{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:46:20Z","timestamp":1762875980163},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s10067-018-4113-3","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T11:59:22Z","timestamp":1524657562000},"page":"2331-2340","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prevalence of cardiovascular disease and major risk factors in patients with rheumatoid arthritis: a multinational cross-sectional study"],"prefix":"10.1007","volume":"37","author":[{"given":"Dimitrios A.","family":"Pappas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredrik","family":"Nyberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel M.","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Lampl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George W.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Horne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meilien","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Onofrei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand N.","family":"Malaviya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar L.","family":"Rillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiao C.","family":"Radominski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janos","family":"Gal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Gibofsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana V.","family":"Popkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leda","family":"Laurindo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo M.","family":"Kerzberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Zahora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernado A.","family":"Pons-Estel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"Curtis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel E.","family":"Furst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,4,25]]},"reference":[{"issue":"Suppl 1","key":"4113_CR1","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1016\/j.amjmed.2008.06.011","volume":"10","author":"SE Gabriel","year":"2008","unstructured":"Gabriel SE (2008) Cardiovascular morbidity and mortality in rheumatoid arthritis. Am J Med 10(Suppl 1):S9\u2013S14","journal-title":"Am J Med"},{"key":"4113_CR2","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/art.509","volume":"46","author":"MF Doran","year":"2002","unstructured":"Doran MF, Pond GR, Crowson CS, O\u2019Fallon WM, Gabriel SE (2002) Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period. Arthritis Rheum 46:625\u2013631","journal-title":"Arthritis Rheum"},{"key":"4113_CR3","first-page":"2529","volume":"26","author":"SE Gabriel","year":"1999","unstructured":"Gabriel SE, Crowson CS, O'Fallon WM (1999) Mortality in rheumatoid arthritis: have we made an impact in 4 decades? J Rheumatol 26:2529\u20132533","journal-title":"J Rheumatol"},{"key":"4113_CR4","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1002\/art.1780370808","volume":"37","author":"LT Jacobsson","year":"1994","unstructured":"Jacobsson LT, Hanson RL, Knowler WC et al (1994) Decreasing incidence and prevalence of rheumatoid arthritis in Pima Indians over a twenty-five-year period. Arthritis Rheum 37:1158\u20131165","journal-title":"Arthritis Rheum"},{"key":"4113_CR5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1080\/030097400750001770","volume":"29","author":"AG Kvalvik","year":"2000","unstructured":"Kvalvik AG, Jones MA, Symmons DP (2000) Mortality in a cohort of Norwegian patients with rheumatoid arthritis followed from 1977 to 1992. Scand J Rheumatol 29:29\u201337","journal-title":"Scand J Rheumatol"},{"key":"4113_CR6","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1002\/1529-0131(200001)43:1<14::AID-ANR3>3.0.CO;2-7","volume":"43","author":"D Krause","year":"2000","unstructured":"Krause D, Schleusser B, Herborn G, Rau R (2000) Response to methotrexate treatment is associated with reduced mortality in patients with severe rheumatoid arthritis. Arthritis Rheum 43:14\u201321","journal-title":"Arthritis Rheum"},{"key":"4113_CR7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/PL00011191","volume":"20","author":"T Riise","year":"2001","unstructured":"Riise T, Jacobsen BK, Gran JT, Haga HJ, Arnesen E (2001) Total mortality is increased in rheumatoid arthritis. A 17-year prospective study. Clin Rheumatol 20:123\u2013127","journal-title":"Clin Rheumatol"},{"key":"4113_CR8","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1093\/rheumatology\/kel253","volume":"46","author":"A Young","year":"2007","unstructured":"Young A, Koduri G, Batley M, Kulinskaya E, Gough A, Norton S, Dixey J, Early Rheumatoid Arthritis Study (ERAS) group (2007) Mortality in rheumatoid arthritis. Increased in the early course of disease, in ischaemic heart disease and in pulmonary fibrosis. Rheumatology (Oxford) 46:350\u2013357","journal-title":"Rheumatology (Oxford)"},{"key":"4113_CR9","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/ar2669","volume":"11","author":"SE Gabriel","year":"2009","unstructured":"Gabriel SE, Michaud K (2009) Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases. Arthritis Res Ther 11:229","journal-title":"Arthritis Res Ther"},{"key":"4113_CR10","first-page":"1823","volume":"31","author":"JJ Sacks","year":"2004","unstructured":"Sacks JJ, Helmick CG, Langmaid G (2004) Deaths from arthritis and other rheumatic conditions, United States, 1979-1998. J Rheumatol 31:1823\u20131828","journal-title":"J Rheumatol"},{"key":"4113_CR11","doi-asserted-by":"publisher","first-page":"3583","DOI":"10.1002\/art.22979","volume":"56","author":"A Gonzalez","year":"2007","unstructured":"Gonzalez A, Maradit Kremers H, Crowson CS, Nicola PJ, Davis JM, Therneau TM, Roger VL, Gabriel SE (2007) The widening mortality gap between rheumatoid arthritis patients and the general population. Arthritis Rheum 56:3583\u20133587","journal-title":"Arthritis Rheum"},{"key":"4113_CR12","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1002\/1529-0131(200106)44:6<1467::AID-ART243>3.0.CO;2-6","volume":"44","author":"MM Ward","year":"2001","unstructured":"Ward MM (2001) Recent improvements in survival in patients with rheumatoid arthritis: better outcomes or different study designs? Arthritis Rheum 44:1467\u20131469","journal-title":"Arthritis Rheum"},{"key":"4113_CR13","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1002\/art.1780370408","volume":"37","author":"F Wolfe","year":"1994","unstructured":"Wolfe F, Mitchell DM, Sibley JT, Fries JF, Bloch DA, Williams CA, Spitz PW, Haga M, Kleinheksel SM, Cathey MA (1994) The mortality of rheumatoid arthritis. Arthritis Rheum 37:481\u2013494","journal-title":"Arthritis Rheum"},{"key":"4113_CR14","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1002\/art.23650","volume":"58","author":"HM Kremers","year":"2008","unstructured":"Kremers HM, Crowson CS, Therneau TM, Roger VL, Gabriel SE (2008) High ten-year risk of cardiovascular disease in newly diagnosed rheumatoid arthritis patients: a population-based cohort study. Arthritis Rheum 58:2268\u20132274","journal-title":"Arthritis Rheum"},{"key":"4113_CR15","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1002\/art.24836","volume":"61","author":"MJ Peters","year":"2009","unstructured":"Peters MJ, van Halm VP, Voskuyl AE et al (2009) Does rheumatoid arthritis equal diabetes mellitus as an independent risk factor for cardiovascular disease? A prospective study. Arthritis Rheum 61:1571\u20131579","journal-title":"Arthritis Rheum"},{"key":"4113_CR16","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1002\/art.20878","volume":"52","author":"H Maradit-Kremers","year":"2005","unstructured":"Maradit-Kremers H, Nicola PJ, Crowson CS, Ballman KV, Gabriel SE (2005) Cardiovascular death in rheumatoid arthritis: a population-based study. Arthritis Rheum 52:722\u2013732","journal-title":"Arthritis Rheum"},{"key":"4113_CR17","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1002\/art.21349","volume":"52","author":"CS Crowson","year":"2005","unstructured":"Crowson CS, Nicola PJ, Kremers HM, O'Fallon WM, Therneau TM, Jacobsen SJ (2005) How much of the increased incidence of heart failure in rheumatoid arthritis is attributable to traditional cardiovascular risk factors and ischemic heart disease? Arthritis Rheum 52:3039\u20133044","journal-title":"Arthritis Rheum"},{"key":"4113_CR18","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.autrev.2005.07.006","volume":"5","author":"JM Kremer","year":"2006","unstructured":"Kremer JM (2006) The CORRONA database. Autoimmun Rev 5:46\u201354","journal-title":"Autoimmun Rev"},{"key":"4113_CR19","first-page":"2562","volume":"26","author":"S W\u00e5llberg-Jonsson","year":"1999","unstructured":"W\u00e5llberg-Jonsson S, Johansson H, Ohman ML, Rantap\u00e4\u00e4-Dahlqvist S (1999) Extent of inflammation predicts cardiovascular disease and overall mortality in seropositive rheumatoid arthritis. A retrospective cohort study from disease onset. J Rheumatol 26:2562\u20132571","journal-title":"J Rheumatol"},{"key":"4113_CR20","doi-asserted-by":"publisher","first-page":"R131","DOI":"10.1186\/ar3442","volume":"13","author":"L Innala","year":"2011","unstructured":"Innala L, M\u00f6ller B, Ljung L, Magnusson S, Smedby T, S\u00f6dergren A, \u00d6hman ML, Rantap\u00e4\u00e4-Dahlqvist S, W\u00e5llberg-Jonsson S (2011) Cardiovascular events in early RA are a result of inflammatory burden and traditional risk factors: a five year prospective study. Arthritis Res Ther 13:R131","journal-title":"Arthritis Res Ther"},{"key":"4113_CR21","unstructured":"European Cardiovascular disease statistics 2012. European Society of Cardiology, 2012. [Internet. Accessed April 2014.] available from: \n                    http:\/\/www.escardio.org\/about\/what\/advocacy\/EuroHeart\/Pages\/2012-CVD-statistics.aspx"},{"key":"4113_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054056","volume":"8","author":"JJ Miranda","year":"2013","unstructured":"Miranda JJ, Herrera VM, Chirinos JA, G\u00f3mez LF, Perel P, Pichardo R, Gonz\u00e1lez A, S\u00e1nchez JR, Ferreccio C, Aguilera X, Silva E, Or\u00f3stegui M, Medina-Lezama J, P\u00e9rez CM, Su\u00e1rez E, Ortiz AP, Rosero L, Schapochnik N, Ortiz Z, Ferrante D, Casas JP, Bautista LE (2013) Major cardiovascular risk factors in Latin America: a comparison with the United States. The Latin American Consortium of Studies in Obesity (LASO). PLoS One 8:e54056","journal-title":"PLoS One"},{"key":"4113_CR23","first-page":"235","volume":"124","author":"A Goyal","year":"2006","unstructured":"Goyal A, Yusuf S (2006) The burden of cardiovascular disease in the Indian subcontinent. Indian J Med Res 124:235\u2013244","journal-title":"Indian J Med Res"},{"key":"4113_CR24","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1136\/hrt.2007.132951","volume":"94","author":"R Gupta","year":"2008","unstructured":"Gupta R, Joshi P, Mohan V, Reddy KS, Yusuf S (2008) Epidemiology and causation of coronary heart disease and stroke in India. Heart 94:16\u201326","journal-title":"Heart"},{"key":"4113_CR25","unstructured":"Heart Disease & Stroke Statistics \u22122014 Update. American Heart Association 2014. [Internet. Accessed September 2014.] Available from: \n                    http:\/\/www.heart.org\/HEARTORG\/General\/Heart-and-Stroke-Association-Statistics_UCM_319064_SubHomePage.jsp"},{"key":"4113_CR26","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/art.20853","volume":"52","author":"H Maradit-Kremers","year":"2005","unstructured":"Maradit-Kremers H, Crowson CS, Nicola PJ et al (2005) Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: a population-based cohort study. Arthritis Rheum 52:402\u2013411","journal-title":"Arthritis Rheum"},{"key":"4113_CR27","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1002\/art.23798","volume":"58","author":"JM Davis 3rd","year":"2008","unstructured":"Davis JM 3rd, Roger VL, Crowson CS, Kremers HM, Therneau TM, Gabriel SE (2008) The presentation and outcome of heart failure in patients with rheumatoid arthritis differs from that in the general population. Arthritis Rheum 58:2603\u20132611","journal-title":"Arthritis Rheum"},{"key":"4113_CR28","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1161\/CIRCULATIONAHA.104.490599","volume":"112","author":"TJ Wang","year":"2005","unstructured":"Wang TJ, Vasan RS (2005) Epidemiology of uncontrolled hypertension in the United States. Circulation 112:1651\u20131662","journal-title":"Circulation"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-018-4113-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-018-4113-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-018-4113-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T19:13:37Z","timestamp":1556133217000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-018-4113-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,25]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["4113"],"URL":"https:\/\/doi.org\/10.1007\/s10067-018-4113-3","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,25]]},"assertion":[{"value":"6 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Due to the non-interventional, observational study design, use of a limited dataset (i.e., contains no direct identifiers) is exempt from institutional review board (IRB) and ethics committee (EC) review. Investigative site IRB\/EC approval was sought as a best practice in all participating countries. The CORRONA US protocol was reviewed and approved by a central IRB, New England Independent Review Board (NEIRB ID no.: 120160610). Approval for the International protocol was also obtained when review was accommodated by a site\u2019s governing EC.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"DA Pappas financial: Corrona, LLC Employee and Stock Options, Novartis Instructor. Non-financial: none. F Nyberg: employee and shareholder of AstraZeneca. Non-financial: holds an affiliation as Associate Professor at Sahlgrenska Academy, University of Gothenburg, without special remuneration. JM Kremer: Corrona, LLC employment: Corrona, LLC; stock: Corrona, LLC. Consultant: AbbVie, Amgen, BMS, Genentech, Lilly, Pfizer. Non-financial: none. K Lampl: former employee of AstraZeneca, employee of Genentech. Non-financial: none. GW Reed: employee at Corrona, LLC, stock options Corrona, LLC. Non-financial: appointment at the University of Massachusetts. L Horne: former employee of AstraZeneca, employee of Medical Evidence and Observational Research Centre, Global Medicines Development. Non-financial: none. M Ho: Employee AstraZeneca. Non-financial: none. A Onofrei: Corrona, LLC employee. Non-financial: none. A Malaviya: there are no financial or non-financial conflict of interest of the author related to this research work. O Rillo: there are no financial or non-financial conflict of interest of the author related to this research work. SC Radominski: research grants\u2014Pfizer, BMS, AstraZeneca, Amgen, Sanofi, Novartis, Celltrion, Roche; employment: Prof. of Rheumatology\u2014Universidade Federal do Parana\u2013Curitiba, Brazil; consulting fees: Pfizer, BMS, AstraZeneca, speaker\u2019s bureau\u2014Pfizer, BMS, AstraZeneca, Janssen, Sanofi, GSK. Non-financial: Universidade Federal do Paran\u00e1. J Gal: there are no financial or non-financial conflict of interest of the author related to this research work. A Gibofsky: consultant\u2014Abbvie, Drais, Celgene, Horizon, Iroko, Medac, Pfizer, Relburn, Samumed, Takeda; speaker\u2014AbbVie, Amgen, Celgene, Iroko, Pfizer. Stockholder\u2014AbbVie, Amgen, BMS, GSK, J&J, Pfizer. Non-financial: none. T Popkova: there are no financial or non-financial conflict of interest of the author related to this research work. I Laurindo: consulting fees\u2014Abbott, AstraZeneca, Bristol, Janssen, Pfizer, speaker\u2019s bureau\u2014Abbott, AstraZeneca, Bristol, Janssen, Pfizer, Roche, UCB. Non-financial: none. E Kerzberg: there are no financial or non-financial conflict of interest of the author related to this research work. R Zahora: there are no financial or non-financial conflict of interest of the author related to this research work. BA Pons-Estel: research grant\u2014GLADAR (Grupo Latino Americano de estudio De Artritis Reumatoidea) have received a research grant from ABBOTT Laboratories. Non-financial: none. JR Curtis: grant\/research support\u2014Roche\/Genentech, UCB, Janssen, CORRONA, Amgen, Pfizer, BMS, Crescendo, AbbVie; consultant\u2014Roche\/Genentech, UCB, Janssen, CORRONA, Amgen, Pfizer, BMS, Crescendo, AbbVie. Non-financial: none. D Furst: AbbVie, Actelion, Amgen, BMS, Gilead, GSK, NIH, Novartis, Pfizer, Roche\/Genentech, UCB; consultant\u2014AbbVie, Actelion, Amgen, BMS, Cytori, Janssen, Gilead, GSK, NIH, Novartis, Pfizer, Roche\/Genentech, UCB; speaker\u2019s bureau\u2014Abbvie, Actelion, UCB (CME ONLY). Non-financial: none. JD Greenberg: Corrona, LLC. employee and shareholder\u2014Corrona, LLC.; consultant\u2014AstraZeneca, Celgene, Genentech, Janssen, Novartis and Pfizer. Non-financial: none.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}