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Immunohistochemistry was used to count CD8<jats:sup>+<\/jats:sup> T cells in LSG tissues of 24 pSS patients and of 6 control patients with normal pathology.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>pSS patients had more aCD8<jats:sup>+<\/jats:sup> T cells than aCD4<jats:sup>+<\/jats:sup> T cells (medians 33.13% vs<jats:italic>.<\/jats:italic> 9.43%, <jats:italic>p<\/jats:italic> &lt; 0.0001), and had an increased level of aCD8<jats:sup>+<\/jats:sup> T cells (medians 33.13% vs<jats:italic>.<\/jats:italic> 16.48%, <jats:italic>p<\/jats:italic> &lt; 0.0001) and serum IFN-\u03b3 (medians 1026 pg\/mL vs<jats:italic>.<\/jats:italic> 0.00 pg\/mL, <jats:italic>p<\/jats:italic> &lt; 0.0001) compared to the healthy controls. The levels of aCD8<jats:sup>+<\/jats:sup> T cells and IFN-\u03b3 were both significant positively correlated with European League Against Rheumatism Sj\u00f6gren\u2019s Syndrome Disease Activity Index, IgG, anti-nuclear antibodies, rheumatoid factor. The LSGs focus score (FS) \u22651 group had more CD8<jats:sup>+<\/jats:sup> T cell counts than 0\u2264 FS &lt;1 group and control group (medians 256\/mm<jats:sup>2<\/jats:sup> vs<jats:italic>.<\/jats:italic> 126\/mm<jats:sup>2<\/jats:sup> and 256\/mm<jats:sup>2<\/jats:sup> vs<jats:italic>.<\/jats:italic> 64\/mm<jats:sup>2<\/jats:sup> respectively, both <jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The aCD8<jats:sup>+<\/jats:sup> T cells and IFN-\u03b3 are positively correlated with each other, and predominantly elevated in the blood of pSS patients. In the LSG tissues of pSS, CD8<jats:sup>+<\/jats:sup> T cell counts increase with severity of the lesions. CD8<jats:sup>+<\/jats:sup> T cells may play crucial role in the pathogenesis of pSS.<jats:table-wrap><jats:table><jats:tbody>\n                      <jats:tr>\n                        <jats:td colspan=\"2\"><jats:bold>Key Points<\/jats:bold><jats:italic>\u2022 Primary Sj\u00f6gren\u2019s syndrome (pSS) is a chronic and systemic autoimmune disease. pSS patients had elevated blood levels of CD38<\/jats:italic><jats:sup><jats:italic>+<\/jats:italic><\/jats:sup><jats:italic>HLA-DR<\/jats:italic><jats:sup><jats:italic>+<\/jats:italic><\/jats:sup><jats:italic>CD8<\/jats:italic><jats:sup><jats:italic>+<\/jats:italic><\/jats:sup><jats:italic>T cells and IFN-\u03b3.<\/jats:italic><jats:italic>\u2022 The CD38<\/jats:italic><jats:sup><jats:italic>+<\/jats:italic><\/jats:sup><jats:italic>HLA-DR<\/jats:italic><jats:sup><jats:italic>+<\/jats:italic><\/jats:sup><jats:italic>CD8<\/jats:italic><jats:sup><jats:italic>+<\/jats:italic><\/jats:sup><jats:italic>T cells positively correlated with disease parameters and serum IFN-\u03b3.<\/jats:italic><jats:italic>\u2022 The salivary glands of pSS patients had appreciable CD8<\/jats:italic><jats:sup><jats:italic>+<\/jats:italic><\/jats:sup><jats:italic>lymphocyte infiltration. CD8<\/jats:italic><jats:sup><jats:italic>+<\/jats:italic><\/jats:sup><jats:italic>T cells may play crucial role in the pathogenesis of pSS.<\/jats:italic><\/jats:td>\n                      <\/jats:tr>\n                    <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10067-022-06491-7","type":"journal-article","created":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T06:04:01Z","timestamp":1673071441000},"page":"1327-1338","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Alterations of CD8+ T cells in the blood and salivary glands of patients with primary Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1007","volume":"42","author":[{"given":"Hongxia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0632-9195","authenticated-orcid":false,"given":"Zhenbiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,7]]},"reference":[{"key":"6491_CR1","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1056\/NEJMcp1702514","volume":"378","author":"X Mariette","year":"2018","unstructured":"Mariette X, Criswell LA (2018) Primary Sj\u00f6gren\u2019s syndrome. 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