{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:55:02Z","timestamp":1792709702837,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T00:00:00Z","timestamp":1538784000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1007\/s10067-018-4322-9","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T19:03:09Z","timestamp":1538766189000},"page":"3057-3062","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Dickkopf-1 (Dkk-1) serum levels in systemic sclerosis and rheumatoid arthritis patients: correlation with the Trabecular Bone Score (TBS)"],"prefix":"10.1007","volume":"37","author":[{"given":"Barbara","family":"Ruaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Casabella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Paolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Pizzorni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Ghio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Seriolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Molfetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizio","family":"Odetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Cutolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,6]]},"reference":[{"key":"4322_CR1","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1172\/JCI28551","volume":"116","author":"V Krishnan","year":"2006","unstructured":"Krishnan V, Bryant HU, Macdougald OA (2006) Regulation of bone mass by Wnt signaling. J Clin Invest 116:1202\u20131209","journal-title":"J Clin Invest"},{"key":"4322_CR2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.gene.2004.06.044","volume":"341","author":"JJ Westendorf","year":"2004","unstructured":"Westendorf JJ, Kahler RA, Schroeder TM (2004) Wnt signaling in osteoblasts and bone diseases. Gene 341:19\u201339","journal-title":"Gene"},{"key":"4322_CR3","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nm1538","volume":"13","author":"D Diarra","year":"2007","unstructured":"Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, van der Heide D, Landewe R, Lacey D, Richards WG, Schett G (2007) Dickkopf-1 is a master regulator of joint remodeling. Nat Med 13:156\u2013163","journal-title":"Nat Med"},{"key":"4322_CR4","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.semarthrit.2011.01.006","volume":"41","author":"D Daoussis","year":"2011","unstructured":"Daoussis D, Andonopoulos AP (2011) The emerging role of Dickkopf-1 in bone biology: is it the main switch controlling bone and joint remodeling? Semin Arthritis Rheum 41:170\u2013177","journal-title":"Semin Arthritis Rheum"},{"key":"4322_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/srep18421","volume":"6","author":"R Seror","year":"2016","unstructured":"Seror R, Boudaoud S, Pavy S, Nocturne G, Schaeverbeke T, Saraux A, Chanson P, Gottenberg JE, Devauchelle-Pensec V, Tob\u00f3n GJ, Mariette X, Miceli-Richard C (2016) Increased Dickkopf-1 in recent-onset rheumatoid arthritis is a new biomarker of structural severity. Data from the ESPOIR cohort. Sci Rep 6:18421","journal-title":"Sci Rep"},{"issue":"2","key":"4322_CR6","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.autrev.2011.08.003","volume":"11","author":"Maurizio Cutolo","year":"2011","unstructured":"Cutolo M, Pizzorni C, Sulli A (2011) Vitamin D endocrine system involvement in autoimmune rheumatic diseases. \n                    Autoimmun Rev\n                    \n                  . 11:84\u201387","journal-title":"Autoimmunity Reviews"},{"key":"4322_CR7","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1093\/rheumatology\/kel072","volume":"45","author":"HR Kim","year":"2006","unstructured":"Kim HR, Kim HY, Lee SH (2006) Elevated serum levels of soluble receptor activator of nuclear factors-kappaB ligand (sRANKL) and reduced bone mineral density in patients with ankylosing spondylitis (AS). Rheumatology 45:1197\u20131200","journal-title":"Rheumatology"},{"key":"4322_CR8","doi-asserted-by":"publisher","first-page":"e228","DOI":"10.1038\/emm.2016.12","volume":"48","author":"L Zhang","year":"2016","unstructured":"Zhang L, Ouyang H, Xie Z, Liang ZH, Wu XW (2016) Serum DKK-1 level in the development of ankylosing spondylitis and rheumatic arthritis: a meta-analysis. Exp Mol Med 48:e228","journal-title":"Exp Mol Med"},{"key":"4322_CR9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.intimp.2018.04.019","volume":"59","author":"M Yubo","year":"2018","unstructured":"Yubo M, Xu Z, Mengmeng W et al (2018) The serum level of Dickkopf-1 in patients with rheumatoid arthritis: a systematic review and meta-analysis. Int Immunopharmacol 59:227\u2013232","journal-title":"Int Immunopharmacol"},{"key":"4322_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.cca.2018.03.010","volume":"481","author":"M Wu","year":"2018","unstructured":"Wu M, Chen M, Ma Y, Yang J, Han R, Yuan Y, Hu X, Wang M, Zhang X, Xu S, Liu R, Jiang G, Xu J, Shuai Z, Zou Y, Pan G, Pan F (2018) Dickkopf-1 in ankylosing spondylitis: review and meta-analysis. Clin Chim Acta 481:177\u2013183","journal-title":"Clin Chim Acta"},{"key":"4322_CR11","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.semarthrit.2016.08.014","volume":"46","author":"K Klavdianou","year":"2017","unstructured":"Klavdianou K, Liossis SN, Sakkas L, Daoussis D (2017) The role of Dickkopf-1 in joint remodeling and fibrosis: a link connecting spondyloarthropathies and scleroderma? Semin Arthritis Rheum 46:430\u2013438","journal-title":"Semin Arthritis Rheum"},{"key":"4322_CR12","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13075-016-1017-y","volume":"18","author":"D Daoussis","year":"2016","unstructured":"Daoussis D, Tsamandas A, Antonopoulos I, Filippopoulou A, Papachristou DJ, Papachristou NI, Andonopoulos AP, Liossis SN (2016) B cell depletion therapy up-regulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis. Arthritis Res Ther 18:118","journal-title":"Arthritis Res Ther"},{"key":"4322_CR13","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1136\/annrheumdis-2012-203194","volume":"73","author":"C Dees","year":"2014","unstructured":"Dees C, Schlottmann I, Funke R, Distler A, Palumbo-Zerr K, Zerr P, Lin NY, Beyer C, Distler O, Schett G, Distler JHW (2014) The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis. Ann Rheum Dis 73:1232\u20131239","journal-title":"Ann Rheum Dis"},{"key":"4322_CR14","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/nrrheum.2012.99","volume":"8","author":"R Lafyatis","year":"2012","unstructured":"Lafyatis R (2012) Connective tissue disease: SSc-fibrosis takes flight with Wingless inhibition. Nat Rev Rheumatol 8:441\u2013442","journal-title":"Nat Rev Rheumatol"},{"issue":"9","key":"4322_CR15","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1093\/rheumatology\/key130","volume":"57","author":"Barbara Ruaro","year":"2018","unstructured":"Ruaro B, Casabella A, Paolino S, Pizzorni C, Alessandri E, Seriolo C, Botticella G, Molfetta L, Odetti P, Smith V, Cutolo M (2018) Correlation between bone quality and microvascular damage in systemic sclerosis patients. Rheumatology (Oxford) 2018;57:1548\u20131554","journal-title":"Rheumatology"},{"key":"4322_CR16","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1093\/rheumatology\/keh156","volume":"43","author":"M Cutolo","year":"2004","unstructured":"Cutolo M, Pizzorni C, Tuccio M, Burroni A, Craviotto C, Basso M, Seriolo B, Sulli A (2004) Nailfold videocapillaroscopic patterns and serum autoantibodies in systemic sclerosis. Rheumatology 43:719\u2013726","journal-title":"Rheumatology"},{"key":"4322_CR17","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1136\/ard.2007.079756","volume":"67","author":"A Sulli","year":"2008","unstructured":"Sulli A, Secchi ME, Pizzorni C, Cutolo M (2008) Scoring the nailfold microvascular changes during the capillaroscopic analysis in systemic sclerosis patients. Ann Rheum Dis 67:885\u2013887","journal-title":"Ann Rheum Dis"},{"key":"4322_CR18","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1093\/rheumatology\/kex165","volume":"56","author":"M Cutolo","year":"2017","unstructured":"Cutolo M, Ruaro B, Smith V (2017) Macrocirculation versus microcirculation and digital ulcers in systemic sclerosis patients. Rheumatology 56:1834\u20131836","journal-title":"Rheumatology"},{"key":"4322_CR19","first-page":"1573","volume":"28","author":"EC LeRoy","year":"2001","unstructured":"LeRoy EC, Meedsger TA Jr (2001) Criteria for the classification of early systemic sclerosis. J Rheumatol 28:1573\u20131576","journal-title":"J Rheumatol"},{"key":"4322_CR20","doi-asserted-by":"crossref","unstructured":"Van den Hoogen F, Khanna D et al (2013) Classification criteria for systemic sclerosis: an American college of rheumatology\/European league against rheumatism collaborative initiative. Ann Rheum Dis 72:1747\u20131755","DOI":"10.1136\/annrheumdis-2013-204424"},{"key":"4322_CR21","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1136\/ard.2010.138461","volume":"69","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, Menard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D, Tak PP, Upchurch KS, Vencovsky J, Wolfe F, Hawker G (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League against Rheumatism Collaborative Initiative. Ann Rheum Dis 69:1580\u20131588","journal-title":"Ann Rheum Dis"},{"key":"4322_CR22","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1172\/JCI111096","volume":"72","author":"AM Parfitt","year":"1983","unstructured":"Parfitt AM, Mathews CH, Villanueva AR, Kleerekoper M, Frame B, Rao DS (1983) Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest 72:1396\u20131409","journal-title":"J Clin Invest"},{"key":"4322_CR23","doi-asserted-by":"publisher","first-page":"2762","DOI":"10.1002\/jbmr.499","volume":"26","author":"D Hans","year":"2011","unstructured":"Hans D, Goertzen AL, Krieg MA, Leslie WD (2011) Bone microarchitecture assessed by TBS predicts osteoporotic fractures indipendent of bone density: the Manitoba study. J Bone Miner Res 26:2762\u20132769","journal-title":"J Bone Miner Res"},{"key":"4322_CR24","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.bone.2015.05.016","volume":"78","author":"NC Harvey","year":"2015","unstructured":"Harvey NC, Gl\u00fcer CC, Binkley N, McCloskey EV, Brandi ML, Cooper C, Kendler D, Lamy O, Laslop A, Camargos BM, Reginster JY, Rizzoli R, Kanis JA (2015) Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice. Bone 78:216\u2013224","journal-title":"Bone"},{"key":"4322_CR25","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s11914-005-0014-x","volume":"3","author":"EM Lewiecki","year":"2005","unstructured":"Lewiecki EM (2005) Review of guidelines for bone mineral density testing and treatment of osteoporosis. Curr Osteoporos Rep 3:75\u201383","journal-title":"Curr Osteoporos Rep"},{"key":"4322_CR26","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1053\/j.semnuclmed.2010.12.002","volume":"41","author":"KJ Chun","year":"2011","unstructured":"Chun KJ (2011) Bone densitometry. Semin Nucl Med 41:220\u2013228","journal-title":"Semin Nucl Med"},{"key":"4322_CR27","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1093\/qjmed\/hcn022","volume":"101","author":"A Maghraoui El","year":"2008","unstructured":"El Maghraoui A, Roux C (2008) DXA scanning in clinical practice. QJM 101:605\u2013617","journal-title":"QJM"},{"key":"4322_CR28","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1093\/rheumatology\/ket153","volume":"52","author":"M Cutolo","year":"2013","unstructured":"Cutolo M, Smith V (2013) State of the art on nailfold capillaroscopy: a reliable diagnostic tool and putative biomarker in rheumatology? Rheumatology 52:1933\u20131940","journal-title":"Rheumatology"},{"key":"4322_CR29","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1007\/s10067-016-3442-3","volume":"36","author":"C Pizzorni","year":"2017","unstructured":"Pizzorni C, Sulli A, Smith V, Ruaro B, Trombetta AC, Cutolo M, Paolino S (2017) Primary Raynaud\u2019s phenomenon and nailfold videocapillaroscopy: age-related changes in capillary morphology. Clin Rheumatol 36:1637\u20131642","journal-title":"Clin Rheumatol"},{"key":"4322_CR30","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1093\/rheumatology\/kev441","volume":"55","author":"V Smith","year":"2016","unstructured":"Smith V, Beeckman S, Herrick AL, Decuman S, Deschepper E, de Keyser F, Distler O, Foeldvari I, Ingegnoli F, M\u00fcller-Ladner U, Riccieri V, Riemekasten G, Sulli A, Voskuyl A, Cutolo M, on behalf of the EULAR study group on microcirculation (2016) An EULAR study group pilot study on reliability of simple capillaroscopic definitions to describe capillary morphology in rheumatic diseases. Rheumatology 55:883\u2013890","journal-title":"Rheumatology"},{"key":"4322_CR31","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nm1538","volume":"13","author":"D Diarra","year":"2007","unstructured":"Diarra D, Stolina M, Polzer K et al (2007) Dickkopf- 1 is a master regulator of joint remodeling. Nat Med 13:156\u2013163","journal-title":"Nat Med"},{"key":"4322_CR32","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/ncomms1734","volume":"3","author":"A Akhmetshina","year":"2012","unstructured":"Akhmetshina A, Palumbo K, Dees C, Bergmann C, Venalis P, Zerr P, Horn A, Kireva T, Beyer C, Zwerina J, Schneider H, Sadowski A, Riener MO, MacDougald OA, Distler O, Schett G, Distler JHW (2012) Activation of canonical Wnt signaling is required for TGF-\u03b2-mediated fibrosis. Nat Commun 3:735","journal-title":"Nat Commun"},{"key":"4322_CR33","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.3899\/jrheum.080356","volume":"35","author":"P Garnero","year":"2008","unstructured":"Garnero P, Tabassi NC, Voorzanger-Rousselot N (2008) Circulating dickkopf-1 and radiological progression in patients with early rheumatoid arthritis treated with etanercept. J Rheumatol 35:2313\u20132315","journal-title":"J Rheumatol"},{"key":"4322_CR34","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1007\/s10067-002-8274-7","volume":"21","author":"K Shibuya","year":"2002","unstructured":"Shibuya K, Hagino H, Morio Y, Teshima R (2002) Cross-sectional and longitudinal study of osteoporosis in patients with rheumatoid arthritis. Clin Rheumatol 21:150\u2013158","journal-title":"Clin Rheumatol"},{"key":"4322_CR35","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s40520-013-0107-9","volume":"25","author":"B Seriolo","year":"2013","unstructured":"Seriolo B, Paolino S, Casabella A, Botticella G, Seriolo C, Molfetta L (2013) Osteoporosis in the elderly. Aging Clin Exp Res 25:27\u201329","journal-title":"Aging Clin Exp Res"},{"key":"4322_CR36","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/s10067-003-0743-0","volume":"22","author":"M Boyanov","year":"2003","unstructured":"Boyanov M, Robeva R, Popivanov P (2003) Bone mineral density changes in women with systemic lupus erythematosus. Clin Rheumatol 22:318\u2013323","journal-title":"Clin Rheumatol"},{"key":"4322_CR37","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s100670050024","volume":"19","author":"N Yilmaz","year":"2000","unstructured":"Yilmaz N, Ozaslan J (2000) Biochemical bone turnover markers in patients with ankylosing spondylitis. Clin Rheumatol 19:92\u201398","journal-title":"Clin Rheumatol"},{"key":"4322_CR38","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/nyas.12432","volume":"1317","author":"M Cutolo","year":"2014","unstructured":"Cutolo M, Paolino S, Sulli A, Smith V, Pizzorni C, Seriolo B (2014) Vitamin D, steroid hormones, and autoimmunity. Ann N Y Acad Sci 1317:39\u201346","journal-title":"Ann N Y Acad Sci"},{"key":"4322_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179062","volume":"12","author":"AC Trombetta","year":"2017","unstructured":"Trombetta AC, Smith V, Gotelli E, Ghio M, Paolino S, Pizzorni C, Vanhaecke A, Ruaro B, Sulli A, Cutolo M (2017) Vitamin D deficiency and clinical correlations in systemic sclerosis patients: a retrospective analysis for possible future developments. PLoS One 12:e0179062","journal-title":"PLoS One"},{"key":"4322_CR40","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s10067-011-1684-7","volume":"30","author":"B Seriolo","year":"2011","unstructured":"Seriolo B, Molfetta L, Cutolo M (2011) Seasonal variations in serum levels of 25-hydroxyvitamin D in patients with systemic sclerosis. Clin Rheumatol 30:445\u2013446","journal-title":"Clin Rheumatol"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-018-4322-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-018-4322-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-018-4322-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T19:12:04Z","timestamp":1570302724000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-018-4322-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,6]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["4322"],"URL":"https:\/\/doi.org\/10.1007\/s10067-018-4322-9","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,6]]},"assertion":[{"value":"22 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"This prospective study was carried out in accordance with the ethical standards stipulated in the 1964 Declaration of Helsinki and its later amendments and was evaluated by the local IRB.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}