{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:57:57Z","timestamp":1762955877118},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Research Foundation of Central Region, Denmark"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s10067-018-4034-1","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T11:13:05Z","timestamp":1519384385000},"page":"2455-2463","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Characteristics of children with acute lymphoblastic leukemia presenting with arthropathy"],"prefix":"10.1007","volume":"37","author":[{"given":"Ninna","family":"Brix","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hasle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steen","family":"Rosth\u00f8j","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troels","family":"Herlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"issue":"20","key":"4034_CR1","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1093\/jnci\/djg064","volume":"95","author":"L Hjalgrim","year":"2003","unstructured":"Hjalgrim L, Rostgaard K, Schmiegelow K et al (2003) Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries. J Nat Cancer Inst 95(20):1539\u20131544","journal-title":"J Nat Cancer Inst"},{"issue":"9","key":"4034_CR2","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1136\/archdischild-2014-307751","volume":"100","author":"N Brix","year":"2015","unstructured":"Brix N, Rosth\u00f8j S, Herlin T, Hasle H (2015) Arthritis as presenting manifestation of acute lymphoblastic leukaemia in children. Arch Dis Child 100(9):821\u2013825","journal-title":"Arch Dis Child"},{"issue":"3","key":"4034_CR3","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s00277-009-0826-3","volume":"89","author":"R Marwaha","year":"2010","unstructured":"Marwaha R, Kulkarn K, Amita T, Bansal D (2010) Acute lymphoblastic leukemia masquerading as juvenile rheumatoid arthritis: diagnostic pitfall and association with survival. Ann Hematol 89(3):249\u2013254","journal-title":"Ann Hematol"},{"issue":"3","key":"4034_CR4","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1097\/BPB.0b013e32835d731c","volume":"22","author":"I Riccio","year":"2013","unstructured":"Riccio I, Marcarelli M, Nicola D et al (2013) Musculoskeletal problems in pediatric acute leukemia. J Pediatr Orthop B 22(3):264\u2013269","journal-title":"J Pediatr Orthop B"},{"issue":"5","key":"4034_CR5","doi-asserted-by":"publisher","first-page":"e840","DOI":"10.1542\/peds.2005-1515","volume":"117","author":"OY Jones","year":"2006","unstructured":"Jones OY, Spencer CH, Bowyer SL, Dent PB, Gottlieb BS, Rabinovich C (2006) A multicenter case-control study on predictive factors distinguishing childhood leukemia from juvenile rheumatoid arthritis. Pediatrics 117(5):e840\u2013e844","journal-title":"Pediatrics"},{"key":"4034_CR6","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1097\/MPH.0b013e3181468c55","volume":"29","author":"T Robazzi","year":"2007","unstructured":"Robazzi T, Barreto J, Silva L, Mendonca N (2007) Osteoarticular manifestations as initial presentation of acute Leukemias in children and adolescents in Bahia, Brazil. J Pediatr Hematol Oncol 29:622\u2013626","journal-title":"J Pediatr Hematol Oncol"},{"issue":"8","key":"4034_CR7","first-page":"A4883","volume":"61","author":"N Brix","year":"2014","unstructured":"Brix N, Rosth\u00f8j S (2014) Bone marrow involvement is not manifest in the early stages of childhood acute lymphoblastic leukaemia. Dan Med J 61(8):A4883","journal-title":"Dan Med J"},{"key":"4034_CR8","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0022-3476(99)70372-0","volume":"134","author":"D Cabral","year":"1999","unstructured":"Cabral D, Tucker L (1999) Malignancies in children who initially present with rheumatic complaints. J Pediatr 134:53\u201357","journal-title":"J Pediatr"},{"key":"4034_CR9","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0022-3476(05)80535-9","volume":"117","author":"O Jonsson","year":"1990","unstructured":"Jonsson O, Sartain P, Ducore J, Buchanan G (1990) Bone pain as an initial symptom of childhood acute lymphoblastic leukemia: association with nearly normal hematologic indexes. J Pediatr 117:233\u2013237","journal-title":"J Pediatr"},{"issue":"6","key":"4034_CR10","doi-asserted-by":"publisher","first-page":"481","DOI":"10.2223\/JPED.903","volume":"78","author":"C Barbosa","year":"2002","unstructured":"Barbosa C, Nakamura C, Terreri M, Lee M, Petrilli A, Hil\u00e1rio M (2002) Musculoskeletal manifestations as the onset of acute leukemias in childhood. J Pediatr 78(6):481\u2013484","journal-title":"J Pediatr"},{"issue":"2","key":"4034_CR11","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1590\/S0104-42302008000200015","volume":"54","author":"L Campos","year":"2008","unstructured":"Campos L, Goldstein S, Santiago R et al (2008) Musculoskeletal involvement as a first manifestation of neoplasm disease. Rev Assoc Med Bras 54(2):132\u2013138","journal-title":"Rev Assoc Med Bras"},{"issue":"11","key":"4034_CR12","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1007\/s10067-009-1221-0","volume":"28","author":"F Tafaghodi","year":"2009","unstructured":"Tafaghodi F, Aghighi Y, Yazdi H, Shakiba M, Adibi A (2009) Predictive plain X-ray findings in distinguishing early stage acute lymphoblastic leukemia from juvenile idiopathic arthritis. Clin Rheumatol 28(11):1253\u20131258","journal-title":"Clin Rheumatol"},{"key":"4034_CR13","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1136\/ard.54.10.787","volume":"54","author":"S Menon","year":"1995","unstructured":"Menon S, Isenberg DA, Menon S (1995) Rheumatological manifestations of haematological diseases. Ann ofthe Rheum Dis 54:787\u2013795","journal-title":"Ann ofthe Rheum Dis"},{"issue":"8","key":"4034_CR14","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1002\/1097-0142(19850415)55:8<1637::AID-CNCR2820550804>3.0.CO;2-H","volume":"55","author":"T Revesz","year":"1985","unstructured":"Revesz T, Kardos G, Schuler D (1985) The adverse effect of prolonged prednisolone pretreatment in children with acute lymphoblastic leukemia. Cancer 55(8):1637\u20131640","journal-title":"Cancer"},{"issue":"6","key":"4034_CR15","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s00296-009-1064-7","volume":"30","author":"D Gupta","year":"2010","unstructured":"Gupta D, Singh S, Suri D, Ahluwalia J, Das R, Varma N (2010) Arthritic presentation of acute leukemia in children: experience from a tertiary care centre in North India. Rheumatol Int 30(6):767\u2013770","journal-title":"Rheumatol Int"},{"issue":"10","key":"4034_CR16","first-page":"1665","volume":"66","author":"M Tamashiro","year":"2011","unstructured":"Tamashiro M, Aikawa N, Campos L, Cristofani L, Odone-Filho V, Silva C (2011) Discrimination of acute lymphoblastic leukemia from systemic-onset juvenile idiopathic arthritis at disease onset. Clinics 66(10):1665\u20131669","journal-title":"Clinics"},{"issue":"4","key":"4034_CR17","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/S0022-3476(05)83543-7","volume":"122","author":"B Ostrov","year":"1993","unstructured":"Ostrov B, Goldsmith D, Athreya B (1993) Differentiation of systemic juvenile rheumatoid arthritis from acute leukemia near the onset of disease. J Pediatr 122(4):595\u2013598","journal-title":"J Pediatr"},{"issue":"1","key":"4034_CR18","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1546-0096-11-20","volume":"11","author":"L Zombori","year":"2013","unstructured":"Zombori L, Kovacs G, Csoka M, Derfalvi B (2013) Rheumatic symptoms in childhood leukaemia and lymphoma-a ten-year retrospective study. Pediatr Rheumatol Online J [Internet] 11(1):20 Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3645950&tool=pmcentrez&rendertype=abstract","journal-title":"Pediatr Rheumatol Online J [Internet]"},{"key":"4034_CR19","unstructured":"Hansen O, Herlin T (2005) Acute lymphatic leukemia masquering as polyarticular juvenil arthritis. Clin Exp Rheumatol. 23(s37)"},{"issue":"5","key":"4034_CR20","first-page":"903","volume":"10","author":"S Biswas","year":"2009","unstructured":"Biswas S, Chakrabarti S, Chakraborty J, Paul P, Konar A, Das S (2009) Childhood acute leukemia in West Bengal, India with an emphasis on uncommon clinical features. Asian Pac J Cancer Prev 10(5):903\u2013906","journal-title":"Asian Pac J Cancer Prev"},{"issue":"1","key":"4034_CR21","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1097\/BPO.0b13e31815ff350","volume":"28","author":"R Sinigaglia","year":"2008","unstructured":"Sinigaglia R, Gigante C, Bisinella G, Varotto S, Zanesco L, Turra S (2008) Musculoskeletal manifestations in pediatric acute leukemia. J Pediatr Orthop 28(1):20\u201328","journal-title":"J Pediatr Orthop"},{"issue":"4","key":"4034_CR22","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/S0022-3476(05)83543-7","volume":"122","author":"B Ostrov","year":"1993","unstructured":"Ostrov B, Goldsmith D, Athreya B (1993) Differentiation of systemic juvenile rheumatoid arthritis from acute leukemia near the onset of disease. J Pediatr 122(4):595\u2013598","journal-title":"J Pediatr"},{"issue":"6","key":"4034_CR23","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1007\/s00296-010-1584-1","volume":"31","author":"D Suri","year":"2011","unstructured":"Suri D, Ahluwalia J, Sachdeva M, Das R, Varma N, Singh S (2011) Arthritic presentation of childhood malignancy: beware of normal blood counts. Rheumatol Int 31(6):827\u2013829","journal-title":"Rheumatol Int"},{"key":"4034_CR24","first-page":"85","volume":"21","author":"A Rashid","year":"2005","unstructured":"Rashid A, Al Mamun A, Rasu L et al (2005) Leukaemia mimicking juvenile rheumatoid arthritis. Pak J Med Sci 21:85\u201387","journal-title":"Pak J Med Sci"},{"key":"4034_CR25","unstructured":"Tsai M, Yan D, Lin K et al. (1995) Childhood leukemia mimicking juvenile rheumatoid arthritis. ;36(4):274\u20138"},{"issue":"6","key":"4034_CR26","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1055\/s-0029-1239538","volume":"221","author":"B Bernbeck","year":"2012","unstructured":"Bernbeck B, W\u00fcller D, Janssen GWR et al (2012) Symptoms of childhood acute lymphoblastic leukemia: red flags to recognize leukemia in daily practice. Klin Padiatr 221(6):369\u2013373","journal-title":"Klin Padiatr"},{"issue":"10","key":"4034_CR27","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1136\/archdischild-2016-311251","volume":"101","author":"RT Clarke","year":"2016","unstructured":"Clarke RT, Van den Bruel A, Thompson MJ et al (2016) Clinical presentation of childhood leukaemia: a systematic review and meta-analysis. Arch Dis Child 101(10):894\u2013901","journal-title":"Arch Dis Child"},{"issue":"10","key":"4034_CR28","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1093\/rheumatology\/41.10.1183","volume":"41","author":"W Thomson","year":"2002","unstructured":"Thomson W, Barrett J, Donn R (2002) Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients. Rheumatology 41(10):1183\u20131189","journal-title":"Rheumatology"},{"issue":"9563","key":"4034_CR29","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S0140-6736(07)60363-8","volume":"369","author":"A Ravelli","year":"2007","unstructured":"Ravelli A, Martini A (2007) Juvenile idiopathic arthritis. Lancet 369(9563):767\u2013778","journal-title":"Lancet"},{"issue":"4","key":"4034_CR30","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1136\/adc.77.4.299","volume":"77","author":"PN Malleson","year":"1997","unstructured":"Malleson PN, Sailer M, Mackinnon MJ (1997) Usefulness of antinuclear antibody testing to screen for rheumatic diseases. Arch Dis Child 77(4):299\u2013304","journal-title":"Arch Dis Child"},{"issue":"1","key":"4034_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000040913","volume":"101","author":"H Gur","year":"1999","unstructured":"Gur H, Koren V, Ehrenfeld M, Ben-Bassat I, Sidi Y (1999) Rheumatic manifestations preceding adult acute leukemia: characteristics and implication in course and prognosis. Acta Haematol 101(1):1\u20136","journal-title":"Acta Haematol"},{"issue":"7472","key":"4034_CR32","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1136\/bmj.329.7472.959","volume":"329","author":"M Murray","year":"2004","unstructured":"Murray M, Tang T, Ryde C, Mabin D, Nicholson J (2004) Childhood leukaemia masquerading as juvenile idiopathic arthritis. BMJ 329(7472):959\u2013961","journal-title":"BMJ"},{"key":"4034_CR33","doi-asserted-by":"crossref","unstructured":"Dang-tan T, Franco EL. Diagnosis Delays in Childhood Cancer. 2007;(July)","DOI":"10.1002\/cncr.22849"},{"issue":"1\u20132","key":"4034_CR34","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3109\/10428199609054810","volume":"23","author":"T Kai","year":"1996","unstructured":"Kai T, Ishii E, Matsuzaki A, Okamura J, Ikuno Y, Tasaka E, Ueda K (1996) Clinical and prognostic implications of bone lesions in childhood leukemia at diagnosis. Leuk Lymphoma 23(1\u20132):119\u2013123","journal-title":"Leuk Lymphoma"},{"key":"4034_CR35","doi-asserted-by":"crossref","unstructured":"Ahrensberg JM, Fenger-gr\u00f8n M, Vedsted P. (2013) Use of primary care during the year before childhood cancer diagnosis: a nationwide population-based matched comparative study. 8(3):1\u20138","DOI":"10.1371\/journal.pone.0059098"},{"issue":"5","key":"4034_CR36","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/j.1365-2141.2011.08871.x","volume":"155","author":"A Vora","year":"2011","unstructured":"Vora A (2011) Management of osteonecrosis in children and young adults with acute lymphoblastic leukaemia. Br J Haematol 155(5):549\u2013560","journal-title":"Br J Haematol"},{"key":"4034_CR37","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3109\/08880019809167227","volume":"15","author":"HLM M\u00fcller","year":"1998","unstructured":"M\u00fcller HLM et al (1998) Acute lymphoblastic leukemia with severe skeletal involvement: a subset of childhood leukemia with a good prognosis Patients and Skeletal Surveys. Pediatr Hematol Oncol 15:121\u2013133","journal-title":"Pediatr Hematol Oncol"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-018-4034-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-018-4034-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-018-4034-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T14:23:37Z","timestamp":1570803817000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-018-4034-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,21]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["4034"],"URL":"https:\/\/doi.org\/10.1007\/s10067-018-4034-1","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,21]]},"assertion":[{"value":"18 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}