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The primary outcome was muscle strength assessed with hand-grip strength (Grippit) and leg muscle strength (timed stand test). Secondary outcomes were cardiorespiratory fitness, body composition, and physical functioning (SF-36PCS). Outcomes were assessed at baseline, 6 (M6), and 12\u00a0months (M12). Nonparametric statistics were used.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Median weight reduction at M6 was 18.9\u00a0kg in patients and 23.0\u00a0kg in controls, (<jats:italic>p<\/jats:italic>\u2009=\u20090.546). At M12, patients\u2019 median weight loss from baseline was 16.1\u00a0kg, corresponding with significant loss of total fat mass (\u2212\u200930.1%), and lean mass (total\u2009\u2212\u20097.0%, arm\u2009\u2212\u200913.7%, and leg\u2009\u2212\u20096.0%). Leg muscle strength improved in patients and controls at M6 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and remained improved at M12 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), while hand-grip strength was unchanged in both groups. Cardiorespiratory fitness increased in controls at M6 (<jats:italic>p<\/jats:italic>\u2009=\u20090.018) and M12 (<jats:italic>p<\/jats:italic>\u2009=\u20090.028) but not in patients. Physical functioning improved in both groups at M6 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and remained improved at M12 (<jats:italic>p<\/jats:italic>\u2009=\u20090.008) and (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The intervention resulted in positive effects on body weight and total body fat. Despite reduced lean body mass, the muscle strength did not deteriorate in patients with PsA and controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration <\/jats:title>\n                <jats:p>ClinicalTrials.gov identifier: NCT02917434, registered on September 21, 2016-retrospectively registered.<\/jats:p>\n              <jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>Key Points<\/jats:bold><jats:italic>\u2022 Patients with PsA and obesity can benefit from weight loss treatment without the risk of deterioration in muscle strength and cardiorespiratory fitness.<\/jats:italic><jats:italic>\u2022 Muscle strength and cardiorespiratory fitness were below suggested normative values for the majority of the patients at all time points, implying that more structured exercise strategies might be warranted to counteract physical fitness deficiencies in patients with PsA undergoing weight loss treatment.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:sec>","DOI":"10.1007\/s10067-022-06164-5","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T09:02:46Z","timestamp":1654074166000},"page":"2745-2754","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The impact of a structured weight-loss treatment on physical fitness in patients with psoriatic arthritis and obesity compared to matched controls: a prospective interventional study"],"prefix":"10.1007","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1822-0285","authenticated-orcid":false,"given":"Annelie","family":"Bilberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Bj\u00f6rkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Eliasson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Klingberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"issue":"10","key":"6164_CR1","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1056\/NEJMra1505557","volume":"376","author":"CT Ritchlin","year":"2017","unstructured":"Ritchlin CT, Colbert RA, Gladman DD (2017) Psoriatic Arthritis. 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All participants gave their written informed consent prior to their inclusion in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare that they have no financial or nonfinancial competing interests. The patients were able to buy the VLED at a reduced price from Cambridge Weight Plan Limited, Solna, Sweden.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}