{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:59:39Z","timestamp":1793743179279,"version":"4.6.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Project of the Ministry of Health of the Czech Republic for conceptual research development by organization","award":["023728"],"award-info":[{"award-number":["023728"]}]},{"name":"Specific Academy Research Projects","award":["260373"],"award-info":[{"award-number":["260373"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s10067-018-4091-5","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T03:58:23Z","timestamp":1523678303000},"page":"2055-2062","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Serum calprotectin may reflect inflammatory activity in patients with active rheumatoid arthritis despite normal to low C-reactive protein"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1139-539X","authenticated-orcid":false,"given":"Jana","family":"Hurnakova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Hulejova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Zavada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Komarc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie Andres","family":"Cerezo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Vencovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Pavelka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladislav","family":"Senolt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,14]]},"reference":[{"issue":"2","key":"4091_CR1","doi-asserted-by":"publisher","first-page":"R42","DOI":"10.1186\/ar2951","volume":"12","author":"T Sokka","year":"2010","unstructured":"Sokka T, Kautiainen H, Pincus T, Verstappen SM, Aggarwal A, Alten R, Andersone D, Badsha H, Baecklund E, Belmonte M, Craig-Muller J, da Mota LM, Dimic A, Fathi NA, Ferraccioli G, Fukuda W, Geher P, Gogus F, Hajjaj-Hassouni N, Hamoud H, Haugeberg G, Henrohn D, Horslev-Petersen K, Ionescu R, Karateew D, Kuuse R, Laurindo IM, Lazovskis J, Luukkainen R, Mofti A, Murphy E, Nakajima A, Oyoo O, Pandya SC, Pohl C, Predeteanu D, Rexhepi M, Rexhepi S, Sharma B, Shono E, Sibilia J, Sierakowski S, Skopouli FN, Stropuviene S, Toloza S, Valter I, Woolf A, Yamanaka H, Quest RA (2010) Work disability remains a major problem in rheumatoid arthritis in the 2000s: data from 32 countries in the QUEST-RA study. Arthritis Res Ther 12(2):R42. \n                    https:\/\/doi.org\/10.1186\/ar2951","journal-title":"Arthritis Res Ther"},{"issue":"9313","key":"4091_CR2","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/S0140-6736(02)08213-2","volume":"359","author":"HK Choi","year":"2002","unstructured":"Choi HK, Hernan MA, Seeger JD, Robins JM, Wolfe F (2002) Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study. Lancet 359(9313):1173\u20131177. \n                    https:\/\/doi.org\/10.1016\/S0140-6736(02)08213-2","journal-title":"Lancet"},{"issue":"4","key":"4091_CR3","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1136\/ard.2009.123919","volume":"69","author":"JS Smolen","year":"2010","unstructured":"Smolen JS, Aletaha D, Bijlsma JW, Breedveld FC, Boumpas D, Burmester G, Combe B, Cutolo M, de Wit M, Dougados M, Emery P, Gibofsky A, Gomez-Reino JJ, Haraoui B, Kalden J, Keystone EC, Kvien TK, McInnes I, Martin-Mola E, Montecucco C, Schoels M, van der Heijde D, Committee TTE (2010) Treating rheumatoid arthritis to target: recommendations of an international task force. Ann Rheum Dis 69(4):631\u2013637. \n                    https:\/\/doi.org\/10.1136\/ard.2009.123919","journal-title":"Ann Rheum Dis"},{"issue":"4 Suppl 73","key":"4091_CR4","first-page":"S10","volume":"30","author":"T Pincus","year":"2012","unstructured":"Pincus T, Castrejon I, Bergman MJ, Yazici Y (2012) Treat-to-target: not as simple as it appears. Clin Exp Rheumatol 30(4 Suppl 73):S10\u2013S20","journal-title":"Clin Exp Rheumatol"},{"issue":"7","key":"4091_CR5","first-page":"1227","volume":"21","author":"F Wolfe","year":"1994","unstructured":"Wolfe F, Michaud K (1994) The clinical and research significance of the erythrocyte sedimentation rate. J Rheumatol 21(7):1227\u20131237","journal-title":"J Rheumatol"},{"issue":"4","key":"4091_CR6","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.rdc.2009.10.007","volume":"35","author":"T Pincus","year":"2009","unstructured":"Pincus T, Sokka T (2009) Laboratory tests to assess patients with rheumatoid arthritis: advantages and limitations. Rheum Dis Clin N Am 35(4):731\u2013734, vi-vii. \n                    https:\/\/doi.org\/10.1016\/j.rdc.2009.10.007","journal-title":"Rheum Dis Clin N Am"},{"issue":"7","key":"4091_CR7","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.3899\/jrheum.080770","volume":"36","author":"T Sokka","year":"2009","unstructured":"Sokka T, Pincus T (2009) Erythrocyte sedimentation rate, C-reactive protein, or rheumatoid factor are normal at presentation in 35%-45% of patients with rheumatoid arthritis seen between 1980 and 2004: analyses from Finland and the United States. J Rheumatol 36(7):1387\u20131390. \n                    https:\/\/doi.org\/10.3899\/jrheum.080770","journal-title":"J Rheumatol"},{"issue":"5 Suppl 85","key":"4091_CR8","first-page":"S-23-28","volume":"32","author":"T Pincus","year":"2014","unstructured":"Pincus T, Gibson KA, Shmerling RH (2014) An evidence-based approach to laboratory tests in usual care of patients with rheumatoid arthritis. Clin Exp Rheumatol 32(5 Suppl 85):S-23-28","journal-title":"Clin Exp Rheumatol"},{"issue":"6143","key":"4091_CR9","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/330080a0","volume":"330","author":"K Odink","year":"1987","unstructured":"Odink K, Cerletti N, Bruggen J, Clerc RG, Tarcsay L, Zwadlo G, Gerhards G, Schlegel R, Sorg C (1987) Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis. Nature 330(6143):80\u201382. \n                    https:\/\/doi.org\/10.1038\/330080a0","journal-title":"Nature"},{"issue":"12","key":"4091_CR10","doi-asserted-by":"publisher","first-page":"3762","DOI":"10.1002\/art.20631","volume":"50","author":"D Foell","year":"2004","unstructured":"Foell D, Roth J (2004) Proinflammatory S100 proteins in arthritis and autoimmune disease. Arthritis Rheum 50(12):3762\u20133771. \n                    https:\/\/doi.org\/10.1002\/art.20631","journal-title":"Arthritis Rheum"},{"issue":"3","key":"4091_CR11","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1136\/mp.50.3.113","volume":"50","author":"B Johne","year":"1997","unstructured":"Johne B, Fagerhol MK, Lyberg T, Prydz H, Brandtzaeg P, Naess-Andresen CF, Dale I (1997) Functional and clinical aspects of the myelomonocyte protein calprotectin. Mol Pathol 50(3):113\u2013123","journal-title":"Mol Pathol"},{"issue":"1","key":"4091_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1189\/jlb.0306164","volume":"81","author":"ME Bianchi","year":"2007","unstructured":"Bianchi ME (2007) DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 81(1):1\u20135. \n                    https:\/\/doi.org\/10.1189\/jlb.0306164","journal-title":"J Leukoc Biol"},{"issue":"3","key":"4091_CR13","doi-asserted-by":"publisher","first-page":"R69","DOI":"10.1186\/ar1939","volume":"8","author":"K Sunahori","year":"2006","unstructured":"Sunahori K, Yamamura M, Yamana J, Takasugi K, Kawashima M, Yamamoto H, Chazin WJ, Nakatani Y, Yui S, Makino H (2006) The S100A8\/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis. Arthritis Res Ther 8(3):R69. \n                    https:\/\/doi.org\/10.1186\/ar1939","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"4091_CR14","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3109\/03009749109165280","volume":"20","author":"HB Berntzen","year":"1991","unstructured":"Berntzen HB, Olmez U, Fagerhol MK, Munthe E (1991) The leukocyte protein L1 in plasma and synovial fluid from patients with rheumatoid arthritis and osteoarthritis. Scand J Rheumatol 20(2):74\u201382","journal-title":"Scand J Rheumatol"},{"issue":"4","key":"4091_CR15","doi-asserted-by":"publisher","first-page":"R122","DOI":"10.1186\/ar3426","volume":"13","author":"L Andres Cerezo","year":"2011","unstructured":"Andres Cerezo L, Mann H, Pecha O, Plestilova L, Pavelka K, Vencovsky J, Senolt L (2011) Decreases in serum levels of S100A8\/9 (calprotectin) correlate with improvements in total swollen joint count in patients with recent-onset rheumatoid arthritis. Arthritis Res Ther 13(4):R122. \n                    https:\/\/doi.org\/10.1186\/ar3426","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"4091_CR16","first-page":"859","volume":"19","author":"JG Brun","year":"1992","unstructured":"Brun JG, Haga HJ, Boe E, Kallay I, Lekven C, Berntzen HB, Fagerhol MK (1992) Calprotectin in patients with rheumatoid arthritis: relation to clinical and laboratory variables of disease activity. J Rheumatol 19(6):859\u2013862","journal-title":"J Rheumatol"},{"issue":"4","key":"4091_CR17","first-page":"733","volume":"21","author":"JG Brun","year":"1994","unstructured":"Brun JG, Jonsson R, Haga HJ (1994) Measurement of plasma calprotectin as an indicator of arthritis and disease activity in patients with inflammatory rheumatic diseases. J Rheumatol 21(4):733\u2013738","journal-title":"J Rheumatol"},{"issue":"5","key":"4091_CR18","doi-asserted-by":"publisher","first-page":"R178","DOI":"10.1186\/ar3503","volume":"13","author":"HB Hammer","year":"2011","unstructured":"Hammer HB, Fagerhol MK, Wien TN, Kvien TK (2011) The soluble biomarker calprotectin (an S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab. Arthritis Res Ther 13(5):R178. \n                    https:\/\/doi.org\/10.1186\/ar3503","journal-title":"Arthritis Res Ther"},{"key":"4091_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0764-5","volume":"17","author":"J Hurnakova","year":"2015","unstructured":"Hurnakova J, Zavada J, Hanova P, Hulejova H, Klein M, Mann H, Sleglova O, Olejarova M, Forejtova S, Ruzickova O, Komarc M, Vencovsky J, Pavelka K, Senolt L (2015) Serum calprotectin (S100A8\/9): an independent predictor of ultrasound synovitis in patients with rheumatoid arthritis. Arthritis Res Ther 17:252. \n                    https:\/\/doi.org\/10.1186\/s13075-015-0764-5","journal-title":"Arthritis Res Ther"},{"issue":"9","key":"4091_CR20","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, Menard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D, Tak PP, Upchurch KS, Vencovsky J, Wolfe F, Hawker G (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62(9):2569\u20132581. \n                    https:\/\/doi.org\/10.1002\/art.27584","journal-title":"Arthritis Rheum"},{"issue":"3","key":"4091_CR21","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1136\/ard.2011.149765","volume":"70","author":"DT Felson","year":"2011","unstructured":"Felson DT, Smolen JS, Wells G, Zhang B, van Tuyl LH, Funovits J, Aletaha D, Allaart CF, Bathon J, Bombardieri S, Brooks P, Brown A, Matucci-Cerinic M, Choi H, Combe B, de Wit M, Dougados M, Emery P, Furst D, Gomez-Reino J, Hawker G, Keystone E, Khanna D, Kirwan J, Kvien TK, Landewe R, Listing J, Michaud K, Martin-Mola E, Montie P, Pincus T, Richards P, Siegel JN, Simon LS, Sokka T, Strand V, Tugwell P, Tyndall A, van der Heijde D, Verstappen S, White B, Wolfe F, Zink A, Boers M (2011) American College of Rheumatology\/European League Against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials. Ann Rheum Dis 70(3):404\u2013413. \n                    https:\/\/doi.org\/10.1136\/ard.2011.149765","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"4091_CR22","first-page":"1138","volume":"30","author":"T Sokka","year":"2003","unstructured":"Sokka T, Pincus T (2003) Most patients receiving routine care for rheumatoid arthritis in 2001 did not meet inclusion criteria for most recent clinical trials or American College of Rheumatology criteria for remission. J Rheumatol 30(6):1138\u20131146","journal-title":"J Rheumatol"},{"issue":"8","key":"4091_CR23","first-page":"1817","volume":"28","author":"F Wolfe","year":"2001","unstructured":"Wolfe F, Pincus T (2001) The level of inflammation in rheumatoid arthritis is determined early and remains stable over the longterm course of the illness. J Rheumatol 28(8):1817\u20131824","journal-title":"J Rheumatol"},{"issue":"1","key":"4091_CR24","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s40291-013-0016-9","volume":"17","author":"M Garcia-Arias","year":"2013","unstructured":"Garcia-Arias M, Pascual-Salcedo D, Ramiro S, Ueberschlag ME, Jermann TM, Cara C, Martin-Mola E, Balsa A (2013) Calprotectin in rheumatoid arthritis: association with disease activity in a cross-sectional and a longitudinal cohort. Mol Diagn Ther 17(1):49\u201356. \n                    https:\/\/doi.org\/10.1007\/s40291-013-0016-9","journal-title":"Mol Diagn Ther"},{"issue":"5","key":"4091_CR25","doi-asserted-by":"publisher","first-page":"760","DOI":"10.3899\/jrheum.140628","volume":"42","author":"M Abildtrup","year":"2015","unstructured":"Abildtrup M, Kingsley GH, Scott DL (2015) Calprotectin as a biomarker for rheumatoid arthritis: a systematic review. J Rheumatol 42(5):760\u2013770. \n                    https:\/\/doi.org\/10.3899\/jrheum.140628","journal-title":"J Rheumatol"},{"issue":"8","key":"4091_CR26","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1136\/ard.2006.064741","volume":"66","author":"HB Hammer","year":"2007","unstructured":"Hammer HB, Odegard S, Fagerhol MK, Landewe R, van der Heijde D, Uhlig T, Mowinckel P, Kvien TK (2007) Calprotectin (a major leucocyte protein) is strongly and independently correlated with joint inflammation and damage in rheumatoid arthritis. Ann Rheum Dis 66(8):1093\u20131097. \n                    https:\/\/doi.org\/10.1136\/ard.2006.064741","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"4091_CR27","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1136\/ard.2008.103739","volume":"69","author":"HB Hammer","year":"2010","unstructured":"Hammer HB, Odegard S, Syversen SW, Landewe R, van der Heijde D, Uhlig T, Mowinckel P, Kvien TK (2010) Calprotectin (a major S100 leucocyte protein) predicts 10-year radiographic progression in patients with rheumatoid arthritis. Ann Rheum Dis 69(1):150\u2013154. \n                    https:\/\/doi.org\/10.1136\/ard.2008.103739","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"4091_CR28","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1093\/rheumatology\/kev251","volume":"54","author":"J Inciarte-Mundo","year":"2015","unstructured":"Inciarte-Mundo J, Ruiz-Esquide V, Hernandez MV, Canete JD, Cabrera-Villalba SR, Ramirez J, Yague J, Sanmarti R (2015) Calprotectin more accurately discriminates the disease status of rheumatoid arthritis patients receiving tocilizumab than acute phase reactants. Rheumatology (Oxford) 54(12):2239\u20132243. \n                    https:\/\/doi.org\/10.1093\/rheumatology\/kev251","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"4091_CR29","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s13075-016-1032-z","volume":"18","author":"J Inciarte-Mundo","year":"2016","unstructured":"Inciarte-Mundo J, Ramirez J, Hernandez MV, Ruiz-Esquide V, Cuervo A, Cabrera-Villalba SR, Pascal M, Yague J, Canete JD, Sanmarti R (2016) Calprotectin and TNF trough serum levels identify power Doppler ultrasound synovitis in rheumatoid arthritis and psoriatic arthritis patients in remission or with low disease activity. Arthritis Res Ther 18(1):160. \n                    https:\/\/doi.org\/10.1186\/s13075-016-1032-z","journal-title":"Arthritis Res Ther"},{"issue":"11","key":"4091_CR30","doi-asserted-by":"publisher","first-page":"e0165498","DOI":"10.1371\/journal.pone.0165498","volume":"11","author":"J Hurnakova","year":"2016","unstructured":"Hurnakova J, Hulejova H, Zavada J, Komarc M, Hanova P, Klein M, Mann H, Sleglova O, Olejarova M, Forejtova S, Ruzickova O, Vencovsky J, Pavelka K, Senolt L (2016) Serum calprotectin discriminates subclinical disease activity from ultrasound-defined remission in patients with rheumatoid arthritis in clinical remission. PLoS One 11(11):e0165498. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0165498","journal-title":"PLoS One"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-018-4091-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-018-4091-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-018-4091-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T19:18:46Z","timestamp":1555183126000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-018-4091-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,14]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["4091"],"URL":"https:\/\/doi.org\/10.1007\/s10067-018-4091-5","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,14]]},"assertion":[{"value":"13 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was performed according to the Declaration of Helsinki and was approved by the local ethics committee of the Institute of Rheumatology in Prague (Reference number 3560\/2010).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}