{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:24:45Z","timestamp":1790717085808,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s10067-022-06053-x","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:05:58Z","timestamp":1641427558000},"page":"1457-1463","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Indications and risk factors for hospitalization in patients with primary Sj\u00f6gren syndrome: experience from a tertiary center in Turkey"],"prefix":"10.1007","volume":"41","author":[{"given":"M\u00fc\u00e7teba Enes","family":"Yayla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didem","family":"\u015eahin Ero\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Uslu Yurteri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe Bahar","family":"Kele\u015fo\u011flu Din\u00e7er","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Sezer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine G\u00f6zde","family":"Aydemir\u00a0G\u00fcl\u00f6ks\u00fcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Levent","family":"Y\u00fcksel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Recep","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u015fk\u0131n","family":"Ate\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahsin Murat","family":"Turgay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclay","family":"K\u0131n\u0131kl\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"6053_CR1","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1093\/rheumatology\/keh714","volume":"44","author":"M Ramos-Casals","year":"2005","unstructured":"Ramos-Casals M, Font J (2005) Primary Sjogren\u2019s syndrome: current and emergent aetiopathogenic concepts. Rheumatology (Oxford) 44:1354\u20131367","journal-title":"Rheumatology (Oxford)"},{"key":"6053_CR2","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1001\/archinte.164.12.1275","volume":"164","author":"SS Kassan","year":"2004","unstructured":"Kassan SS, Moutsopoulos HM (2004) Clinical manifestations and early diagnosis of Sj\u00f6gren syndrome. Arch Intern Med 164:1275\u20131284","journal-title":"Arch Intern Med"},{"key":"6053_CR3","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1056\/NEJMcp1702514","volume":"378","author":"X Mariette","year":"2018","unstructured":"Mariette X, Criswell LA (2018) Primary Sj\u00f6gren\u2019s syndrome. N Engl J Med 378:931\u2013939","journal-title":"N Engl J Med"},{"key":"6053_CR4","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1136\/ard.2009.110619","volume":"69","author":"R Seror","year":"2010","unstructured":"Seror R, Ravaud P, Bowman SJ, Baron G, Tzioufas A, Theander E, Gottenberg J-E, Bootsma H, Mariette X, Vitali C (2010) EULAR Sj\u00f6gren\u2019s syndrome disease activity index: development of a consensus systemic disease activity index for primary Sj\u00f6gren\u2019s syndrome. Ann Rheum Dis 69:1103\u20131109","journal-title":"Ann Rheum Dis"},{"key":"6053_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1136\/annrheumdis-2019-216114","volume":"79","author":"M Ramos-Casals","year":"2020","unstructured":"Ramos-Casals M, Brito-Zer\u00f3n P, Bombardieri S, Bootsma H, De Vita S, D\u00f6rner T, Fisher BA, Gottenberg J-E, Hernandez-Molina G, Kocher A (2020) EULAR recommendations for the management of Sj\u00f6gren\u2019s syndrome with topical and systemic therapies. Ann Rheum Dis 79:3\u201318","journal-title":"Ann Rheum Dis"},{"key":"6053_CR6","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/acr.23015","volume":"69","author":"I R\u00faa-Figueroa","year":"2017","unstructured":"R\u00faa-Figueroa I, Fern\u00e1ndez Castro M, Andreu JL, Sanchez-Piedra C, Mart\u00ednez-Taboada V, Oliv\u00e9 A, L\u00f3pez-Longo J, Rosas J, Galindo M, Calvo-Al\u00e9n J (2017) Comorbidities in patients with primary Sj\u00f6gren\u2019s syndrome and systemic lupus erythematosus: a comparative registries-based study. Arthritis Care Res 69:38\u201345","journal-title":"Arthritis Care Res"},{"key":"6053_CR7","first-page":"S47","volume":"38","author":"JA Singh","year":"2020","unstructured":"Singh JA, Cleveland JD (2020) Serious infections in Sj\u00f6gren\u2019s syndrome patients: a national US study. Clin Exp Rheumatol 38:S47\u2013S52","journal-title":"Clin Exp Rheumatol"},{"key":"6053_CR8","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1093\/rheumatology\/kem273","volume":"46","author":"L Chung","year":"2007","unstructured":"Chung L, Krishnan E, Chakravarty E (2007) Hospitalizations and mortality in systemic sclerosis: results from the Nationwide Inpatient Sample. Rheumatology (Oxford) 46:1808\u20131813","journal-title":"Rheumatology (Oxford)"},{"key":"6053_CR9","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1002\/acr2.11195","volume":"2","author":"AM Manadan","year":"2020","unstructured":"Manadan AM, Kambhatla S, Gauto-Mariotti E, Okoli C, Block JA (2020) Reasons for hospitalization and in-hospital mortality in adult systemic lupus erythematosus. ACR open rheumatology 2:683\u2013689","journal-title":"ACR open rheumatology"},{"key":"6053_CR10","first-page":"721","volume":"33","author":"Y Atisha-Fregoso","year":"2015","unstructured":"Atisha-Fregoso Y, Rivera-Vicencio Y, Ba\u00f1os-Pelaez M, Hern\u00e1ndez-Molina G (2015) Main causes and risk factors for hospitalisation in patients with primary Sj\u00f6gren\u2019s syndrome. Clin Exp Rheumatol 33:721\u2013725","journal-title":"Clin Exp Rheumatol"},{"key":"6053_CR11","doi-asserted-by":"crossref","unstructured":"Maciel G, Servioli L, Nannini C, Berti A, Crowson CS, Achenbach SJ, Matteson EL, Cornec D (2018) Hospitalisation rates among patients with primary Sj\u00f6gren\u2019s syndrome: a population-based study, 1995\u20132016. RMD open 4:e000575.","DOI":"10.1136\/rmdopen-2017-000575"},{"key":"6053_CR12","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/art.39859","volume":"69","author":"CH Shiboski","year":"2017","unstructured":"Shiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, Lietman TM, Rasmussen A, Scofield H, Vitali C, Bowman SJ (2017) 2016 American College of Rheumatology\/European League Against Rheumatism classification criteria for primary Sj\u00f6gren\u2019s syndrome: a consensus and data-driven methodology involving three international patient cohorts. Arthritis Rheumatol 69:35\u201345","journal-title":"Arthritis Rheumatol"},{"key":"6053_CR13","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373\u2013383","journal-title":"J Chronic Dis"},{"key":"6053_CR14","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1177\/0961203316640916","volume":"25","author":"J Lee","year":"2016","unstructured":"Lee J, Park D, Kang J, Choi S, Yim Y, Kim J, Lee K, Wen L, Kim T, Park Y (2016) The rate of and risk factors for frequent hospitalization in systemic lupus erythematosus: results from the Korean lupus network registry. Lupus 25:1412\u20131419","journal-title":"Lupus"},{"key":"6053_CR15","doi-asserted-by":"publisher","first-page":"8061","DOI":"10.12659\/MSM.919381","volume":"25","author":"H Liang","year":"2019","unstructured":"Liang H, Pan HF, Tao JH, Ye DQ (2019) Causes and factors associated with frequent hospitalization in Chinese patients with systemic lupus erythematosus: an ambispective cohort study. Med Sci Monit 25:8061","journal-title":"Med Sci Monit"},{"key":"6053_CR16","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1177\/0961203316676641","volume":"26","author":"A Anandarajah","year":"2017","unstructured":"Anandarajah A, Luc M, Ritchlin C (2017) Hospitalization of patients with systemic lupus erythematosus is a major cause of direct and indirect healthcare costs. Lupus 26:756\u2013761","journal-title":"Lupus"},{"key":"6053_CR17","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s10067-012-2131-0","volume":"32","author":"S Netwijitpan","year":"2013","unstructured":"Netwijitpan S, Foocharoen C, Mahakkanukrauh A, Suwannaroj S, Nanagara R (2013) Indications for hospitalization and in-hospital mortality in Thai systemic sclerosis. Clin Rheumatol 32:361\u2013367","journal-title":"Clin Rheumatol"},{"key":"6053_CR18","doi-asserted-by":"publisher","first-page":"877","DOI":"10.3899\/jrheum.200737","volume":"48","author":"CM Coffey","year":"2021","unstructured":"Coffey CM, Sandhu AS, Crowson CS, Achenbach SJ, Matteson EL, Osborn TG, Warrington KJ, Makol A (2021) Hospitalization rates are highest in the first 5 years of systemic sclerosis: results from a population-based cohort (1980\u20132016). J Rheumatol 48:877\u2013882","journal-title":"J Rheumatol"},{"key":"6053_CR19","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/1756-185X.12031","volume":"16","author":"C Foocharoen","year":"2013","unstructured":"Foocharoen C, Thavornpitak Y, Mahakkanukrauh A, Suwannaroj S, Nanagara R (2013) Admission rate and characteristics of hospitalized systemic connective tissue disorders: analysis from a nationwide Thailand healthcare database. Int J Rheum Dis 16:41\u201346","journal-title":"Int J Rheum Dis"},{"key":"6053_CR20","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1191\/0961203303lu452oa","volume":"12","author":"C Edwards","year":"2003","unstructured":"Edwards C, Lian T, Badsha H, Teh C, Arden N, Chng H (2003) Hospitalization of individuals with systemic lupus erythematosus: characteristics and predictors of outcome. Lupus 12:672\u2013676","journal-title":"Lupus"},{"key":"6053_CR21","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1093\/rheumatology\/kes391","volume":"52","author":"J Lee","year":"2013","unstructured":"Lee J, Dhillon N, Pope J (2013) All-cause hospitalizations in systemic lupus erythematosus from a large Canadian referral centre. Rheumatology (Oxford) 52:905\u2013909","journal-title":"Rheumatology (Oxford)"},{"key":"6053_CR22","doi-asserted-by":"publisher","first-page":"163","DOI":"10.5114\/reum.2017.69776","volume":"55","author":"S Shenavandeh","year":"2017","unstructured":"Shenavandeh S, Naseri R (2017) Assessment of hospitalization and mortality of scleroderma in-patients: a thirteen-year study. Reumatologia 55:163","journal-title":"Reumatologia"},{"key":"6053_CR23","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1111\/1756-185X.13940","volume":"23","author":"Y Park","year":"2020","unstructured":"Park Y, Lee J, Park SH, Kwok SK (2020) Male patients with primary Sj\u00f6gren\u2019s syndrome: a distinct clinical subgroup? Int J Rheum Dis 23:1388\u20131395","journal-title":"Int J Rheum Dis"},{"key":"6053_CR24","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.3390\/jcm9082620","volume":"9","author":"L Chatzis","year":"2020","unstructured":"Chatzis L, Pezoulas VC, Ferro F, Gandolfo S, Donati V, Binutti M, Callegher SZ, Venetsanopoulou A, Zampeli E, Mavrommati M (2020) Sj\u00f6gren\u2019s syndrome: the clinical spectrum of male patients. J Clin Med 9:2620","journal-title":"J Clin Med"},{"key":"6053_CR25","first-page":"S116","volume":"38","author":"J Narvaez","year":"2020","unstructured":"Narvaez J, S\u00e1nchez-Piedra C, Fern\u00e1ndez-Castro M, Mart\u00ednez-Taboada V, Oliv\u00e9 A, Rosas J, Garc\u00eda-Vadillo JA, J\u00fadez E, Ruiz-Lucea E, Romani L (2020) Clinically significant renal involvement in primary Sj\u00f6gren\u2019s syndrome is associated with important morbidity: data from the Spanish Sj\u00f6grenser cohort. Clin Exp Rheumatol 38:S116\u2013S124","journal-title":"Clin Exp Rheumatol"},{"key":"6053_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1756-185X.2009.01444.x","volume":"13","author":"AP Huo","year":"2010","unstructured":"Huo AP, Lin KC, Chou CT (2010) Predictive and prognostic value of antinuclear antibodies and rheumatoid factor in primary Sjogren\u2019s syndrome. Int J Rheum Dis 13:39\u201347","journal-title":"Int J Rheum Dis"},{"key":"6053_CR27","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1093\/rheumatology\/ket349","volume":"53","author":"M Ramos-Casals","year":"2014","unstructured":"Ramos-Casals M, Brito-Zer\u00f3n P, Solans R, Camps M-T, Casanovas A, Sope\u00f1a B, D\u00edaz-L\u00f3pez B, Rasc\u00f3n F-J, Qanneta R, Fraile G (2014) Systemic involvement in primary Sj\u00f6gren\u2019s syndrome evaluated by the EULAR-SS disease activity index: analysis of 921 Spanish patients (GEAS-SS Registry). Rheumatology (Oxford) 53:321\u2013331","journal-title":"Rheumatology (Oxford)"},{"key":"6053_CR28","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1136\/ard.2006.068676","volume":"66","author":"GS Alarc\u00f3n","year":"2007","unstructured":"Alarc\u00f3n GS, McGwin G, Bertoli AM, Fessler BJ, Calvo-Al\u00e9n J, Bastian HM, Vil\u00e1 LM, Reveille JD (2007) Effect of hydroxychloroquine on the survival of patients with systemic lupus erythematosus: data from LUMINA, a multiethnic US cohort (LUMINA L). Ann Rheum Dis 66:1168\u20131172","journal-title":"Ann Rheum Dis"},{"key":"6053_CR29","doi-asserted-by":"publisher","first-page":"831","DOI":"10.3899\/jrheum.120572","volume":"40","author":"PS Akhavan","year":"2013","unstructured":"Akhavan PS, Su J, Lou W, Gladman DD, Urowitz MB, Fortin PR (2013) The early protective effect of hydroxychloroquine on the risk of cumulative damage in patients with systemic lupus erythematosus. J Rheumatol 40:831\u2013841","journal-title":"J Rheumatol"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-022-06053-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-022-06053-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-022-06053-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T23:22:05Z","timestamp":1744154525000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-022-06053-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,6]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["6053"],"URL":"https:\/\/doi.org\/10.1007\/s10067-022-06053-x","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,6]]},"assertion":[{"value":"11 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.CNS central nervous system, GIS gastrointestinal system, ILD interstitial lung disease, N number of patients, PAH pulmonary arterial hypertension.ANA anti-nuclear antibody, CNS central nervous system, N number of patients, PNS peripheral nervous system, RF rheumatoid factor.*Data presented as numbers and percentages.\u2020Data presented as medians and interquartile range.ANA anti-nuclear antibody, CI confidence interval, CNS central nervous system, OR odds ratio, PNS peripheral nervous system.ANA anti-nuclear antibody, CI confidence interval, CNS central nervous system, OR odds ratio.*Hosmer and Lemeshow test p\u2009=\u20090.431; Chi-Square: 8.203.**Hosmer and Lemeshow test p\u2009=\u20090.635; Chi-Square: 6.111; since there was a high correlation between extra-glandular involvement and skin, pulmonary, CNS, and hematological involvement, extra-glandular involvement was excluded, and modeling was performed in Model 2.***Hosmer and Lemeshow test p\u2009=\u20090.451; Chi-Square: 7.819; since there was a high correlation between extra-glandular involvement and skin, pulmonary, CNS and hematological involvement, modeling was performed by excluding skin, pulmonary, CNS and hematological involvement in Model 3.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}