{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:59:38Z","timestamp":1793224778721,"version":"4.5.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30-AR070254"],"award-info":[{"award-number":["P30-AR070254"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01 AR-073208"],"award-info":[{"award-number":["R01 AR-073208"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chresanthe Staurulakis Memorial Discovery Fund"},{"name":"Donald B. and Dorothy L. Stabler Foundation"},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","award":["1K23AR075898."],"award-info":[{"award-number":["1K23AR075898."]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Johns Hopkins inHealth Precision Medicine Initiative"},{"DOI":"10.13039\/100015629","name":"Jerome L Greene Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015629","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001845","name":"Scleroderma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001845","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s10067-021-05586-x","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T09:03:07Z","timestamp":1610960587000},"page":"2763-2769","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["PM-Scl and Th\/To in systemic sclerosis: a comparison of different autoantibody assays"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1429-8392","authenticated-orcid":false,"given":"C. A.","family":"Mecoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Gutierrez-Alamillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sampedro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. K.","family":"Hummers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Wigley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Casciola-Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"issue":"6","key":"5586_CR1","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1097\/BOR.0000000000000550","volume":"30","author":"CA Mecoli","year":"2018","unstructured":"Mecoli CA, Casciola-Rosen L (2018) An update on autoantibodies in scleroderma. Curr Opin Rheumatol 30(6):548\u2013553","journal-title":"Curr Opin Rheumatol"},{"key":"5586_CR2","doi-asserted-by":"crossref","unstructured":"Mecoli CA, Adler BL, Yang Q, Rosen A, Casciola-Rosen L, Shah AA (2020) Cancer in Systemic Sclerosis: analysis of antibodies against components of the Th\/To Complex. Arthritis Rheum","DOI":"10.1002\/art.41493"},{"issue":"3 Suppl 29","key":"5586_CR3","first-page":"S42","volume":"21","author":"TA Medsger Jr","year":"2003","unstructured":"Medsger TA Jr et al (2003) Assessment of disease severity and prognosis. Clin Exp Rheumatol 21(3 Suppl 29):S42\u2013S46","journal-title":"Clin Exp Rheumatol"},{"key":"5586_CR4","doi-asserted-by":"crossref","unstructured":"Cottrell TR, Wise RA, Wigley FM, Boin F (2014) The degree of skin involvement identifies distinct lung disease outcomes and survival in systemic sclerosis. Ann Rheum Dis 73(6):1060\u20131066","DOI":"10.1136\/annrheumdis-2012-202849"},{"issue":"9","key":"5586_CR5","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1007\/s10067-018-4148-5","volume":"37","author":"CA Mecoli","year":"2018","unstructured":"Mecoli CA, Shah AA, Boin F, Wigley FM, Hummers LK (2018) Vascular complications in systemic sclerosis: a prospective cohort study. Clin Rheumatol 37(9):2429\u20132437","journal-title":"Clin Rheumatol"},{"key":"5586_CR6","doi-asserted-by":"crossref","unstructured":"Simonneau G et al (2019) Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J 53(1)","DOI":"10.1183\/13993003.01913-2018"},{"issue":"1","key":"5586_CR7","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jaad.2010.09.016","volume":"65","author":"D Fiorentino","year":"2011","unstructured":"Fiorentino D, Chung L, Zwerner J, Rosen A, Casciola-Rosen L (2011) The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): a retrospective study. J Am Acad Dermatol 65(1):25\u201334","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"5586_CR8","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/ar147","volume":"3","author":"R Brouwer","year":"2001","unstructured":"Brouwer R, Pruijn GJ, van Venrooij WJ (2001) The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma. Arthritis Res 3(2):102\u2013106","journal-title":"Arthritis Res"},{"issue":"1","key":"5586_CR9","doi-asserted-by":"publisher","first-page":"R22","DOI":"10.1186\/ar2614","volume":"11","author":"K Hanke","year":"2009","unstructured":"Hanke K, Br\u00fcckner CS, D\u00e4hnrich C, Huscher D, Komorowski L, Meyer W, Janssen A, Backhaus M, Becker M, Kill A, Egerer K, Burmester GR, Hiepe F, Schlumberger W, Riemekasten G (2009) Antibodies against PM\/Scl-75 and PM\/Scl-100 are independent markers for different subsets of systemic sclerosis patients. Arthritis Res Ther 11(1):R22","journal-title":"Arthritis Res Ther"},{"key":"5586_CR10","doi-asserted-by":"publisher","first-page":"3489","DOI":"10.1007\/s10067-020-04973-0","volume":"39","author":"Y Hamaguchi","year":"2020","unstructured":"Hamaguchi Y, Kuwana M, Takehara K (2020) Performance evaluation of a commercial line blot assay system for detection of myositis- and systemic sclerosis-related autoantibodies. Clin Rheumatol 39:3489\u20133497","journal-title":"Clin Rheumatol"},{"issue":"1","key":"5586_CR11","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s13075-020-02210-2","volume":"22","author":"SL Tansley","year":"2020","unstructured":"Tansley SL et al (2020) The promise, perceptions, and pitfalls of immunoassays for autoantibody testing in myositis. Arthritis Res Ther 22(1):117","journal-title":"Arthritis Res Ther"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-021-05586-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-021-05586-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-021-05586-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T16:10:30Z","timestamp":1623255030000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-021-05586-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,18]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["5586"],"URL":"https:\/\/doi.org\/10.1007\/s10067-021-05586-x","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,18]]},"assertion":[{"value":"14 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"All participants provided written informed consent prior to inclusion in this study. This study was approved by the Johns Hopkins IRB.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}