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Adult patients with RA from a large observational US registry (Corrona RA), with \u2265\u20091 visit for assessment of SS status between 22 April 2010 and 28 February 2018, were considered. Patients with RA with versus without SS were compared. SS status was determined from a yes\/no variable and reported at enrollment into the Corrona RA registry and follow-up visits. Outcomes were unadjusted prevalence of SS in patients with RA, prevalence of SS by RA disease duration, and baseline characteristics in patients with RA by SS status. Of 24,528 eligible patients, 7870 (32.1%) had a diagnosis of RA and SS. The unadjusted overall rate for SS prevalence in patients with RA was 0.30 (95% confidence interval 0.29, 0.31). SS prevalence increased with increasing RA duration. Patients with RA with versus without SS were more likely to be older, female, and seropositive; had a longer RA duration; higher disease activity; and a higher incidence of comorbidities (hypertension, cardiovascular disease, malignancies, and serious infections), erosive disease, and subcutaneous nodules at index date. Patients with RA and SS had a higher disease burden than those with RA only. The prevalence of SS increased as duration of RA increased. RA with SS was associated with seropositivity, more severe RA, extra-articular manifestations, and comorbidities.<jats:table-wrap><jats:table><jats:tbody><jats:tr><jats:td colspan=\"2\"><jats:bold>Key Points<\/jats:bold>\u2022 <jats:italic>The overall prevalence of SS among patients with RA was 30%.<\/jats:italic><jats:italic>\u2022 The prevalence of SS increased with increasing RA disease duration.<\/jats:italic><jats:italic>\u2022 Identifying specific clinical characteristics of patients with RA with SS, such as a greater incidence of extra-articular manifestations and comorbidities, may help clinicians to better characterize this patient population.<\/jats:italic><\/jats:td><\/jats:tr><\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s10067-020-05004-8","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T11:03:01Z","timestamp":1583319781000},"page":"1899-1905","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Prevalence of Sj\u00f6gren\u2019s syndrome associated with rheumatoid arthritis in the USA: an observational study from the Corrona registry"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0170-2747","authenticated-orcid":false,"given":"Leslie R.","family":"Harrold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0201-4030","authenticated-orcid":false,"given":"Sabrina","family":"Rebello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean E.","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evo","family":"Alemao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7681-4615","authenticated-orcid":false,"given":"Elliot D.","family":"Rosenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"5004_CR1","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.12688\/f1000research.8352.1","volume":"5","author":"Nicholas Holdgate","year":"2016","unstructured":"Holdgate N, St Clair EW (2016) Recent advances in primary Sjogren\u2019s syndrome. 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All participating investigators obtained full board approval for conducting non-interventional research involving human subjects with a limited dataset. Sponsor approval and continuing review were obtained through a central Institutional Review Board (IRB; New England Independent Review Board, NEIRB No. 120160610). For academic investigative sites that did not receive a waiver to use the central IRB, full board approval was obtained from the respective governing IRBs and documentation of approval was submitted to Corrona, LLC, prior to initiating study procedures. All patients provided written informed consent and authorization prior to participating.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Leslie R. Harrold is an employee of Corrona, LLC, and a shareholder in Corrona, LLC, and has received grant\/research support from Pfizer and consulting fees from AbbVie, Bristol-Myers Squibb, and Roche. Ying Shan and Sabrina Rebello are employees of Corrona, LLC. Neil Kramer has nothing to declare. Evo Alemao, Sean E. Connolly, and Sheila Kelly have stock options\/bond holdings in, and are employees of, Bristol-Myers Squibb. Joel Kremer has stock options\/bond holdings in, and is an employee of, Corrona, LLC; has received consultancy fees from AbbVie, Amgen, Bristol-Myers Squibb, Genentech, Lilly, Regeneron, Sanofi, and Pfizer; and has received grant\/research support from AbbVie, Bristol-Myers Squibb, Genentech, Lilly, Novartis, and Pfizer. Elliot D. Rosenstein has received consultancy fees from Amgen and Bristol-Myers Squibb; has received grant\/research support from Myriad Genetics and Novartis; and is on speakers\u2019 bureaus for AbbVie, Amgen, and Bristol-Myers Squibb.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}