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The prevalence of anti-RNAP III was higher in SSc patients than in the CTD and HC groups (<jats:italic>p<\/jats:italic> = 0.02, <jats:italic>p<\/jats:italic> = 0.001, respectively). Renal crisis was significantly more common in patients with anti-RNAP III than patients without anti-RNAP III (42.9 vs. 4.1%, <jats:italic>p<\/jats:italic> &lt; 0.0001). Gastrointestinal involvement was significantly more common in patients without anti-RNAP III than patients with anti-RNAP III (53.6 vs. 21.4%, <jats:italic>p<\/jats:italic> = 0.039). There was good agreement between the ELISA and line immunoassay (LIA) detection capabilities for anti-RNAP III.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The anti-RNAP III antibody, which was detected by ELISA, has diagnostic value for SSc and predictive value for SSc-related renal crisis. Both ELISA and LIA are very reliable methods for anti-RNAP III.<jats:table-wrap><jats:table><jats:tbody><jats:tr><jats:td colspan=\"2\"><jats:bold>Key Points<\/jats:bold><jats:italic>\u2022 The prevalence of anti-RNAP III antibody was determined in Chinese SSc patients and performed ethnic differences.<\/jats:italic><jats:italic>\u2022 The clinical association between anti-RNAP III antibody and Chinese SSc patients was evaluated in this research.<\/jats:italic><jats:italic>\u2022 Methodological consistency of detection of anti-RNAP III antibody using commercial ELISA and LIA methods was evaluated in this research.<\/jats:italic><\/jats:td><\/jats:tr><\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s10067-019-04806-9","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T19:07:57Z","timestamp":1576782477000},"page":"1191-1197","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of anti-RNA polymerase III antibodies in Chinese Han systemic sclerosis patients"],"prefix":"10.1007","volume":"39","author":[{"given":"Chenxi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liubing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songxin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,19]]},"reference":[{"issue":"2","key":"4806_CR1","first-page":"202","volume":"15","author":"EC LeRoy","year":"1988","unstructured":"LeRoy EC et al (1988) Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. 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