{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:55:05Z","timestamp":1792709705141,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T00:00:00Z","timestamp":1576281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T00:00:00Z","timestamp":1576281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860292"],"award-info":[{"award-number":["81860292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["81760295"],"award-info":[{"award-number":["81760295"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009329","name":"Scientific Research and Technology Development Program of Guangxi","doi-asserted-by":"crossref","award":["S2018084"],"award-info":[{"award-number":["S2018084"]}],"id":[{"id":"10.13039\/501100009329","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s10067-019-04847-0","type":"journal-article","created":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T22:02:20Z","timestamp":1576360940000},"page":"1181-1189","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A meta-analysis of fracture risk and bone mineral density in patients with systemic sclerosis"],"prefix":"10.1007","volume":"39","author":[{"given":"Juan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2221-7740","authenticated-orcid":false,"given":"Ling","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,14]]},"reference":[{"issue":"2","key":"4847_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1136\/ard.41.2.147","volume":"41","author":"M Baron","year":"1982","unstructured":"Baron M, Lee P (1982) The articular manifestations of progressive systemic sclerosis (scleroderma). Ann Rheum Dis 41(2):147\u2013152","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"4847_CR2","first-page":"1117","volume":"33","author":"SR Johnson","year":"2006","unstructured":"Johnson SR, Glaman DD, Schentag CT (2006) Quality of life and functional status in systemic sclerosis compared to other rheumatic diseases. J Rheumatol 33(6):1117\u20131122","journal-title":"J Rheumatol"},{"issue":"1","key":"4847_CR3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1097\/MAJ.0b013e3182a55d24","volume":"347","author":"LA Saketkoo","year":"2014","unstructured":"Saketkoo LA, Magnus JH, Doyle MK (2014) The primary care physician in the early diagnosis of systemic sclerosis:the cornerstone of recognition and hope. Am J Med Sci 347(1):54\u201363. https:\/\/doi.org\/10.1097\/MAJ.0b013e3182a55d24","journal-title":"Am J Med Sci"},{"issue":"2","key":"4847_CR4","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.arr.2012.01.001","volume":"11","author":"AY Bijlsma","year":"2012","unstructured":"Bijlsma AY, Meskers CG, Westendorp RG, Maier AB (2012) Chronology of age-related disease definitions: osteoporosis and sarcopenia. Ageing Res Rev 11(2):320\u2013324. https:\/\/doi.org\/10.1016\/j.arr.2012.01.001","journal-title":"Ageing Res Rev"},{"issue":"9773","key":"4847_CR5","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","volume":"377","author":"TD Rachner","year":"2011","unstructured":"Rachner TD, Khosla S (2011) Osteoporosis: now and the future. Lancet 377(9773):1276\u20131287. https:\/\/doi.org\/10.1016\/S0140-6736(10)62349-5","journal-title":"Lancet"},{"issue":"11","key":"4847_CR6","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.3899\/jrheum.130032","volume":"40","author":"MA Omair","year":"2013","unstructured":"Omair MA, Pagnoux C, McDonald-Blumer H, Johnson SR (2013) Low bone density in systemic sclerosis a systematic review. Rheumatol 40(11):1881\u20131890. https:\/\/doi.org\/10.3899\/jrheum.130032","journal-title":"Rheumatol"},{"issue":"11","key":"4847_CR7","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1359\/jbmr.2003.18.11.1947","volume":"18","author":"KL Stone","year":"2003","unstructured":"Stone KL, Seeley DG, Lui LY, Cauley JA, Ensrud K, Browner WS, Nevitt MC, Cummings SR, Osteoporotic Fractures Research Group (2003) BMD at multiple sites and risk of fracture of multiple types:long-term results from the Study of Osteoporotic Fractures. Bone Miner Res 18(11):1947\u20131954. https:\/\/doi.org\/10.1359\/jbmr.2003.18.11.1947","journal-title":"Bone Miner Res"},{"key":"4847_CR8","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.bone.2018.06.004","volume":"114","author":"K Trajanoska","year":"2018","unstructured":"Trajanoska K, Schoufour JD, de Jonge EAL, Kieboom BCT, Mulder M, Stricker BH, Voortman T, Uitterlinden AG, Oei EHG (2018) Fracture incidence and secular trends between 1989 and 2013 in a population based cohort: the Rotterdam study. Bone 114:116\u2013124. https:\/\/doi.org\/10.1016\/j.bone.2018.06.004","journal-title":"Bone"},{"key":"4847_CR9","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.bone.2017.09.017","volume":"105","author":"JE Lee","year":"2017","unstructured":"Lee JE, Kim KM, Kim LK, Kim KY, Oh TJ, Moon JH, Choi SH, Lim S, Kim SW, Shin CS, Jang HC (2017) Comparisons of TBS and lumbar spine BMD in theassociations with vertebral fractures according to the T-scores: a cross-sectional observation. Bone 105:269\u2013275. https:\/\/doi.org\/10.1016\/j.bone.2017.09.017","journal-title":"Bone"},{"issue":"11","key":"4847_CR10","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.3899\/jrheum.100363","volume":"37","author":"RJ Weiss","year":"2010","unstructured":"Weiss RJ, Wick MC, Ackermann PW, Montgomery SM (2010) Increased fracture risk in patients with rheumatic disorders and other inflammatory diseases--a case-control study with 53,108 patients with fracture. J Rheumatol 37(11):2247\u20132250. https:\/\/doi.org\/10.3899\/jrheum.100363","journal-title":"J Rheumatol"},{"issue":"4","key":"4847_CR11","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1007\/s00198-015-3449-7","volume":"27","author":"X Wang","year":"2016","unstructured":"Wang X, Yan S, Liu C, Xu Y, Wan L, Wang Y, Gao W, Meng S, Liu Y, Liu R, Xu D (2016) Fracture risk and bone mineral density levels in patients with syste mic lupus erythematosus: a systematic review and meta-analysis. Osteoporos Int 27(4):1413\u20131423. https:\/\/doi.org\/10.1007\/s00198-015-3449-7","journal-title":"Osteoporos Int"},{"issue":"7","key":"4847_CR12","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1136\/annrheumdis-2013-204832","volume":"74","author":"CC Lai","year":"2015","unstructured":"Lai CC, Wang SH, Chen WS, Liu CJ, Chen TJ, Lee PC, Chang YS (2015) Increased risk of osteoporotic fractures in patients with systemic sclerosis:a nationwide population-based study. Ann Rheum Dis 74(7):1347\u20131352. https:\/\/doi.org\/10.1136\/annrheumdis-2013-204832","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"4847_CR13","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1111\/1756-185X.12395","volume":"17","author":"YN Wan","year":"2014","unstructured":"Wan YN, Zhang L, Wang YJ, Yan JW, Wang BX, Wang J (2014) The association between systemic sclerosis and bone mineral density-a meta-analysis of observational studies. Int J Rheum Dis 17(8):845\u2013855. https:\/\/doi.org\/10.1111\/1756-185X.12395","journal-title":"Int J Rheum Dis"},{"key":"4847_CR14","doi-asserted-by":"publisher","first-page":"b2700","DOI":"10.1136\/bmj.b2700","volume":"339","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700","journal-title":"BMJ"},{"issue":"1","key":"4847_CR15","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/jebm.12141","volume":"8","author":"X Zeng","year":"2015","unstructured":"Zeng X, Zhang Y, Kwong JS, Zhang C, Li S, Sun F, Niu Y, Du L (2015) The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. Evid Based Med 8(1):2\u201310. https:\/\/doi.org\/10.1111\/jebm.12141","journal-title":"Evid Based Med"},{"issue":"7414","key":"4847_CR16","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JP Higgins","year":"2003","unstructured":"Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557\u2013560. https:\/\/doi.org\/10.1136\/bmj.327.7414.557","journal-title":"BMJ"},{"issue":"9","key":"4847_CR17","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1093\/rheumatology\/key130","volume":"57","author":"B Ruaro","year":"2018","unstructured":"Ruaro B, Casabella A, Paolino S, Pizzorni C, Alessandri E, Seriolo C, Botticella G, Molfetta L, Odetti P, Smith V (2018) Correlation between bone quality and microvascular damage in systemic sclerosis patients. Rheumatology(Oxford) 57(9):1548\u20131554. https:\/\/doi.org\/10.1093\/rheumatology\/key130","journal-title":"Rheumatology(Oxford)"},{"issue":"4","key":"4847_CR18","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/BF02207673","volume":"14","author":"O Di Munno","year":"1995","unstructured":"Di Munno O, Mazzantini M, Massei P, Massei P, Ferdeghini M, Pitaro N, Latorraca A, Ferri C (1995) Reduced bone mass and normal calcium metabolism in systemic sclerosis with and without calcinosis. Clin Rheumatol 14(4):407\u2013412","journal-title":"Clin Rheumatol"},{"key":"4847_CR19","unstructured":"da Silva HC,Szejnfeld VL,Assis LS, Sato EI (1997) [Study of bone density in systemic scleroderma. Rev Assoc Med Bras(1992)43(1):40\u201346"},{"issue":"4","key":"4847_CR20","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1093\/rheumatology\/38.4.371","volume":"38","author":"L Carbone","year":"1999","unstructured":"Carbone L, Tylavsky F, Wan J, McKown K, Cheng S (1999) Bone mineral density in scleroderma. Rheumatology(Oxford) 38(4):371\u2013372","journal-title":"Rheumatology(Oxford)"},{"issue":"3","key":"4847_CR21","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1136\/ard.2003.011064","volume":"63","author":"B Frediani","year":"2004","unstructured":"Frediani B, Baldi F, Falsetti P, Acciai C, Filippou G, Spreafico A, Chellini F, Capperucci C, Filipponi P, Galeazzi M (2004) Bone mineral density in patients with systemic sclerosis. Ann Rheum Dis 63(3):326\u2013327","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"4847_CR22","first-page":"180","volume":"23","author":"PD Sampaio-Barros","year":"2005","unstructured":"Sampaio-Barros PD, Costa-Paiva L, Filardi S, Sachetto Z, Samara AM, Marques-Neto JF (2005) Prognostic factors of low bone mineral density in systemic sclerosis. Clin Exp Rheumatol 23(2):180\u2013184","journal-title":"Clin Exp Rheumatol"},{"issue":"5","key":"4847_CR23","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1080\/03009740600704296","volume":"35","author":"RB Souza","year":"2006","unstructured":"Souza RB, Borges CT, Takayama L, Aldrighi JM, Pereira RM (2006) Systemic sclerosis and bone loss:the role of the disease and body composition. Scand J Rheumatol 35(5):384\u2013387. https:\/\/doi.org\/10.1080\/03009740600704296","journal-title":"Scand J Rheumatol"},{"issue":"2","key":"4847_CR24","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1093\/rheumatology\/kes240","volume":"52","author":"CC Mok","year":"2013","unstructured":"Mok CC, Chan PT, Chan KL, Ma KM (2013) Prevalence and risk factors of low bone mineral density in Chinese patients with systemic sclerosis:a case-control study. Rheumatology(Oxford) 52(2):296\u2013303. https:\/\/doi.org\/10.1093\/rheumatology\/kes240","journal-title":"Rheumatology(Oxford)"},{"issue":"4","key":"4847_CR25","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/1756-185X.12242","volume":"19","author":"G Kilic","year":"2016","unstructured":"Kilic G, Kilic E, Akgul O, Ozgocmen S (2016) Increased risk for bone loss in women with systemic sclerosis:a comparative study with rheumatoid arthritis. Int J Rheum Dis 19(4):405\u2013411. https:\/\/doi.org\/10.1111\/1756-185X.12242","journal-title":"Int J Rheum Dis"},{"issue":"2","key":"4847_CR26","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3899\/jrheum.140752","volume":"42","author":"E Koumakis","year":"2015","unstructured":"Koumakis E, Avouac J, Winzenrieth R, Toth E, Payet J, Kahan A, Allanore Y, Cormier C (2015) Trabecular bone score in female patients with systemic sclerosis:comparison with rheumatoid arthritis and influence of glucocorticoid exposure. J Rheumatol 42(2):228\u2013235. https:\/\/doi.org\/10.3899\/jrheum.140752","journal-title":"J Rheumatol"},{"issue":"17","key":"4847_CR27","doi-asserted-by":"publisher","first-page":"14865","DOI":"10.18632\/oncotarget.3806","volume":"6","author":"M Marot","year":"2015","unstructured":"Marot M, Val\u00e9ry A, Esteve E, Bens G, M\u00fcller A, Rist S, Toumi H, Lespessailles E (2015) Prevalence and predictive factors of osteoporosis in systemic sclerosis patients: a case-control study. Oncotarget 6(17):14865\u201314873. https:\/\/doi.org\/10.18632\/oncotarget.3806","journal-title":"Oncotarget"},{"issue":"5","key":"4847_CR28","doi-asserted-by":"publisher","first-page":"37","DOI":"10.17116\/terarkh201688537-42","volume":"88","author":"R\u0422 Alekperov","year":"2016","unstructured":"Alekperov R\u0422, Smirnov AV, Toroptsova NV, Kudinsky DM (2016) Bone mineral density in patients with scleroderma systematica. Ter Arkh 88(5):37\u201342","journal-title":"Ter Arkh"},{"issue":"10","key":"4847_CR29","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1007\/s00296-011-2150-1","volume":"32","author":"Y Ibn Yacoub","year":"2012","unstructured":"Ibn Yacoub Y, Amine B, Laatiris A, Wafki F, Znat F, Hajjaj-Hassouni N (2012) Bone density in Moroccan women with systemic scleroderma and its relationships with disease-related parameters and vitamin D status. Rheumatol Int 32(10):3143\u20133148. https:\/\/doi.org\/10.1007\/s00296-011-2150-1","journal-title":"Rheumatol Int"},{"key":"4847_CR30","doi-asserted-by":"publisher","unstructured":"Atteritano M,Sorbara S,Bagnato G,Miceli G,Sangari D,Morgante S,Visalli E,Bagnato G(2013) Bone mineral density,bone turnover markers and fractures in patients with systemic sclerosis: a case control study. PLoS One 8(6):e66991.DOI:https:\/\/doi.org\/10.1371\/journal.pone.0066991,","DOI":"10.1371\/journal.pone.0066991"},{"issue":"6","key":"4847_CR31","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1007\/s002239900635","volume":"64","author":"S Cheng","year":"1999","unstructured":"Cheng S, Tylavsky FA, Orwoll ES, Rho JY, Carbone LD (1999) The role of collagen abnormalities in ultrasound and densitometry assessment: in vivo evidence. Calcif Tissue Int 64(6):470\u2013476","journal-title":"Calcif Tissue Int"},{"issue":"12","key":"4847_CR32","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1002\/acr.21761","volume":"64","author":"J Avouac","year":"2012","unstructured":"Avouac J, Koumakis E, Toth E, Meunier M, Maury E, Kahan A, Cormier C, Allanore Y (2012) Increased risk of osteoporosis and fracture in women with systemic sclerosis:a comparative study with rheumatoid arthritis. Arthritis Care Res(Hoboken) 64(12):1871\u20131878. https:\/\/doi.org\/10.1002\/acr.21761","journal-title":"Arthritis Care Res(Hoboken)"},{"issue":"7","key":"4847_CR33","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1007\/s10067-013-2235-1","volume":"32","author":"TF Marighela","year":"2013","unstructured":"Marighela TF, Genaro Pde S, Pinheiro MM, Szejnfeld VL, Kayser C (2013) Risk factors for body composition abnormalities in systemic sclerosis. Clin Rheumatol 32(7):1037\u20131044. https:\/\/doi.org\/10.1007\/s10067-013-2235-1","journal-title":"Clin Rheumatol"},{"key":"4847_CR34","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.2147\/DDDT.S144860","volume":"11","author":"L An","year":"2017","unstructured":"An L, Sun MH, Chen F, Li JR (2017) Vitamin D levels in systemic sclerosis patients:a meta-analysis. Drug Des Devel Ther 11:3119\u20133125. https:\/\/doi.org\/10.2147\/DDDT.S144860","journal-title":"Drug Des Devel Ther"},{"issue":"50","key":"4847_CR35","doi-asserted-by":"publisher","first-page":"29484","DOI":"10.18632\/oncotarget.25681","volume":"9","author":"L Atlan","year":"2018","unstructured":"Atlan L, Ibrahim-Nasser N, Valery A, Bazzi C, Rollin F, Bens G, Marot M, Est\u00e8ve E, Lespessailles E (2018) Bone mineral density and microarchitecture linkages with micro-and macro-vascular impairments at the hand in systemic sclerosis: an HRpQCT study. Oncotarget 9(50):29484\u201329494. https:\/\/doi.org\/10.18632\/oncotarget.25681","journal-title":"Oncotarget"},{"issue":"5","key":"4847_CR36","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/ejcn.2010.280","volume":"65","author":"E Robberecht","year":"2011","unstructured":"Robberecht E, Vandewalle S, Wehlou C, Kaufman JM, De Schepper J (2011) Sunlight is an important determinant of vitamin D serum concentrations in cystic fibrosis. Eur J Clin Nutr 65(5):574\u2013579. https:\/\/doi.org\/10.1038\/ejcn.2010.280","journal-title":"Eur J Clin Nutr"},{"issue":"8","key":"4847_CR37","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.autrev.2011.02.002","volume":"10","author":"Y Arnson","year":"2011","unstructured":"Arnson Y, Amital H, Agmon-Levin N, Alon D, S\u00e1nchez-Casta\u00f1\u00f3n M, L\u00f3pez-Hoyos M, Matucci-Cerinic M, Sz\u00fccs G, Shapira Y (2011) Serum 25-OH vitamin D concentrations are linked with various clinical aspects in patients with systemic sclerosis: a retrospective cohort study and review of the literature. Autoimmun Rev 10(8):490\u2013494. https:\/\/doi.org\/10.1016\/j.autrev.2011.02.002","journal-title":"Autoimmun Rev"},{"issue":"8","key":"4847_CR38","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1002\/jbmr.3442","volume":"33","author":"HM Macdonald","year":"2018","unstructured":"Macdonald HM, Reid IR, Gamble GD, Fraser WD, Tang JC, Wood AD (2018) 25-hydroxyvitamin D threshold for the effects of vitamin d supplements on bone density: secondary analysis of a randomized controlled trial. J Bone Miner Res 33(8):1464\u20131469. https:\/\/doi.org\/10.1002\/jbmr.3442","journal-title":"J Bone Miner Res"},{"issue":"2","key":"4847_CR39","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1210\/jc.2013-2572","volume":"99","author":"DK Liang","year":"2014","unstructured":"Liang DK, Bai XJ, Wu B, Han LL, Wang XN, Yang J, Chen XM (2014) Associations between bone mineral density and subclinical atherosclerosis:a cross-sectional study of a Chinese population. J Clin Endocrinol Metab 99(2):469\u2013477. https:\/\/doi.org\/10.1210\/jc.2013-2572","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"4847_CR40","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.1210\/jc.2016-1934","volume":"101","author":"LE Wagenknecht","year":"2016","unstructured":"Wagenknecht LE, Divers J, Register TC, Russell GB, Bowden DW, Xu J, Langefeld CD, Lenchik L, Hruska KA, Carr JJ (2016) Bone mineral density and progression of subclinical atherosclerosis in African-Americans with type 2 diabetes. J Clin Endocrinol Metab 101(11):4135\u20134141. https:\/\/doi.org\/10.1210\/jc.2016-1934","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"4847_CR41","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.rdc.2015.04.005","volume":"41","author":"L Cappelli","year":"2015","unstructured":"Cappelli L, Wigley FM (2015) Management of Raynaud phenomenon and digital ulcers in scleroderma. Rheum Dis Clin N Am 41(3):419\u2013438. https:\/\/doi.org\/10.1016\/j.rdc.2015.04.005","journal-title":"Rheum Dis Clin N Am"},{"issue":"3","key":"4847_CR42","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1002\/acr.22672","volume":"68","author":"L Morardet","year":"2016","unstructured":"Morardet L, Avouac J, Sammour M, Baron M, Kahan A, Feydy A, Allanore Y (2016) Late nailfold videocapillaroscopy pattern associated with hand calcinosis and acro-osteolysis in systemic sclerosis. Arthritis Care Res(Hoboken) 68(3):366\u2013373. https:\/\/doi.org\/10.1002\/acr.22672","journal-title":"Arthritis Care Res(Hoboken)"},{"issue":"3","key":"4847_CR43","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.semarthrit.2016.05.008","volume":"46","author":"A Valenzuela","year":"2016","unstructured":"Valenzuela A, Baron M et al (2016) Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: a scleroderma clinical trials consortium study. Semin Arthritis Rheum 46(3):344\u2013349. https:\/\/doi.org\/10.1016\/j.semarthrit.2016.05.008","journal-title":"Semin Arthritis Rheum"},{"issue":"10","key":"4847_CR44","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/nrrheum.2012.120","volume":"8","author":"CE Lampropoulos","year":"2012","unstructured":"Lampropoulos CE, Papaioannou I, D\u2019Cruz DP (2012) Osteoporosis--a risk factor for cardiovascular disease? Nat Rev Rheumatol 8(10):587\u2013598. https:\/\/doi.org\/10.1038\/nrrheum.2012.120","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"4847_CR45","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s00223-013-9712-z","volume":"93","author":"M Wu","year":"2013","unstructured":"Wu M, Rementer C, Giachelli CM (2013) Vascular calcification: an update on mechanisms and challenges in treatment. Calcif Tissue Int 93(4):365\u2013373. https:\/\/doi.org\/10.1007\/s00223-013-9712-z","journal-title":"Calcif Tissue Int"},{"issue":"11","key":"4847_CR46","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.3899\/jrheum.080192","volume":"35","author":"A Dovio","year":"2008","unstructured":"Dovio A, Data V, Carignola R, Calzolari G, Vitetta R, Ventura M, Saba L, Severino A, Angeli A (2008) Circulating osteoprotegerin and soluble RANK ligand in systemic sclerosis. J Rheumatol 35(11):2206\u20132213","journal-title":"J Rheumatol"},{"key":"4847_CR47","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.bone.2017.08.022","volume":"115","author":"S Stegen","year":"2018","unstructured":"Stegen S, Carmeliet G (2018) The skeletal vascular system-breathing life into bone tissue. Bone 115:50\u201358. https:\/\/doi.org\/10.1016\/j.bone.2017.08.022","journal-title":"Bone"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-019-04847-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-019-04847-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-019-04847-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T00:22:47Z","timestamp":1607818967000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-019-04847-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,14]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["4847"],"URL":"https:\/\/doi.org\/10.1007\/s10067-019-04847-0","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,14]]},"assertion":[{"value":"9 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}