{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:28:47Z","timestamp":1786980527370,"version":"build-2736575974"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s10067-020-05446-0","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T10:02:43Z","timestamp":1602496963000},"page":"1709-1715","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Calprotectin, an available prognostic biomarker in systemic sclerosis: a systematic review"],"prefix":"10.1007","volume":"40","author":[{"given":"Bahareh","family":"Ebrahimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MohamadAli","family":"Nazarinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Molayem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"key":"5446_CR1","doi-asserted-by":"publisher","unstructured":"Asano Y, Sato S (2015) Vasculopathy in scleroderma. Semin Immunopathol 37(5):489\u2013500. https:\/\/doi.org\/10.1007\/s00281-015-0505-5","DOI":"10.1007\/s00281-015-0505-5"},{"issue":"7","key":"5446_CR2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nrrheum.2014.53","volume":"10","author":"YY Ho","year":"2014","unstructured":"Ho YY, Lagares D, Tager AM, Kapoor M (2014) Fibrosis\u2014a lethal component of systemic sclerosis. Nat Rev Rheumatol 10(7):390\u2013402","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"5446_CR3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5301\/jsrd.5000249","volume":"2","author":"J Varga","year":"2017","unstructured":"Varga J, Trojanowska M, Kuwana M (2017) Pathogenesis of systemic sclerosis: recent insights of molecular and cellular mechanisms and therapeutic opportunities. J Scleroderma Relat Disord 2(3):137\u2013152","journal-title":"J Scleroderma Relat Disord"},{"issue":"1","key":"5446_CR4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3899\/jrheum.080269","volume":"36","author":"T Hara","year":"2009","unstructured":"Hara T, Ogawa F, Yanaba K, Iwata Y, Muroi E, Komura K, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M (2009) Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: association with pulmonary fibrosis. J Rheumatol 36(1):99\u2013105","journal-title":"J Rheumatol"},{"issue":"2","key":"5446_CR5","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1136\/ard.2010.133587","volume":"70","author":"TC Barnes","year":"2011","unstructured":"Barnes TC, Spiller DG, Anderson ME, Edwards SW, Moots RJ (2011) Endothelial activation and apoptosis mediated by neutrophil-dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis? Ann Rheum Dis 70(2):366\u2013372","journal-title":"Ann Rheum Dis"},{"key":"5446_CR6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jaut.2013.01.012","volume":"41","author":"Y Luo","year":"2013","unstructured":"Luo Y, Wang Y, Wang Q, Xiao R, Lu Q (2013) Systemic sclerosis: genetics and epigenetics. J Autoimmun 41:161\u2013167","journal-title":"J Autoimmun"},{"issue":"7","key":"5446_CR7","first-page":"1630","volume":"30","author":"PA Merkel","year":"2003","unstructured":"Merkel PA, Clements PJ, Reveille JD, Suarez-Almazor ME, Valentini G, Furst DE (2003) Current status of outcome measure development for clinical trials in systemic sclerosis. Report from OMERACT 6. J Rheumatol 30(7):1630\u20131647","journal-title":"J Rheumatol"},{"issue":"1","key":"5446_CR8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1365-2796.2010.02340.x","volume":"270","author":"K Andr\u00e9asson","year":"2011","unstructured":"Andr\u00e9asson K, Scheja A, Saxne T, Ohlsson B, Hesselstrand R (2011) Faecal Calprotectin : a biomarker of gastrointestinal disease in systemic sclerosis. J Intern Med 270(1):50\u201357","journal-title":"J Intern Med"},{"issue":"11","key":"5446_CR9","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/resp.13383","volume":"23","author":"KC Norman","year":"2018","unstructured":"Norman KC, Moore BB, Arnold KB, O'Dwyer DN (2018) Proteomics: clinical and research applications in respiratory diseases. Respirology 23(11):993\u20131003","journal-title":"Respirology"},{"issue":"2","key":"5446_CR10","first-page":"99","volume":"27","author":"NM Verrills","year":"2006","unstructured":"Verrills NM (2006) Clinical proteomics: present and future prospects. Clin Biochem Rev 27(2):99","journal-title":"Clin Biochem Rev"},{"issue":"9","key":"5446_CR11","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/prca.200700217","volume":"1","author":"SM Ahn","year":"2007","unstructured":"Ahn SM, Simpson RJ (2007) Body fluid proteomics: prospects for biomarker discovery. Proteomics Clin Appl 1(9):1004\u20131015","journal-title":"Proteomics Clin Appl"},{"key":"5446_CR12","first-page":"07030","volume-title":"arthritis & rheumatology","author":"R Taherian","year":"2018","unstructured":"Taherian R, Mohan V, Ying J, Theodore S, Charles J, Pham H, Wu M, Mayes MD, Assassi S (2018) Higher Neutrophil Count Predicts More Severe Skin\/Lung Disease and Increased Mortality in Early Systemic Sclerosis. In: arthritis & rheumatology. WILEY 111 RIVER ST, HOBOKEN, pp 07030\u201305774"},{"issue":"3","key":"5446_CR13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1189\/jlb.1008647","volume":"86","author":"JM Ehrchen","year":"2009","unstructured":"Ehrchen JM, Sunderk\u00f6tter C, Foell D, Vogl T, Roth J (2009) The endogenous toll\u2013like receptor 4 agonist S100A8\/S100A9 (Calprotectin ) as innate amplifier of infection, autoimmunity, and cancer. J Leukoc Biol 86(3):557\u2013566","journal-title":"J Leukoc Biol"},{"issue":"1","key":"5446_CR14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1189\/jlb.0306170","volume":"81","author":"D Foell","year":"2007","unstructured":"Foell D, Wittkowski H, Vogl T, Roth J (2007) S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J Leukoc Biol 81(1):28\u201337","journal-title":"J Leukoc Biol"},{"issue":"3","key":"5446_CR15","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.3390\/ijms13032893","volume":"13","author":"T Vogl","year":"2012","unstructured":"Vogl T, Gharibyan AL, Morozova-Roche LA (2012) Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes. Int J Mol Sci 13(3):2893\u20132917","journal-title":"Int J Mol Sci"},{"issue":"7","key":"5446_CR16","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1182\/blood-2004-07-2520","volume":"105","author":"D Viemann","year":"2005","unstructured":"Viemann D, Strey A, Janning A, Jurk K, Klimmek K, Vogl T, Hirono K, Ichida F, Foell D, Kehrel B (2005) Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells. Blood 105(7):2955\u20132962","journal-title":"Blood"},{"issue":"1","key":"5446_CR17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s40291-013-0016-9","volume":"17","author":"M Garc\u00eda-Arias","year":"2013","unstructured":"Garc\u00eda-Arias M, Pascual-Salcedo D, Ramiro S, Ueberschlag M-E, Jermann TM, Cara C, Mart\u00edn-Mola E, Balsa A (2013) Calprotectin in rheumatoid arthritis. Mol Diagn Ther 17(1):49\u201356","journal-title":"Mol Diagn Ther"},{"issue":"2","key":"5446_CR18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/MCG.0000000000000312","volume":"50","author":"R Ferreiro-Iglesias","year":"2016","unstructured":"Ferreiro-Iglesias R, Barreiro-de Acosta M, Otero Santiago M, Lorenzo Gonzalez A, Alonso de la Pena C, Benitez Estevez AJ, Dominguez-Mu\u00f1oz JE (2016) Fecal Calprotectin as predictor of relapse in patients with inflammatory bowel disease under maintenance infliximab therapy. J Clin Gastroenterol 50(2):147\u2013151","journal-title":"J Clin Gastroenterol"},{"issue":"1","key":"5446_CR19","first-page":"49","volume":"7","author":"S Sayar","year":"2020","unstructured":"Sayar S, Kurbuz K, Kahraman R, Caliskan Z, Atalay R, Ozturk O, Doganay HL, Ozdil K (2020) A practical marker to determining acute severe ulcerative colitis: CRP\/albumin ratio. North Clin Istanb 7(1):49\u201355","journal-title":"North Clin Istanb"},{"issue":"6","key":"5446_CR20","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.autrev.2015.01.018","volume":"14","author":"I Marie","year":"2015","unstructured":"Marie I, Leroi A-M, Menard J-F, Levesque H, Quillard M, Ducrotte P (2015) Fecal Calprotectin in systemic sclerosis and review of the literature. Autoimmun Rev 14(6):547\u2013554","journal-title":"Autoimmun Rev"},{"issue":"11","key":"5446_CR21","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1038\/jid.2014.253","volume":"134","author":"J Nikitorowicz-Buniak","year":"2014","unstructured":"Nikitorowicz-Buniak J, Shiwen X, Denton CP, Abraham D, Stratton R (2014) Abnormally differentiating keratinocytes in the epidermis of systemic sclerosis patients show enhanced secretion of CCN2 and S100A9. J Investig Dermatol 134(11):2693\u20132702","journal-title":"J Investig Dermatol"},{"issue":"10","key":"5446_CR22","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s10067-013-2305-4","volume":"32","author":"X Xu","year":"2013","unstructured":"Xu X, Wu W-y, W-z T, H-y C, Zhu X-x, Liang M-r, Xue Y, Wang J-c, H-j Z (2013) Increased expression of S100A8 and S100A9 in patients with diffuse cutaneous systemic sclerosis. A correlation with organ involvement and immunological abnormalities. Clin Rheumatol 32(10):1501\u20131510","journal-title":"Clin Rheumatol"},{"issue":"1","key":"5446_CR23","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13075-016-1182-z","volume":"18","author":"K Andr\u00e9asson","year":"2016","unstructured":"Andr\u00e9asson K, Alrawi Z, Persson A, J\u00f6nsson G, Marsal J (2016) Intestinal dysbiosis is common in systemic sclerosis and associated with gastrointestinal and extraintestinal features of disease. Arthritis Res Ther 18(1):278","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"5446_CR24","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s10753-008-9085-z","volume":"31","author":"E Bargagli","year":"2008","unstructured":"Bargagli E, Olivieri C, Prasse A, Bianchi N, Magi B, Cianti R, Bini L, Rottoli P (2008) Calgranulin B (S100A9) levels in bronchoalveolar lavage fluid of patients with interstitial lung diseases. Inflammation 31(5):351\u2013354","journal-title":"Inflammation"},{"issue":"1","key":"5446_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","volume":"4","author":"D Moher","year":"2015","unstructured":"Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA (2015) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev 4(1):1","journal-title":"Syst Rev"},{"key":"5446_CR26","doi-asserted-by":"publisher","unstructured":"Abdolahi N, Aghaie M, Mofidi HH, Gharib MH (2019) AB0633 fecal calprotectin in patients with systemic sclerosis. Ann Rheum Dis 78(2):1778. https:\/\/doi.org\/10.1136\/annrheumdis-2019-eular.7663","DOI":"10.1136\/annrheumdis-2019-eular.7663"},{"issue":"3","key":"5446_CR27","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3899\/jrheum.171445","volume":"46","author":"C Caimmi","year":"2019","unstructured":"Caimmi C, Bertoldo E, Venturini A, Caramaschi P, Frulloni L, Ciccocioppo R, Brunelli S, Idolazzi L, Gatti D, Rossini M (2019) Relationship between increased fecal Calprotectin levels and interstitial lung disease in systemic sclerosis. J Rheumatol 46(3):274\u2013278","journal-title":"J Rheumatol"},{"issue":"6","key":"5446_CR28","doi-asserted-by":"crossref","first-page":"R160","DOI":"10.1186\/ar2067","volume":"8","author":"AM Fietta","year":"2006","unstructured":"Fietta AM, Bardoni AM, Salvini R, Passadore I, Morosini M, Cavagna L, Codullo V, Pozzi E, Meloni F, Montecucco C (2006) Analysis of bronchoalveolar lavage fluid proteome from systemic sclerosis patients with or without functional, clinical and radiological signs of lung fibrosis. Arthritis Res Ther 8(6):R160","journal-title":"Arthritis Res Ther"},{"issue":"10","key":"5446_CR29","first-page":"2063","volume":"34","author":"L Giusti","year":"2007","unstructured":"Giusti L, Bazzichi L, Baldini C, Ciregia F, Mascia G, Giannaccini G, Del Rosso M, Bombardieri S, Lucacchini A (2007) Specific proteins identified in whole saliva from patients with diffuse systemic sclerosis. J Rheumatol 34(10):2063\u20132069","journal-title":"J Rheumatol"},{"issue":"7","key":"5446_CR30","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.rmed.2013.03.015","volume":"107","author":"R Hesselstrand","year":"2013","unstructured":"Hesselstrand R, Wildt M, Bozovic G, Andersson-Sj\u00f6land A, Andr\u00e9asson K, Scheja A, Westergren-Thorsson G, Bjermer L, Wuttge DM (2013) Biomarkers from bronchoalveolar lavage fluid in systemic sclerosis patients with interstitial lung disease relate to severity of lung fibrosis. Respir Med 107(7):1079\u20131086","journal-title":"Respir Med"},{"key":"5446_CR31","first-page":"411","volume-title":"Seminars in arthritis and rheumatism","author":"AHL Low","year":"2019","unstructured":"Low AHL, Teng GG, Pettersson S, de Sessions PF, Ho EXP, Fan Q, Chu CW, Law AHN, Santosa A, Lim AYNA (2019) double-blind randomized placebo-controlled trial of probiotics in systemic sclerosis associated gastrointestinal disease. In: Seminars in arthritis and rheumatism, vol 3. Elsevier, pp 411\u2013419"},{"issue":"8","key":"5446_CR32","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1136\/annrheumdis-2013-205013","volume":"73","author":"L Van Bon","year":"2014","unstructured":"Van Bon L, Cossu M, Loof A, Gohar F, Wittkowski H, Vonk M, Roth J, Van Den Berg W, Van Heerde W, Broen J (2014) Proteomic analysis of plasma identifies the toll-like receptor agonists S100A8\/A9 as a novel possible marker for systemic sclerosis phenotype. Ann Rheum Dis 73(8):1585\u20131589","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"5446_CR33","doi-asserted-by":"crossref","first-page":"R46","DOI":"10.1186\/ar4475","volume":"16","author":"K Andr\u00e9asson","year":"2014","unstructured":"Andr\u00e9asson K, Saxne T, Scheja A, Bartosik I, Mandl T, Hesselstrand R (2014) Faecal levels of Calprotectin in systemic sclerosis are stable over time and are higher compared to primary Sj\u00f6gren\u2019s syndrome and rheumatoid arthritis. Arthritis Res Ther 16(1):R46","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"5446_CR34","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s10067-017-3932-y","volume":"37","author":"C Caimmi","year":"2018","unstructured":"Caimmi C, Caramaschi P, Venturini A, Bertoldo E, Vantaggiato E, Viapiana O, Ferrari M, Lippi G, Frulloni L, Rossini M (2018) Malnutrition and sarcopenia in a large cohort of patients with systemic sclerosis. Clin Rheumatol 37(4):987\u2013997","journal-title":"Clin Rheumatol"},{"key":"5446_CR35","doi-asserted-by":"publisher","unstructured":"Li L, Zuo X, Xiao Y, Liu D, Luo H, Zhu H (2020) Neutrophil-derived exosome from systemic sclerosis inhibits the proliferation and migration of endothelial cells. Biochem Bioph Res Commun 526(2):334\u201340. https:\/\/doi.org\/10.1016\/j.bbrc.2020.03.088","DOI":"10.1016\/j.bbrc.2020.03.088"},{"issue":"1","key":"5446_CR36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.7326\/0003-4819-140-1-200401060-00010","volume":"140","author":"SA Jimenez","year":"2004","unstructured":"Jimenez SA, Derk CT (2004) Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis. Ann Intern Med 140(1):37\u201350","journal-title":"Ann Intern Med"},{"issue":"1","key":"5446_CR37","first-page":"165","volume":"58","author":"C Landi","year":"2019","unstructured":"Landi C, Bargagli E, Carleo A, Refini RM, Bennett D, Bianchi L, Cillis G, Prasse A, Bini L, Rottoli P (2019) Bronchoalveolar lavage proteomic analysis in pulmonary fibrosis associated with systemic sclerosis: S100A6 and 14-3-3\u03b5 as potential biomarkers. Rheumatology 58(1):165\u2013178","journal-title":"Rheumatology"},{"issue":"8","key":"5446_CR38","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1177\/1535370216681551","volume":"242","author":"F Ometto","year":"2017","unstructured":"Ometto F, Friso L, Astorri D, Botsios C, Raffeiner B, Punzi L, Doria A (2017) Calprotectin in rheumatic diseases. Exp Biol Med 242(8):859\u2013873","journal-title":"Exp Biol Med"},{"issue":"6","key":"5446_CR39","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.4049\/jimmunol.170.6.3233","volume":"170","author":"C Ryckman","year":"2003","unstructured":"Ryckman C, Vandal K, Rouleau P, Talbot M, Tessier PA (2003) Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8\/A9 induce neutrophil chemotaxis and adhesion. J Immunol 170(6):3233\u20133242","journal-title":"J Immunol"},{"issue":"13","key":"5446_CR40","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1182\/blood-2004-02-0446","volume":"104","author":"T Vogl","year":"2004","unstructured":"Vogl T, Ludwig S, Goebeler M, Strey A, Thorey IS, Reichelt R, Foell D, Gerke V, Manitz MP, Nacken W (2004) MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes. Blood 104(13):4260\u20134268","journal-title":"Blood"},{"issue":"3","key":"5446_CR41","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/mi.2013.13","volume":"6","author":"M Fukata","year":"2013","unstructured":"Fukata M, Arditi M (2013) The role of pattern recognition receptors in intestinal inflammation. Mucosal Immunol 6(3):451\u2013463","journal-title":"Mucosal Immunol"},{"issue":"6","key":"5446_CR42","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","volume":"9","author":"L Chen","year":"2018","unstructured":"Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L (2018) Inflammatory responses and inflammation-associated diseases in organs. Oncotarget 9(6):7204\u20137218","journal-title":"Oncotarget"},{"issue":"3","key":"5446_CR43","first-page":"77","volume":"39","author":"WGW Pathirana","year":"2018","unstructured":"Pathirana WGW, Chubb SP, Gillett MJ, Vasikaran SD (2018) Faecal Calprotectin. Clin Biochem Rev 39(3):77","journal-title":"Clin Biochem Rev"},{"key":"5446_CR44","doi-asserted-by":"publisher","unstructured":"Hoffmann-Vold A-M, Volkmann ER (2019) Gastrointestinal involvement in systemic sclerosis: effects on morbidity and mortality and new therapeutic approaches. Journal of Scleroderma and Related Disorders 0(0):2397198319891282. https:\/\/doi.org\/10.1177\/2397198319891282","DOI":"10.1177\/2397198319891282"},{"issue":"11","key":"5446_CR45","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/mp.2011.63","volume":"16","author":"R Perlis","year":"2011","unstructured":"Perlis R (2011) Translating biomarkers to clinical practice. Mol Psychiatry 16(11):1076\u20131087","journal-title":"Mol Psychiatry"},{"issue":"3","key":"5446_CR46","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00408-017-9993-5","volume":"195","author":"J Guiot","year":"2017","unstructured":"Guiot J, Moermans C, Henket M, Corhay J-L, Louis R (2017) Blood biomarkers in idiopathic pulmonary fibrosis. Lung 195(3):273\u2013280","journal-title":"Lung"},{"key":"5446_CR47","doi-asserted-by":"publisher","unstructured":"Salazar GA, Assassi S, Wigley F, Hummers L, Varga J, Hinchcliff M et al (2015) Antinuclear antibody-negative systemic sclerosis. Semin Arthritis Rheum 44(6):680\u2013686. https:\/\/doi.org\/10.1016\/j.semarthrit.2014.11.006","DOI":"10.1016\/j.semarthrit.2014.11.006"},{"issue":"19","key":"5446_CR48","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1212\/01.wnl.0000334474.88923.e3","volume":"71","author":"I Kister","year":"2008","unstructured":"Kister I, Inglese M, Laxer RM, Herbert J (2008) Neurologic manifestations of localized scleroderma: a case report and literature review. Neurology 71(19):1538\u20131545","journal-title":"Neurology"},{"key":"5446_CR49","doi-asserted-by":"crossref","first-page":"245","DOI":"10.33549\/physiolres.930448","volume":"53","author":"I St\u0159\u00ed\u017e","year":"2004","unstructured":"St\u0159\u00ed\u017e I, Trebichavsk\u00fd I (2004) Calprotectin \u2014a pleiotropic molecule in acute and chronic inflammation. Physiol Res 53:245\u2013253","journal-title":"Physiol Res"},{"issue":"4","key":"5446_CR50","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1165\/rcmb.2002-0286OC","volume":"29","author":"A Ahmad","year":"2003","unstructured":"Ahmad A, Bayley DL, He S, Stockley RA (2003) Myeloid related protein-8\/14 stimulates interleukin-8 production in airway epithelial cells. Am J Respir Cell Mol Biol 29(4):523\u2013530","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"11","key":"5446_CR51","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1111\/j.1432-1033.2004.04129.x","volume":"271","author":"F Shibata","year":"2004","unstructured":"Shibata F, Miyama K, Shinoda F, Mizumoto J, Takano K, Nakagawa H (2004) Fibroblast growth-stimulating activity of S100A9 (MRP-14). Eur J Biochem 271(11):2137\u20132143","journal-title":"Eur J Biochem"},{"issue":"3","key":"5446_CR52","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1258\/acb.2009.009061","volume":"47","author":"S Joshi","year":"2010","unstructured":"Joshi S, Lewis SJ, Creanor S, Ayling RM (2010) Age-related faecal Calprotectin , lactoferrin and tumour M2-PK concentrations in healthy volunteers. Ann Clin Biochem 47(3):259\u2013263","journal-title":"Ann Clin Biochem"},{"issue":"2","key":"5446_CR53","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/00365521.2019.1566493","volume":"54","author":"D Lundgren","year":"2019","unstructured":"Lundgren D, Ekl\u00f6f V, Palmqvist R, Hultdin J, Karling P (2019) Proton pump inhibitor use is associated with elevated faecal Calprotectin levels. A cross-sectional study on subjects referred for colonoscopy. Scand J Gastroenterol 54(2):152\u2013157","journal-title":"Scand J Gastroenterol"},{"issue":"3","key":"5446_CR54","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1136\/gut.45.3.362","volume":"45","author":"J Tibble","year":"1999","unstructured":"Tibble J, Sigthorsson G, Foster R, Scott D, Fagerhol M, Roseth A, Bjarnason I (1999) High prevalence of NSAID enteropathy as shown by a simple faecal test. Gut 45(3):362\u2013366","journal-title":"Gut"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-020-05446-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-020-05446-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-020-05446-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T11:30:40Z","timestamp":1696851040000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-020-05446-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,12]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["5446"],"URL":"https:\/\/doi.org\/10.1007\/s10067-020-05446-0","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,12]]},"assertion":[{"value":"17 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}