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Yet the feasibility of such an intervention remains untested. Therefore, the purpose of this study is to examine the feasibility of a combined exercise protocol (aerobic and resistance training) in people with limited cutaneous SSc (lcSSc).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p> Thirty-two lcSSc patients (66.5\u2009\u00b1\u200912\u00a0years old) were randomly allocated in two groups (exercise and control group). The exercise group underwent a 12-week exercise programme, twice per week. All patients performed the baseline, three- and six-month follow-up measurements where functional ability, body composition and QoL were assessed. Participants\u2019 experiences were explored through interviews.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p> Compliance was 92.6% with no dropouts. The individuals\u2019 confidence to participate in the study\u2019s exercise protocol for twice per week was 95%. The average value for the physical activity enjoyment scale was 103\u2009\u00b1\u200910 out of 119 (highest score). The mean values for the intention to engage in exercise twice per week were 6.4\u2009\u00b1\u20091 (likely) out of 7 (very likely). QoL for the exercise group showed to have a better life satisfaction, less anxiety and Raynaud\u2019s phenomenon-accompanied pain. <\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Our results suggest that a combined exercise protocol was feasible for people with lcSSc, with no adverse events,\u00a0resulting in high adherence and low attrition rates, high enjoyment levels and intentions for future engagement to this exercise. Thus, the specific protocol is a safe adjunct therapy for people with lcSSc.<\/jats:p>\n<jats:p><jats:bold>Trial registration:<\/jats:bold><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> (NCT number): NCT03058887, February 23, 2017, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03058887?term=NCT03058887&amp;rank=1\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03058887?term=NCT03058887&amp;rank=1<\/jats:ext-link><jats:table-wrap><jats:table><jats:tbody><jats:tr><jats:td colspan=\"2\"><jats:bold>Key Points<\/jats:bold><jats:italic>\u2022 High-intensity interval training in combination with resistance training constitutes a feasible exercise protocol for people with lcSSc<\/jats:italic>.<jats:italic>\u2022 Overall, the exercise programme demonstrated high adherence and enjoyment levels and low attrition rates.<\/jats:italic><jats:italic>\u2022 The exercise protocol was proved to be safe with no adverse events for people with lcSSc<\/jats:italic>.<\/jats:td><\/jats:tr><\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s10067-019-04921-7","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T05:50:26Z","timestamp":1578981026000},"page":"1889-1898","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Exploring the feasibility of an exercise programme including aerobic and resistance training in people with limited cutaneous systemic sclerosis"],"prefix":"10.1007","volume":"39","author":[{"given":"Alexandros","family":"Mitropoulos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Gumber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Crank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Akil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8864-4403","authenticated-orcid":false,"given":"Markos","family":"Klonizakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,14]]},"reference":[{"key":"4921_CR1","doi-asserted-by":"publisher","first-page":"272","DOI":"10.3389\/fimmu.2015.00272","volume":"6","author":"D Pattanaik","year":"2015","unstructured":"Pattanaik D, Brown M, Postlethwaite BC, Postlethwaite AE (2015) Pathogenesis of systemic sclerosis. 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