{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:20:04Z","timestamp":1783074004249,"version":"3.54.6"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T00:00:00Z","timestamp":1586304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s10067-020-05064-w","type":"journal-article","created":{"date-parts":[[2020,4,8]],"date-time":"2020-04-08T13:03:17Z","timestamp":1586350997000},"page":"2881-2888","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["TGF-\u03b21 +869C\/T polymorphism increases susceptibility to rheumatoid arthritis in North Indian population"],"prefix":"10.1007","volume":"39","author":[{"given":"Sipahee Lal","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaya","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,8]]},"reference":[{"key":"5064_CR1","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB Mcinnes","year":"2011","unstructured":"Mcinnes IB, Schett G (2011) The pathogenesis of rheumatoid arthritis. N Engl J Med 365:2205\u20132219. https:\/\/doi.org\/10.1056\/NEJMra1004965","journal-title":"N Engl J Med"},{"key":"5064_CR2","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1186\/ar1736","volume":"7","author":"L Moreland","year":"2005","unstructured":"Moreland L (2005) Unmet needs in rheumatoid arthritis. Arthritis Res Ther 7:S2\u2013S7. https:\/\/doi.org\/10.1186\/ar1736","journal-title":"Arthritis Res Ther"},{"key":"5064_CR3","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1097\/00002281-200405000-00007","volume":"16","author":"C Turesson","year":"2004","unstructured":"Turesson C, Matteson EL (2004) Management of extra-articular disease manifestations in rheumatoid arthritis. Curr Opin Rheumatol 16:206\u2013211. https:\/\/doi.org\/10.1097\/00002281-200405000-00007","journal-title":"Curr Opin Rheumatol"},{"key":"5064_CR4","first-page":"S128","volume":"20","author":"A Gibofsky","year":"2014","unstructured":"Gibofsky A (2014) Epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis: a synopsis. Am J Manag Care 20:S128\u2013S135","journal-title":"Am J Manag Care"},{"key":"5064_CR5","first-page":"286","volume":"5","author":"M Cojocaru","year":"2010","unstructured":"Cojocaru M, Cojocaru IM, Silosi I, Vrabie CD, Tanasescu R (2010) Extra-articular manifestations in rheumatoid arthritis. Maedica. 5:286","journal-title":"Maedica."},{"key":"5064_CR6","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1093\/rheumatology\/kep417","volume":"49","author":"WW Chang","year":"2010","unstructured":"Chang WW, Su H, He L, Zhao KF, Wu JL, Xu ZW (2010) Association between transforming growth factor-\u03b21 T869C polymorphism and rheumatoid arthritis: a meta-analysis. Rheumatology (Oxford) 49:652\u2013656. https:\/\/doi.org\/10.1093\/rheumatology\/kep417","journal-title":"Rheumatology (Oxford)"},{"key":"5064_CR7","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1093\/rheumatology\/ken005","volume":"47","author":"J Bowes","year":"2008","unstructured":"Bowes J, Barton A (2008) Recent advances in the genetics of RA susceptibility. Rheumatology (Oxford) 47:399\u2013302. https:\/\/doi.org\/10.1093\/rheumatology\/ken005","journal-title":"Rheumatology (Oxford)"},{"key":"5064_CR8","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1146\/annurev.pathol.4.110807.092254","volume":"4","author":"JB Imboden","year":"2009","unstructured":"Imboden JB (2009) The immunopathogenesis of rheumatoid arthritis. Annu Rev Pathol-Mech 4:417\u2013434. https:\/\/doi.org\/10.1146\/annurev.pathol.4.110807.092254","journal-title":"Annu Rev Pathol-Mech"},{"key":"5064_CR9","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/1529-0131(200001)43:1<30:AID-ANR5>3.0.CO;2-B","volume":"43","author":"AJ Macgregor","year":"2000","unstructured":"Macgregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K et al (2000) Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum 43:30\u201337. https:\/\/doi.org\/10.1002\/1529-0131(200001)43:1<30:AID-ANR5>3.0.CO;2-B","journal-title":"Arthritis Rheum"},{"key":"5064_CR10","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1136\/ard.57.6.361","volume":"57","author":"S John","year":"1998","unstructured":"John S, Myerscough A, Marlow A, Hajeer A, Silman A, Ollier W, Worthington J (1998) Linkage of cytokine genes to rheumatoid arthritis. Evidence of genetic heterogeneity. Ann Rheum Dis 57:361\u2013365. https:\/\/doi.org\/10.1136\/ard.57.6.361","journal-title":"Ann Rheum Dis"},{"key":"5064_CR11","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1046\/j.1365-2249.2002.01785.x","volume":"127","author":"H Cheon","year":"2002","unstructured":"Cheon H, Yu SJ, Yoo DH, Chae IJ, Song GG, Sohn J (2002) Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-\u03b21 in synovial fibroblasts from rheumatoid arthritis and normal individuals. Clin Exp Immunol 127:547\u2013552. https:\/\/doi.org\/10.1046\/j.1365-2249.2002.01785.x","journal-title":"Clin Exp Immunol"},{"key":"5064_CR12","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/j.1365-2249.1991.tb02941.x","volume":"86","author":"CQ Chu","year":"1991","unstructured":"Chu CQ, Field M, Abney E, Zheng RQH, Allard S, Feldmann M, Maini RN (1991) Transforming growth factor-\u03b21 in rheumatoid synovial membrane and cartilage pannus junction. Clin Exp Immunol 86:380\u2013386. https:\/\/doi.org\/10.1111\/j.1365-2249.1991.tb02941.x","journal-title":"Clin Exp Immunol"},{"key":"5064_CR13","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/bf01570787","volume":"12","author":"D Fujii","year":"1986","unstructured":"Fujii D, Brissenden JE, Derynck R, Francke U (1986) Transforming growth factor \u03b2 gene maps to human chromosome 19 long arm and to mouse chromosome 7. Somat Cell Mol Genet 12:281\u2013288. https:\/\/doi.org\/10.1007\/bf01570787","journal-title":"Somat Cell Mol Genet"},{"key":"5064_CR14","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1056\/NEJM200005043421807","volume":"342","author":"GC Blobe","year":"2000","unstructured":"Blobe GC, Schiemann WP, Lodish HF (2000) Role of transforming growth factor \u03b2 in human disease. N Engl J Med 342:1350\u20131358. https:\/\/doi.org\/10.1056\/NEJM200005043421807","journal-title":"N Engl J Med"},{"key":"5064_CR15","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1161\/01.HYP.33.1.271","volume":"33","author":"B Li","year":"1999","unstructured":"Li B, Khanna A, Sharma V, Singh T, Suthanthiran M, August P (1999) TGF-\u03b21 DNA polymorphisms, protein levels, and blood pressure. Hypertension 33:271\u2013275. https:\/\/doi.org\/10.1161\/01.HYP.33.1.271","journal-title":"Hypertension"},{"key":"5064_CR16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/s0165-5728(98)00003-4","volume":"86","author":"B He","year":"1998","unstructured":"He B, Xu C, Yang B, Landtblom AM, Fredrikson S, Hillert J (1998) Linkage and association analysis of genes encoding cytokines and myelin proteins in multiple sclerosis. J Neuroimmunol 86:13\u201319. https:\/\/doi.org\/10.1016\/s0165-5728(98)00003-4","journal-title":"J Neuroimmunol"},{"key":"5064_CR17","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1359\/jbmr.1998.13.10.1569","volume":"13","author":"Y Yamada","year":"1998","unstructured":"Yamada Y, Miyauchi A, Goto J, Takagi Y, Okuizumi H, Kanematsu M, Hase M, Takai H, Harada A, Ikeda K (1998) Association of a polymorphism of the transforming growth factor-\u03b21 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women. J Bone Miner Res 13:1569\u20131576. https:\/\/doi.org\/10.1359\/jbmr.1998.13.10.1569","journal-title":"J Bone Miner Res"},{"key":"5064_CR18","first-page":"1112","volume":"32","author":"Y Zhu","year":"2006","unstructured":"Zhu Y, Liu F, Zhang F, Yao DF, Chen XD (2006) Correlation of transforming growth factor beta1 gene T869C polymorphism and rheumatoid arthritis in Chinese population. Chin Med J 32:1112","journal-title":"Chin Med J"},{"key":"5064_CR19","first-page":"1405","volume":"23","author":"YP Wang","year":"2007","unstructured":"Wang YP, Xiao LS, Zhou Y, Fei Y, Li JP (2007) Gene polymorphisms of transforming growth factor-beta 1 with rheumatoid arthritis. Asia Pac J Public Health 23:1405","journal-title":"Asia Pac J Public Health"},{"key":"5064_CR20","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jbspin.2008.02.012","volume":"76","author":"G Alayli","year":"2009","unstructured":"Alayli G, Kara N, Tander B, Canturk F, Gunes S, Bagci H (2009) Association of transforming growth factor \u03b21 gene polymorphism with rheumatoid arthritis in a Turkish population. Joint Bone Spine 76:20\u201323. https:\/\/doi.org\/10.1016\/j.jbspin.2008.02.012","journal-title":"Joint Bone Spine"},{"key":"5064_CR21","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/rheumatology\/ken443","volume":"48","author":"VF Panoulas","year":"2008","unstructured":"Panoulas VF, Douglas KMJ, Smith JP, Stavropoulos-Kalinoglou A, Metsios GS, Nightingale P et al (2008) Transforming growth factor-\u03b21 869T\/C, but not interleukin-6-174G\/C, polymorphism associates with hypertension in rheumatoid arthritis. Rheumatology(Oxford) 48:113\u2013118. https:\/\/doi.org\/10.1093\/rheumatology\/ken443","journal-title":"Rheumatology(Oxford)"},{"key":"5064_CR22","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1080\/03009740410010344","volume":"33","author":"SY Kim","year":"2004","unstructured":"Kim SY, Han SW, Kim GW, Lee JM, Kang YM (2004) TGF-\u00df1 polymorphism determines the progression of joint damage in rheumatoid arthritis. Scand J Rheumatol 33:389\u2013394. https:\/\/doi.org\/10.1080\/03009740410010344","journal-title":"Scand J Rheumatol"},{"key":"5064_CR23","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1136\/ard.62.9.907","volume":"62","author":"V Pokorny","year":"2003","unstructured":"Pokorny V, Chau J, Wu L, Yeoman S, Black P, Mcqueen F et al (2003) Transforming growth factor \u03b21 gene (HSTGFB1) nucleotide T869C (codon 10) polymorphism is not associated with prevalence or severity of rheumatoid arthritis in a Caucasian population. Ann Rheum Dis 62:907\u2013908. https:\/\/doi.org\/10.1136\/ard.62.9.907","journal-title":"Ann Rheum Dis"},{"key":"5064_CR24","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/BCO.0000000000000213","volume":"26","author":"SL Patel","year":"2015","unstructured":"Patel SL, Kumar V, Mishra R, Chandra V, Prakash J, Gupta V et al (2015) Effectiveness of methotrexate therapy with occasional corticosteroid in rheumatoid arthritis. Curr Orthop Pract 26:148\u2013154. https:\/\/doi.org\/10.1097\/BCO.0000000000000213","journal-title":"Curr Orthop Pract"},{"key":"5064_CR25","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1002\/art.178010302","volume":"31","author":"FC Arnett","year":"1988","unstructured":"Arnett FC, Edworthy SM, Bloch DA, Mcshane DJ, Fries JF, Cooper NS et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315\u2013324. https:\/\/doi.org\/10.1002\/art.178010302","journal-title":"Arthritis Rheum"},{"key":"5064_CR26","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","volume":"16","author":"SA Miller","year":"1988","unstructured":"Miller SA, Dykes DD, Polesky HFRN (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215. https:\/\/doi.org\/10.1093\/nar\/16.3.1215","journal-title":"Nucleic Acids Res"},{"key":"5064_CR27","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/s0966-3274(99)80030-6","volume":"2","author":"C Perrey","year":"1999","unstructured":"Perrey C, Turner SJ, Pravica V, Howell WM, Hutchinson IV (1999) ARMS-PCR methodologies to determine IL-10, TNF-\u03b1, TNF-\u03b2 and TGF-\u03b21 gene polymorphisms. Transpl Immunol 2:127\u2013128. https:\/\/doi.org\/10.1016\/s0966-3274(99)80030-6","journal-title":"Transpl Immunol"},{"key":"5064_CR28","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/j.1744-313x.1994.tb00217.x","volume":"21","author":"A Aldener-cannav\u00e1","year":"1994","unstructured":"Aldener-cannav\u00e1 A, Olerup O (1994) HLA-DQB1 \u2018LOW-RESOLUTION\u2019TYPING BY PCR AMPLIFICATION WITH SEQUENCE-SPECIFIC PRIMERS (PCR-SSP). Int J Immunogenet 21:447\u2013455. https:\/\/doi.org\/10.1111\/j.1744-313x.1994.tb00217.x","journal-title":"Int J Immunogenet"},{"key":"5064_CR29","unstructured":"Gauderman WJ, Morrison JM (2006) \"QUANTO 1.1: a computer program for power and sample size calculations for genetic-epidemiology studies.; http:\/\/hydra. usc. edu\/gxe"},{"key":"5064_CR30","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1136\/ard.61.9.826","volume":"61","author":"Y Sugiura","year":"2002","unstructured":"Sugiura Y, Niimi T, Sato S, Yoshinouchi T, Banno S, Naniwa T, Maeda H, Shimizu S, Ueda R (2002) Transforming growth factor \u03b21 gene polymorphism in rheumatoid arthritis. Ann Rheum Dis 61:826\u2013828. https:\/\/doi.org\/10.1136\/ard.61.9.826","journal-title":"Ann Rheum Dis"},{"key":"5064_CR31","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.gene.2013.11.042","volume":"536","author":"YM Hussein","year":"2014","unstructured":"Hussein YM, Mohamed RH, EE EL-S, Alzahrani SS (2014) Interaction between TGF-\u03b21 (869C\/T) polymorphism and biochemical risk factor for prediction of disease progression in rheumatoid arthritis. Gene 536:393\u2013397. https:\/\/doi.org\/10.1016\/j.gene.2013.11.042","journal-title":"Gene"},{"key":"5064_CR32","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1002\/art.21886","volume":"54","author":"CH Evans","year":"2006","unstructured":"Evans CH, Ghivizzani SC, Robbins PD (2006) Gene therapy for arthritis: what next? Arthritis Rheum 54:1714\u20131729. https:\/\/doi.org\/10.1002\/art.21886","journal-title":"Arthritis Rheum"},{"key":"5064_CR33","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1161\/01.cir.101.24.2783","volume":"101","author":"M Yokota","year":"2000","unstructured":"Yokota M, Ichihara S, Lin TL, Nakashima N, Yamada Y (2000) Association of a T29\u2192C polymorphism of the transforming growth factor-\u03b21 gene with genetic susceptibility to myocardial infarction in Japanese. Circulation 101:2783\u20132787. https:\/\/doi.org\/10.1161\/01.cir.101.24.2783","journal-title":"Circulation"},{"key":"5064_CR34","doi-asserted-by":"publisher","first-page":"469","DOI":"10.3109\/10799893.2014.919594","volume":"34","author":"TB Zhou","year":"2014","unstructured":"Zhou TB, Zhao HL, Fang SL, Drummen GP (2014) Association of transforming growth factor-\u03b21 T869C, G915C, and C509T gene polymorphisms with rheumatoid arthritis risk. J Recept Sig Transduct 34:469\u2013475. https:\/\/doi.org\/10.3109\/10799893.2014.919594","journal-title":"J Recept Sig Transduct"},{"key":"5064_CR35","doi-asserted-by":"publisher","first-page":"4811","DOI":"10.1007\/s11033-013-2577-4","volume":"40","author":"L Zhang","year":"2013","unstructured":"Zhang L (2013) Yan jw, Wang YX, Wan YN, Li JP, Liu P et al. Association of TGF-\u03b21+ 869C\/T promoter polymorphism with susceptibility to autoimmune diseases: a meta-analysis. Mol Biol Rep 40:4811\u20134817. https:\/\/doi.org\/10.1007\/s11033-013-2577-4","journal-title":"Mol Biol Rep"},{"key":"5064_CR36","doi-asserted-by":"publisher","first-page":"R111","DOI":"10.1186\/ar3396","volume":"13","author":"F Ceccarelli","year":"2011","unstructured":"Ceccarelli F, Perricone C, Fabris M, Alessandri C, Iagnocco A, Fabro C et al (2011) Transforming growth factor \u03b2 869C\/T and interleukin 6-174G\/C polymorphisms relate to the severity and progression of bone-erosive damage detected by ultrasound in rheumatoid arthritis. Arthritis Res Ther 13:R111. https:\/\/doi.org\/10.1186\/ar3396","journal-title":"Arthritis Res Ther"},{"key":"5064_CR37","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1136\/ard.2004.031674","volume":"64","author":"DL Mattey","year":"2005","unstructured":"Mattey DL, Nixon N, Dawes PT, Kerr J (2005) Association of polymorphism in the transforming growth factor \u03b21 gene with disease outcome and mortality in rheumatoid arthritis. Ann Rheum Dis 64:1190\u20131194. https:\/\/doi.org\/10.1136\/ard.2004.031674","journal-title":"Ann Rheum Dis"},{"key":"5064_CR38","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1136\/ard.61.8.678","volume":"61","author":"A Crilly","year":"2002","unstructured":"Crilly A, Hamilton J, Clark CJ, Jardine A, Madhok R (2002) Analysis of transforming growth factor \u03b21 gene polymorphisms in patients with systemic sclerosis. Ann Rheum Dis 61:678\u2013681. https:\/\/doi.org\/10.1136\/ard.61.8.678","journal-title":"Ann Rheum Dis"},{"key":"5064_CR39","first-page":"2610","volume":"63","author":"AM Dunning","year":"2003","unstructured":"Dunning AM, Ellis PD, Mcbride S, Kirschenlohr HL, Healey CS, Kemp PR et al (2003) A transforming growth factor\u03b21 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer. Cancer Res 63:2610\u20132615","journal-title":"Cancer Res"},{"key":"5064_CR40","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1136\/thorax.2003.005769","volume":"41","author":"L Wu","year":"2004","unstructured":"Wu L, Chau J, Young RP, Pokorny V, Mills GD, Hopkins R et al (2004) Transforming growth factor-\u03b21 genotype and susceptibility to chronic obstructive pulmonary disease. J Med Genet 41:285\u2013285. https:\/\/doi.org\/10.1136\/thorax.2003.005769","journal-title":"J Med Genet"},{"key":"5064_CR41","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s002230020024","volume":"69","author":"V Hinke","year":"2001","unstructured":"Hinke V, Seck T, Clanget C, Scheidt-Nave C, Ziegler R, Pfeilschifter J (2001) Association of transforming growth factor-b1 (TGF\u03b21) T29? C gene polymorphism with bone mineral density (BMD), changes in BMD, and serum concentrations of TGF-b1 in a population-based sample of postmenopausal German women. Calcif Tissue Int 69:315\u2013320. https:\/\/doi.org\/10.1007\/s002230020024","journal-title":"Calcif Tissue Int"},{"key":"5064_CR42","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1136\/thorax.55.6.459","volume":"55","author":"PD Arkwright","year":"2000","unstructured":"Arkwright PD, Laurie S, Super M, Pravica V, Schwarz MJ, Webb AK, Hutchinson IV (2000) TGF-\u03b21 genotype and accelerated decline in lung function of patients with cystic fibrosis. Thorax 55:459\u2013462. https:\/\/doi.org\/10.1136\/thorax.55.6.459","journal-title":"Thorax"},{"key":"5064_CR43","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/sj.gene.6364341","volume":"7","author":"MA Garcia-Gonzalez","year":"2006","unstructured":"Garcia-Gonzalez MA, Strunk M, Piazuelo E, Benito R, Santolaria S, Jim\u00e9nez P, Sope\u00f1a F, Pascual C, Sim\u00f3n MA, Sainz R, Lanas A (2006) TGFB1 gene polymorphisms: their relevance in the susceptibility to Helicobacter pylori-related diseases. Genes Immun 7:640\u2013646","journal-title":"Genes Immun"},{"issue":"5","key":"5064_CR44","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1177\/0300060517705719","volume":"45","author":"L Ning","year":"2017","unstructured":"Ning L, Jianwei L, Chenhe Z, FuHua Z (2017) Association between transforming growth factor-beta 1 gene single nucleotide polymorphisms and knee osteoarthritis susceptibility in a Chinese Han population. J Int Med Res 45(5):1495\u20131504","journal-title":"J Int Med Res"},{"issue":"7","key":"5064_CR45","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1046\/j.1365-2036.2002.01284.x","volume":"16","author":"P Zentilin","year":"2002","unstructured":"Zentilin P, Seriolo B, Dulbecco P, Caratto E, Iiritano E, Fasciolo D, Bilardi C, Mansi C (2002) Testa E &Savarino V Eradication of Helicobacter pylori may reduce disease severity in rheumatoid arthritis. Aliment Pharmacol Ther 16(7):1291\u20131299","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"5064_CR46","doi-asserted-by":"publisher","first-page":"53","DOI":"10.14715\/cmb\/2017.63.1.11","volume":"63","author":"YH Lee","year":"2017","unstructured":"Lee YH, Bae SC (2017) Association between circulating transforming growth factor-\u03b21 level and polymorphisms in systemic lupus erythematosus and rheumatoid arthritis: a meta-analysis. Cell Mol Biol (Noisy-le-grand) 63(1):53\u201359. https:\/\/doi.org\/10.14715\/cmb\/2017.63.1.11","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"5064_CR47","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1002\/1529-0131(200002)43:2<452::AID-ANR28>3.0.CO;2-C","volume":"43","author":"Y Yamada","year":"2000","unstructured":"Yamada Y, Okuizumi H, Miyauchi A, Takagi Y, Ikeda K, Harada A (2000) Association of transforming growth factor \u03b21 genotype with spinal osteophytosis in Japanese women. Arthritis Rheum 43:452\u2013460","journal-title":"Arthritis Rheum"},{"key":"5064_CR48","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1001\/archinternmed.2008.605","volume":"169","author":"CY Hsu","year":"2009","unstructured":"Hsu CY, Iribarren C, McCulloch CE, Darbinian J, Go AS (2009) Risk factors for end-stage renal disease: 25-year follow-up. Arch Intern Med 169:342\u2013350. https:\/\/doi.org\/10.1001\/archinternmed.2008.605","journal-title":"Arch Intern Med"},{"key":"5064_CR49","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1093\/rheumatology\/keg175","volume":"42","author":"GD Kitas","year":"2003","unstructured":"Kitas GD, Erb N (2003) Tackling ischaemic heart disease in rheumatoid arthritis. Rheumatology (Oxford) 42:607\u2013613. https:\/\/doi.org\/10.1093\/rheumatology\/keg175","journal-title":"Rheumatology (Oxford)"},{"key":"5064_CR50","first-page":"1403","volume":"30","author":"PH Dessein","year":"2003","unstructured":"Dessein PH, Joffe BI, Stanwix AE (2003) Inflammation, insulin resistance, and aberrant lipid metabolism as cardiovascular risk factors in rheumatoid arthritis. J Rheumatol 30:1403\u20131405","journal-title":"J Rheumatol"},{"key":"5064_CR51","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1093\/rheumatology\/kem159","volume":"46","author":"VF Panoulas","year":"2007","unstructured":"Panoulas VF, Milionis HJ, Douglas KM, Nightingale P, Kita MD, Klocke R, Elisaf MS, Kitas GD (2007) Association of serum uric acid with cardiovascular disease in rheumatoid arthritis. Rheumatology (Oxford) 46:1466\u20131470. https:\/\/doi.org\/10.1093\/rheumatology\/kem159","journal-title":"Rheumatology (Oxford)"},{"key":"5064_CR52","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.metabol.2006.05.013","volume":"55","author":"SG Tsouli","year":"2006","unstructured":"Tsouli SG, Liberopoulos EN, Mikhailidis DP, Athyros VG, Elisaf MS (2006) Elevated serum uric acid levels in metabolic syndrome: an active component or an innocent bystander? Metabolism. 55:1293\u20131301. https:\/\/doi.org\/10.1016\/j.metabol.2006.05.013","journal-title":"Metabolism."},{"key":"5064_CR53","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jaut.2018.01.004","volume":"90","author":"RS Peres","year":"2018","unstructured":"Peres RS, Donate PB, Talbot J, Cecilio NT, Lobo PR, Machado CC, Lima KWA, Oliveira RD, Carregaro V, Nakaya HI, Cunha TM, Alves-Filho JC, Liew FY, Louzada-Junior P, Cunha FQ (2018) TGF-\u03b2 signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis. J Autoimmun 90:49\u201358. https:\/\/doi.org\/10.1016\/j.jaut.2018.01.004","journal-title":"J Autoimmun"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-020-05064-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10067-020-05064-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-020-05064-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T23:53:23Z","timestamp":1617839603000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10067-020-05064-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,8]]},"references-count":53,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["5064"],"URL":"https:\/\/doi.org\/10.1007\/s10067-020-05064-w","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,8]]},"assertion":[{"value":"3 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}