{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:56:59Z","timestamp":1789696619278,"version":"4.0.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s10067-023-06624-6","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T19:26:33Z","timestamp":1683746793000},"page":"2145-2154","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Plasma proteomic profiling reveals KRT19 could be a potential biomarker in patients with anti-MDA5+ dermatomyositis"],"prefix":"10.1007","volume":"42","author":[{"given":"Panpan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofeng","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0426-1705","authenticated-orcid":false,"given":"Shengyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"6624_CR1","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/S1474-4422(18)30254-0","volume":"17","author":"A Selva-O'Callaghan","year":"2018","unstructured":"Selva-O'Callaghan A, Pinal-Fernandez I, Trallero-Aragu\u00e1s E, Milisenda JC, Grau-Junyent JM, Mammen AL (2018) Classification and management of adult inflammatory myopathies. Lancet Neurol 17:816\u2013828","journal-title":"Lancet Neurol"},{"key":"6624_CR2","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1097\/BOR.0000000000000744","volume":"32","author":"LA Cerezo","year":"2020","unstructured":"Cerezo LA, Vencovsk\u00fd J, \u0160enolt L (2020) Cytokines and inflammatory mediators as promising markers of polymyositis\/dermatomyositis. Curr Opin Rheumatol 32:534\u2013541","journal-title":"Curr Opin Rheumatol"},{"key":"6624_CR3","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41572-021-00321-x","volume":"7","author":"IE Lundberg","year":"2021","unstructured":"Lundberg IE, Fujimoto M, Vencovsky J, Aggarwal R, Holmqvist M, Christopher-Stine L et al (2021) Idiopathic inflammatory myopathies. Nat Rev Dis Primers 7:86","journal-title":"Nat Rev Dis Primers"},{"key":"6624_CR4","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1001\/jamaneurol.2018.2598","volume":"75","author":"K Mariampillai","year":"2018","unstructured":"Mariampillai K, Granger B, Amelin D, Guiguet M, Hachulla E, Maurier F et al (2018) Development of a new classification system for idiopathic inflammatory myopathies based on clinical manifestations and myositis-specific autoantibodies. JAMA Neurol 75:1528\u20131537","journal-title":"JAMA Neurol"},{"key":"6624_CR5","doi-asserted-by":"publisher","first-page":"773352","DOI":"10.3389\/fimmu.2021.773352","volume":"12","author":"A Nombel","year":"2021","unstructured":"Nombel A, Fabien N, Coutant F (2021) Dermatomyositis with anti-MDA5 antibodies: bioclinical features, pathogenesis and emerging therapies. Front Immunol 12:773352","journal-title":"Front Immunol"},{"key":"6624_CR6","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1002\/art.41929","volume":"74","author":"M Bianchi","year":"2021","unstructured":"Bianchi M, Kozyrev SV, Notarnicola A, Hultin Rosenberg L, Karlsson \u00c5, Pucholt P et al (2021) Contribution of rare genetic variation to disease susceptibility in a large scandinavian myositis cohort. Arthritis Rheumatol (Hoboken, NJ) 74:342\u2013352","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"key":"6624_CR7","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jaut.2016.12.003","volume":"78","author":"X Lu","year":"2017","unstructured":"Lu X, Tang Q, Lindh M, Dastmalchi M, Alexanderson H, Popovic Silwerfeldt K et al (2017) The host defense peptide LL-37 a possible inducer of the type I interferon system in patients with polymyositis and dermatomyositis. J Autoimmun 78:46\u201356","journal-title":"J Autoimmun"},{"key":"6624_CR8","doi-asserted-by":"publisher","first-page":"e12955","DOI":"10.1111\/bpa.12955","volume":"31","author":"L Bolko","year":"2021","unstructured":"Bolko L, Jiang W, Tawara N, Landon-Cardinal O, Anquetil C, Benveniste O et al (2021) The role of interferons type I, II and III in myositis: a review. Brain Pathol (Zurich, Switzerland) 31:e12955","journal-title":"Brain Pathol (Zurich, Switzerland)"},{"key":"6624_CR9","doi-asserted-by":"publisher","first-page":"7144","DOI":"10.7150\/thno.59152","volume":"11","author":"Y Li","year":"2021","unstructured":"Li Y, Bax C, Patel J, Vazquez T, Ravishankar A, Bashir MM et al (2021) Plasma-derived DNA containing-extracellular vesicles induce STING-mediated proinflammatory responses in dermatomyositis. Theranostics 11:7144\u20137158","journal-title":"Theranostics"},{"key":"6624_CR10","doi-asserted-by":"crossref","unstructured":"Seto N, Torres-Ruiz JJ, Carmona-Rivera C, Pinal-Fernandez I, Pak K, Purmalek MM et al (2020) Neutrophil dysregulation is pathogenic in idiopathic inflammatory myopathies. JCI Insight 5","DOI":"10.1172\/jci.insight.134189"},{"key":"6624_CR11","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nrrheum.2018.48","volume":"14","author":"FW Miller","year":"2018","unstructured":"Miller FW, Lamb JA, Schmidt J, Nagaraju K (2018) Risk factors and disease mechanisms in myositis. Nat Rev Rheumatol 14:255\u2013268","journal-title":"Nat Rev Rheumatol"},{"key":"6624_CR12","doi-asserted-by":"publisher","first-page":"260","DOI":"10.55563\/clinexprheumatol\/ohsmuj","volume":"40","author":"Y Wang","year":"2021","unstructured":"Wang Y, Zhu L, Ju B, Luo J, Li Q, Lv X et al (2021) Alterations of peripheral blood B cell subsets in Chinese patients with adult idiopathic inflammatory myopathies. Clin Exp Rheumatol 40:260\u2013266","journal-title":"Clin Exp Rheumatol"},{"key":"6624_CR13","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/art.41075","volume":"72","author":"AS Galindo-Feria","year":"2020","unstructured":"Galindo-Feria AS, Albrecht I, Fernandes-Cerqueira C, Notarnicola A, James EA, Herrath J et al (2020) Proinflammatory histidyl-transfer RNA synthetase-specific CD4+ T cells in the blood and lungs of patients with idiopathic inflammatory myopathies. Arthritis Rheumatol (Hoboken, NJ) 72:179\u2013191","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"key":"6624_CR14","first-page":"194","volume":"59","author":"MGL Wilkinson","year":"2020","unstructured":"Wilkinson MGL, Radziszewska A, Wincup C, Ioannou Y, Isenberg DA, Manson JJ et al (2020) Using peripheral blood immune signatures to stratify patients with adult and juvenile inflammatory myopathies. Rheumatol (Oxford, England) 59:194\u2013204","journal-title":"Rheumatol (Oxford, England)"},{"key":"6624_CR15","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1002\/art.41554","volume":"73","author":"M Nakazawa","year":"2021","unstructured":"Nakazawa M, Suzuki K, Takeshita M, Inamo J, Kamata H, Ishii M et al (2021) Distinct expression of coinhibitory molecules on alveolar T cells in patients with rheumatoid arthritis-associated and idiopathic inflammatory myopathy-associated interstitial lung disease. Arthritis Rheumatol (Hoboken, NJ) 73:576\u2013586","journal-title":"Arthritis Rheumatol (Hoboken, NJ)"},{"key":"6624_CR16","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.semarthrit.2020.05.008","volume":"50","author":"D Liu","year":"2020","unstructured":"Liu D, Zuo X, Luo H, Zhu H (2020) The altered metabolism profile in pathogenesis of idiopathic inflammatory myopathies. Semin Arthritis Rheum 50:627\u2013635","journal-title":"Semin Arthritis Rheum"},{"key":"6624_CR17","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1093\/rheumatology\/key386","volume":"58","author":"N Ono","year":"2019","unstructured":"Ono N, Kai K, Maruyama A, Sakai M, Sadanaga Y, Koarada S et al (2019) The relationship between type 1 IFN and vasculopathy in anti-MDA5 antibody-positive dermatomyositis patients. Rheumatol (Oxford, England) 58:786\u2013791","journal-title":"Rheumatol (Oxford, England)"},{"key":"6624_CR18","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.chest.2020.01.033","volume":"158","author":"R Jablonski","year":"2020","unstructured":"Jablonski R, Bhorade S, Strek ME, Dematte J (2020) Recognition and management of myositis-associated rapidly progressive interstitial lung disease. Chest 158:252\u2013263","journal-title":"Chest"},{"key":"6624_CR19","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1093\/rheumatology\/kez301","volume":"59","author":"S Matsuda","year":"2020","unstructured":"Matsuda S, Kotani T, Ishida T, Fukui K, Fujiki Y, Suzuka T et al (2020) Exploration of pathomechanism using comprehensive analysis of serum cytokines in polymyositis\/dermatomyositis-interstitial lung disease. Rheumatol (Oxford, England) 59:310\u2013318","journal-title":"Rheumatol (Oxford, England)"},{"key":"6624_CR20","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1007\/s10067-020-05339-2","volume":"40","author":"J Bai","year":"2021","unstructured":"Bai J, Wu C, Zhong D, Xu D, Wang Q, Zeng X (2021) Hierarchical cluster analysis of cytokine profiles reveals a cutaneous vasculitis-associated subgroup in dermatomyositis. Clin Rheumatol 40:999\u20131008","journal-title":"Clin Rheumatol"},{"key":"6624_CR21","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1056\/NEJM197502132920706","volume":"292","author":"A Bohan","year":"1975","unstructured":"Bohan A, Peter JB (1975) Polymyositis and dermatomyositis (first of two parts). N Engl J Med 292:344\u2013347","journal-title":"N Engl J Med"},{"key":"6624_CR22","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1067\/mjd.2002.120621","volume":"46","author":"RD Sontheimer","year":"2002","unstructured":"Sontheimer RD (2002) Would a new name hasten the acceptance of amyopathic dermatomyositis (dermatomyositis sin\u00e9 myositis) as a distinctive subset within the idiopathic inflammatory dermatomyopathies spectrum of clinical illness? J Am Acad Dermatol 46:626\u2013636","journal-title":"J Am Acad Dermatol"},{"key":"6624_CR23","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1136\/annrheumdis-2017-211468","volume":"76","author":"IE Lundberg","year":"2017","unstructured":"Lundberg IE, Tj\u00e4rnlund A, Bottai M, Werth VP, Pilkington C, Visser M et al (2017) 2017 European League Against Rheumatism\/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Ann Rheum Dis 76:1955\u20131964","journal-title":"Ann Rheum Dis"},{"key":"6624_CR24","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1093\/rheumatology\/keg427","volume":"43","author":"DA Isenberg","year":"2004","unstructured":"Isenberg DA, Allen E, Farewell V, Ehrenstein MR, Hanna MG, Lundberg IE et al (2004) International consensus outcome measures for patients with idiopathic inflammatory myopathies. Development and initial validation of myositis activity and damage indices in patients with adult onset disease. Rheumatol (Oxford, England) 43:49\u201354","journal-title":"Rheumatol (Oxford, England)"},{"key":"6624_CR25","doi-asserted-by":"publisher","first-page":"805705","DOI":"10.3389\/fimmu.2021.805705","volume":"12","author":"MG Danieli","year":"2021","unstructured":"Danieli MG, Verga JU, Mezzanotte C, Terrenato I, Svegliati S, Bilo MB et al (2021) Replacement and immunomodulatory activities of 20% subcutaneous immunoglobulin treatment: a single-center retrospective study in autoimmune myositis and CVID patients. Front Immunol 12:805705","journal-title":"Front Immunol"},{"key":"6624_CR26","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.cellimm.2006.08.006","volume":"242","author":"CS Curran","year":"2006","unstructured":"Curran CS, Demick KP, Mansfield JM (2006) Lactoferrin activates macrophages via TLR4-dependent and -independent signaling pathways. Cell Immunol 242:23\u201330","journal-title":"Cell Immunol"},{"key":"6624_CR27","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.3389\/fimmu.2017.01438","volume":"8","author":"ML Kruzel","year":"2017","unstructured":"Kruzel ML, Zimecki M, Actor JK (2017) Lactoferrin in a context of inflammation-induced pathology. Front Immunol 8:1438","journal-title":"Front Immunol"},{"key":"6624_CR28","first-page":"834","volume":"37","author":"K Umekita","year":"2019","unstructured":"Umekita K, Miyauchi S, Nomura H, Umeki K, Okayama A (2019) Neutrophil-derived lactoferrin induces the inflammatory responses of rheumatoid arthritis synovial fibroblasts via Toll-like receptor 4. Clin Exp Rheumatol 37:834\u2013841","journal-title":"Clin Exp Rheumatol"},{"key":"6624_CR29","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1038\/nrrheum.2011.139","volume":"7","author":"AB Robinson","year":"2011","unstructured":"Robinson AB, Reed AM (2011) Clinical features, pathogenesis and treatment of juvenile and adult dermatomyositis. Nat Rev Rheumatol 7:664\u2013675","journal-title":"Nat Rev Rheumatol"},{"key":"6624_CR30","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1111\/bjd.15607","volume":"179","author":"C Thompson","year":"2018","unstructured":"Thompson C, Piguet V, Choy E (2018) The pathogenesis of dermatomyositis. Br J Dermatol 179:1256\u20131262","journal-title":"Br J Dermatol"},{"issue":"2","key":"6624_CR31","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1093\/rheumatology\/keab371","volume":"60","author":"T Gono","year":"2021","unstructured":"Gono T, Okazaki Y, Kuwana M (2021) Antiviral proinflammatory phenotype of monocytes in anti-MDA5 antibody-associated interstitial lung disease. Rheumatology (Oxford, England) 60(2):806\u2013814","journal-title":"Rheumatology (Oxford, England)"},{"issue":"6","key":"6624_CR32","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1093\/rheumatology\/keab753","volume":"61","author":"L Li","year":"2021","unstructured":"Li L, Zuo X, Liu D, Luo H, Zhang H, Peng Q et al (2021) Plasma exosomal RNAs has potential as both clinical biomarkers and therapeutic targets of dermatomyositis. Rheumatology (Oxford, England) 61(6):2672\u20132681","journal-title":"Rheumatology (Oxford, England)"},{"key":"6624_CR33","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1002\/bies.201100093","volume":"33","author":"WA McEwan","year":"2011","unstructured":"McEwan WA, Mallery DL, Rhodes DA, Trowsdale J, James LC (2011) Intracellular antibody-mediated immunity and the role of TRIM21. BioEssays 33:803\u2013809","journal-title":"BioEssays"},{"key":"6624_CR34","doi-asserted-by":"publisher","first-page":"738473","DOI":"10.3389\/fimmu.2021.738473","volume":"12","author":"EL Jones","year":"2021","unstructured":"Jones EL, Laidlaw SM, Dustin LB (2021) TRIM21\/Ro52 - roles in innate immunity and autoimmune disease. Front Immunol 12:738473","journal-title":"Front Immunol"},{"key":"6624_CR35","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3389\/fimmu.2020.00098","volume":"11","author":"Y Kunishita","year":"2020","unstructured":"Kunishita Y, Yoshimi R, Kamiyama R, Kishimoto D, Yoshida K, Hashimoto E et al (2020) TRIM21 dysfunction enhances aberrant B-cell differentiation in autoimmune pathogenesis. Front Immunol 11:98","journal-title":"Front Immunol"},{"key":"6624_CR36","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.bbrc.2011.12.010","volume":"417","author":"SN Jauharoh","year":"2012","unstructured":"Jauharoh SN, Saegusa J, Sugimoto T, Ardianto B, Kasagi S, Sugiyama D et al (2012) SS-A\/Ro52 promotes apoptosis by regulating Bcl-2 production. Biochem Biophys Res Commun 417:582\u2013587","journal-title":"Biochem Biophys Res Commun"},{"key":"6624_CR37","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/joim.12375","volume":"278","author":"S Brauner","year":"2015","unstructured":"Brauner S, Zhou W, Backlin C, Green TM, Folkersen L, Ivanchenko M et al (2015) Reduced expression of TRIM21\/Ro52 predicts poor prognosis in diffuse large B-cell lymphoma patients with and without rheumatic disease. J Intern Med 278:323\u2013332","journal-title":"J Intern Med"},{"key":"6624_CR38","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.7150\/jca.51179","volume":"12","author":"X Yuan","year":"2021","unstructured":"Yuan X, Yi M, Dong B, Chu Q, Wu K (2021) Prognostic significance of KRT19 in Lung Squamous Cancer. J Cancer 12:1240\u20131248","journal-title":"J Cancer"},{"key":"6624_CR39","doi-asserted-by":"crossref","unstructured":"Lv C, You H, Xu L, Wang L, Yuan F, Li J et al (2022) Coexisting of anti-Ro52 autoantibodies on anti-MDA5 autoantibodies-positive dermatomyositis is highly associated with rapidly progressive interstitial lung disease and mortality risk. J Rheumatol","DOI":"10.3899\/jrheum.220139"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-023-06624-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-023-06624-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-023-06624-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T03:11:09Z","timestamp":1689217869000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-023-06624-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,9]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["6624"],"URL":"https:\/\/doi.org\/10.1007\/s10067-023-06624-6","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,9]]},"assertion":[{"value":"8 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}