{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:05:24Z","timestamp":1787238324517,"version":"build-2736575974"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Mixed connective tissue disease (MCTD) is a rare disease with clinical picture consisted of multiple organ manifestations, including skin changes resembling systemic lupus erythematosus (SLE), systemic sclerosis (SSc), or dermatomyositis (DM). On the background of these manifestations are microvascular changes \u2014 alteration of endothelial function and impairment of endothelial progenitor cell. Nailfold capillaroscopy (NFC) is a simple, non-invasive technique for investigating microvascular involvement in rheumatic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the relationship between type of skin lesions and NFC pattern in MCTD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed the clinical picture and NFC patterns in 79 patients with MCTD. The NFC changes were classified into Normal, \u201cEarly,\u201d \u201cActive,\u201d and \u201cLate\u201d scleroderma-like patterns (SD-like pattern) based on Cutolo classification.<\/jats:p>\n                    <jats:p>In all patients, subjective and physical examinations were carried out, specifically the occurrence of skin lesions in the course of MCTD was assessed (systemic sclerosis-like (Ssc-like), systemic lupus erythematosus-like (SLE-like), dermatomysitis-like (DM-like)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Skin changes were present in 64 (81%) patients, involving 43 (54%) SLE-like, 48 (61%) SSc-like, and 4 (5.1%) DM-like. NFC changes were observed in a total of 55 (69.6 %) patients with predominance of the \u201cEarly\u201d pattern \u2014 41 (51.9 %) patients. According to skin change phenotypes, NFC changes were observed in 31 (72%) patients with SLE-like and in 32 (66.7%) patients with SSc-like skin phenotypes. The \u201cearly\u201d pattern predominated in both group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We did not find any correlation between NFC pattern and the type skin changes.\n                      <jats:table-wrap>\n                        <jats:table>\n                          <jats:tbody>\n                            <jats:tr>\n                              <jats:td colspan=\"2\">\n                                <jats:bold>Key Points<\/jats:bold>\n                                <jats:italic>\u2022 The study did not show a correlation between the presence and absence of skin lesions and NFC pattern.<\/jats:italic>\n                                <jats:italic>\u2022 Scleroderma-like patterns were found in over 60% of patients with mixed connective tissue disease.<\/jats:italic>\n                                <jats:italic>\u2022 The \u201cearly\u201d pattern is dominant regardless of the occurrence or absence of skin lesions in patients with MCTD.<\/jats:italic>\n                                <jats:italic>\u2022 Skin lesions, regardless of their type (SLE or SSc), do not correlate with type of lesion found in the NFC examination.<\/jats:italic>\n                              <\/jats:td>\n                            <\/jats:tr>\n                          <\/jats:tbody>\n                        <\/jats:table>\n                      <\/jats:table-wrap>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10067-021-05717-4","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:02:45Z","timestamp":1628467365000},"page":"281-288","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Relationship between type of skin lesions and nailfold capillaroscopy pattern in mixed connective tissue disease"],"prefix":"10.1007","volume":"41","author":[{"given":"Anna","family":"Felis-Giemza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-4178","authenticated-orcid":false,"given":"Sylwia","family":"Ornowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Ha\u0142adyj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenobia","family":"Czuszy\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Olesi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"issue":"Suppl 1","key":"5717_CR1","doi-asserted-by":"publisher","first-page":"e000783","DOI":"10.1136\/rmdopen-2018-000783","volume":"4","author":"B Chaigne","year":"2018","unstructured":"Chaigne B, Scir\u00e8 CA, Talarico R, Alexander T, Amoura Z et al (2018) Mixed connective tissue disease: state of the art on clinical practice guidelines. 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