{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:44:36Z","timestamp":1771652676675,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s10067-023-06644-2","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T02:02:18Z","timestamp":1684980138000},"page":"2427-2435","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Outcomes of remission induction therapy for ANCA-associated vasculitis in the elderly"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4928-0926","authenticated-orcid":false,"given":"Faten","family":"Aqeel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Salas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumeng","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaker M.","family":"Eid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duvuru","family":"Geetha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"issue":"2","key":"6644_CR1","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1093\/ndt\/gfs428","volume":"28","author":"M Hilhorst","year":"2013","unstructured":"Hilhorst M, Wilde B, van Paassen P, Winkens B, van Breda Vriesman P, Cohen Tervaert JW, Registry LR (2013) Improved outcome in anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis: a 30-year follow-up study. Nephrol, Dialysis, Transplant: Off Publ Eur Dialysis Transplant Assoc \u2013 Eur Renal Assoc 28(2):373\u2013379. https:\/\/doi.org\/10.1093\/ndt\/gfs428","journal-title":"Nephrol, Dialysis, Transplant: Off Publ Eur Dialysis Transplant Assoc \u2013 Eur Renal Assoc"},{"issue":"9","key":"6644_CR2","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1136\/annrheumdis-2016-210942","volume":"76","author":"JA Tan","year":"2017","unstructured":"Tan JA, Dehghan N, Chen W, Xie H, Esdaile JM, Avina-Zubieta JA (2017) Mortality in ANCA-associated vasculitis: ameta-analysis of observational studies. Ann Rheum Dis 76(9):1566\u20131574. https:\/\/doi.org\/10.1136\/annrheumdis-2016-210942","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"6644_CR3","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1002\/1529-0131(200002)43:2<414::AID-ANR23>3.0.CO;2-0","volume":"43","author":"RA Watts","year":"2000","unstructured":"Watts RA, Lane SE, Bentham G, Scott DG (2000) Epidemiology of systemic vasculitis: a ten-year study in the United Kingdom. Arthritis Rheum 43(2):414\u2013419. https:\/\/doi.org\/10.1002\/1529-0131(200002)43:2%3c414::AID-ANR23%3e3.0.CO;2-0","journal-title":"Arthritis Rheum"},{"issue":"2","key":"6644_CR4","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1097\/RHU.0b013e31816b2fbd","volume":"14","author":"DD Hoganson","year":"2008","unstructured":"Hoganson DD, From AM, Michet CJ (2008) ANCA vasculitis in the elderly. J Clin Rheumatol: Pract Rep Rheum Musculoskelet Dis 14(2):78\u201381. https:\/\/doi.org\/10.1097\/RHU.0b013e31816b2fbd","journal-title":"J Clin Rheumatol: Pract Rep Rheum Musculoskelet Dis"},{"issue":"4","key":"6644_CR5","doi-asserted-by":"publisher","first-page":"c142","DOI":"10.1159\/000079173","volume":"97","author":"SC Satchell","year":"2004","unstructured":"Satchell SC, Nicholls AJ, D\u2019Souza RJ, Beaman M (2004) Renal vasculitis: increasingly a disease of the elderly? Nephron Clin Pract 97(4):c142\u2013c146. https:\/\/doi.org\/10.1159\/000079173","journal-title":"Nephron Clin Pract"},{"issue":"7","key":"6644_CR6","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.2215\/CJN.00480115","volume":"10","author":"M Weiner","year":"2015","unstructured":"Weiner M, Goh SM, Mohammad AJ, Hruskova Z, Tanna A, Bruchfeld A, Selga D, Chocova Z, Westman K, Eriksson P, Pusey CD, Tesar V, Salama AD, Segelmark M (2015) Outcome and treatment of elderly patients with ANCA-associated vasculitis. Clin J Am Soc Nephrol: CJASN 10(7):1128\u20131135. https:\/\/doi.org\/10.2215\/CJN.00480115","journal-title":"Clin J Am Soc Nephrol: CJASN"},{"issue":"6","key":"6644_CR7","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1136\/ard.2009.109389","volume":"69","author":"MA Little","year":"2010","unstructured":"Little MA, Nightingale P, Verburgh CA, Hauser T, De Groot K, Savage C, Jayne D, Harper L, European Vasculitis Study (EUVAS) Group (2010) Early mortality in systemic vasculitis: relative contribution of adverse events and active vasculitis. Ann Rheum Dis 69(6):1036\u20131043. https:\/\/doi.org\/10.1136\/ard.2009.109389","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"6644_CR8","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1016\/j.semarthrit.2020.02.008","volume":"50","author":"A Berti","year":"2020","unstructured":"Berti A, Felicetti M, Monti S, Ortolan A, Padoan R, Brunori G, Bortolotti R, Caporali R, Montecucco C, Schiavon F, Paolazzi G (2020) Disease and treatment-related morbidity in young and elderly patients with granulomatosis with polyangiitis and microscopic polyangiitis. Semin Arthritis Rheum 50(6):1441\u20131448. https:\/\/doi.org\/10.1016\/j.semarthrit.2020.02.008","journal-title":"Semin Arthritis Rheum"},{"issue":"6","key":"6644_CR9","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1136\/annrheumdis-2011-200477","volume":"71","author":"L Harper","year":"2012","unstructured":"Harper L, Morgan MD, Walsh M, Hoglund P, Westman K, Flossmann O, Tesar V, Vanhille P, de Groot K, Luqmani R, Flores-Suarez LF, Watts R, Pusey C, Bruchfeld A, Rasmussen N, Blockmans D, Savage CO, Jayne D, EUVAS investigators (2012) Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up. Ann Rheum Dis 71(6):955\u2013960. https:\/\/doi.org\/10.1136\/annrheumdis-2011-200477","journal-title":"Ann Rheum Dis"},{"key":"6644_CR10","doi-asserted-by":"publisher","unstructured":"Stone JH, Merkel PA, Spiera R, Seo P, Langford CA, Hoffman GS, Kallenberg CG, St Clair EW, Turkiewicz A, Tchao NK, Webber L, Ding L, Sejismundo LP, Mieras K, Weitzenkamp D, Ikle D, Seyfert-Margolis V, Mueller M, Brunetta P, Allen NB, \u2026 RAVE-ITN Research Group (2010). Rituximab versus cyclophosphamide for ANCA-associated vasculitis. N Engl J Med 363(3):221\u2013232https:\/\/doi.org\/10.1056\/NEJMoa0909905","DOI":"10.1056\/NEJMoa0909905"},{"issue":"3","key":"6644_CR11","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1136\/annrheumdis-2018-214245","volume":"78","author":"RB Jones","year":"2019","unstructured":"Jones RB, Hiemstra TF, Ballarin J, Blockmans DE, Brogan P, Bruchfeld A, Cid MC, Dahlsveen K, de Zoysa J, Espigol-Frigol\u00e9 G, Lanyon P, Peh CA, Tesar V, Vaglio A, Walsh M, Walsh D, Walters G, Harper L, Jayne D, European Vasculitis Study Group (EUVAS) (2019) Mycophenolate mofetil versus cyclophosphamide for remission induction in ANCA-associated vasculitis: a randomised, non-inferiority trial. Ann Rheum Dis 78(3):399\u2013405. https:\/\/doi.org\/10.1136\/annrheumdis-2018-214245","journal-title":"Ann Rheum Dis"},{"key":"6644_CR12","doi-asserted-by":"publisher","unstructured":"Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, Flores-Suarez LF, Gross WL, Guillevin L, Hagen EC, Hoffman GS, Jayne DR, Kallenberg CG, Lamprecht P, Langford CA, Luqmani RA, Mahr AD, Matteson EL, Merkel PA, Ozen S, \u2026 Watts RA (2013) 2012 revised international chapel hill consensus conference nomenclature of vasculitides. Arthritis Rheum 65(1):1\u201311. https:\/\/doi.org\/10.1002\/art.37715","DOI":"10.1002\/art.37715"},{"issue":"10","key":"6644_CR13","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1681\/ASN.2010050477","volume":"21","author":"AE Berden","year":"2010","unstructured":"Berden AE, Ferrario F, Hagen EC, Jayne DR, Jennette JC, Joh K, Neumann I, No\u00ebl LH, Pusey CD, Waldherr R, Bruijn JA, Bajema IM (2010) Histopathologic classification of ANCA-associated glomerulonephritis. J Am Soc Nephrol 21(10):1628\u20131636. https:\/\/doi.org\/10.1681\/ASN.2010050477","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"6644_CR14","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1136\/ard.2008.101279","volume":"68","author":"C Mukhtyar","year":"2009","unstructured":"Mukhtyar C, Lee R, Brown D et al (2009) Modification and validation of the Birmingham vasculitis activity score (version 3). Ann Rheum Dis 68(12):1827\u20131832. https:\/\/doi.org\/10.1136\/ard.2008.101279","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"6644_CR15","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1007\/s11255-014-0717-y","volume":"46","author":"\u00c1 Haris","year":"2014","unstructured":"Haris \u00c1, Polner K, Ar\u00e1nyi J, Braunitzer H, Kasz\u00e1s I, Mucsi I (2014) Clinical outcomes of ANCA-associated vasculitis in elderly patients. Int Urol Nephrol 46(8):1595\u20131600. https:\/\/doi.org\/10.1007\/s11255-014-0717-y","journal-title":"Int Urol Nephrol"},{"issue":"7","key":"6644_CR16","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/ki.2010.489","volume":"79","author":"AS Bomback","year":"2011","unstructured":"Bomback AS, Appel GB, Radhakrishnan J, Shirazian S, Herlitz LC, Stokes B, D\u2019Agati VD, Markowitz GS (2011) ANCA-associated glomerulonephritis in the very elderly. Kidney Int 79(7):757\u2013764. https:\/\/doi.org\/10.1038\/ki.2010.489","journal-title":"Kidney Int"},{"issue":"5","key":"6644_CR17","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1093\/rheumatology\/kez388","volume":"59","author":"D McGovern","year":"2020","unstructured":"McGovern D, Williams SP, Parsons K, Farrah TE, Gallacher PJ, Miller-Hodges E, Kluth DC, Hunter RW, Dhaun N (2020) Long-term outcomes in elderly patients with ANCA-associated vasculitis. Rheumatology (Oxford) 59(5):1076\u20131083. https:\/\/doi.org\/10.1093\/rheumatology\/kez388","journal-title":"Rheumatology (Oxford)"},{"issue":"7","key":"6644_CR18","doi-asserted-by":"publisher","first-page":"e2220925","DOI":"10.1001\/jamanetworkopen.2022.20925","volume":"5","author":"S Thietart","year":"2022","unstructured":"Thietart S, Karras A, Augusto JF, Philipponnet C, Carron PL, Delbrel X, Mesbah R, Blaison G, Duffau P, El Karoui K, Smets P, London J, Mouthon L, Guillevin L, Terrier B, Pu\u00e9chal X, French Vasculitis Study Group (2022) Evaluation of rituximab for induction and maintenance therapy in patients 75 years and older with antineutrophil cytoplasmic antibody-associated vasculitis. JAMA Netw Open 5(7):e2220925. https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.20925","journal-title":"JAMA Netw Open"},{"issue":"1","key":"6644_CR19","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.semarthrit.2015.02.005","volume":"45","author":"H Timlin","year":"2015","unstructured":"Timlin H, Lee SM, Manno RL, Seo P, Geetha D (2015) Rituximab for remission induction in elderly patients with ANCA-associated vasculitis. Semin Arthritis Rheum 45(1):67\u201369. https:\/\/doi.org\/10.1016\/j.semarthrit.2015.02.005","journal-title":"Semin Arthritis Rheum"},{"key":"6644_CR20","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12882-015-0082-9","volume":"16","author":"RL Manno","year":"2015","unstructured":"Manno RL, Seo P, Geetha D (2015) Older patients with ANCA-associated vasculitis and dialysis dependent renal failure: a retrospective study. BMC Nephrol 16:88. https:\/\/doi.org\/10.1186\/s12882-015-0082-9","journal-title":"BMC Nephrol"},{"issue":"2","key":"6644_CR21","doi-asserted-by":"publisher","first-page":"209","DOI":"10.23876\/j.krcp.21.008","volume":"41","author":"HJ Kim","year":"2022","unstructured":"Kim HJ, Han M, Song SH, Seong EY (2022) Clinical features and outcomes of elderly patients with antineutrophil cytoplasmic antibody-positive vasculitis: a single-center retrospective study. Kidney Res Clin Pract 41(2):209\u2013218. https:\/\/doi.org\/10.23876\/j.krcp.21.008","journal-title":"Kidney Res Clin Pract"},{"issue":"Suppl 5","key":"6644_CR22","doi-asserted-by":"publisher","first-page":"v5","DOI":"10.1093\/ndt\/gfg1033","volume":"18","author":"S Kaplan-Pavlovcic","year":"2003","unstructured":"Kaplan-Pavlovcic S, Cerk K, Kveder R, Lindic J, Vizjak A (2003) Clinical prognostic factors of renal outcome in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated glomerulonephritis in elderly patients. Nephrol, Dialysis, Transplant: Off Publ Eur Dialysis Transplant Assoc \u2013 Eur Renal Assoc 18(Suppl 5):v5\u2013v7. https:\/\/doi.org\/10.1093\/ndt\/gfg1033","journal-title":"Nephrol, Dialysis, Transplant: Off Publ Eur Dialysis Transplant Assoc \u2013 Eur Renal Assoc"},{"issue":"4","key":"6644_CR23","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1159\/000506532","volume":"51","author":"AD Morris","year":"2020","unstructured":"Morris AD, Elsayed ME, Ponnusamy A, Rowbottom A, Martin F, Geetha D, Dhaygude AP (2020) Treatment outcomes of anti-neutrophil cytoplasmic autoantibody-associated vasculitis in patients over age 75 years: a meta-analysis. Am J Nephrol 51(4):327\u2013336. https:\/\/doi.org\/10.1159\/000506532","journal-title":"Am J Nephrol"},{"issue":"9","key":"6644_CR24","doi-asserted-by":"publisher","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J, CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150(9):604\u2013612. https:\/\/doi.org\/10.7326\/0003-4819-150-9-200905050-00006","journal-title":"Ann Intern Med"},{"issue":"4","key":"6644_CR25","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1093\/rheumatology\/keh522","volume":"44","author":"L Harper","year":"2005","unstructured":"Harper L, Savage CO (2005) ANCA-associated renal vasculitis at the end of the twentieth century\u2013a disease of older patients. Rheumatology (Oxford) 44(4):495\u2013501. https:\/\/doi.org\/10.1093\/rheumatology\/keh522","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"6644_CR26","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12882-019-1226-0","volume":"20","author":"D Chanouzas","year":"2019","unstructured":"Chanouzas D, McGregor JAG, Nightingale P, Salama AD, Szpirt WM, Basu N, Morgan MD, Poulton CJ, Draibe JB, Krarup E, Dospinescu P, Dale JA, Pendergraft WF, Lee K, Egfjord M, Hogan SL, Harper L (2019) Intravenous pulse methylprednisolone for induction of remission in severe ANCA associated Vasculitis: a multi-center retrospective cohort study. BMC Nephrol 20(1):58. https:\/\/doi.org\/10.1186\/s12882-019-1226-0","journal-title":"BMC Nephrol"},{"key":"6644_CR27","doi-asserted-by":"publisher","unstructured":"Walsh M, Merkel PA, Peh CA, Szpirt WM, Pu\u00e9chal X, Fujimoto S, Hawley CM, Khalidi N, Flo\u00dfmann O, Wald R, Girard LP, Levin A, Gregorini G, Harper L, Clark WF, Pagnoux C, Specks U, Smyth L, Tesar V, Ito-Ihara T, \u2026 PEXIVAS Investigators (2020). Plasma exchange and glucocorticoids in severe anca-associated vasculitis. N Engl J Med 382(7):622\u2013631. https:\/\/doi.org\/10.1056\/NEJMoa1803537","DOI":"10.1056\/NEJMoa1803537"},{"issue":"6","key":"6644_CR28","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.34067\/KID.0000502021","volume":"2","author":"L Floyd","year":"2021","unstructured":"Floyd L, Morris A, Joshi M, Dhaygude A (2021) Glucocorticoid therapy in anca vasculitis: using the glucocorticoid toxicity index as an outcome measure. Kidney360 2(6):1002\u20131010. https:\/\/doi.org\/10.34067\/KID.0000502021","journal-title":"Kidney360"},{"key":"6644_CR29","doi-asserted-by":"publisher","unstructured":"Mukhtyar C, Guillevin L, Cid MC, Dasgupta B, de Groot K, Gross W, Hauser T, Hellmich B, Jayne D, Kallenberg CG, Merkel PA, Raspe H, Salvarani C, Scott DG, Stegeman C, Watts R, Westman K, Witter J, Yazici H, Luqmani R, \u2026 European Vasculitis Study Group (2009) EULAR recommendations for the management of primary small and medium vessel vasculitis. Ann Rheum Dis 68(3):310\u2013317https:\/\/doi.org\/10.1136\/ard.2008.088096","DOI":"10.1136\/ard.2008.088096"},{"issue":"4S","key":"6644_CR30","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.kint.2021.05.021","volume":"100","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group","year":"2021","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group (2021) KDIGO 2021 clinical practice guideline for the management of glomerular diseases. Kidney Int 100(4S):S1\u2013S276. https:\/\/doi.org\/10.1016\/j.kint.2021.05.021","journal-title":"Kidney Int"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-023-06644-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-023-06644-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-023-06644-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T11:08:17Z","timestamp":1691579297000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-023-06644-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,25]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["6644"],"URL":"https:\/\/doi.org\/10.1007\/s10067-023-06644-2","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,25]]},"assertion":[{"value":"25 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 May 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Duvuru Geetha: Consultant to ChemoCentryx, GSK and Aurinia Inc.Faten Aqeel: None.Lillian Xu: None.Antonio Salas: None.Yumeng Wen: None.Shaker Eid: None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}