journal-title":"Biomark Med"},{"key":"3802_CR14","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1002\/art.37843","volume":"65","author":"AC Bay-Jensen","year":"2013","unstructured":"Bay-Jensen AC, Karsdal MA, Vassiliadis E et al (2013) Circulating citrullinated vimentin fragments reflect disease burden in ankylosing spondylitis and have prognostic capacity for radiographic progression. Arthritis Rheum 65:972\u2013980. \n                    https:\/\/doi.org\/10.1002\/art.37843","journal-title":"Arthritis Rheum"},{"key":"3802_CR15","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1136\/ard.62.1.20","volume":"62","author":"LC Doward","year":"2003","unstructured":"Doward LC, Spoorenberg A, Cook SA et al (2003) Development of the ASQoL: a quality of life instrument specific to ankylosing spondylitis. Ann Rheum Dis 62:20\u201326. \n                    https:\/\/doi.org\/10.1136\/ard.62.1.20","journal-title":"Ann Rheum Dis"},{"key":"3802_CR16","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3109\/07853890109002087","volume":"33","author":"R Rabin","year":"2001","unstructured":"Rabin R, De CF (2001) EQ-5D: a measure of health status from the EuroQol Group. Ann Med 33:337\u2013343. \n                    https:\/\/doi.org\/10.3109\/07853890109002087","journal-title":"Ann Med"},{"key":"3802_CR17","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1007\/s10067-016-3264-3","volume":"35","author":"LS Gensler","year":"2016","unstructured":"Gensler LS (2016) Physical activity in axial spondyloarthritis\u2014tails from bench to bedside. Clin Rheumatol 35:1443\u20131445. \n                    https:\/\/doi.org\/10.1007\/s10067-016-3264-3","journal-title":"Clin Rheumatol"},{"key":"3802_CR18","doi-asserted-by":"publisher","first-page":"e2254","DOI":"10.1097\/MD.0000000000002254","volume":"94","author":"H Liang","year":"2015","unstructured":"Liang H, Li W-R, Zhang H et al (2015) Concurrent intervention with exercises and stabilized tumor necrosis factor inhibitor therapy reduced the disease activity in patients with ankylosing spondylitis. Medicine (Baltimore) 94:e2254. \n                    https:\/\/doi.org\/10.1097\/MD.0000000000002254","journal-title":"Medicine (Baltimore)"},{"key":"3802_CR19","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.semarthrit.2014.09.012","volume":"44","author":"E Lubrano","year":"2015","unstructured":"Lubrano E, Spadaro A, Amato G et al (2015) Tumour necrosis factor alpha inhibitor therapy and rehabilitation for the treatment of ankylosing spondylitis: a systematic review. Semin Arthritis Rheum 44:542\u2013550. \n                    https:\/\/doi.org\/10.1016\/j.semarthrit.2014.09.012","journal-title":"Semin Arthritis Rheum"},{"key":"3802_CR20","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s00296-013-2869-y","volume":"34","author":"MO Ro\u015fu","year":"2014","unstructured":"Ro\u015fu MO, \u0162opa I, Chirieac R, Ancuta C (2014) Effects of Pilates, McKenzie and Heckscher training on disease activity, spinal motility and pulmonary function in patients with ankylosing spondylitis: a randomized controlled trial. Rheumatol Int 34:367\u2013372. \n                    https:\/\/doi.org\/10.1007\/s00296-013-2869-y","journal-title":"Rheumatol Int"},{"key":"3802_CR21","first-page":"261","volume":"51","author":"OM Rosu","year":"2015","unstructured":"Rosu OM, Ancuta C (2015) McKenzie training in patients with early stages of ankylosing spondylitis: results of a 24-week controlled study. Eur J Phys Rehabil Med 51:261\u2013268","journal-title":"Eur J Phys Rehabil Med"},{"key":"3802_CR22","first-page":"228","volume":"17","author":"G Kraag","year":"1990","unstructured":"Kraag G, Stokes B, Groh J et al (1990) The effects of comprehensive home physiotherapy and supervision on patients with ankylosing spondylitis\u2014a randomized controlled trial. J Rheumatol 17:228\u2013233","journal-title":"J Rheumatol"},{"key":"3802_CR23","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1002\/acr.21688","volume":"64","author":"U Kiltz","year":"2012","unstructured":"Kiltz U, Baraliakos X, Karakostas P et al (2012) Do patients with non-radiographic axial spondylarthritis differ from patients with ankylosing spondylitis? Arthritis Care Res (Hoboken) 64:1415\u20131422. \n                    https:\/\/doi.org\/10.1002\/acr.21688","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"3802_CR24","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12955-015-0268-7","volume":"13","author":"S Kreis","year":"2015","unstructured":"Kreis S, Molto A, Bailly F et al (2015) Relationship between optimism and quality of life in patients with two chronic rheumatic diseases: axial spondyloarthritis and chronic low back pain: a cross sectional study of 288 patients. Health Qual Life Outcomes 13:78. \n                    https:\/\/doi.org\/10.1186\/s12955-015-0268-7","journal-title":"Health Qual Life Outcomes"},{"key":"3802_CR25","doi-asserted-by":"publisher","first-page":"109502","DOI":"10.1155\/2008\/109502","volume":"2008","author":"N Mathur","year":"2008","unstructured":"Mathur N, Pedersen BK (2008) Exercise as a mean to control low-grade systemic inflammation. Mediat Inflamm 2008:109502. \n                    https:\/\/doi.org\/10.1155\/2008\/109502","journal-title":"Mediat Inflamm"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-017-3802-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-017-3802-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-017-3802-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T09:39:26Z","timestamp":1568972366000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-017-3802-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,30]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["3802"],"URL":"https:\/\/doi.org\/10.1007\/s10067-017-3802-7","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,30]]},"assertion":[{"value":"29 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All patients signed informed consent (approved by the Ethics Committee of the Institute of Rheumatology) and have all data and biomarkers analysed after study conclusion. Principles of Good Clinical Practice and the Declaration of Helsinki were reflected in this study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}