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IS has received consulting fees from Novartis Pharma K.K.; and holds stock in Daiichi Sankyo Company, Ltd.; Astellas Pharma Inc.; and AbbVie Inc. MK and TS declare no conflicts of interest. KK has received research funds from Eisai Co., Ltd.; Kyowa Kirin Co., Ltd.; Sumitomo Dainippon Pharma Co., Ltd.; Pfizer Inc.; Stella Pharma Corporation; CMIC Co., Ltd.; Suntory Beverage & Food Ltd.; Mitsubishi Corporation, and Real World Data Co., Ltd.; consulting fees from Leber Inc.; JMDC Inc.; Shin Nippon Biomedical Laboratories Ltd.; Kaken Pharmaceutical Co., Ltd.; and Advanced Medical Care Inc.; executive compensation from Cancer Intelligence Care Systems; Inc.; honoraria from Mitsubishi Chemical Holdings Corp., Mitsubishi Corp., and Pharma Business Academy; and holds stock in Real World Data Co., Ltd.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}