{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:30:01Z","timestamp":1762900201862,"version":"3.37.3"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s10067-021-05996-x","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T13:02:53Z","timestamp":1638190973000},"page":"1131-1137","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Repolarization in systemic sclerosis: a meta-analysis"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9586-9109","authenticated-orcid":false,"given":"Yehuda","family":"Wexler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3931-8003","authenticated-orcid":false,"given":"Udi","family":"Nussinovitch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"5996_CR1","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1056\/NEJM198401193100302","volume":"310","author":"WP Follansbee","year":"1984","unstructured":"WP Follansbee EI Curtiss TA Medsger  1984 Physiologic abnormalities of cardiac function in progressive systemic sclerosis with diffuse scleroderma N Engl J Med 310 142 148 https:\/\/doi.org\/10.1056\/NEJM198401193100302","journal-title":"N Engl J Med"},{"key":"5996_CR2","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/0002-9343(76)90373-9","volume":"61","author":"RL Ridolfi","year":"1976","unstructured":"RL Ridolfi BH Bulkley GM Hutchins 1976 The cardiac conduction system in progressive systemic sclerosis. Clinical and pathologic features of 35 patients Am J Med 61 361 366 https:\/\/doi.org\/10.1016\/0002-9343(76)90373-9","journal-title":"Am J Med"},{"key":"5996_CR3","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1161\/01.CIR.53.3.483","volume":"53","author":"BH Bulkley","year":"1976","unstructured":"BH Bulkley RL Ridolfi WR Salyer GM Hutchins 1976 Myocardial lesions of progressive systemic sclerosis A cause of cardiac dysfunction Circulation 53 483 490 https:\/\/doi.org\/10.1161\/01.CIR.53.3.483","journal-title":"A cause of cardiac dysfunction Circulation"},{"key":"5996_CR4","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.rdc.2007.12.002","volume":"34","author":"HC Champion","year":"2008","unstructured":"HC Champion 2008 The heart in scleroderma Rheum Dis Clin North Am 34 181 190","journal-title":"Rheum Dis Clin North Am"},{"key":"5996_CR5","doi-asserted-by":"publisher","first-page":"993","DOI":"10.4330\/wjc.v6.i9.993","volume":"6","author":"S Lambova","year":"2014","unstructured":"S Lambova 2014 Cardiac manifestations in systemic sclerosis World J Cardiol 6 993 https:\/\/doi.org\/10.4330\/wjc.v6.i9.993","journal-title":"World J Cardiol"},{"key":"5996_CR6","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1136\/ard.2009.114264","volume":"69","author":"AJ Tyndall","year":"2010","unstructured":"AJ Tyndall B Bannert M Vonk  2010 Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database Ann Rheum Dis 69 1809 1815 https:\/\/doi.org\/10.1136\/ard.2009.114264","journal-title":"Ann Rheum Dis"},{"key":"5996_CR7","first-page":"1172","volume":"53","author":"A Vacca","year":"2014","unstructured":"A Vacca C Meune J Gordon  2014 Cardiac arrhythmias and conduction defects in systemic sclerosis Rheumatol (United Kingdom) 53 1172 1177","journal-title":"Rheumatol (United Kingdom)"},{"key":"5996_CR8","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.semarthrit.2008.06.002","volume":"39","author":"FF Al-Dhaher","year":"2010","unstructured":"FF Al-Dhaher JE Pope JM Ouimet 2010 Determinants of morbidity and mortality of systemic sclerosis in Canada Semin Arthritis Rheum 39 269 277","journal-title":"Semin Arthritis Rheum"},{"key":"5996_CR9","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1136\/ard.2006.066340","volume":"67","author":"L Czirj\u00e1k","year":"2008","unstructured":"L Czirj\u00e1k G Kum\u00e1novics C Varj\u00fa  2008 Survival and causes of death in 366 Hungarian patients with systemic sclerosis Ann Rheum Dis 67 59 63 https:\/\/doi.org\/10.1136\/ard.2006.066340","journal-title":"Ann Rheum Dis"},{"key":"5996_CR10","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s00296-018-4207-x","volume":"39","author":"P. B, M. C, B. K,","year":"2019","unstructured":"P. B, M. C, B. K,   2019 Comparison of non-invasive assessment of arrhythmias, conduction disturbances and cardiac autonomic tone in systemic sclerosis and systemic lupus erythematosus Rheumatol Int 39 301 310 https:\/\/doi.org\/10.1007\/s00296-018-4207-x","journal-title":"Rheumatol Int"},{"key":"5996_CR11","first-page":"127","volume":"243","author":"A. S, S. M, L. F,","year":"1998","unstructured":"A. S, S. M, L. F,   1998 QT interval and QT dispersion in systemic sclerosis (scleroderma) J Intern Med 243 127 132","journal-title":"J Intern Med"},{"key":"5996_CR12","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.ijcard.2015.11.004","volume":"203","author":"A Gigante","year":"2016","unstructured":"A Gigante E Rosato M Liberatori  2016 In systemic sclerosis prolonged QTc interval is associated with reduced exercise tolerance Int J Cardiol 203 570 572 https:\/\/doi.org\/10.1016\/j.ijcard.2015.11.004","journal-title":"Int J Cardiol"},{"key":"5996_CR13","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0167-5273(96)02808-2","volume":"57","author":"S Morelli","year":"1996","unstructured":"S Morelli A Sgreccia L Ferrante  1996 Relationships between electrocardiographic and echocardiographic findings in systemic sclerosis (scleroderma) Int J Cardiol 57 151 160 https:\/\/doi.org\/10.1016\/S0167-5273(96)02808-2","journal-title":"Int J Cardiol"},{"key":"5996_CR14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.5606\/ArchRheumatol.2016.5753","volume":"31","author":"\u00c7. Y, M.E. Y, K. GY,","year":"2016","unstructured":"\u00c7. Y, M.E. Y, K. GY,   2016 The assessment of Tp-e interval and Tp-e\/QT ratio in patients with systemic sclerosis Arch Rheumatol 31 139 144 https:\/\/doi.org\/10.5606\/ArchRheumatol.2016.5753","journal-title":"Arch Rheumatol"},{"key":"5996_CR15","doi-asserted-by":"publisher","first-page":"242","DOI":"10.5603\/CJ.a2016.0021","volume":"23","author":"S Okutucu","year":"2016","unstructured":"S Okutucu UN Karakulak H Aksoy  2016 Prolonged Tp-e interval and Tp-e\/Qt correlates well with modified Rodnan skin severity score in patients with systemic sclerosis Cardiol J 23 242 249 https:\/\/doi.org\/10.5603\/CJ.a2016.0021","journal-title":"Cardiol J"},{"key":"5996_CR16","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3109\/03009742.2013.843720","volume":"43","author":"A Nordin","year":"2014","unstructured":"A Nordin L Bj\u00f6rn\u00e5dal A Larsson  2014 Electrocardiography in 110 patients with systemic sclerosis: a cross-sectional comparison with population-based controls Scand J Rheumatol 43 221 225 https:\/\/doi.org\/10.3109\/03009742.2013.843720","journal-title":"Scand J Rheumatol"},{"key":"5996_CR17","doi-asserted-by":"publisher","first-page":"179","DOI":"10.5152\/eurjrheum.2019.19074","volume":"6","author":"U Nussinovitch","year":"2019","unstructured":"U Nussinovitch S Rubin Y Levy  2019 QT variability index in patients with systemic sclerosis Eur J Rheumatol 6 179 183 https:\/\/doi.org\/10.5152\/eurjrheum.2019.19074","journal-title":"Eur J Rheumatol"},{"key":"5996_CR18","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1148\/RADIOL.2016160816\/ASSET\/IMAGES\/LARGE\/RADIOL.2016160816.TBL4.JPEG","volume":"282","author":"YY Inoue","year":"2017","unstructured":"YY Inoue B Ambale-Venkatesh N Mewton  2017 Electrocardiographic impact of myocardial diffuse fibrosis and scar: MESA (Multi-Ethnic study of atherosclerosis Radiology 282 690 698 https:\/\/doi.org\/10.1148\/RADIOL.2016160816\/ASSET\/IMAGES\/LARGE\/RADIOL.2016160816.TBL4.JPEG","journal-title":"Radiology"},{"key":"5996_CR19","first-page":"233","volume":"18","author":"N El-Sherif","year":"2011","unstructured":"N El-Sherif G Turitto 2011 Electrolyte disorders and arrhythmogenesis Cardiol J 18 233 245","journal-title":"Cardiol J"},{"key":"5996_CR20","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/0002-9149(87)91107-6","volume":"59","author":"M Laakso","year":"1987","unstructured":"M Laakso \u00c5 \u00c5berg J Savola  1987 Diseases and drugs causing prolongation of the QT interval Am J Cardiol 59 862 865 https:\/\/doi.org\/10.1016\/0002-9149(87)91107-6","journal-title":"Am J Cardiol"},{"key":"5996_CR21","doi-asserted-by":"publisher","first-page":"687","DOI":"10.3238\/ARZTEBL.2011.0687","volume":"108","author":"K Wenzel-Seifert","year":"2011","unstructured":"K Wenzel-Seifert M Wittmann E Haen 2011 QTc prolongation by psychotropic drugs and the risk of Torsade de Pointes Dtsch Arztebl Int 108 687 https:\/\/doi.org\/10.3238\/ARZTEBL.2011.0687","journal-title":"Dtsch Arztebl Int"},{"key":"5996_CR22","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1093\/RHEUMATOLOGY\/KEZ644","volume":"59","author":"V Sebesty\u00e9n","year":"2020","unstructured":"V Sebesty\u00e9n G Szucs D P\u00e1ll  2020 Electrocardiographic markers for the prediction of ventricular arrhythmias in patients with systemic sclerosis Rheumatology 59 478 486 https:\/\/doi.org\/10.1093\/RHEUMATOLOGY\/KEZ644","journal-title":"Rheumatology"},{"doi-asserted-by":"publisher","unstructured":"Liberati A, Altman DG, Tetzlaff J, et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:. https:\/\/doi.org\/10.1136\/bmj.b2700","key":"5996_CR23","DOI":"10.1136\/bmj.b2700"},{"key":"5996_CR24","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JPT Higgins","year":"2003","unstructured":"JPT Higgins SG Thompson JJ Deeks DG Altman 2003 Measuring inconsistency in meta-analyses Br Med J 327 557 560","journal-title":"Br Med J"},{"key":"5996_CR25","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2020.19215","author":"U Nussinovitch","year":"2020","unstructured":"U Nussinovitch G Beeri S Rubin  2020 Repolarization dispersion in patients with systemic sclerosis Eur J Rheumatol https:\/\/doi.org\/10.5152\/eurjrheum.2020.19215","journal-title":"Eur J Rheumatol"},{"key":"5996_CR26","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00380-009-1197-3","volume":"25","author":"T Karaahmet","year":"2010","unstructured":"T Karaahmet   Tigen \u00b7 K, Gurel \u00b7 E,   2010 Impact of systemic sclerosis on electromechanical characteristics of the heart Hear Vessel 25 223 228 https:\/\/doi.org\/10.1007\/s00380-009-1197-3","journal-title":"Hear Vessel"},{"key":"5996_CR27","doi-asserted-by":"publisher","first-page":"591","DOI":"10.3949\/ccjm.75.8.591","volume":"75","author":"E Levine","year":"2008","unstructured":"E Levine SZ Rosero AS Budzikowski  2008 Congenital long QT syndrome: considerations for primary care physicians Cleve Clin J Med 75 591 600","journal-title":"Cleve Clin J Med"},{"key":"5996_CR28","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.1161\/CIRCULATIONAHA.106.661082","volume":"115","author":"NW Taggart","year":"2007","unstructured":"NW Taggart CM Haglund DJ Tester MJ Ackerman 2007 Diagnostic miscues in congenital long-QT syndrome Circulation 115 2613 2620 https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.106.661082","journal-title":"Circulation"},{"key":"5996_CR29","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1136\/bjsm.2008.054734","volume":"43","author":"JN Johnson","year":"2009","unstructured":"JN Johnson MJ Ackerman 2009 QTc: how long is too long? Br J Sports Med 43 657 662","journal-title":"Br J Sports Med"},{"key":"5996_CR30","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.jacc.2008.12.014","volume":"53","author":"PM Rautaharju","year":"2009","unstructured":"PM Rautaharju B Surawicz LS Gettes 2009 AHA\/ACCF\/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram. Part IV: The ST Segment, T and U Waves, and the QT Interval A Scientific Statement From the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society J Am Coll Cardiol 53 982 991","journal-title":"J Am Coll Cardiol"},{"key":"5996_CR31","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1002\/ART.40560","volume":"70","author":"A Fern\u00e1ndez-Codina","year":"2018","unstructured":"A Fern\u00e1ndez-Codina KM Walker JE Pope 2018 Treatment algorithms for systemic sclerosis according to experts Arthritis Rheumatol (Hoboken, NJ) 70 1820 1828 https:\/\/doi.org\/10.1002\/ART.40560","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"key":"5996_CR32","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/15563650500514558","volume":"44","author":"CY Chen","year":"2006","unstructured":"CY Chen FL Wang CC Lin 2006 Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia Clin Toxicol (Phila) 44 173 175 https:\/\/doi.org\/10.1080\/15563650500514558","journal-title":"Clin Toxicol (Phila)"},{"key":"5996_CR33","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/j.jacc.2018.01.078","volume":"71","author":"A Mazzanti","year":"2018","unstructured":"A Mazzanti R Maragna G Vacanti  2018 Interplay between genetic substrate, QTc duration, and arrhythmia risk in patients with long QT syndrome J Am Coll Cardiol 71 1663 1671 https:\/\/doi.org\/10.1016\/j.jacc.2018.01.078","journal-title":"J Am Coll Cardiol"},{"key":"5996_CR34","first-page":"1388","volume":"29","author":"M Paradiso","year":"2002","unstructured":"M Paradiso M Franco Di A Musca  2002 Ventricular late potentials in systemic sclerosis: Relationship with skin involvement J Rheumatol 29 1388 1392","journal-title":"J Rheumatol"},{"key":"5996_CR35","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1002\/art.1780281110","volume":"28","author":"C Ferri","year":"1985","unstructured":"C Ferri L Bernini MG Bongiorni  1985 Noninvasive evaluation of cardiac dysrhythmias, and their relationship with multisystemic symptoms, in progressive systemic sclerosis patients Arthritis Rheum 28 1259 1266 https:\/\/doi.org\/10.1002\/art.1780281110","journal-title":"Arthritis Rheum"},{"key":"5996_CR36","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.semarthrit.2014.07.001","volume":"44","author":"C Massie","year":"2014","unstructured":"C Massie M Hudson S Tatibouet  2014 Absence of an association between anti-Ro antibodies and prolonged QTc interval in systemic sclerosis: a multicenter study of 689 patients Semin Arthritis Rheum 44 338 344 https:\/\/doi.org\/10.1016\/j.semarthrit.2014.07.001","journal-title":"Semin Arthritis Rheum"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-021-05996-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-021-05996-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-021-05996-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T16:38:34Z","timestamp":1647016714000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-021-05996-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,29]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["5996"],"URL":"https:\/\/doi.org\/10.1007\/s10067-021-05996-x","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"type":"print","value":"0770-3198"},{"type":"electronic","value":"1434-9949"}],"subject":[],"published":{"date-parts":[[2021,11,29]]},"assertion":[{"value":"5 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}