{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:03:43Z","timestamp":1790856223979,"version":"4.1.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s10067-020-05017-3","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T09:02:40Z","timestamp":1585299760000},"page":"2689-2696","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Early onset primary Sj\u00f6gren syndrome, clinical and laboratory characteristics"],"prefix":"10.1007","volume":"39","author":[{"given":"M\u00fc\u00e7teba Enes","family":"Yayla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Karaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Torgutalp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe Bahar","family":"Kele\u015fo\u011flu Din\u00e7er","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine G\u00f6zde","family":"Aydemir G\u00fcl\u00f6ks\u00fcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Sezer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didem","family":"\u015eahin Ero\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Levent","family":"Y\u00fcksel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahsin Murat","family":"Turgay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclay","family":"K\u0131n\u0131kl\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u015fk\u0131n","family":"Ate\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"issue":"5","key":"5017_CR1","doi-asserted-by":"publisher","first-page":"A305","DOI":"10.1016\/j.autrev.2009.11.004","volume":"9","author":"CP Mavragani","year":"2010","unstructured":"Mavragani CP, Moutsopoulos HM (2010) The geoepidemiology of Sj\u00f6gren\u2019s syndrome. Autoimmun Rev 9(5):A305\u2013A310","journal-title":"Autoimmun Rev"},{"issue":"9","key":"5017_CR2","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1007\/s10067-018-4159-2","volume":"37","author":"M J\u00fclich","year":"2018","unstructured":"J\u00fclich M, Kanne A-M, Sehnert B, Budweiser S, Voll RE, Kollert F (2018) Serological lymphocytic activity and patient-reported outcomes in Sj\u00f6gren\u2019s syndrome. Clin Rheumatol 37(9):2361\u20132366","journal-title":"Clin Rheumatol"},{"issue":"3","key":"5017_CR3","first-page":"450","volume":"55","author":"AG Singh","year":"2015","unstructured":"Singh AG, Singh S, Matteson EL (2015) Rate, risk factors and causes of mortality in patients with Sj\u00f6gren\u2019s syndrome: a systematic review and meta-analysis of cohort studies. Rheumatology 55(3):450\u2013460","journal-title":"Rheumatology"},{"issue":"11","key":"5017_CR4","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1093\/rheumatology\/keh714","volume":"44","author":"M Ramos-Casals","year":"2005","unstructured":"Ramos-Casals M, Font J (2005) Primary Sjogren\u2019s syndrome: current and emergent aetiopathogenic concepts. Rheumatology 44(11):1354\u20131367","journal-title":"Rheumatology"},{"issue":"1","key":"5017_CR5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/art.23177","volume":"58","author":"CG Helmick","year":"2008","unstructured":"Helmick CG, Felson DT, Lawrence RC, Gabriel S, Hirsch R, Kwoh CK, Liang MH, Kremers HM, Mayes MD, Merkel PA (2008) Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: part I. Arthritis Rheum 58(1):15\u201325","journal-title":"Arthritis Rheum"},{"issue":"12","key":"5017_CR6","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1001\/archinte.164.12.1275","volume":"164","author":"SS Kassan","year":"2004","unstructured":"Kassan SS, Moutsopoulos HM (2004) Clinical manifestations and early diagnosis of Sj\u00f6gren syndrome. Arch Intern Med 164(12):1275\u20131284","journal-title":"Arch Intern Med"},{"key":"5017_CR7","doi-asserted-by":"crossref","unstructured":"Amador-Patarroyo MJ, Rodriguez-Rodriguez A, Montoya-Ortiz G (2012) How does age at onset influence the outcome of autoimmune diseases? Autoimmune Dis 2012","DOI":"10.1155\/2012\/251730"},{"issue":"3","key":"5017_CR8","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1191\/096120398678920019","volume":"7","author":"M Ramos-Casals","year":"1998","unstructured":"Ramos-Casals M, Cervera R, Font J, Garc\u00f3a-Carrasco M, Espinosa G, Reino S, Pallares L, Ingelmo M (1998) Young onset of primary Sj\u00f6gren\u2019s syndrome: clinical and immunological characteristics. Lupus 7(3):202\u2013206","journal-title":"Lupus"},{"issue":"4","key":"5017_CR9","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1097\/00005792-200207000-00003","volume":"81","author":"M Garcia-Carrasco","year":"2002","unstructured":"Garcia-Carrasco M, Ramos-Casals M, Rosas J, Pallares L, Calvo-Alen J, Cervera R, Font J, Ingelmo M (2002) Primary Sj\u00f6gren syndrome: clinical and immunologic disease patterns in a cohort of 400 patients. Medicine 81(4):270\u2013280","journal-title":"Medicine"},{"issue":"4","key":"5017_CR10","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1097\/MD.0b013e318181e6af","volume":"87","author":"M Ramos-Casals","year":"2008","unstructured":"Ramos-Casals M, Solans R, Rosas J, Camps MT, Gil A, del Pino-Montes J, Calvo-Alen J, Jim\u00e9nez-Alonso J, Mic\u00f3 M-L, Beltr\u00e1n J (2008) Primary Sj\u00f6gren syndrome in Spain: clinical and immunologic expression in 1010 patients. Medicine 87(4):210\u2013219","journal-title":"Medicine"},{"issue":"4","key":"5017_CR11","first-page":"795","volume":"28","author":"M Tishler","year":"2001","unstructured":"Tishler M, Yaron I, Shirazi I, Yaron M (2001) Clinical and immunological characteristics of elderly onset Sj\u00f6gren\u2019s syndrome: a comparison with younger onset disease. J Rheumatol 28(4):795\u2013797","journal-title":"J Rheumatol"},{"issue":"2","key":"5017_CR12","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jbspin.2010.05.008","volume":"78","author":"C Botsios","year":"2011","unstructured":"Botsios C, Furlan A, Ostuni P, Sfriso P, Andretta M, Ometto F, Raffeiner B, Todesco S, Punzi L (2011) Elderly onset of primary Sj\u00f6gren\u2019s syndrome: clinical manifestations, serological features and oral\/ocular diagnostic tests. Comparison with adult and young onset of the disease in a cohort of 336 Italian patients. Joint Bone Spine 78(2):171\u2013174","journal-title":"Joint Bone Spine"},{"issue":"1","key":"5017_CR13","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/art.39859","volume":"69","author":"CH Shiboski","year":"2017","unstructured":"Shiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, Lietman TM, Rasmussen A, Scofield H, Vitali C, Bowman SJ (2017) 2016 American College of Rheumatology\/European League Against Rheumatism classification criteria for primary Sj\u00f6gren\u2019s syndrome: a consensus and data-driven methodology involving three international patient cohorts. Arthritis Rheumatol 69(1):35\u201345","journal-title":"Arthritis Rheumatol"},{"issue":"11","key":"5017_CR14","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1177\/0961203317696593","volume":"26","author":"R Aljohani","year":"2017","unstructured":"Aljohani R, Gladman D, Su J, Urowitz M (2017) Disease evolution in late-onset and early-onset systemic lupus erythematosus. Lupus 26(11):1190\u20131196","journal-title":"Lupus"},{"issue":"4","key":"5017_CR15","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1177\/0961203307087875","volume":"17","author":"L Tucker","year":"2008","unstructured":"Tucker L, Uribe A, Fernandez M, Vila L, McGwin G, Apte M, Fessler B, Bastian H, Reveille J, Alarc\u00f3n G (2008) Adolescent onset of lupus results in more aggressive disease and worse outcomes: results of a nested matched case\u2013control study within LUMINA, a multiethnic US cohort (LUMINA LVII). Lupus 17(4):314\u2013322","journal-title":"Lupus"},{"issue":"1","key":"5017_CR16","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1080\/03009742.2018.1459830","volume":"48","author":"PE Carreira","year":"2019","unstructured":"Carreira PE, Carmona L, Joven B, Loza E, Andr\u00e9u J, Riemekasten G, Vettori S, Balbir-Gurman A, Air\u00f2 P, Walker U (2019) Differences associated with age at onset in early systemic sclerosis patients: a report from the EULAR Scleroderma Trials and Research Group (EUSTAR) database. Scand J Rheumatol 48(1):42\u201351","journal-title":"Scand J Rheumatol"},{"issue":"7","key":"5017_CR17","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1093\/rheumatology\/key392","volume":"58","author":"C Anquetil","year":"2019","unstructured":"Anquetil C, Hachulla E, Machuron F, Mariette X, Le Guern V, Vittecoq O, Dernis E, Larroche C, Dubost J-J, Perdriger A (2019) Is early-onset primary Sj\u00f6gren\u2019s syndrome a worse prognosis form of the disease? Rheumatology 58(7):1163\u20131167","journal-title":"Rheumatology"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-020-05017-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-020-05017-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-020-05017-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T00:33:18Z","timestamp":1616805198000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-020-05017-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,27]]},"references-count":17,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["5017"],"URL":"https:\/\/doi.org\/10.1007\/s10067-020-05017-3","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,27]]},"assertion":[{"value":"30 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors have declared no conflict interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}