{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:53:59Z","timestamp":1791910439160,"version":"4.3.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Sohag University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>\nAbstract\n<\/jats:title><jats:sec>\n                <jats:title>Objectives\n<\/jats:title>\n                <jats:p>To examine the serum irisin level in a group of Behcet\u2019s disease patients, its association with illness parameters, and its utility in diagnosing subclinical atherosclerosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This randomized case\u2013control study included 50 patients and 50 age- and sex-matched controls. Carotid Doppler ultrasound for the measurement of the carotid artery intima-media thickness (CIMT) and ankle-brachial pressure index (ABPI) were performed. A clinical evaluation, lipogram, and serum irisin were also performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Between the patients and the control group, there was a significant difference in CIMT, S. irisin level, and ankle-brachial pressure index; however, gender and BMI did not significantly affect CIMT, ABPI, or S. irisin level. CIMT demonstrated a substantial negative correlation with both S. irisin and ABPI (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.62, <jats:italic>P<\/jats:italic> 0.0001).<\/jats:p>\n                <jats:p>With a sensitivity of up to 94.30% and a specificity of 93.30%, the ROC analysis revealed that a decrease in S. irisin level in Behcet\u2019s patients was indicative of subclinical atherosclerosis. The drop in the ABPI level demonstrated a sensitivity of up to 94.30% and a specificity of 100%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Subclinical atherosclerosis is prevalent among Egyptian Behcet\u2019s patients, and S. irisin can be employed as a biomarker for diagnosing subclinical atherosclerosis in Behcet\u2019s illness.<\/jats:p>\n                <jats:p><jats:table-wrap><jats:table><jats:tbody>\n                      <jats:tr>\n                        <jats:td align=\"left\" colspan=\"2\"><jats:bold>Key Points<\/jats:bold>\u2022 <jats:italic>Serum irisin has been studied in numerous autoimmune disorders as a marker for subclinical atherosclerosis, although its importance in Behcet\u2019s disease remains unclear (BD)<\/jats:italic>.\u2022 <jats:italic>We examined the change in serum irisin levels in Behcet\u2019s disease patients and healthy controls. In addition, its association with carotid artery intima-media thickness (CIMT) and ankle-brachial pressure index was investigated (ABPI)<\/jats:italic>.\u2022 <jats:italic>Changes in serum irisin levels are significant in BD, and a decrease in irisin level indicates subclinical atherosclerosis<\/jats:italic>.<\/jats:td>\n                      <\/jats:tr>\n                    <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10067-022-06368-9","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T06:03:09Z","timestamp":1663308189000},"page":"179-186","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exists a role for serum irisin in Egyptian Behcet\u2019s patients with subclinical atherosclerosis?"],"prefix":"10.1007","volume":"42","author":[{"given":"Mohamed A.","family":"Ismail","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Mounir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Sedky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisham A.","family":"Algahlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esam A.","family":"Abda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed R.","family":"Radwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan Sayed","family":"Abozaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"issue":"2","key":"6368_CR1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.revmed.2013.12.002","volume":"35","author":"A Desbois","year":"2014","unstructured":"Desbois A, Wechsler B, Cluzel P, Helft G, Boutin D, Piette J et al (2014) Cardiovascular involvement in Beh\u00e7et\u2019s disease. 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