{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:22:43Z","timestamp":1783833763153,"version":"3.55.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s10067-021-05918-x","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T02:03:31Z","timestamp":1631757811000},"page":"513-521","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association of quantitative computed tomography \u0131ndices with lung function and extent of pulmonary fibrosis in patients with systemic sclerosis"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5891-2032","authenticated-orcid":false,"given":"Duygu","family":"Temiz Karadag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6565-9488","authenticated-orcid":false,"given":"Ozgur","family":"Cakir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-1019","authenticated-orcid":false,"given":"Senar","family":"San","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2167-4509","authenticated-orcid":false,"given":"Ayten","family":"Yazici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4992-9043","authenticated-orcid":false,"given":"Ercument","family":"Ciftci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-7969","authenticated-orcid":false,"given":"Ayse","family":"Cefle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"5918_CR1","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1016\/S0140-6736(17)30933-9","volume":"390","author":"C Denton","year":"2017","unstructured":"Denton C, Khanna D (2017) Systemic sclerosis. Lancet 390:1685\u20131699. https:\/\/doi.org\/10.1016\/S0140-6736(17)30933-9","journal-title":"Lancet"},{"key":"5918_CR2","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1136\/annrheumdis-2017-211448","volume":"76","author":"M Elhai","year":"2017","unstructured":"Elhai M, Meune C, Boubaya M, Avouac J, Hachulla E, Balbir-Gurman A et al (2017) Mapping and predicting mortality from systemic sclerosis. Ann Rheum Dis 76:1897\u20131905. https:\/\/doi.org\/10.1136\/annrheumdis-2017-211448","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"5918_CR3","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/acr.21583","volume":"64","author":"Steele R, Hudson M, Lo E, Baron M; Canadian Scleroderma Research Group","year":"2012","unstructured":"Steele R, Hudson M, Lo E, Baron M; Canadian Scleroderma Research Group (2012) Clinical decision rule to predict the presence of interstitial lung disease in systemic sclerosis. Arthritis Care Res 64(4):519\u2013524. https:\/\/doi.org\/10.1002\/acr.21583","journal-title":"Arthritis Care Res"},{"issue":"11","key":"5918_CR4","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1164\/rccm.200706-877OC","volume":"177","author":"NS Goh","year":"2008","unstructured":"Goh NS, Desai SR, Veeraraghavan S, Hansell DM, Copley SJ, Maher TM, Corte TJ, Sander CR, Ratoff J, Devaraj A, Bozovic G, Denton CP, Black CM, du Bois RM, Wells AU (2008) Interstitial lung disease in systemic sclerosis: a simple staging system. Am J Respir Crit Care Med 177(11):1248\u20131254. https:\/\/doi.org\/10.1164\/rccm.200706-877OC","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"5918_CR5","doi-asserted-by":"publisher","first-page":"322","DOI":"10.5606\/ArchRheumatol.2018.6630","volume":"33","author":"E Jung","year":"2018","unstructured":"Jung E, Suh CH, Kim HA, Jung JY (2018) Clinical characteristics of systemic sclerosis with \u0131nterstitial lung disease. Arch Rheumatol 33(3):322\u2013327. https:\/\/doi.org\/10.5606\/ArchRheumatol.2018.6630","journal-title":"Arch Rheumatol"},{"issue":"3","key":"5918_CR6","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1148\/radiol.12112516","volume":"266","author":"T Watadani","year":"2013","unstructured":"Watadani T, Sakai F, Johkoh T, Noma S, Akira M, Fujimoto K, Bankier AA, Lee KS, M\u00fcller NL, Song JW, Park JS, Lynch DA, Hansell DM, Remy-Jardin M, Franquet T, Sugiyama Y (2013) Interobserver variability in the CT assessment of honeycombing in the lungs. Radiology 266(3):936\u2013944. https:\/\/doi.org\/10.1148\/radiol.12112516","journal-title":"Radiology"},{"issue":"1","key":"5918_CR7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1136\/thoraxjnl-2015-207252","volume":"71","author":"SL Walsh","year":"2016","unstructured":"Walsh SL, Calandriello L, Sverzellati N, Wells AU, Hansell DM (2016) UIP Observer Consort. Interobserver agreement for the ATS\/ERS\/JRS\/ALAT criteria for a UIP pattern on CT. Thorax 71(1):45\u201351. https:\/\/doi.org\/10.1136\/thoraxjnl-2015-207252","journal-title":"Thorax"},{"issue":"5 Suppl 62","key":"5918_CR8","first-page":"S26","volume":"28","author":"HG Kim","year":"2010","unstructured":"Kim HG, Tashkin DP, Clements PJ, Li G, Brown MS, Elashoff R, Gjertson DW, Abtin F, Lynch DA, Strollo DC, Goldin JG (2010) A computer-aided diagnosis system for quantitative scoring of extent of lung fibrosis in scleroderma patients. Clin Exp Rheumatol 28(5 Suppl 62):S26-35","journal-title":"Clin Exp Rheumatol"},{"issue":"1","key":"5918_CR9","doi-asserted-by":"publisher","first-page":"9468","DOI":"10.1038\/s41598-019-45990-7","volume":"9","author":"M Bocchino","year":"2019","unstructured":"Bocchino M, Bruzzese D, D\u2019Alto M, Argiento P, Borgia A, Capaccio A, Romeo E, Russo B, Sanduzzi A, Valente T, Sverzellati N, Rea G, Vettori S (2019) Performance of a new quantitative computed tomography index for interstitial lung disease assessment in systemic sclerosis. Sci Rep 9(1):9468. https:\/\/doi.org\/10.1038\/s41598-019-45990-7","journal-title":"Sci Rep"},{"issue":"3","key":"5918_CR10","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1378\/chest.06-1401","volume":"131","author":"G Camiciottoli","year":"2007","unstructured":"Camiciottoli G, Orlandi I, Bartolucci M, Meoni E, Nacci F, Diciotti S, Barcaroli C, Conforti ML, Pistolesi M, Matucci-Cerinic M, Mascalchi M (2007) Lung CT densitometry in systemic sclerosis: correlation with lung function, exercise testing, and quality of life. Chest 131(3):672\u2013681. https:\/\/doi.org\/10.1378\/chest.06-1401","journal-title":"Chest"},{"issue":"9","key":"5918_CR11","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1016\/j.rmed.2007.04.016","volume":"101","author":"J Stolk","year":"2007","unstructured":"Stolk J, Putter H, Bakker EM, Shaker SB, Parr DG, Piitulainen E, Russi EW, Grebski E, Dirksen A, Stockley RA, Reiber JH, Stoel BC (2007) Progression parameters for emphysema: a clinical investigation. Respir Med 101(9):1924\u20131930. https:\/\/doi.org\/10.1016\/j.rmed.2007.04.016","journal-title":"Respir Med"},{"issue":"11","key":"5918_CR12","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","volume":"72","author":"F van den Hoogen","year":"2013","unstructured":"van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A et al (2013) Classification criteria for systemic sclerosis: an American college of rheumatology\/European league against rheumatism collaborative initiative. Ann Rheum Dis 72(11):1747\u20131755. https:\/\/doi.org\/10.1136\/annrheumdis-2013-204424","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"5918_CR13","first-page":"202","volume":"15","author":"EC LeRoy","year":"1988","unstructured":"LeRoy EC, Black C, Fleischmajer R, Jablonska S, Krieg T, Medsger TA Jr, Rowell N, Wollheim F (1988) Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 15(2):202\u2013205","journal-title":"J Rheumatol"},{"issue":"12","key":"5918_CR14","doi-asserted-by":"publisher","first-page":"3256","DOI":"10.1002\/art.39405","volume":"67","author":"YA Suliman","year":"2015","unstructured":"Suliman YA, Dobrota R, Huscher D, Nguyen-Kim TD, Maurer B, Jordan S, Speich R, Frauenfelder T, Distler O (2015) Brief report: pulmonary function tests: high rate of false-negative results in the early detection and screening of scleroderma-related \u0131nterstitial lung disease. Arthritis Rheumatol 67(12):3256\u20133261. https:\/\/doi.org\/10.1002\/art.39405","journal-title":"Arthritis Rheumatol"},{"issue":"2","key":"5918_CR15","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1097\/RCT.0b013e31820ccf18","volume":"35","author":"KE Shin","year":"2011","unstructured":"Shin KE, Chung MJ, Jung MP, Choe BK, Lee KS (2011) Quantitative computed tomographic indexes in diffuse interstitial lung disease: correlation with physiologic tests and computed tomography visual scores. J Comput Assist Tomogr 35(2):266\u2013271. https:\/\/doi.org\/10.1097\/RCT.0b013e31820ccf18","journal-title":"J Comput Assist Tomogr"},{"issue":"5","key":"5918_CR16","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.2214\/ajr.175.5.1751329","volume":"175","author":"HU Kauczor","year":"2000","unstructured":"Kauczor HU, Heitmann K, Heussel CP, Marwede D, Uthmann T, Thelen M (2000) Automatic detection and quantification of ground-glass opacities on high-resolution CT using multiple neural networks: comparison with a density mask. AJR Am J Roentgenol 175(5):1329\u20131334. https:\/\/doi.org\/10.2214\/ajr.175.5.1751329","journal-title":"AJR Am J Roentgenol"},{"key":"5918_CR17","unstructured":"Cohen J (2003) Applied multiple regression\/correlation analysis for the behavioral sciences. 3rd ed. Mahwah, Erlbaum L Associates, p 703"},{"issue":"4","key":"5918_CR18","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13931","volume":"75","author":"D TemizKaradag","year":"2021","unstructured":"TemizKaradag D, Cakir O, Komac A, Yazici A, Cefle A (2021) Software-based quantitative analysis of lung parenchyma in patients with systemic sclerosis may provide new generation data for pulmonary fibrosis. Int J Clin Pract 75(4):e13931. https:\/\/doi.org\/10.1111\/ijcp.13931","journal-title":"Int J Clin Pract"},{"issue":"6","key":"5918_CR19","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1111\/crj.12451","volume":"11","author":"A Ariani","year":"2017","unstructured":"Ariani A, Aiello M, Silva M, Alfieri V, Bonati E, Lumetti F, Delsante G, Sverzellati N, Chetta A (2017) Quantitative CT indexes are significantly associated with exercise oxygen desaturation in interstitial lung disease related to systemic sclerosis. Clin Respir J 11(6):983\u2013989. https:\/\/doi.org\/10.1111\/crj.12451","journal-title":"Clin Respir J"},{"issue":"3","key":"5918_CR20","doi-asserted-by":"publisher","first-page":"e0152505","DOI":"10.1371\/journal.pone.0152505","volume":"11","author":"H Ohkubo","year":"2016","unstructured":"Ohkubo H, Kanemitsu Y, Uemura T, Takakuwa O, Takemura M, Maeno K, Ito Y, Oguri T, Kazawa N, Mikami R, Niimi A (2016) Normal lung quantification in usual \u0131nterstitial pneumonia pattern: the \u0131mpact of threshold-based volumetric CT analysis for the staging of \u0131diopathic pulmonary fibrosis. PLoS One 11(3):e0152505. https:\/\/doi.org\/10.1371\/journal.pone.0152505","journal-title":"PLoS One"},{"issue":"7","key":"5918_CR21","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1513\/AnnalsATS.201910-741OC","volume":"17","author":"DC Saldana","year":"2020","unstructured":"Saldana DC, Hague CJ, Murphy D, Coxson HO, Tschirren J, Peterson S, Sieren JP, Kirby M, Ryerson CJ (2020) Association of computed tomography densitometry with disease severity, functional decline, and survival in systemic sclerosis-associated \u0131nterstitial lung disease. Ann Am Thorac 17(7):813\u2013820. https:\/\/doi.org\/10.1513\/AnnalsATS.201910-741OC","journal-title":"Ann Am Thorac"},{"issue":"1","key":"5918_CR22","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1148\/radiol.2017161177","volume":"285","author":"SM Humphries","year":"2017","unstructured":"Humphries SM, Yagihashi K, Huckleberry J, Rho BH, Schroeder JD, Strand M, Schwarz MI, Flaherty KR, Kazerooni EA, van Beek EJR, Lynch DA (2017) Idiopathic pulmonary fibrosis: data-driven textural analysis of extent of fibrosis at baseline and 15-month follow-up. Radiology 285(1):270\u2013278. https:\/\/doi.org\/10.1148\/radiol.2017161177","journal-title":"Radiology"},{"issue":"15","key":"5918_CR23","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12890-015-0069-0","volume":"24","author":"K Tanizawa","year":"2015","unstructured":"Tanizawa K, Handa T, Nagai S, Hirai T, Kubo T, Oguma T, Ito I, Ito Y, Watanabe K, Aihara K, Ikezoe K, Oga T, Chin K, Izumi T, Mishima M (2015) Clinical impact of high-attenuation and cystic areas on computed tomography in fibrotic idiopathic interstitial pneumonias. BMC Pulm Med 24(15):74. https:\/\/doi.org\/10.1186\/s12890-015-0069-0","journal-title":"BMC Pulm Med"},{"issue":"6","key":"5918_CR24","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1093\/rheumatology\/kew480","volume":"56","author":"A Ariani","year":"2017","unstructured":"Ariani A, Silva M, Seletti V, Bravi E, Saracco M, Parisi S, De Gennaro F, Idolazzi L, Caramaschi P, Benini C, Bodini FC, Scir\u00e8 CA, Carrara G, Lumetti F, Alfieri V, Bonati E, Lucchini G, Aiello M, Santilli D, Mozzani F, Imberti D, Michieletti E, Arrigoni E, Delsante G, Pellerito R, Fusaro E, Chetta A, Sverzellati N (2017) Quantitative chest computed tomography is associated with two prediction models of mortality in interstitial lung disease related to systemic sclerosis. Rheumatology (Oxford) 56(6):922\u2013927. https:\/\/doi.org\/10.1093\/rheumatology\/kew480","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"5918_CR25","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1136\/ard.2006.062901","volume":"66","author":"UA Walker","year":"2007","unstructured":"Walker UA, Tyndall A, Czirj\u00e1k L, Denton C, Farge-Bancel D, Kowal-Bielecka O, M\u00fcller-Ladner U, Bocelli-Tyndall C, Matucci-Cerinic M (2007) Clinical risk assessment of organ manifestations in systemic sclerosis: a report from the EULAR Scleroderma Trials And Research group database. Ann Rheum Dis 66(6):754\u2013763. https:\/\/doi.org\/10.1136\/ard.2006.062901","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"5918_CR26","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.acra.2009.08.007","volume":"17","author":"DS Gierada","year":"2010","unstructured":"Gierada DS, Bierhals AJ, Choong CK et al (2010) Effects of CT section thickness and reconstruction kernel on emphysema quantification relationship to the magnitude of the CT emphysema index. Acad Radiol 17(2):146\u2013156. https:\/\/doi.org\/10.1016\/j.acra.2009.08.007","journal-title":"Acad Radiol"},{"key":"5918_CR27","doi-asserted-by":"publisher","unstructured":"Ye Xu, Edwin J.R. van Beek, Geoffrey McLennan, Junfeng Guo, Milan Sonka, Eric Hoffman Effect of mixing scanner types and reconstruction kernels on the characterization of lung parenchymal pathologies: emphysema, interstitial pulmonary fibrosis and normal non-smokers. Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61430M (13 March 2006). https:\/\/doi.org\/10.1117\/12.657595","DOI":"10.1117\/12.657595"},{"issue":"1","key":"5918_CR28","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1148\/radiology.191.1.8134584","volume":"191","author":"MT Wu","year":"1994","unstructured":"Wu MT, Chang JM, Chiang AA, Lu JY, Hsu HK, Hsu WH, Yang CF (1994) Use of quantitative CT to predict postoperative lung function in patients with lung cancer. Radiology 191(1):257\u2013262. https:\/\/doi.org\/10.1148\/radiology.191.1.8134584","journal-title":"Radiology"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-021-05918-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-021-05918-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-021-05918-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T06:32:26Z","timestamp":1642746746000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-021-05918-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,16]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["5918"],"URL":"https:\/\/doi.org\/10.1007\/s10067-021-05918-x","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,16]]},"assertion":[{"value":"22 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with animals performed by any of the authors. The corresponding author certifies that all authors approved the entirety of the submitted material and contributed actively to the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}