{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:40:02Z","timestamp":1785404402815,"version":"3.56.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Chongqing Science and Health Joint Traditional Chinese Medicine Technology Key Project","award":["2024ZYZD010"],"award-info":[{"award-number":["2024ZYZD010"]}]},{"name":"Chongqing Traditional Chinese Medicine Research Project","award":["2023MSXM167"],"award-info":[{"award-number":["2023MSXM167"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The study aims to assess the diagnostic and clinical significance of autoantibodies against aquaporin-1 (anti-AQP1) and aquaporin-5 (anti-AQP5) in primary Sj\u00f6gren\u2019s syndrome (pSS). A total of 163 participants were categorized into three groups: pSS group, other connective tissue diseases (CTD) group, and healthy control (HC) group. The levels of anti-AQP1 and anti-AQP5 autoantibodies in serum were determined using enzyme-linked immunosorbent assay (ELISA), and clinical data from patients were collected for statistical analysis. Our results showed that the level of anti-AQP1 in the pSS group was higher than in the HC group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and no significant difference was observed between the pSS group and the CTD group (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). ROC showed that the anti-AQP1 had no diagnostic value for pSS (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). The anti-AQP5 level of 39 healthy adults was all below the cut-off value (14.10\u00a0ng\/ml) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The level of anti-AQP5 in the pSS group was higher than the CTD group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), the AUC was 0.86 (95% CI 0.80\u20130.93), with a sensitivity of 0.95 (95% CI 0.87\u20130.99) and a specificity of 0.70 (95% CI 0.58\u20130.84). No correlation was found between anti-AQP5 levels and the EULAR primary Sj\u00f6gren\u2019s syndrome disease activity index score, anti-SSA, anti-SSB, antinuclear antibodies, rheumatoid factor, anti-ds-DNA, salivary gland flow rate, complement 3, and lymphocyte count in pSS samples (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05), respectively. Therefore, the elevated anti-AQP5 may emerge as a novel diagnostic biomarker for pSS patients due to high sensitivity and specificity.<\/jats:p><jats:p><jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>Key Points<\/jats:bold><jats:italic>\u2022 The elevated anti-AQP5 may emerge as a novel diagnostic biomarker for pSS patients due to high sensitivity and specificity.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s10067-024-07190-1","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T07:02:18Z","timestamp":1729666938000},"page":"3781-3787","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Autoantibody against aquaporin-5 may be a new diagnostic biomarker for primary Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1007","volume":"43","author":[{"given":"Xiaoyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4505-9690","authenticated-orcid":false,"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"issue":"12","key":"7190_CR1","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.55563\/clinexprheumatol\/43z8gu","volume":"40","author":"V Manfr\u00e8","year":"2022","unstructured":"Manfr\u00e8 V, Chatzis LG, Cafaro G, Fonzetti S, Calvacchi S, Fulvio G et al (2022) Sj\u00f6gren\u2019s syndrome: one year in review 2022. 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