{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:45:45Z","timestamp":1787755545371,"version":"build-2784847793"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1007\/s10067-023-06722-5","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T06:02:38Z","timestamp":1690524158000},"page":"3123-3129","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical features and predictors of osteoarticular manifestations in common variable immunodeficiency"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-7515","authenticated-orcid":false,"given":"Monia","family":"Ben Khaled","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amani","family":"Merdassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Rekaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhem Ben","family":"Fraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takwa","family":"Lamouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikram","family":"Zaiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ridha","family":"Kouki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Bejaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fethi","family":"Mellouli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Ouederni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"6722_CR1","doi-asserted-by":"publisher","unstructured":"Gathmann B, Mahlaoui N, G\u00e9rard L, Oksenhendler E, Warnatz K, Schulze I et al (2014) Clinical picture and treatment of 2212 patients with common variable immunodeficiency. J Allergy Clin Immunol 134:116\u201326. https:\/\/doi.org\/10.1016\/j.jaci.2013.12.1077","DOI":"10.1016\/j.jaci.2013.12.1077"},{"key":"6722_CR2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/b978-0-12-385991-4.00002-7","volume":"111","author":"PF Yong","year":"2011","unstructured":"Yong PF, Thaventhiran JE, Grimbacher B (2011) \u201cA rose is a rose is a rose\u201d, but CVID is Not CVID common variable immune deficiency (CVID), what do we know in 2011? Adv Immunol 111:47\u2013107. https:\/\/doi.org\/10.1016\/b978-0-12-385991-4.00002-7","journal-title":"Adv Immunol"},{"issue":"4","key":"6722_CR3","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1097\/BOR.0b013e3282fd6e70","volume":"20","author":"KA Bloom","year":"2008","unstructured":"Bloom KA, Chung D, Cunningham-Rundles C (2008) Osteoarticular infectious complications in patients with primary immunodeficiencies. Curr Opin Rheumatol 20(4):480\u2013485. https:\/\/doi.org\/10.1097\/BOR.0b013e3282fd6e70","journal-title":"Curr Opin Rheumatol"},{"issue":"6","key":"6722_CR4","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.jbspin.2004.07.012","volume":"72","author":"C Sordet","year":"2005","unstructured":"Sordet C, Cantagrel A, Schaeverbeke T, Sibilia J (2005) Bone and joint disease associated with primary immune deficiencies. Jt Bone Spine 72(6):503\u2013514. https:\/\/doi.org\/10.1016\/j.jbspin.2004.07.012","journal-title":"Jt Bone Spine"},{"key":"6722_CR5","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3389\/fimmu.2020.00149","volume":"11","author":"HE Ho","year":"2020","unstructured":"Ho HE, Cunningham-Rundles C (2020) Non-infectious complications of common variable immunodeficiency: updated clinical spectrum, sequelae, and insights to pathogenesis. Front Immunol 11:149. https:\/\/doi.org\/10.3389\/fimmu.2020.00149","journal-title":"Front Immunol"},{"key":"6722_CR6","doi-asserted-by":"publisher","unstructured":"Viallard JF, Lebail B, Begueret H, Fieschi C (2021 ) Common variable immunodeficiency disorders: Part 2. Updated clinical manifestations and therapeutic management. Rev Med Int 42(7):473\u201381. https:\/\/doi.org\/10.1016\/j.revmed.2020.12.015","DOI":"10.1016\/j.revmed.2020.12.015"},{"issue":"6","key":"6722_CR7","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1016\/j.jaip.2019.02.004","volume":"7","author":"MG Seidel","year":"2019","unstructured":"Seidel MG, Kindle G, Gathmann B, Quinti I, Buckland M, van Montfrans J et al (2019) The European Society for Immunodeficiencies (ESID) Registry working definitions for the clinical diagnosis of inborn errors of immunity. J Allergy Clin Immunol Pract 7(6):1763\u20131770. https:\/\/doi.org\/10.1016\/j.jaip.2019.02.004","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"3","key":"6722_CR8","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1111\/cei.13272","volume":"196","author":"C Bethune","year":"2019","unstructured":"Bethune C, Egner W, Garcez T, Huissoon A, Jolles S, Karim Y et al (2019) British Society for Immunology\/United Kingdom Primary Immunodeficiency Network consensus statement on managing non-infectious complications of common variable immunodeficiency disorders. Clin Exp Immunol 196(3):328\u2013335. https:\/\/doi.org\/10.1111\/cei.13272","journal-title":"Clin Exp Immunol"},{"issue":"9","key":"6722_CR9","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman A et al (2010) Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62(9):2569\u20132581","journal-title":"Arthritis Rheum"},{"issue":"4","key":"6722_CR10","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1007\/s12098-016-2038-x","volume":"83","author":"B Saikia","year":"2016","unstructured":"Saikia B, Gupta S (2016) Common variable immunodeficiency. indian. J Pediatr 83(4):338\u2013344. https:\/\/doi.org\/10.1007\/s12098-016-2038-x","journal-title":"J Pediatr"},{"issue":"5","key":"6722_CR11","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/ar4032","volume":"14","author":"U Salzer","year":"2012","unstructured":"Salzer U, Warnatz K, Peter HH (2012) Common variable immunodeficiency: an update. Arthritis Res Ther 14(5):223. https:\/\/doi.org\/10.1186\/ar4032","journal-title":"Arthritis Res Ther"},{"issue":"23","key":"6722_CR12","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1556\/650.2018.31084","volume":"159","author":"MZ Szab\u00f3","year":"2018","unstructured":"Szab\u00f3 MZ (2018) Rheumatological manifestations in primary immunodeficiency diseases. Orv Hetil 159(23):919\u2013928. https:\/\/doi.org\/10.1556\/650.2018.31084","journal-title":"Orv Hetil"},{"issue":"3","key":"6722_CR13","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/s0163-4453(96)92441-x","volume":"33","author":"A Steuer","year":"1996","unstructured":"Steuer A, Franz A, Furr PM, Taylor-Robinson D, Webster AD, Hughes GR (1996) Common variable immunodeficiency presenting as a Mycoplasma hominis septic arthritis. J Infect 33(3):235\u2013237. https:\/\/doi.org\/10.1016\/s0163-4453(96)92441-x","journal-title":"J Infect"},{"issue":"4","key":"6722_CR14","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/0049-0172(93)80073-o","volume":"22","author":"AH Lee","year":"1993","unstructured":"Lee AH, Levinson AI, Schumacher HR Jr (1993) Hypogammaglobulinemia and rheumatic disease. Semin Arthritis Rheum 22(4):252\u2013264. https:\/\/doi.org\/10.1016\/0049-0172(93)80073-o","journal-title":"Semin Arthritis Rheum"},{"issue":"5","key":"6722_CR15","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s11882-001-0027-1","volume":"1","author":"C Cunningham-Rundles","year":"2001","unstructured":"Cunningham-Rundles C (2001) Common variable immunodeficiency. Curr Allergy Asthma Rep 1(5):421\u2013429. https:\/\/doi.org\/10.1007\/s11882-001-0027-1","journal-title":"Curr Allergy Asthma Rep"},{"issue":"1","key":"6722_CR16","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s10067-005-1141-6","volume":"25","author":"J Swierkot","year":"2006","unstructured":"Swierkot J, Lewandowicz-Uszynska A, Chlebicki A, Szmyrka-Kaczmarek M, Pola\u0144ska B, Jankowski A et al (2006) Rheumatoid arthritis in a patient with common variable immunodeficiency: difficulty in diagnosis and therapy. Clin Rheumatol 25(1):92\u201394. https:\/\/doi.org\/10.1007\/s10067-005-1141-6","journal-title":"Clin Rheumatol"},{"issue":"1","key":"6722_CR17","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1046\/j.1365-2249.1998.00479.x","volume":"111","author":"ME North","year":"1998","unstructured":"North ME, Webster AD, Farrant J (1998) Primary defect in CD8+ lymphocytes in the antibody deficiency disease (common variable immunodeficiency): abnormalities in intracellular production of interferon-gamma (IFN-gamma) in CD28+ ('cytotoxic\u2019) and CD28- ('suppressor\u2019) CD8+ subsets. Clin Exp Immunol 111(1):70\u201375. https:\/\/doi.org\/10.1046\/j.1365-2249.1998.00479.x","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"6722_CR18","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.aller.2016.07.001","volume":"45","author":"R Yazdani","year":"2017","unstructured":"Yazdani R, Seify R, Ganjalikhani-Hakemi M, Abolhassani H, Eskandari N, Golsaz-Shirazi F et al (2017) Comparison of various classifications for patients with common variable immunodeficiency (CVID) using measurement of B-cell subsets. Allergol Immunopathol (Madr) 45(2):183\u2013192. https:\/\/doi.org\/10.1016\/j.aller.2016.07.001","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"2","key":"6722_CR19","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.aller.2017.04.004","volume":"46","author":"G Azizi","year":"2018","unstructured":"Azizi G, Abolhassani H, Kiaee F, Tavakolinia N, Rafiemanesh H, Yazdani R et al (2018) Autoimmunity and its association with regulatory T cells and B cell subsets in patients with common variable immunodeficiency. Allergol Immunopathol (Madr) 46(2):127\u2013135. https:\/\/doi.org\/10.1016\/j.aller.2017.04.004","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"7","key":"6722_CR20","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1111\/j.1399-3038.2011.01187.x","volume":"22","author":"S Baris","year":"2011","unstructured":"Baris S, Ozen A, Ercan H, Karakoc-Aydiner E, Cagan H, Ozdemir C et al (2011) Osteoporosis: an ignored complication of CVID. Pediatr Allergy Immunol 22(7):676\u2013683. https:\/\/doi.org\/10.1111\/j.1399-3038.2011.01187.x","journal-title":"Pediatr Allergy Immunol"},{"issue":"2","key":"6722_CR21","doi-asserted-by":"publisher","first-page":"134","DOI":"10.2174\/1871530317666170612093906","volume":"17","author":"A Mohebbi","year":"2017","unstructured":"Mohebbi A, Azizi G, Tavakolinia N, Abbasi F, Sayarifard F, Karimipour M et al (2017) Comparison of bone mineral density in common variable immunodeficiency and x-linked agammaglobulinaemia patients. Endocr Metab Immune Disord Drug Targets 17(2):134\u2013140. https:\/\/doi.org\/10.2174\/1871530317666170612093906","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"6","key":"6722_CR22","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.jaip.2013.09.013","volume":"1","author":"M Kuruvilla","year":"2013","unstructured":"Kuruvilla M, de la Morena MT (2013) Antibiotic prophylaxis in primary immune deficiency disorders. J Allergy Clin Immunol Pract 1(6):573\u201382. https:\/\/doi.org\/10.1016\/j.jaip.2013.09.013","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"5","key":"6722_CR23","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.aller.2019.03.004","volume":"47","author":"JRS Cruz","year":"2019","unstructured":"Cruz JRS, Silva R, Andrade IGA, Fonseca FLA, Costa-Carvalho BT, Sarni ROS (2019) Assessment of vitamin D status in common variable immunodeficiency or ataxia-telangiectasia patients. Allergol Immunopathol (Madr) 47(5):499\u2013505. https:\/\/doi.org\/10.1016\/j.aller.2019.03.004","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"1","key":"6722_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/cei\/uxac070","volume":"210","author":"S Grigoriadou","year":"2022","unstructured":"Grigoriadou S, Clubbe R, Garcez T, Huissoon A, Grosse-Kreul D, Jolles S et al (2022) British Society for Immunology and United Kingdom Primary Immunodeficiency Network (UKPIN) consensus guideline for the management of immunoglobulin replacement therapy. Clin Exp Immunol 210(1):1\u201313. https:\/\/doi.org\/10.1093\/cei\/uxac070","journal-title":"Clin Exp Immunol"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-023-06722-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-023-06722-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-023-06722-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T06:13:37Z","timestamp":1697696017000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-023-06722-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,28]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["6722"],"URL":"https:\/\/doi.org\/10.1007\/s10067-023-06722-5","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,28]]},"assertion":[{"value":"4 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}