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Patients were categorized into groups according to the disease phenotypes and severity. A total of 94.8% of patients were males. The patients\u2019 mean age at onset was 26.1\u2009\u00b1\u20098\u00a0years. The median (IQR) disease duration was 8.5(4\u201313) years. No difference was observed between the patients and controls concerning the frequency of the two SNPs\u2019 different genotypes, models, and alleles. Moreover, neither disease phenotypes nor severity were associated with rs2542151 or rs7234029 SNPs.<jats:italic> PTPN2<\/jats:italic> rs2542151 and rs7234029 SNPs do not seem to have associations with BD occurrence, phenotypes, or severity in the Egyptian patients.<\/jats:p><jats:p><jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td align=\"left\"><jats:bold>Key Points<\/jats:bold><\/jats:td>\n                    <\/jats:tr>\n                    <jats:tr>\n                      <jats:td align=\"left\">\u2022 <jats:italic>PTPN2 rs2542151 and rs7234029 SNPs do not seem to have associations with BD occurrence, phenotypes, or severity in the Egyptian patients.<\/jats:italic>\u2022 <jats:italic>Further studies involving a larger sample size with variable clinical diversity are recommended to verify the results.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s10067-024-07128-7","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T20:46:20Z","timestamp":1727297180000},"page":"3439-3448","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene polymorphisms (rs2542151, rs7234029) in Egyptian Beh\u00e7et\u2019s disease patients: a preliminary report"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1349-265X","authenticated-orcid":false,"given":"Doaa H. 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