{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:28:49Z","timestamp":1786980529716,"version":"build-2736575974"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Funds of China","doi-asserted-by":"crossref","award":["82074234"],"award-info":[{"award-number":["82074234"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Funds of China","doi-asserted-by":"crossref","award":["82073901"],"award-info":[{"award-number":["82073901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202340274"],"award-info":[{"award-number":["202340274"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research and development of traditional therapies and preparations for arthropathy and transformation of doctoral innovative talent base","award":["RCJD2021B04"],"award-info":[{"award-number":["RCJD2021B04"]}]},{"name":"Sponsored by Shanghai Sailing Program","award":["23YF1436300"],"award-info":[{"award-number":["23YF1436300"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s10067-024-07158-1","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T04:46:21Z","timestamp":1732682781000},"page":"115-123","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["HIPK3 hypomethylation as a potential epigenetic biomarker in rheumatic immune diseases with emphasis on rheumatoid arthritis"],"prefix":"10.1007","volume":"44","author":[{"given":"Ping","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9948-6332","authenticated-orcid":false,"given":"Dongyi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"7158_CR1","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB McInnes","year":"2011","unstructured":"McInnes IB, Schett G (2011) The pathogenesis of rheumatoid arthritis. N Engl J Med 365:2205\u20132219. https:\/\/doi.org\/10.1056\/NEJMra1004965","journal-title":"N Engl J Med"},{"key":"7158_CR2","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s10067-016-3482-8","volume":"36","author":"K Shimada","year":"2017","unstructured":"Shimada K, Komiya A, Yokogawa N, Nishino J, Sugii S, Tohma S (2017) Impact of the size and number of swollen joints on serum C-reactive protein level and erythrocyte sedimentation rate in rheumatoid arthritis: a cross-sectional study in Japan. Clin Rheumatol 36:427\u2013431. https:\/\/doi.org\/10.1007\/s10067-016-3482-8","journal-title":"Clin Rheumatol"},{"key":"7158_CR3","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1111\/1756-185X.12698","volume":"19","author":"KM Son","year":"2016","unstructured":"Son KM, Kim SY, Lee SH, Yang CM, Seo YI, Kim HA (2016) Comparison of the disease activity score using the erythrocyte sedimentation rate and C-reactive protein levels in Koreans with rheumatoid arthritis. Int J Rheum Dis 19:1278\u20131283. https:\/\/doi.org\/10.1111\/1756-185X.12698","journal-title":"Int J Rheum Dis"},{"key":"7158_CR4","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.tig.2022.03.010","volume":"38","author":"AL Mattei","year":"2022","unstructured":"Mattei AL, Bailly N, Meissner A (2022) DNA methylation: a historical perspective. Trends Genet 38:676\u2013707. https:\/\/doi.org\/10.1016\/j.tig.2022.03.010","journal-title":"Trends Genet"},{"key":"7158_CR5","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/S0140-6736(18)31268-6","volume":"392","author":"Y Dor","year":"2018","unstructured":"Dor Y, Cedar H (2018) Principles of DNA methylation and their implications for biology and medicine. Lancet 392:777\u2013786. https:\/\/doi.org\/10.1016\/S0140-6736(18)31268-6","journal-title":"Lancet"},{"key":"7158_CR6","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s13075-017-1382-1","volume":"19","author":"J Hao","year":"2017","unstructured":"Hao J, Liu Y, Xu J, Wang W, Wen Y, He A, Fan Q, Guo X, Zhang F (2017) Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis. Arthritis Res Ther 19:177. https:\/\/doi.org\/10.1186\/s13075-017-1382-1","journal-title":"Arthritis Res Ther"},{"key":"7158_CR7","doi-asserted-by":"publisher","first-page":"e1003678","DOI":"10.1371\/journal.pgen.1003678","volume":"9","author":"DM Absher","year":"2013","unstructured":"Absher DM, Li X, Waite LL, Gibson A, Roberts K, Edberg J, Chatham WW, Kimberly RP (2013) Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations. PLoS Genet 9:e1003678. https:\/\/doi.org\/10.1371\/journal.pgen.1003678","journal-title":"PLoS Genet"},{"key":"7158_CR8","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1136\/annrheumdis-2019-215355","volume":"78","author":"J Rodr\u00edguez-Ubreva","year":"2019","unstructured":"Rodr\u00edguez-Ubreva J, de la Calle-Fabregat C, Li T, Ciudad L, Ballestar ML, Catal\u00e0-Moll F, Morante-Palacios O, Garcia-Gomez A, Celis R, Humby F et al (2019) Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis. Ann Rheum Dis 78:1505\u20131516. https:\/\/doi.org\/10.1136\/annrheumdis-2019-215355","journal-title":"Ann Rheum Dis"},{"key":"7158_CR9","doi-asserted-by":"publisher","first-page":"863703","DOI":"10.3389\/fimmu.2022.863703","volume":"13","author":"J Zhao","year":"2022","unstructured":"Zhao J, Wei K, Chang C, Xu L, Jiang P, Guo S, Schrodi SJ, He D (2022) DNA Methylation of T Lymphocytes as a Therapeutic Target: Implications for Rheumatoid Arthritis Etiology. Front Immunol 13:863703. https:\/\/doi.org\/10.3389\/fimmu.2022.863703","journal-title":"Front Immunol"},{"key":"7158_CR10","doi-asserted-by":"publisher","first-page":"1054451","DOI":"10.3389\/fimmu.2022.1054451","volume":"13","author":"J Zhao","year":"2022","unstructured":"Zhao J, Xu L, Chang C, Jiang P, Wei K, Shi Y, Xu L, Zheng Y, Shan Y, Bian Y et al (2022) Circulating methylation level of HTR2A is associated with inflammation and disease activity in rheumatoid arthritis. Front Immunol 13:1054451. https:\/\/doi.org\/10.3389\/fimmu.2022.1054451","journal-title":"Front Immunol"},{"key":"7158_CR11","doi-asserted-by":"publisher","first-page":"e902","DOI":"10.1002\/iid3.902","volume":"11","author":"Y Shi","year":"2023","unstructured":"Shi Y, Chang C, Xu L, Jiang P, Wei K, Zhao J, Xu L, Jin Y, Zhang R, Wang H et al (2023) Circulating DNA methylation level of CXCR5 correlates with inflammation in patients with rheumatoid arthritis. Immun Inflamm Dis 11:e902. https:\/\/doi.org\/10.1002\/iid3.902","journal-title":"Immun Inflamm Dis"},{"key":"7158_CR12","doi-asserted-by":"publisher","first-page":"3536","DOI":"10.18632\/aging.202294","volume":"13","author":"W Xiao","year":"2021","unstructured":"Xiao W, Wang T, Ye Y, Wang X, Chen B, Xing J, Yang H, Zhang X (2021) Identification of HIPK3 as a potential biomarker and an inhibitor of clear cell renal cell carcinoma. Aging (Albany NY) 13:3536\u20133553. https:\/\/doi.org\/10.18632\/aging.202294","journal-title":"Aging (Albany NY)"},{"key":"7158_CR13","doi-asserted-by":"publisher","first-page":"1087279","DOI":"10.3389\/fimmu.2022.1087279","volume":"13","author":"P Jiang","year":"2023","unstructured":"Jiang P, Wei K, Xu L, Chang C, Zhang R, Zhao J, Jin Y, Xu L, Shi Y, Qian Y et al (2023) DNA methylation change of HIPK3 in Chinese rheumatoid arthritis and its effect on inflammation. Front Immunol 13:1087279. https:\/\/doi.org\/10.3389\/fimmu.2022.1087279","journal-title":"Front Immunol"},{"key":"7158_CR14","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/nbt.2487","volume":"31","author":"Y Liu","year":"2013","unstructured":"Liu Y, Aryee MJ, Padyukov L, Fallin MD, Hesselberg E, Runarsson A, Reinius L, Acevedo N, Taub M, Ronninger M et al (2013) Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nat Biotechnol 31:142\u2013147. https:\/\/doi.org\/10.1038\/nbt.2487","journal-title":"Nat Biotechnol"},{"key":"7158_CR15","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1002\/art.39590","volume":"68","author":"D Plant","year":"2016","unstructured":"Plant D, Webster A, Nair N, Oliver J, Smith SL, Eyre S, Hyrich KL, Wilson AG, Morgan AW, Isaacs JD et al (2016) Differential Methylation as a Biomarker of Response to Etanercept in Patients With Rheumatoid Arthritis. Arthritis Rheumatol 68:1353\u20131360. https:\/\/doi.org\/10.1002\/art.39590","journal-title":"Arthritis Rheumatol"},{"key":"7158_CR16","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.1038\/s41467-018-05044-4","volume":"9","author":"S Tasaki","year":"2018","unstructured":"Tasaki S, Suzuki K, Kassai Y, Takeshita M, Murota A, Kondo Y, Ando T, Nakayama Y, Okuzono Y, Takiguchi M et al (2018) Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission. Nat Commun 9:2755. https:\/\/doi.org\/10.1038\/s41467-018-05044-4","journal-title":"Nat Commun"},{"key":"7158_CR17","doi-asserted-by":"publisher","first-page":"7459","DOI":"10.2147\/OTT.S166878","volume":"11","author":"Y Liu","year":"2018","unstructured":"Liu Y, Qian L, Yang J, Huang H, Feng J, Li X, Bian T, Ke H, Liu J, Zhang J (2018) The expression level and prognostic value of HIPK3 among non-small-cell lung cancer patients in China. OTT 11:7459\u20137469. https:\/\/doi.org\/10.2147\/OTT.S166878","journal-title":"OTT"},{"key":"7158_CR18","doi-asserted-by":"publisher","first-page":"676105","DOI":"10.3389\/fimmu.2021.676105","volume":"12","author":"GS Jutley","year":"2021","unstructured":"Jutley GS, Sahota K, Sahbudin I, Filer A, Arayssi T, Young SP, Raza K (2021) Relationship Between Inflammation and Metabolism in Patients With Newly Presenting Rheumatoid Arthritis. Front Immunol 12:676105. https:\/\/doi.org\/10.3389\/fimmu.2021.676105","journal-title":"Front Immunol"},{"key":"7158_CR19","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/ar2384","volume":"10","author":"AHM van der Helm-van Mil","year":"2008","unstructured":"van der Helm-van Mil AHM, Huizinga TWJ (2008) Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets. Arthritis Res Ther 10:205. https:\/\/doi.org\/10.1186\/ar2384","journal-title":"Arthritis Res Ther"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-024-07158-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-024-07158-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-024-07158-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T08:40:00Z","timestamp":1736757600000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-024-07158-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["7158"],"URL":"https:\/\/doi.org\/10.1007\/s10067-024-07158-1","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]},"assertion":[{"value":"11 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors listed in this manuscript have participated in the whole writing process of the manuscript and have informed consent to the publication of the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The author claim that none of the material in the paper has been published or is under consideration for publication elsewhere.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}