{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:07:22Z","timestamp":1777860442241,"version":"3.51.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"the Clinical Science Innovation Program of Shanghai Shenkang Hospital Development Center","award":["SHDC12017129"],"award-info":[{"award-number":["SHDC12017129"]}]},{"name":"the General Program of National Natural Science Foundation of China","award":["81871276"],"award-info":[{"award-number":["81871276"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s10067-020-05386-9","type":"journal-article","created":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T11:02:34Z","timestamp":1599908554000},"page":"1465-1471","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Risk factors of disease activity in patients with Beh\u00e7et\u2019s syndrome"],"prefix":"10.1007","volume":"40","author":[{"given":"Cheng-cheng","family":"Hou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-long","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,12]]},"reference":[{"key":"5386_CR1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/nrrheum.2017.208","volume":"14","author":"H Yazici","year":"2018","unstructured":"Yazici H, Seyahi E, Hatemi G, Yazici Y (2018) Behcet syndrome: a contemporary view. Nat Rev Rheumatol 14:107\u2013119","journal-title":"Nat Rev Rheumatol"},{"key":"5386_CR2","doi-asserted-by":"publisher","first-page":"665","DOI":"10.3389\/fimmu.2019.00665","volume":"10","author":"BN Tong","year":"2019","unstructured":"Tong BN, Liu XL, Xiao J, Su GF (2019) Immunopathogenesis of Behcet's disease. Front Immunol 10:665","journal-title":"Front Immunol"},{"key":"5386_CR3","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s00772-019-0509-x","volume":"24","author":"U Pleyer","year":"2019","unstructured":"Pleyer U, Stubiger N, Kotter I (2019) Behcet's syndrome. Gefasschirurgie 24:144\u2013151","journal-title":"Gefasschirurgie"},{"key":"5386_CR4","doi-asserted-by":"publisher","first-page":"8055","DOI":"10.1002\/jcp.27576","volume":"234","author":"A Salmaninejad","year":"2019","unstructured":"Salmaninejad A, Zamani MR, Shabgah AG, Hosseini S, Mollaei F, Hosseini N, Sahebkar A (2019) Behcet's disease: an immunogenetic perspective. J Cell Physiol 234:8055\u20138074","journal-title":"J Cell Physiol"},{"key":"5386_CR5","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1007\/s10067-018-4194-z","volume":"37","author":"M Hammad","year":"2018","unstructured":"Hammad M, Shehata OZ, Abdel-Latif SM, El-Din AMM (2018) Neutrophil\/lymphocyte ratio and platelet\/lymphocyte ratio in Behcet's disease: which and when to use? Clin Rheumatol 37:2811\u20132817","journal-title":"Clin Rheumatol"},{"key":"5386_CR6","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1097\/BOR.0000000000000447","volume":"30","author":"G Hatemi","year":"2018","unstructured":"Hatemi G, Esatoglu SN, Yazici Y (2018) Biomarkers in vasculitis. Curr Opin Rheumatol 30:30\u201335","journal-title":"Curr Opin Rheumatol"},{"key":"5386_CR7","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.imlet.2016.12.001","volume":"186","author":"N Gholijani","year":"2017","unstructured":"Gholijani N, Ataollahi MR, Samiei A, Aflaki E, Shenavandeh S, Kamali-Sarvestani E (2017) An elevated pro-inflammatory cytokines profile in Behcet's disease: a multiplex analysis. Immunol Lett 186:46\u201351","journal-title":"Immunol Lett"},{"key":"5386_CR8","doi-asserted-by":"publisher","unstructured":"Sadeghi A, Davatchi F, Shahram F, Karimimoghadam A, Alikhani M, Pezeshgi A, Mazloomzadeh S, Sadeghi-Abdollahi B, Asadi-Khiavi M (2017) Serum profiles of cytokines in Behcet's disease. J Clin Med 6. https:\/\/doi.org\/10.3390\/jcm6050049","DOI":"10.3390\/jcm6050049"},{"key":"5386_CR9","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/1756-185X.12832","volume":"20","author":"JS Park","year":"2017","unstructured":"Park JS, Kang MI, Ha YJ, Song JJ, Park YB, Lee SK, Lee SW (2017) Serum anti-lysozyme is associated with disease activity of Behcet's disease. Int J Rheum Dis 20:261\u2013268","journal-title":"Int J Rheum Dis"},{"key":"5386_CR10","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1111\/1756-185X.13404","volume":"21","author":"YH Lee","year":"2018","unstructured":"Lee YH, Song GG (2018) Neutrophil-to-lymphocyte ratio, mean platelet volume and platelet-to-lymphocyte ratio in Behcet's disease and their correlation with disease activity: a meta-analysis. Int J Rheum Dis 21:2180\u20132187","journal-title":"Int J Rheum Dis"},{"key":"5386_CR11","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s10067-015-2907-0","volume":"35","author":"M Yuksel","year":"2016","unstructured":"Yuksel M, Yildiz A, Oylumlu M, Turkcu FM, Bilik MZ, Ekinci A, Elbey B, Tekbas E, Alan S (2016) Novel markers of endothelial dysfunction and inflammation in Behcet's disease patients with ocular involvement: epicardial fat thickness, carotid intima media thickness, serum ADMA level, and neutrophil-to-lymphocyte ratio. Clin Rheumatol 35:701\u2013708","journal-title":"Clin Rheumatol"},{"key":"5386_CR12","doi-asserted-by":"crossref","unstructured":"(2014) The International Criteria for Behcet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol 28:338\u2013347","DOI":"10.1111\/jdv.12107"},{"key":"5386_CR13","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1093\/rheumatology\/keg453","volume":"43","author":"G Lawton","year":"2004","unstructured":"Lawton G, Bhakta BB, Chamberlain MA, Tennant A (2004) The Behcet's disease activity index. Rheumatology (Oxford) 43:73\u201378","journal-title":"Rheumatology (Oxford)"},{"key":"5386_CR14","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1093\/rheumatology\/38.8.728","volume":"38","author":"BB Bhakta","year":"1999","unstructured":"Bhakta BB, Brennan P, James TE, Chamberlain MA, Noble BA, Silman AJ (1999) Behcet's disease: evaluation of a new instrument to measure clinical activity. Rheumatology (Oxford) 38:728\u2013733","journal-title":"Rheumatology (Oxford)"},{"key":"5386_CR15","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.clindermatol.2019.01.001","volume":"37","author":"N Akdeniz","year":"2019","unstructured":"Akdeniz N, Elmas OF, Karadag AS (2019) Behcet syndrome: a great imitator. Clin Dermatol 37:227\u2013239","journal-title":"Clin Dermatol"},{"key":"5386_CR16","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.berh.2018.08.010","volume":"32","author":"N Akkoc","year":"2018","unstructured":"Akkoc N (2018) Update on the epidemiology, risk factors and disease outcomes of Behcet's disease. Best Pract Res Clin Rheumatol 32:261\u2013270","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"5386_CR17","first-page":"90","volume":"36","author":"SN Esatoglu","year":"2018","unstructured":"Esatoglu SN, Hatemi I, Ozguler Y, Hatemi G, Uzun H, Celik AF, Yazici H (2018) Faecal but not serum calprotectin levels look promising in predicting active disease in Behcet's syndrome patients with gastrointestinal involvement. Clin Exp Rheumatol 36:90\u201396","journal-title":"Clin Exp Rheumatol"},{"key":"5386_CR18","doi-asserted-by":"publisher","first-page":"101512","DOI":"10.1016\/j.msard.2019.101512","volume":"38","author":"EC Bolek","year":"2019","unstructured":"Bolek EC, Sari A, Kilic L, Kalyoncu U, Kurne A et al (2019) Clinical features and disease course of neurological involvement in Behcet's disease: HUVAC experience. Mult Scler Relat Disord 38:101512","journal-title":"Mult Scler Relat Disord"},{"key":"5386_CR19","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s12016-014-8425-z","volume":"49","author":"Y Ozyazgan","year":"2015","unstructured":"Ozyazgan Y, Ucar D, Hatemi G, Yazici Y (2015) Ocular involvement of Behcet's syndrome: a comprehensive review. Clin Rev Allergy Immunol 49:298\u2013306","journal-title":"Clin Rev Allergy Immunol"},{"key":"5386_CR20","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1136\/ard.43.6.783","volume":"43","author":"H Yazici","year":"1984","unstructured":"Yazici H, Tuzun Y, Pazarli H, Yurdakul S, Ozyazgan Y, Ozdogan H, Serdaroglu S, Ersanli M, Ulku BY, Muftuoglu AU (1984) Influence of age of onset and patient's sex on the prevalence and severity of manifestations of Behcet's syndrome. Ann Rheum Dis 43:783\u2013789","journal-title":"Ann Rheum Dis"},{"key":"5386_CR21","doi-asserted-by":"publisher","first-page":"e6981","DOI":"10.1097\/MD.0000000000006981","volume":"96","author":"Y Jiang","year":"2017","unstructured":"Jiang Y, Zang M, Li S (2017) Serum PLR and LMR in Behcet's disease: can they show the disease activity? Medicine (Baltimore) 96:e6981","journal-title":"Medicine (Baltimore)"},{"key":"5386_CR22","doi-asserted-by":"publisher","unstructured":"D'Amico E, Zanghi A, Romano A, Sciandra M, Palumbo GAM, Patti F (2019) The neutrophil-to-lymphocyte ratio is related to disease activity in relapsing remitting multiple sclerosis. Cells 8. https:\/\/doi.org\/10.3390\/cells8101114","DOI":"10.3390\/cells8101114"},{"key":"5386_CR23","doi-asserted-by":"publisher","first-page":"e13037","DOI":"10.1111\/eci.13037","volume":"49","author":"GL Erre","year":"2019","unstructured":"Erre GL, Paliogiannis P, Castagna F, Mangoni AA, Carru C, Passiu G, Zinellu A (2019) Meta-analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in rheumatoid arthritis. Eur J Clin Investig 49:e13037","journal-title":"Eur J Clin Investig"},{"key":"5386_CR24","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1007\/s10067-017-3792-5","volume":"36","author":"HA Kim","year":"2017","unstructured":"Kim HA, Jung JY, Suh CH (2017) Usefulness of neutrophil-to-lymphocyte ratio as a biomarker for diagnosing infections in patients with systemic lupus erythematosus. Clin Rheumatol 36:2479\u20132485","journal-title":"Clin Rheumatol"},{"key":"5386_CR25","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.semarthrit.2018.02.012","volume":"48","author":"OC Kwon","year":"2018","unstructured":"Kwon OC, Lee JS, Ghang B, Kim YG, Lee CK, Yoo B, Hong S (2018) Predicting eventual development of lupus nephritis at the time of diagnosis of systemic lupus erythematosus. Semin Arthritis Rheum 48:462\u2013466","journal-title":"Semin Arthritis Rheum"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-020-05386-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-020-05386-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-020-05386-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T01:19:29Z","timestamp":1668734369000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-020-05386-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,12]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["5386"],"URL":"https:\/\/doi.org\/10.1007\/s10067-020-05386-9","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,12]]},"assertion":[{"value":"21 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the Research Ethics Committee of Huadong Hospital Affiliated to Fudan University, and informed consent was signed by all participants.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}