{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:47:50Z","timestamp":1788176870945,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s10067-022-06358-x","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T06:04:39Z","timestamp":1663135479000},"page":"197-202","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Can RDW be used as a screening test for subclinical inflammation in children with FMF? Is RDW related to MEFV gene mutations?"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2373-1837","authenticated-orcid":false,"given":"G\u00f6n\u00fcl","family":"Parmaks\u0131z","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. Ayt\u00fcl","family":"Noyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"issue":"1","key":"6358_CR1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1093\/rheumatology\/keaa378","volume":"60","author":"H Babaoglu","year":"2021","unstructured":"Babaoglu H, Armagan B, Bodakci E, Satis H, Atas N, Sari A et al (2021) Predictors of persistent inflammation in familial Mediterranean fever and association with damage. Rheumatology 60(1):333\u2013339. https:\/\/doi.org\/10.1093\/rheumatology\/keaa378","journal-title":"Rheumatology"},{"issue":"2","key":"6358_CR2","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nrrheum.2010.181","volume":"7","author":"I Ben-Zvi","year":"2011","unstructured":"Ben-Zvi I, Livneh A (2011) Chronic inflammation in FMF: markers, risk factors, outcomes and therapy. Nat Rev Rheumatol 7(2):105\u2013112. https:\/\/doi.org\/10.1038\/nrrheum.2010.181","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"6358_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/RHU.0000000000001134","volume":"27","author":"M \u00c7akan","year":"2021","unstructured":"\u00c7akan M, Karada\u011f \u015eG, Tanatar A, S\u00f6nmez HE, Aktay AN (2021) The value of serum amyloid a levels in familial mediterranean fever to identify occult \u0131nflammation during asymptomatic periods. J Clin Rheumatol 27(1):1\u20134. https:\/\/doi.org\/10.1097\/RHU.0000000000001134","journal-title":"J Clin Rheumatol"},{"issue":"3","key":"6358_CR4","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s10238-005-0071-6","volume":"5","author":"JCH van der Hilst","year":"2005","unstructured":"van der Hilst JCH, Simon A, Drenth JPH (2005) Hereditary periodic fever and reactive amyloidosis. Clin Exp Med 5(3):87\u201398. https:\/\/doi.org\/10.1007\/s10238-005-0071-6","journal-title":"Clin Exp Med"},{"issue":"1","key":"6358_CR5","doi-asserted-by":"publisher","first-page":"e61","DOI":"10.1016\/j.lpm.2018.08.014","volume":"48","author":"H Ozdogan","year":"2019","unstructured":"Ozdogan H, Ugurlu S (2019) Familial Mediterranean fever. Presse Med 48(1):e61\u2013e76. https:\/\/doi.org\/10.1016\/j.lpm.2018.08.014","journal-title":"Presse Med"},{"key":"6358_CR6","doi-asserted-by":"publisher","first-page":"298","DOI":"10.12659\/MSM.892289","volume":"21","author":"O Demir","year":"2015","unstructured":"Demir O (2015) Simple markers for subclinical \u0131nflammation in patients with familial Mediterranean fever. Med Sci Monit 21:298\u2013303. https:\/\/doi.org\/10.12659\/MSM.892289","journal-title":"Med Sci Monit"},{"key":"6358_CR7","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.cca.2013.08.007","volume":"425","author":"Z-D Hu","year":"2013","unstructured":"Hu Z-D, Chen Y, Zhang L, Sun Y, Huang YL, Wang QQ et al (2013) Red blood cell distribution width is a potential index to assess the disease activity of systemic lupus erythematosus. Clin Chim Acta 425:202\u2013205. https:\/\/doi.org\/10.1016\/j.cca.2013.08.007","journal-title":"Clin Chim Acta"},{"issue":"6","key":"6358_CR8","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.amjcard.2008.05.006","volume":"102","author":"UU Tamhane","year":"2008","unstructured":"Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS (2008) Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol 102(6):653\u2013657. https:\/\/doi.org\/10.1016\/j.amjcard.2008.05.006","journal-title":"Am J Cardiol"},{"key":"6358_CR9","doi-asserted-by":"publisher","first-page":"35","DOI":"10.4103\/1735-1995.202140","volume":"22","author":"O Ba\u015faran","year":"2017","unstructured":"Ba\u015faran O, Uncu N, Acar Celikel B, Ayd\u0131n F, Cakar N (2017) Assessment of neutrophil to lymphocyte ratio and mean platelet volume in pediatric familial Mediterranean fever patients. J Res Med Sci 22:35. https:\/\/doi.org\/10.4103\/1735-1995.202140","journal-title":"J Res Med Sci"},{"issue":"10","key":"6358_CR10","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1002\/art.1780401023","volume":"40","author":"A Livneh","year":"1997","unstructured":"Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T et al (1997) Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 40(10):1879\u20131885. https:\/\/doi.org\/10.1002\/art.1780401023","journal-title":"Arthritis Rheum"},{"issue":"8","key":"6358_CR11","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1007\/s00296-015-3227-z","volume":"35","author":"MT Bayram","year":"2015","unstructured":"Bayram MT, \u00c7ankaya T, Bora E, Kavuk\u00e7u S, \u00dclgenalp A, Soylu A, T\u00fcrkmen M (2015) Risk factors for subclinical inflammation in children with familial Mediterranean fever. Rheumatol Int 35(8):1393\u20131398. https:\/\/doi.org\/10.1007\/s00296-015-3227-z","journal-title":"Rheumatol Int"},{"issue":"2","key":"6358_CR12","doi-asserted-by":"publisher","first-page":"213","DOI":"10.5799\/ahinjs.01.2013.02.0268","volume":"4","author":"E \u00c7akmak","year":"2013","unstructured":"\u00c7akmak E, Ece A, Kelek\u00e7i S, Yolba\u015f \u0130, G\u00fcne\u015f A, \u015een V (2013) Comparison of acute phase response during attack and attack-free period in children with familial Mediterranean fever. J Clin Exp Invest 4(2):213\u2013218. https:\/\/doi.org\/10.5799\/ahinjs.01.2013.02.0268","journal-title":"J Clin Exp Invest"},{"issue":"4","key":"6358_CR13","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1136\/ard.2009.114363","volume":"69","author":"T Kallinich","year":"2010","unstructured":"Kallinich T, Wittkowski H, Keitzer R, Roth J, Foell D (2010) Neutrophil-derived S100A12 as novel biomarker of inflammation in familial Mediterranean fever. Ann Rheum Dis 69(4):677\u2013682. https:\/\/doi.org\/10.1136\/ard.2009.114363","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"6358_CR14","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s00296-006-0265-6","volume":"27","author":"F Yal\u00e7inkaya","year":"2007","unstructured":"Yal\u00e7inkaya F, Cakar N, Acar B, Tutar E, G\u00fcriz H, Elhan AH et al (2007) The value of the levels of acute phase reactants for the prediction of familial Mediterranean fever associated amyloidosis: a case control study. Rheumatol Int 27(6):517\u2013522. https:\/\/doi.org\/10.1007\/s00296-006-0265-6","journal-title":"Rheumatol Int"},{"issue":"4","key":"6358_CR15","first-page":"509","volume":"21","author":"A Duzova","year":"2003","unstructured":"Duzova A, Bakkaloglu A, Besbas N, Topaloglu R, Ozen S, Ozaltin F et al (2003) Role of A-SAA in monitoring subclinical inflammation and in colchicine dosage in familial Mediterranean fever. Clin Exp Rheumatol 21(4):509\u2013514","journal-title":"Clin Exp Rheumatol"},{"key":"6358_CR16","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/152616","volume":"2015","author":"H Marzouk","year":"2015","unstructured":"Marzouk H, Lotfy HM, Farag Y, Rashed LA, El-Garf K (2015) Mean platelet volume and splenomegaly as useful markers of subclinical activity in Egyptian children with familial Mediterranean fever: a cross-sectional study. Int J Chronic Dis 2015:152616. https:\/\/doi.org\/10.1155\/2015\/152616","journal-title":"Int J Chronic Dis"},{"issue":"6","key":"6358_CR17","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1007\/s10753-013-9675-2","volume":"36","author":"A Ahsen","year":"2013","unstructured":"Ahsen A, Ulu MS, Yuksel \u015e, Demir K, Uysal M, Erdogan M, Acarturk G (2013) As a new inflammatory marker for familial Mediterranean fever: neutrophil-to-lymphocyte ratio. Inflammation 36(6):1357\u20131362. https:\/\/doi.org\/10.1007\/s10753-013-9675-2","journal-title":"Inflammation"},{"key":"6358_CR18","doi-asserted-by":"publisher","first-page":"127426","DOI":"10.1155\/2014\/127426","volume":"2014","author":"GY Cetin","year":"2014","unstructured":"Cetin GY, Gul O, Kesici-Metin F, Gokalp \u0130, Mehmet Sayarl\u0131oglu M (2014) Evaluation of the mean platelet volume and red cell distribution width in FMF: are they related to subclinical inflammation or not? Int J Chronic Dis 2014:127426. https:\/\/doi.org\/10.1155\/2014\/127426","journal-title":"Int J Chronic Dis"},{"issue":"4","key":"6358_CR19","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.kjms.2016.03.009","volume":"32","author":"AU Uslu","year":"2016","unstructured":"Uslu AU, Yonem O, Aydin B, Uncu T, Seven D, Balta \u015e, Cicekli E (2016) Red cell distribution width is associated with albuminuria in adults with familial Mediterranean fever. Kaohsiung J Med Sci 32(4):216\u2013220. https:\/\/doi.org\/10.1016\/j.kjms.2016.03.009","journal-title":"Kaohsiung J Med Sci"},{"issue":"2","key":"6358_CR20","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1097\/MAJ.0b013e3182996a96","volume":"347","author":"Y Solak","year":"2014","unstructured":"Solak Y, Yilmaz MI, Saglam M, Caglar K, Verim S, Unal HU et al (2014) Red cell distribution width is independently related to endothelial dysfunction in patients with chronic kidney disease. Am J Med Sci 347(2):118\u2013124. https:\/\/doi.org\/10.1097\/MAJ.0b013e3182996a96","journal-title":"Am J Med Sci"},{"issue":"4","key":"6358_CR21","doi-asserted-by":"publisher","first-page":"3550","DOI":"10.1016\/j.ijcard.2013.05.002","volume":"168","author":"ME Emans","year":"2013","unstructured":"Emans ME, Gaillard CAJM, Pfister R, Tanck MW, Boekholdt SM, Wareham NJ, Khaw KT (2013) Red cell distribution width is associated with physical inactivity and heart failure, independent of established risk factors, inflammation or iron metabolism; the EPIC-Norfolk study. Int J Cardiol 168(4):3550\u20133555. https:\/\/doi.org\/10.1016\/j.ijcard.2013.05.002","journal-title":"Int J Cardiol"},{"issue":"2","key":"6358_CR22","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1191\/0267659105pf793oa","volume":"20","author":"CN Pierce","year":"2005","unstructured":"Pierce CN, Larson DF (2005) Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device. Perfusion 20(2):83\u201390. https:\/\/doi.org\/10.1191\/0267659105pf793oa","journal-title":"Perfusion"},{"issue":"2","key":"6358_CR23","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3109\/10408363.2014.992064","volume":"52","author":"GL Salvagno","year":"2015","unstructured":"Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G (2015) Red blood cell distribution width: a simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci 52(2):86\u2013105. https:\/\/doi.org\/10.3109\/10408363.2014.992064","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"3","key":"6358_CR24","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3233\/CH-131738","volume":"54","author":"A Vay\u00e1","year":"2013","unstructured":"Vay\u00e1 A, Alis R, Hern\u00e1ndez JL, Calvo J, Mic\u00f3 L, Romagnoli M, Ricarte JM (2013) RDW in patients with systemic lupus erythematosus. Influence of anaemia and inflammatory markers. Clin Hemorheol Microcirc 54(3):333\u2013339. https:\/\/doi.org\/10.3233\/CH-131738","journal-title":"Clin Hemorheol Microcirc"},{"issue":"4","key":"6358_CR25","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3233\/CH-131744","volume":"56","author":"A Vay\u00e1","year":"2014","unstructured":"Vay\u00e1 A, Rivera L, Todol\u00ed J, Hernandez JL, Laiz BJM (2014) Haematological, biochemical and inflammatory parameters in inactive Beh\u00e7et\u2019s disease. Its association with red blood cell distribution width. Clin Hemorheol Microcirc 56(4):319\u2013324. https:\/\/doi.org\/10.3233\/CH-131744","journal-title":"Clin Hemorheol Microcirc"},{"issue":"8","key":"6358_CR26","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1007\/s10067-017-3715-5","volume":"36","author":"M Alghamdi","year":"2017","unstructured":"Alghamdi M (2017) Familial Mediterranean fever, review of the literature. Clin Rheumatol 36(8):1707\u20131713. https:\/\/doi.org\/10.1007\/s10067-017-3715-5","journal-title":"Clin Rheumatol"},{"issue":"8","key":"6358_CR27","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3389\/fimmu.2017.00253","volume":"23","author":"S \u00d6zen","year":"2017","unstructured":"\u00d6zen S, Batu ED, Demir S (2017) Familial Mediterranean fever: recent developments in pathogenesis and new recommendations for management. Front Immunol 23(8):253. https:\/\/doi.org\/10.3389\/fimmu.2017.00253","journal-title":"Front Immunol"},{"issue":"4","key":"6358_CR28","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1093\/rheumatology\/ket400","volume":"53","author":"T Kasifoglu","year":"2014","unstructured":"Kasifoglu T, Yasar Bilge \u015e, Sari I, Solmaz D, Senel S, Emmungil H et al (2014) Amyloidosis and its related factors in Turkish patients with familial Mediterranean fever: a multicentre study. Rheumatology 53(4):741\u2013745. https:\/\/doi.org\/10.1093\/rheumatology\/ket400","journal-title":"Rheumatology"},{"issue":"1","key":"6358_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01.md.0000152370.84628.0c","volume":"84","author":"Turkish FMF study Group","year":"2005","unstructured":"Turkish FMF study Group (2005) Familial Mediterranean fever (FMF) in Turkey: results of a nationwide multicenter study. Medicine 84(1):1\u201311. https:\/\/doi.org\/10.1097\/01.md.0000152370.84628.0c","journal-title":"Medicine"},{"issue":"2","key":"6358_CR30","doi-asserted-by":"publisher","first-page":"151","DOI":"10.5144\/0256-4947.2015.151","volume":"35","author":"AU Uslu","year":"2015","unstructured":"Uslu AU, Aydin B, Inal S, Balta \u015e, Uncu T, Seven D et al (2015) The relationship between red cell distribution width and homozygous M694V mutation in familial Mediterranean fever patients. Ann Saudi Med 35(2):151\u2013156. https:\/\/doi.org\/10.5144\/0256-4947.2015.151","journal-title":"Ann Saudi Med"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-022-06358-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-022-06358-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-022-06358-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T05:12:17Z","timestamp":1672981937000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-022-06358-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,14]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["6358"],"URL":"https:\/\/doi.org\/10.1007\/s10067-022-06358-x","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,14]]},"assertion":[{"value":"30 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Ba\u015fkent University Institutional Review Board and Ethics Committee (Project no: KA17\/85, date: 5th of April 2017) and supported by Ba\u015fkent University Research Fund.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ba\u015fkent University Institutional Review Board and Ethics Committee (Project no: KA17\/85, date: 5th of April 2017) and supported by Ba\u015fkent University Research Fund.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}