{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:52:50Z","timestamp":1789271570351,"version":"build-2803163510"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974251"],"award-info":[{"award-number":["81974251"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801593"],"award-info":[{"award-number":["81801593"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s10067-021-05765-w","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T12:06:06Z","timestamp":1621425966000},"page":"4269-4277","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dihydroartemisinin alleviates skin fibrosis and endothelial dysfunction in bleomycin-induced skin fibrosis models"],"prefix":"10.1007","volume":"40","author":[{"given":"Rui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingran","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9116-6038","authenticated-orcid":false,"given":"Liangjing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"5765_CR1","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1097\/bor.0000000000000551","volume":"30","author":"DR Poudel","year":"2018","unstructured":"Poudel DR, Derk CT (2018) Mortality and survival in systemic sclerosis: a review of recent literature. Curr Opin Rheumatol 30:588\u2013593. https:\/\/doi.org\/10.1097\/bor.0000000000000551","journal-title":"Curr Opin Rheumatol"},{"key":"5765_CR2","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1016\/s0140-6736(17)30933-9","volume":"390","author":"CP Denton","year":"2017","unstructured":"Denton CP, Khanna D (2017) Systemic sclerosis. Lancet 390:1685\u20131699. https:\/\/doi.org\/10.1016\/s0140-6736(17)30933-9","journal-title":"Lancet"},{"key":"5765_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.trsl.2019.02.010","volume":"209","author":"B Korman","year":"2019","unstructured":"Korman B (2019) Evolving insights into the cellular and molecular pathogenesis of fibrosis in systemic sclerosis. Transl Res 209:77\u201389. https:\/\/doi.org\/10.1016\/j.trsl.2019.02.010","journal-title":"Transl Res"},{"key":"5765_CR4","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1080\/1744666x.2019.1614915","volume":"15","author":"M Cutolo","year":"2019","unstructured":"Cutolo M, Soldano S, Smith V (2019) Pathophysiology of systemic sclerosis: current understanding and new insights. Expert Rev Clin Immunol 15:753\u2013764. https:\/\/doi.org\/10.1080\/1744666x.2019.1614915","journal-title":"Expert Rev Clin Immunol"},{"key":"5765_CR5","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.bcp.2019.06.021","volume":"168","author":"X Lu","year":"2019","unstructured":"Lu X, Gong J, Dennery PA, Yao H (2019) Endothelial-to-mesenchymal transition: pathogenesis and therapeutic targets for chronic pulmonary and vascular diseases. Biochem Pharmacol 168:100\u2013107. https:\/\/doi.org\/10.1016\/j.bcp.2019.06.021","journal-title":"Biochem Pharmacol"},{"key":"5765_CR6","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/annrheumdis-2016-210229","volume":"76","author":"M Manetti","year":"2017","unstructured":"Manetti M, Romano E, Rosa I, Guiducci S, Bellando-Randone S, De Paulis A, Ibba-Manneschi L, Matucci-Cerinic M (2017) Endothelial-to-mesenchymal transition contributes to endothelial dysfunction and dermal fibrosis in systemic sclerosis. Ann Rheum Dis 76:924\u2013934. https:\/\/doi.org\/10.1136\/annrheumdis-2016-210229","journal-title":"Ann Rheum Dis"},{"key":"5765_CR7","doi-asserted-by":"publisher","first-page":"616","DOI":"10.2353\/ajpath.2009.081061","volume":"175","author":"A Kitao","year":"2009","unstructured":"Kitao A, Sato Y, Sawada-Kitamura S, Harada K, Sasaki M, Morikawa H, Shiomi S, Honda M, Matsui O, Nakanuma Y (2009) Endothelial to mesenchymal transition via transforming growth factor-beta1\/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension. Am J Pathol 175:616\u2013626. https:\/\/doi.org\/10.2353\/ajpath.2009.081061","journal-title":"Am J Pathol"},{"key":"5765_CR8","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/s1473-3099(16)30378-4","volume":"17","author":"J Gutman","year":"2017","unstructured":"Gutman J, Kovacs S, Dorsey G, Stergachis A, Ter Kuile FO (2017) Safety, tolerability, and efficacy of repeated doses of dihydroartemisinin-piperaquine for prevention and treatment of malaria: a systematic review and meta-analysis. Lancet Infect Dis 17:184\u2013193. https:\/\/doi.org\/10.1016\/s1473-3099(16)30378-4","journal-title":"Lancet Infect Dis"},{"key":"5765_CR9","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s13046-017-0531-3","volume":"36","author":"F Zhang","year":"2017","unstructured":"Zhang F, Ma Q, Xu Z, Liang H, Li H, Ye Y, Xiang S, Zhang Y, Jiang L, Hu Y, Wang Z, Wang X, Zhang Y, Gong W, Liu Y (2017) Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer. J Exp Clin Cancer Res 36:68. https:\/\/doi.org\/10.1186\/s13046-017-0531-3","journal-title":"J Exp Clin Cancer Res"},{"key":"5765_CR10","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.lfs.2018.05.022","volume":"205","author":"DX Yang","year":"2018","unstructured":"Yang DX, Qiu J, Zhou HH, Yu Y, Zhou DL, Xu Y, Zhu MZ, Ge XP, Li JM, Lv CJ, Zhang HQ, Yuan WD (2018) Dihydroartemisinin alleviates oxidative stress in bleomycin-induced pulmonary fibrosis. Life Sci 205:176\u2013183. https:\/\/doi.org\/10.1016\/j.lfs.2018.05.022","journal-title":"Life Sci"},{"key":"5765_CR11","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.canlet.2016.07.033","volume":"381","author":"R Lin","year":"2016","unstructured":"Lin R, Zhang Z, Chen L, Zhou Y, Zou P, Feng C, Wang L, Liang G (2016) Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells. Cancer Lett 381:165\u2013175. https:\/\/doi.org\/10.1016\/j.canlet.2016.07.033","journal-title":"Cancer Lett"},{"key":"5765_CR12","doi-asserted-by":"publisher","first-page":"594","DOI":"10.2174\/1568026619666190304142802","volume":"19","author":"K Kalani","year":"2019","unstructured":"Kalani K, Chaturvedi V, Trivedi P, Tondon S, Srivastava SK (2019) Dihydroartemisinin and its analogs: a new class of antitubercular agents. Curr Top Med Chem 19:594\u2013599. https:\/\/doi.org\/10.2174\/1568026619666190304142802","journal-title":"Curr Top Med Chem"},{"key":"5765_CR13","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1111\/jcmm.13448","volume":"22","author":"L Li","year":"2018","unstructured":"Li L, Chen X, Dong F, Liu Q, Zhang C, Xu D, Allen TD, Liu J (2018) Dihydroartemisinin up-regulates VE-cadherin expression in human renal glomerular endothelial cells. J Cell Mol Med 22:2028\u20132032. https:\/\/doi.org\/10.1111\/jcmm.13448","journal-title":"J Cell Mol Med"},{"key":"5765_CR14","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s00296-013-2827-8","volume":"34","author":"T Frech","year":"2014","unstructured":"Frech T, De Domenico I, Murtaugh MA, Revelo MP, Li DY, Sawitzke AD, Drakos S (2014) Autophagy is a key feature in the pathogenesis of systemic sclerosis. Rheumatol Int 34:435\u2013439. https:\/\/doi.org\/10.1007\/s00296-013-2827-8","journal-title":"Rheumatol Int"},{"key":"5765_CR15","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1038\/jid.2014.69","volume":"134","author":"VI Dumit","year":"2014","unstructured":"Dumit VI, K\u00fcttner V, K\u00e4ppler J, Piera-Velazquez S, Jimenez SA, Bruckner-Tuderman L, Uitto J, Dengjel J (2014) Altered MCM protein levels and autophagic flux in aged and systemic sclerosis dermal fibroblasts. J Invest Dermatol 134:2321\u20132330. https:\/\/doi.org\/10.1038\/jid.2014.69","journal-title":"J Invest Dermatol"},{"key":"5765_CR16","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1111\/acel.12357","volume":"14","author":"ML Sosulski","year":"2015","unstructured":"Sosulski ML, Gongora R, Danchuk S, Dong C, Luo F, Sanchez CG (2015) Deregulation of selective autophagy during aging and pulmonary fibrosis: the role of TGF\u03b21. Aging Cell 14:774\u2013783. https:\/\/doi.org\/10.1111\/acel.12357","journal-title":"Aging Cell"},{"key":"5765_CR17","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.phymed.2018.09.221","volume":"52","author":"L Wang","year":"2019","unstructured":"Wang L, Li J, Shi X, Li S, Tang PM, Li Z, Li H, Wei C (2019) Antimalarial dihydroartemisinin triggers autophagy within HeLa cells of human cervical cancer through Bcl-2 phosphorylation at Ser70. Phytomedicine 52:147\u2013156. https:\/\/doi.org\/10.1016\/j.phymed.2018.09.221","journal-title":"Phytomedicine"},{"key":"5765_CR18","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1002\/mc.22893","volume":"57","author":"S Thongchot","year":"2018","unstructured":"Thongchot S, Vidoni C, Ferraresi A, Loilome W, Yongvanit P, Namwat N, Isidoro C (2018) Dihydroartemisinin induces apoptosis and autophagy-dependent cell death in cholangiocarcinoma through a DAPK1-BECLIN1 pathway. Mol Carcinog 57:1735\u20131750. https:\/\/doi.org\/10.1002\/mc.22893","journal-title":"Mol Carcinog"},{"key":"5765_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.255","volume":"8","author":"Z Zhang","year":"2017","unstructured":"Zhang Z, Yao Z, Zhao S, Shao J, Chen A, Zhang F, Zheng S (2017) Interaction between autophagy and senescence is required for dihydroartemisinin to alleviate liver fibrosis. Cell Death Dis 8:e2886. https:\/\/doi.org\/10.1038\/cddis.2017.255","journal-title":"Cell Death Dis"},{"key":"5765_CR20","doi-asserted-by":"publisher","first-page":"6057","DOI":"10.7150\/jca.33704","volume":"10","author":"J Liu","year":"2019","unstructured":"Liu J, Ren Y, Hou Y, Zhang C, Wang B, Li X, Sun R, Liu J (2019) Dihydroartemisinin induces endothelial cell autophagy through suppression of the Akt\/mTOR pathway. J Cancer 10:6057\u20136064. https:\/\/doi.org\/10.7150\/jca.33704","journal-title":"J Cancer"},{"key":"5765_CR21","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1016\/j.ajpath.2011.06.001","volume":"179","author":"S Piera-Velazquez","year":"2011","unstructured":"Piera-Velazquez S, Li Z, Jimenez SA (2011) Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders. Am J Pathol 179:1074\u20131080. https:\/\/doi.org\/10.1016\/j.ajpath.2011.06.001","journal-title":"Am J Pathol"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-021-05765-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-021-05765-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-021-05765-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T18:01:44Z","timestamp":1632506504000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-021-05765-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,19]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["5765"],"URL":"https:\/\/doi.org\/10.1007\/s10067-021-05765-w","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,19]]},"assertion":[{"value":"22 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration"}},{"value":"Sample collection and written informed consent were approved by the ethics committee of Shanghai Jiao Tong University School of Medicine that is affiliated with Renji Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}