{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:55:11Z","timestamp":1774608911641,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501396"],"award-info":[{"award-number":["81501396"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016 M600874"],"award-info":[{"award-number":["2016 M600874"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Peking University International Hospital Research Funds","award":["YN2016QN01 and YN2017QX01"],"award-info":[{"award-number":["YN2016QN01 and YN2017QX01"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s10067-020-05093-5","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:03:03Z","timestamp":1588809783000},"page":"3295-3302","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Serum homocysteine levels and their association with clinical characteristics of inflammatory arthritis"],"prefix":"10.1007","volume":"39","author":[{"given":"Jianlong","family":"Shu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengzhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianjie","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"issue":"1","key":"5093_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1136\/annrheumdis-2016-209775","volume":"76","author":"R Agca","year":"2017","unstructured":"Agca R, Heslinga SC, Rollefstad S, Heslinga M, McInnes IB, Peters MJ, Kvien TK, Dougados M, Radner H, Atzeni F, Primdahl J, Sodergren A, Wallberg Jonsson S, van Rompay J, Zabalan C, Pedersen TR, Jacobsson L, de Vlam K, Gonzalez-Gay MA, Semb AG, Kitas GD, Smulders YM, Szekanecz Z, Sattar N, Symmons DP, Nurmohamed MT (2017) EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015\/2016 update. Ann Rheum Dis 76(1):17\u201328. https:\/\/doi.org\/10.1136\/annrheumdis-2016-209775","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"5093_CR2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s11926-015-0495-2","volume":"17","author":"AM Abeles","year":"2015","unstructured":"Abeles AM (2015) Hyperuricemia, gout, and cardiovascular disease: an update. Curr Rheumatol Rep 17(3):13. https:\/\/doi.org\/10.1007\/s11926-015-0495-2","journal-title":"Curr Rheumatol Rep"},{"key":"5093_CR3","doi-asserted-by":"publisher","first-page":"574817","DOI":"10.1155\/2012\/574817","volume":"2012","author":"L Rodriguez-Rodriguez","year":"2012","unstructured":"Rodriguez-Rodriguez L, Lopez-Mejias R, Garcia-Bermudez M, Gonzalez-Juanatey C, Gonzalez-Gay MA, Martin J (2012) Genetic markers of cardiovascular disease in rheumatoid arthritis. Mediat Inflamm Mediators Inflamm 2012:574817\u2013574814. https:\/\/doi.org\/10.1155\/2012\/574817","journal-title":"Mediat Inflamm Mediators Inflamm"},{"issue":"1","key":"5093_CR4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.semarthrit.2005.03.004","volume":"35","author":"MA Gonzalez-Gay","year":"2005","unstructured":"Gonzalez-Gay MA, Gonzalez-Juanatey C, Martin J (2005) Rheumatoid arthritis: a disease associated with accelerated atherogenesis. Semin Arthritis Rheum 35(1):8\u201317. https:\/\/doi.org\/10.1016\/j.semarthrit.2005.03.004","journal-title":"Semin Arthritis Rheum"},{"issue":"1\u20132","key":"5093_CR5","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/s0163-7258(02)00176-6","volume":"94","author":"M Sack","year":"2002","unstructured":"Sack M (2002) Tumor necrosis factor-alpha in cardiovascular biology and the potential role for anti-tumor necrosis factor-alpha therapy in heart disease. Pharmacol Ther 94(1\u20132):123\u2013135. https:\/\/doi.org\/10.1016\/s0163-7258(02)00176-6","journal-title":"Pharmacol Ther"},{"key":"5093_CR6","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.ijcard.2018.06.099","volume":"270","author":"NAB Ntusi","year":"2018","unstructured":"Ntusi NAB, Francis JM, Sever E, Liu A, Piechnik SK, Ferreira VM, Matthews PM, Robson MD, Wordsworth PB, Neubauer S, Karamitsos TD (2018) Anti-TNF modulation reduces myocardial inflammation and improves cardiovascular function in systemic rheumatic diseases. Int J Cardiol 270:253\u2013259. https:\/\/doi.org\/10.1016\/j.ijcard.2018.06.099","journal-title":"Int J Cardiol"},{"issue":"2","key":"5093_CR7","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1136\/heartjnl-2017-311279","volume":"104","author":"JM Baena-Diez","year":"2018","unstructured":"Baena-Diez JM, Garcia-Gil M, Comas-Cufi M, Ramos R, Prieto-Alhambra D, Salvador-Gonzalez B, Elosua R, Degano IR, Penafiel J, Grau M (2018) Association between chronic immune-mediated inflammatory diseases and cardiovascular risk. Heart 104(2):119\u2013126. https:\/\/doi.org\/10.1136\/heartjnl-2017-311279","journal-title":"Heart"},{"issue":"1","key":"5093_CR8","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1136\/annrheumdis-2017-211735","volume":"77","author":"CS Crowson","year":"2018","unstructured":"Crowson CS, Rollefstad S, Ikdahl E, Kitas GD, van Riel P, Gabriel SE, Matteson EL, Kvien TK, Douglas K, Sandoo A, Arts E, Wallberg-Jonsson S, Innala L, Karpouzas G, Dessein PH, Tsang L, El-Gabalawy H, Hitchon C, Ramos VP, Yanez IC, Sfikakis PP, Zampeli E, Gonzalez-Gay MA, Corrales A, Laar MV, Vonkeman HE, Meek I, Semb AG, Arthritis AT-ACCfR (2018) Impact of risk factors associated with cardiovascular outcomes in patients with rheumatoid arthritis. Ann Rheum Dis 77(1):48\u201354. https:\/\/doi.org\/10.1136\/annrheumdis-2017-211735","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"5093_CR9","doi-asserted-by":"publisher","first-page":"R258","DOI":"10.1186\/ar4103","volume":"14","author":"A Sandoo","year":"2012","unstructured":"Sandoo A, Protogerou AD, Hodson J, Smith JP, Zampeli E, Sfikakis PP, Kitas GD (2012) The role of inflammation, the autonomic nervous system and classical cardiovascular disease risk factors on subendocardial viability ratio in patients with RA: a cross-sectional and longitudinal study. Arthritis Res Ther 14(6):R258. https:\/\/doi.org\/10.1186\/ar4103","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"5093_CR10","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1093\/jn\/129.4.779","volume":"129","author":"LB Bailey","year":"1999","unstructured":"Bailey LB, Gregory JF 3rd (1999) Folate metabolism and requirements. J Nutr 129(4):779\u2013782. https:\/\/doi.org\/10.1093\/jn\/129.4.779","journal-title":"J Nutr"},{"issue":"6","key":"5093_CR11","doi-asserted-by":"publisher","first-page":"788","DOI":"10.3346\/jkms.2014.29.6.788","volume":"29","author":"ST Choi","year":"2014","unstructured":"Choi ST, Kim JS, Song JS (2014) Elevated serum homocysteine levels were not correlated with serum uric acid levels, but with decreased renal function in gouty patients. J Korean Med Sci 29(6):788\u2013792. https:\/\/doi.org\/10.3346\/jkms.2014.29.6.788","journal-title":"J Korean Med Sci"},{"issue":"17","key":"5093_CR12","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1056\/NEJM199104253241701","volume":"324","author":"R Clarke","year":"1991","unstructured":"Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I (1991) Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 324(17):1149\u20131155. https:\/\/doi.org\/10.1056\/NEJM199104253241701","journal-title":"N Engl J Med"},{"issue":"4","key":"5093_CR13","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1056\/NEJM199707243370403","volume":"337","author":"O Nygard","year":"1997","unstructured":"Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE (1997) Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 337(4):230\u2013236. https:\/\/doi.org\/10.1056\/NEJM199707243370403","journal-title":"N Engl J Med"},{"issue":"7","key":"5093_CR14","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1093\/rheumatology\/keq037","volume":"49","author":"E Krishnan","year":"2010","unstructured":"Krishnan E (2010) Inflammation, oxidative stress and lipids: the risk triad for atherosclerosis in gout. Rheumatology (Oxford) 49(7):1229\u20131238. https:\/\/doi.org\/10.1093\/rheumatology\/keq037","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"5093_CR15","doi-asserted-by":"publisher","first-page":"403","DOI":"10.2188\/jea.10.403","volume":"10","author":"M Tomita","year":"2000","unstructured":"Tomita M, Mizuno S, Yamanaka H, Hosoda Y, Sakuma K, Matuoka Y, Odaka M, Yamaguchi M, Yosida H, Morisawa H, Murayama T (2000) Does hyperuricemia affect mortality? A prospective cohort study of Japanese male workers. J Epidemiol 10(6):403\u2013409. https:\/\/doi.org\/10.2188\/jea.10.403","journal-title":"J Epidemiol"},{"issue":"7374","key":"5093_CR16","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1136\/bmj.325.7374.1202","volume":"325","author":"DS Wald","year":"2002","unstructured":"Wald DS, Law M, Morris JK (2002) Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 325(7374):1202\u20131206. https:\/\/doi.org\/10.1136\/bmj.325.7374.1202","journal-title":"BMJ"},{"issue":"2","key":"5093_CR17","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/acr.22419","volume":"67","author":"CE Barber","year":"2015","unstructured":"Barber CE, Smith A, Esdaile JM, Barnabe C, Martin LO, Faris P, Hazlewood G, Noormohamed R, Alvarez N, Mancini GB, Lacaille D, Keeling S, Avina-Zubieta JA, Marshall D (2015) Best practices for cardiovascular disease prevention in rheumatoid arthritis: a systematic review of guideline recommendations and quality indicators. Arthritis Care Res 67(2):169\u2013179. https:\/\/doi.org\/10.1002\/acr.22419","journal-title":"Arthritis Care Res"},{"issue":"12","key":"5093_CR18","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1056\/NEJM200003233421202","volume":"342","author":"PM Ridker","year":"2000","unstructured":"Ridker PM, Hennekens CH, Buring JE, Rifai N (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342(12):836\u2013843. https:\/\/doi.org\/10.1056\/NEJM200003233421202","journal-title":"N Engl J Med"},{"issue":"12","key":"5093_CR19","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1093\/rheumatology\/kei012","volume":"44","author":"FC Hall","year":"2005","unstructured":"Hall FC, Dalbeth N (2005) Disease modification and cardiovascular risk reduction: two sides of the same coin? Rheumatology (Oxford) 44(12):1473\u20131482. https:\/\/doi.org\/10.1093\/rheumatology\/kei012","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"5093_CR20","doi-asserted-by":"publisher","first-page":"380","DOI":"10.4103\/njcp.njcp_291_18","volume":"22","author":"F Wang","year":"2019","unstructured":"Wang F, Sui X, Xu N, Yang J, Zhao H, Fei X, Zhang Z, Luo Z, Xin Y, Qin B, Zhao X, Cao S, Zhang Y, Yang Z (2019) The relationship between plasma homocysteine levels and MTHFR gene variation, age, and sex in Northeast China. Niger J Clin Pract 22(3):380\u2013385. https:\/\/doi.org\/10.4103\/njcp.njcp_291_18","journal-title":"Niger J Clin Pract"},{"issue":"3","key":"5093_CR21","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1136\/annrheumdis-2012-202023","volume":"72","author":"O Slot","year":"2013","unstructured":"Slot O (2013) Homocysteine, a marker of cardiovascular disease risk, is markedly elevated in patients with gout. Ann Rheum Dis 72(3):457. https:\/\/doi.org\/10.1136\/annrheumdis-2012-202023","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"5093_CR22","first-page":"1805","volume":"29","author":"Z Tsutsumi","year":"2002","unstructured":"Tsutsumi Z, Moriwaki Y, Yamamoto T, Takahashi S, Hada T, Fukuchi M (2002) Total plasma homocysteine is not increased in Japanese patients with gout. J Rheumatol 29(8):1805\u20131806","journal-title":"J Rheumatol"},{"key":"5093_CR23","doi-asserted-by":"publisher","unstructured":"Capelli I, Cianciolo G, Gasperoni L, Zappulo F, Tondolo F, Cappuccilli M, La Manna G (2019) Folic acid and vitamin B12 administration in CKD, why not? Nutrients 11(2). https:\/\/doi.org\/10.3390\/nu11020383","DOI":"10.3390\/nu11020383"},{"issue":"4","key":"5093_CR24","doi-asserted-by":"publisher","first-page":"882","DOI":"10.3945\/ajcn.116.143131","volume":"105","author":"X Qin","year":"2017","unstructured":"Qin X, Li Y, He M, Tang G, Yin D, Liang M, Wang B, Nie J, Huo Y, Xu X, Hou FF (2017) Folic acid therapy reduces serum uric acid in hypertensive patients: a substudy of the China Stroke Primary Prevention Trial (CSPPT). Am J Clin Nutr 105(4):882\u2013889. https:\/\/doi.org\/10.3945\/ajcn.116.143131","journal-title":"Am J Clin Nutr"},{"issue":"15","key":"5093_CR25","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1056\/NEJMoa060900","volume":"354","author":"E Lonn","year":"2006","unstructured":"Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, McQueen MJ, Probstfield J, Fodor G, Held C, Genest J Jr, Heart Outcomes Prevention Evaluation I (2006) Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 354(15):1567\u20131577. https:\/\/doi.org\/10.1056\/NEJMoa060900","journal-title":"N Engl J Med"},{"key":"5093_CR26","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3389\/fphar.2017.00585","volume":"8","author":"WW Wang","year":"2017","unstructured":"Wang WW, Wang XS, Zhang ZR, He JC, Xie CL (2017) A meta-analysis of folic acid in combination with anti-hypertension drugs in patients with hypertension and hyperhomocysteinemia. Front Pharmacol 8:585. https:\/\/doi.org\/10.3389\/fphar.2017.00585","journal-title":"Front Pharmacol"},{"key":"5093_CR27","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1475-2891-3-4","volume":"3","author":"MR Hayden","year":"2004","unstructured":"Hayden MR, Tyagi SC (2004) Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: the pleiotropic effects of folate supplementation. Nutr J 3:4. https:\/\/doi.org\/10.1186\/1475-2891-3-4","journal-title":"Nutr J"},{"issue":"6","key":"5093_CR28","doi-asserted-by":"publisher","first-page":"361","DOI":"10.4103\/0019-5359.32687","volume":"61","author":"MA Kothekar","year":"2007","unstructured":"Kothekar MA (2007) Homocysteine in cardiovascular disease: a culprit or an innocent bystander? Indian J Med Sci 61(6):361\u2013371. https:\/\/doi.org\/10.4103\/0019-5359.32687","journal-title":"Indian J Med Sci"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-020-05093-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-020-05093-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-020-05093-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T00:14:11Z","timestamp":1620346451000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-020-05093-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,7]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["5093"],"URL":"https:\/\/doi.org\/10.1007\/s10067-020-05093-5","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,7]]},"assertion":[{"value":"20 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Patient\u2019 consent was obtained according to the Declaration of Helsinki. This study was conducted with the approval of the ethics committee of Peking University International Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}