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Each subject was matched with up to 5 general population comparators per AS-patient (<jats:italic>n<\/jats:italic>\u2009=\u20091276). Follow-up started at the date of admission for AMI and extended until death or 365\u00a0days of follow-up. Cox regression was used to assess mortality in two time intervals: days 0\u201330 and days 31\u2013365. For a subgroup with available data, clinical presentation at admission, course, treatment for AMI, and secondary prevention were compared.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>During the 365-day follow-up, 56\/292 (19%) AS patients and 184\/1276 (14%) comparators died. There were no difference in mortality due to cardiovascular-related causes, although the overall mortality day 31\u2013365 was increased among patients with AS compared with comparators (HR [95% CI]\u2009=\u20092.0 [1.3;3.0]). At admission, AS patients had a higher prevalence of cardiovascular comorbidities compared with comparators. At discharge, patients with AS were less often prescribed lipid-lowering drugs and non-aspirin antiplatelet therapy<jats:bold>.<\/jats:bold><\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Patients with AS tend to have a higher comorbidity burden at admission for first AMI. The mortality after a first AMI due to cardiovascular-related causes does not seem to be elevated, despite an increased overall mortality during days 31\u2013365 among patients with AS compared with the general population.<jats:table-wrap><jats:table><jats:tbody>\n                      <jats:tr>\n                        <jats:td colspan=\"2\"><jats:bold>Key Points<\/jats:bold><jats:italic>\u2022 The all-cause mortality after a first AMI was higher in patients with AS.<\/jats:italic><jats:italic>\u2022 Mortality after a first AMI due to CVD-related causes does not seem to be elevated for patients with AS.<\/jats:italic><jats:italic>\u2022 In patients with AS suffering a first AMI, more attention should be given to other comorbidities causing an excess in mortality.<\/jats:italic><\/jats:td>\n                      <\/jats:tr>\n                    <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10067-020-05354-3","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T09:03:00Z","timestamp":1598432580000},"page":"1321-1329","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Characteristics and outcome of a first acute myocardial infarction in patients with ankylosing spondylitis"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7436-7900","authenticated-orcid":false,"given":"Anna","family":"S\u00f6dergren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Askling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Bengtsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Forsblad-d\u2019Elia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Jernberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Lindstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotta","family":"Ljung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c4ngla","family":"Mantel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart T. 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For these, JA has been principal investigator. None of the other co-authors has any conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was conducted in accordance with the principles outlined in the Declaration of Helsinki and principles of Good Clinical Practice (GCP). The study protocol was approved by the Regional Ethics Committee in Stockholm, Sweden (registration number 2015\/1844-31\/2).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}