{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:07:00Z","timestamp":1761664020260,"version":"3.37.3"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1007\/s10067-019-04887-6","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T21:02:23Z","timestamp":1578517343000},"page":"1513-1520","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of a special concept of physical therapy in spondyloarthritis: German multimodal rheumatologic complex treatment for spondyloarthritis"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7911-4235","authenticated-orcid":false,"given":"Philipp","family":"Klemm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Hudowenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Asendorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Dischereit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"M\u00fcller-Ladner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo H.","family":"Tarner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"key":"4887_CR1","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1136\/annrheumdis-2013-204311","volume":"74","author":"D Huscher","year":"2015","unstructured":"Huscher D, Mittendorf T, von Hin\u00fcber U et al (2015) Evolution of cost structures in rheumatoid arthritis over the past decade. Ann Rheum Dis 74:738\u2013745","journal-title":"Ann Rheum Dis"},{"key":"4887_CR2","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jbspin.2018.04.003","volume":"86","author":"P Claudepierre","year":"2019","unstructured":"Claudepierre P, Fagnani F, Cukierman G, de Chalus T, Joubert JM, Laurendeau C, Gourmelen J, Breban M (2019) Burden of severe spondyloarthritis in France: a nationwide assessment of prevalence, associated comorbidities and cost. Joint Bone Spine 86:69\u201375","journal-title":"Joint Bone Spine"},{"key":"4887_CR3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1055\/s-0042-116425","volume":"42","author":"K Albrecht","year":"2017","unstructured":"Albrecht K, Huscher D (2017) Do we prescribe physical medicine sufficiently? Current data from the National Database of the German collaborative arthritis centers. Akt Rheumatol 42:118\u2013121","journal-title":"Akt Rheumatol"},{"key":"4887_CR4","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1136\/annrheumdis-2016-210770","volume":"76","author":"D Van Der Heijde","year":"2017","unstructured":"Van Der Heijde D, Ramiro S, Landew\u00e9 R et al (2017) 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis 76:978\u2013991","journal-title":"Ann Rheum Dis"},{"key":"4887_CR5","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1136\/annrheumdis-2018-213585","volume":"77","author":"A-K Rausch Osthoff","year":"2018","unstructured":"Rausch Osthoff A-K, Niedermann K, Braun J, Adams J, Brodin N, Dagfinrud H, Duruoz T, Esbensen BA, G\u00fcnther KP, Hurkmans E, Juhl CB, Kennedy N, Kiltz U, Knittle K, Nurmohamed M, Pais S, Severijns G, Swinnen TW, Pitsillidou IA, Warburton L, Yankov Z, Vliet Vlieland TPM (2018) 2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis. Ann Rheum Dis 77:1251\u20131260","journal-title":"Ann Rheum Dis"},{"key":"4887_CR6","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1055\/s-0035-1548866","volume":"40","author":"U Lange","year":"2015","unstructured":"Lange U, M\u00fcller-Ladner U (2015) Physiotherapy for rheumatic diseases: what is evidence-based? Akt Rheumatol 40:475\u2013478","journal-title":"Akt Rheumatol"},{"key":"4887_CR7","unstructured":"DIMDI - OPS Version 2018, https:\/\/www.dimdi.de\/static\/de\/klassifikationen\/ops\/kode-suche\/opshtml2018\/block-8-97...8-98.htm"},{"key":"4887_CR8","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s00393-005-0783-8","volume":"64","author":"HJ Lakomek","year":"2005","unstructured":"Lakomek HJ, Fiori W, Buscham K et al (2005) Complex and multimodal rheumatologic treatment (OPS 8-983) \u2013 challenges, solutions and perspectives. Z Rheumatol 64:557\u2013563","journal-title":"Z Rheumatol"},{"key":"4887_CR9","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s00393-018-0470-1","volume":"77","author":"H-J Lakomek","year":"2018","unstructured":"Lakomek H-J, Fiori W (2018) Complex treatments in rheumatology and geriatrics \u2013 challenges \u2013 differences \u2013 chances. Z Rheumatol 77:385\u2013396","journal-title":"Z Rheumatol"},{"key":"4887_CR10","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1136\/ard.2009.108233","volume":"68","author":"M Rudwaleit","year":"2009","unstructured":"Rudwaleit M, van der Heijde D, Landewe R et al (2009) The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis 68:777\u2013783","journal-title":"Ann Rheum Dis"},{"key":"4887_CR11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1136\/ard.2010.133645","volume":"70","author":"M Rudwaleit","year":"2011","unstructured":"Rudwaleit M, van der Heijde D, Landewe R et al (2011) The Assessment of SpondyloArthritis international Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general. Ann Rheum Dis 70:25\u201331","journal-title":"Ann Rheum Dis"},{"key":"4887_CR12","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1002\/art.21972","volume":"54","author":"W Taylor","year":"2006","unstructured":"Taylor W, Gladman D, Helliwell P et al (2006) Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum 54:2665\u20132673","journal-title":"Arthritis Rheum"},{"key":"4887_CR13","first-page":"1","volume":"67","author":"D Bates","year":"2014","unstructured":"Bates D, M\u00e4chler M, Bolker B et al (2014) Fitting linear mixed-effects models using lme4. J Stat Softw 67:1\u201348","journal-title":"J Stat Softw"},{"key":"4887_CR14","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1136\/annrheumdis-2013-205079","volume":"74","author":"MM Ward","year":"2015","unstructured":"Ward MM, Guthrie LC, Alba MI (2015) Clinically important changes in individual and composite measures of rheumatoid arthritis activity: thresholds applicable in clinical trials. Ann Rheum Dis 74:1691\u20131696","journal-title":"Ann Rheum Dis"},{"key":"4887_CR15","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.3899\/jrheum.151244","volume":"43","author":"MJ Kviatkovsky","year":"2016","unstructured":"Kviatkovsky MJ, Ramiro S, Landewe R et al (2016) The minimum clinically important improvement and patient-acceptable symptom state in the BASDAI and BASFI for patients with ankylosing spondylitis. J Rheumatol 43:1680\u20131686","journal-title":"J Rheumatol"},{"key":"4887_CR16","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1136\/annrheumdis-2017-212378","volume":"77","author":"A Molt\u00f3","year":"2018","unstructured":"Molt\u00f3 A, Etcheto A, Gossec L et al (2018) Evaluation of the impact of concomitant fibromyalgia on TNF alpha blockers\u2019 effectiveness in axial spondyloarthritis: results of a prospective, multicentre study. Ann Rheum Dis 77:533\u2013540","journal-title":"Ann Rheum Dis"},{"key":"4887_CR17","first-page":"1899","volume":"32","author":"H Dagfinrud","year":"2005","unstructured":"Dagfinrud H, Kvien TK, Hagen KB (2005) The Cochrane review of physiotherapy interventions for ankylosing spondylitis. J Rheumatol 32:1899\u20131906","journal-title":"J Rheumatol"},{"key":"4887_CR18","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/1529-0131(200110)45:5<430::AID-ART362>3.0.CO;2-F","volume":"45","author":"A van Tubergen","year":"2001","unstructured":"van Tubergen A, Landew\u00e9 R, van der Heijde D, Hidding A, Wolter N, Asscher M, Falkenbach A, Genth E, Th\u00e8 HG, van der Linden S (2001) Combined spa-exercise therapy is effective in patients with ankylosing spondylitis: a randomized controlled trial. Arthritis Rheum 45:430\u2013438","journal-title":"Arthritis Rheum"},{"key":"4887_CR19","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.3899\/jrheum.131431","volume":"41","author":"FMP Meier","year":"2014","unstructured":"Meier FMP, M\u00fcller-Ladner U, Lange U (2014) Efficacy of intensive physiotherapy in combination with low-dose etanercept in active spondyloarthritis: a monocentric pilot study. J Rheumatol 41:1897\u20131898","journal-title":"J Rheumatol"},{"key":"4887_CR20","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/s00393-013-1144-7","volume":"72","author":"AM Beer","year":"2013","unstructured":"Beer AM, Fetaj S, Lange U (2013) Peloid therapy an overview of the empirical status and evidence of mud therapy. Z Rheumatol 72:581\u2013589","journal-title":"Z Rheumatol"},{"key":"4887_CR21","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1055\/s-0034-1383589","volume":"39","author":"U Lange","year":"2014","unstructured":"Lange U, Schwab F, Muller-Ladner U et al (2014) Effectiveness of whole-body hyperthermia by mild water-filtered infrared a radiation in psoriatic arthritis: a controlled, randomised, prospective trial. Akt Rheumatol 39:310\u2013316","journal-title":"Akt Rheumatol"},{"key":"4887_CR22","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1055\/s-2004-834601","volume":"15","author":"U Lange","year":"2005","unstructured":"Lange U, Thielen G, Neeck G et al (2005) Effects of whole body hyperthermia on plasma cortisol, total lymphocytes and -subpopulation in patients with ankylosing spondylitis and healthy controls. Phys Med Rehab Kuror 15:44\u201347","journal-title":"Phys Med Rehab Kuror"},{"key":"4887_CR23","first-page":"479","volume":"43","author":"U Lange","year":"2018","unstructured":"Lange U, Dischereit G (2018) Effects of different iterative whole-body hyperthermia on pain and cytokines in rheumatic diseases: a current review. Akt Rheumatol 43:479\u2013483","journal-title":"Akt Rheumatol"},{"key":"4887_CR24","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1007\/s10067-016-3236-7","volume":"35","author":"U Lange","year":"2016","unstructured":"Lange U, Dischereit G, Tarner I, Frommer K, Neumann E, M\u00fcller-Ladner U, K\u00fcrten B (2016) The impact of serial radon and hyperthermia exposure in a therapeutic adit on pivotal cytokines of bone metabolism in rheumatoid arthritis and osteoarthritis. Clin Rheumatol 35:2783\u20132788","journal-title":"Clin Rheumatol"},{"key":"4887_CR25","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s00063-008-1056-5","volume":"103","author":"U Lange","year":"2008","unstructured":"Lange U, Uhlemann C, M\u00fcller-Ladner U (2008) Serial whole-body cryotherapy in the criostream for inflammatory rheumatic diseases. A pilot study. Med Klin 103:383\u2013388","journal-title":"Med Klin"},{"key":"4887_CR26","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1055\/s-0043-113045","volume":"27","author":"U Lange","year":"2017","unstructured":"Lange U, M\u00fcller-Ladner U, Dischereit G (2017) Rheumatic diseases and molecular physical medicine \u2013 new aspects. Phys Med Rehab Kuror 27:205\u2013210","journal-title":"Phys Med Rehab Kuror"},{"key":"4887_CR27","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s10067-008-1059-x","volume":"28","author":"IH Tarner","year":"2009","unstructured":"Tarner IH, M\u00fcller-Ladner U, Uhlemann C, Lange U (2009) The effect of mild whole-body hyperthermia on systemic levels of TNF-alpha, IL-1beta, and IL-6 in patients with ankylosing spondylitis. Clin Rheumatol 28:397\u2013402","journal-title":"Clin Rheumatol"},{"key":"4887_CR28","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/ncprheum0929","volume":"4","author":"IE Lundberg","year":"2008","unstructured":"Lundberg IE, Nader GA (2008) Molecular effects of exercise in patients with inflammatory rheumatic disease. Nat Clin Pract Rheumatol 4:597\u2013604","journal-title":"Nat Clin Pract Rheumatol"},{"key":"4887_CR29","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00393-016-0232-x","volume":"76","author":"U Kiltz","year":"2017","unstructured":"Kiltz U, Rudwaleit M, Sieper J, Braun J (2017) Evidence-based recommendations on diagnostics and therapy of axial spondyloarthritis: S3 guidelines of the German Society of Rheumatology (DGRh) in cooperation with the Association of the Scientific Medical Societies in Germany (AWMF). Z Rheumatol 76:111\u2013117","journal-title":"Z Rheumatol"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-019-04887-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-019-04887-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-019-04887-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:57:53Z","timestamp":1609981073000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-019-04887-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,8]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["4887"],"URL":"https:\/\/doi.org\/10.1007\/s10067-019-04887-6","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"type":"print","value":"0770-3198"},{"type":"electronic","value":"1434-9949"}],"subject":[],"published":{"date-parts":[[2020,1,8]]},"assertion":[{"value":"29 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This study was performed according to the declaration of Helsinki and after receiving approval by the local ethics committee of the Faculty of Medicine of the Justus-Liebig-University Gie\u00dfen (vote no. 231\/16).As this study was conducted retrospectively, informed consent of patients was not obtained. This was approved by the local ethics committee of the Faculty of Medicine of the Justus-Liebig-Universit\u00e4t Gie\u00dfen (vote no. 231\/16).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"Philipp Klemm declares no conflicts of interest.Ole Hudowenz declares no conflicts of interest.Thomas Asendorf declares no conflicts of interest.Gabriel Dischereit declares no conflicts of interest.Ulf M\u00fcller-Ladner declares no conflicts of interest.Uwe Lange declares no conflicts of interest.Ingo H. Tarner declares no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure of interest"}}]}}