{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:46:12Z","timestamp":1788396372472,"version":"build-2803163510"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Shantou Medical Health Science and Technology Plan","award":["2019-106-21"],"award-info":[{"award-number":["2019-106-21"]}]},{"name":"Medical Science Research Foundation of Guangdong Province","award":["A2019244"],"award-info":[{"award-number":["A2019244"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s10067-024-06958-9","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T05:01:17Z","timestamp":1712811677000},"page":"1939-1947","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Characteristics of the oral microbiota in patients with primary Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9755-9059","authenticated-orcid":false,"given":"Yiwen","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4198-5742","authenticated-orcid":false,"given":"Yu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaotong","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"6958_CR1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e3821","volume":"344","author":"M Ramos-Casals","year":"2012","unstructured":"Ramos-Casals M, Brito-Zer\u00f3n P, Sis\u00f3-Almirall A, Bosch X (2012) Primary Sjogren syndrome. Bmj 344:e3821","journal-title":"Bmj"},{"issue":"7","key":"6958_CR2","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1002\/art.39127","volume":"67","author":"CF Kuo","year":"2015","unstructured":"Kuo CF, Grainge MJ, Valdes AM, See LC, Luo SF, Yu KH, Zhang W, Doherty M (2015) Familial risk of Sj\u00f6gren\u2019s syndrome and co-aggregation of autoimmune diseases in affected families: a nationwide population study. Arthritis Rheumatol 67(7):1904\u20131912","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"6958_CR3","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1128\/MMBR.62.1.71-109.1998","volume":"62","author":"H Marcotte","year":"1998","unstructured":"Marcotte H, Lavoie MC (1998) Oral microbial ecology and the role of salivary immunoglobulin A. Microbiol Mol Biol Rev 62(1):71\u2013109","journal-title":"Microbiol Mol Biol Rev"},{"key":"6958_CR4","doi-asserted-by":"publisher","first-page":"16047","DOI":"10.1038\/nrdp.2016.47","volume":"2","author":"P Brito-Zer\u00f3n","year":"2016","unstructured":"Brito-Zer\u00f3n P, Baldini C, Bootsma H, Bowman SJ, Jonsson R, Mariette X, Sivils K, Theander E, Tzioufas A, Ramos-Casals M (2016) Sj\u00f6gren syndrome. Nat Rev Dis Primers 2:16047","journal-title":"Nat Rev Dis Primers"},{"key":"6958_CR5","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.5649","volume":"6","author":"Z Zhou","year":"2018","unstructured":"Zhou Z, Ling G, Ding N, Xun Z, Zhu C, Hua H, Chen X (2018) Molecular analysis of oral microflora in patients with primary Sj\u00f6gren\u2019s syndrome by using high-throughput sequencing. PeerJ 6:e5649","journal-title":"PeerJ"},{"key":"6958_CR6","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.biopha.2018.01.146","volume":"99","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Wang X, Li H, Ni C, Du Z, Yan F (2018) Human oral microbiota and its modulation for oral health. Biomed Pharmacother 99:883\u2013893","journal-title":"Biomed Pharmacother"},{"key":"6958_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.699011","volume":"12","author":"E Doar\u00e9","year":"2021","unstructured":"Doar\u00e9 E, H\u00e9ry-Arnaud G, Devauchelle-Pensec V, Alegria GC (2021) Healthy patients are not the best controls for microbiome-based clinical studies: example of Sj\u00f6gren\u2019s syndrome in a systematic review. Front Immunol 12:699011","journal-title":"Front Immunol"},{"issue":"11","key":"6958_CR8","doi-asserted-by":"publisher","first-page":"4121","DOI":"10.1128\/JCM.01232-10","volume":"48","author":"EL Gross","year":"2010","unstructured":"Gross EL, Leys EJ, Gasparovich SR, Firestone ND, Schwartzbaum JA, Janies DA, Asnani K, Griffen AL (2010) Bacterial 16S sequence analysis of severe caries in young permanent teeth. J Clin Microbiol 48(11):4121\u20134128","journal-title":"J Clin Microbiol"},{"key":"6958_CR9","doi-asserted-by":"publisher","unstructured":"Wilson K (2001) Preparation of genomic DNA from bacteria. Curr Protoc Mol Biol 56:2.4.1\u20132.4.5. https:\/\/doi.org\/10.1002\/047114272","DOI":"10.1002\/047114272"},{"issue":"21","key":"6958_CR10","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","volume":"27","author":"T Mago\u010d","year":"2011","unstructured":"Mago\u010d T, Salzberg SL (2011) FLASH: fast length adjustment of short reads to improve genome assemblies. Bioinformatics 27(21):2957\u20132963","journal-title":"Bioinformatics"},{"issue":"1","key":"6958_CR11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nmeth.2276","volume":"10","author":"NA Bokulich","year":"2013","unstructured":"Bokulich NA, Subramanian S, Faith JJ, Gevers D, Gordon JI, Knight R, Mills DA, Caporaso JG (2013) Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing. Nat Methods 10(1):57\u201359","journal-title":"Nat Methods"},{"issue":"5","key":"6958_CR12","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nmeth.f.303","volume":"7","author":"JG Caporaso","year":"2010","unstructured":"Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, Fierer N, Pe\u00f1a AG, Goodrich JK, Gordon JI et al (2010) QIIME allows analysis of high-throughput community sequencing data. Nat Methods 7(5):335\u2013336","journal-title":"Nat Methods"},{"issue":"16","key":"6958_CR13","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1093\/bioinformatics\/btr381","volume":"27","author":"RC Edgar","year":"2011","unstructured":"Edgar RC, Haas BJ, Clemente JC, Quince C, Knight R (2011) UCHIME improves sensitivity and speed of chimera detection. Bioinformatics 27(16):2194\u20132200","journal-title":"Bioinformatics"},{"issue":"3","key":"6958_CR14","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1101\/gr.112730.110","volume":"21","author":"BJ Haas","year":"2011","unstructured":"Haas BJ, Gevers D, Earl AM, Feldgarden M, Ward DV, Giannoukos G, Ciulla D, Tabbaa D, Highlander SK, Sodergren E et al (2011) Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons. Genome Res 21(3):494\u2013504","journal-title":"Genome Res"},{"key":"6958_CR15","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.bbi.2018.02.016","volume":"70","author":"Y Qian","year":"2018","unstructured":"Qian Y, Yang X, Xu S, Wu C, Song Y, Qin N, Chen SD, Xiao Q (2018) Alteration of the fecal microbiota in Chinese patients with Parkinson\u2019s disease. Brain Behav Immun 70:194\u2013202","journal-title":"Brain Behav Immun"},{"issue":"9894","key":"6958_CR16","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/S0140-6736(13)60954-X","volume":"382","author":"M Wahren-Herlenius","year":"2013","unstructured":"Wahren-Herlenius M, D\u00f6rner T (2013) Immunopathogenic mechanisms of systemic autoimmune disease. Lancet 382(9894):819\u2013831","journal-title":"Lancet"},{"issue":"11","key":"6958_CR17","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1136\/annrheumdis-2014-205375","volume":"74","author":"B Qin","year":"2015","unstructured":"Qin B, Wang J, Yang Z, Yang M, Ma N, Huang F, Zhong R (2015) Epidemiology of primary Sj\u00f6gren\u2019s syndrome: a systematic review and meta-analysis. Ann Rheum Dis 74(11):1983\u20131989","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"6958_CR18","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/odi.12472","volume":"22","author":"TA van der Meulen","year":"2016","unstructured":"van der Meulen TA, Harmsen H, Bootsma H, Spijkervet F, Kroese F, Vissink A (2016) The microbiome-systemic diseases connection. Oral Dis 22(8):719\u2013734","journal-title":"Oral Dis"},{"issue":"6","key":"6958_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218319","volume":"14","author":"S Rusthen","year":"2019","unstructured":"Rusthen S, Kristoffersen AK, Young A, Galtung HK, Petrovski B, Palm \u00d8, Enersen M, Jensen JL (2019) Dysbiotic salivary microbiota in dry mouth and primary Sj\u00f6gren\u2019s syndrome patients. PLoS ONE 14(6):e0218319","journal-title":"PLoS ONE"},{"issue":"12","key":"6958_CR20","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1093\/rheumatology\/key215","volume":"57","author":"TA van der Meulen","year":"2018","unstructured":"van der Meulen TA, Harmsen HJM, Bootsma H, Liefers SC, Vich Vila A, Zhernakova A, Fu J, Wijmenga C, Spijkervet FKL, Kroese FGM et al (2018) Dysbiosis of the buccal mucosa microbiome in primary Sj\u00f6gren\u2019s syndrome patients. Rheumatology (Oxford) 57(12):2225\u20132234","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"6958_CR21","first-page":"4895","volume":"18","author":"S Zhou","year":"2018","unstructured":"Zhou S, Cai Y, Wang M, Yang WD, Duan N (2018) Oral microbial flora of patients with Sicca syndrome. Mol Med Rep 18(6):4895\u20134903","journal-title":"Mol Med Rep"},{"key":"6958_CR22","doi-asserted-by":"publisher","first-page":"31119","DOI":"10.3402\/jom.v8.31119","volume":"8","author":"H Siddiqui","year":"2016","unstructured":"Siddiqui H, Chen T, Aliko A, Mydel PM, Jonsson R, Olsen I (2016) Microbiological and bioinformatics analysis of primary Sjogren\u2019s syndrome patients with normal salivation. J Oral Microbiol 8:31119","journal-title":"J Oral Microbiol"},{"issue":"1","key":"6958_CR23","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1111\/prd.12100","volume":"70","author":"X Gao","year":"2016","unstructured":"Gao X, Jiang S, Koh D, Hsu CY (2016) Salivary biomarkers for dental caries. Periodontol 2000 70(1):128\u2013141","journal-title":"Periodontol 2000"},{"issue":"1","key":"6958_CR24","doi-asserted-by":"publisher","first-page":"2079814","DOI":"10.1080\/20002297.2022.2079814","volume":"14","author":"E K\u00f6n\u00f6nen","year":"2022","unstructured":"K\u00f6n\u00f6nen E, Fteita D, Gursoy UK, Gursoy M (2022) Prevotella species as oral residents and infectious agents with potential impact on systemic conditions. J Oral Microbiol 14(1):2079814","journal-title":"J Oral Microbiol"},{"issue":"3","key":"6958_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230667","volume":"15","author":"J Alam","year":"2020","unstructured":"Alam J, Lee A, Lee J, Kwon DI, Park HK, Park JH, Jeon S, Baek K, Lee J, Park SH et al (2020) Dysbiotic oral microbiota and infected salivary glands in Sj\u00f6gren\u2019s syndrome. PLoS ONE 15(3):e0230667","journal-title":"PLoS ONE"},{"key":"6958_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/froh.2021.774115","volume":"2","author":"P Zhou","year":"2021","unstructured":"Zhou P, Manoil D, Belibasakis GN, Kotsakis GA (2021) Veillonellae: beyond bridging species in oral biofilm ecology. Front Oral Health 2:774115","journal-title":"Front Oral Health"},{"issue":"17","key":"6958_CR27","doi-asserted-by":"publisher","first-page":"6207","DOI":"10.3390\/ijms21176207","volume":"21","author":"N Fujiwara","year":"2020","unstructured":"Fujiwara N, Kitamura N, Yoshida K, Yamamoto T, Ozaki K, Kudo Y (2020) Involvement of Fusobacterium species in oral cancer progression: a literature review including other types of cancer. Int J Mol Sci 21(17):6207","journal-title":"Int J Mol Sci"},{"issue":"1","key":"6958_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2019.101473","volume":"34","author":"MF Konig","year":"2020","unstructured":"Konig MF (2020) The microbiome in autoimmune rheumatic disease. Best Pract Res Clin Rheumatol 34(1):101473","journal-title":"Best Pract Res Clin Rheumatol"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-024-06958-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-024-06958-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-024-06958-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T16:03:46Z","timestamp":1716393826000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-024-06958-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,11]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["6958"],"URL":"https:\/\/doi.org\/10.1007\/s10067-024-06958-9","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,11]]},"assertion":[{"value":"8 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The sample collection was approved by the Regional Ethics Board of Shantou Central Hospital (approval number, 2019-scientific research (042)), and written informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}