{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T11:15:36Z","timestamp":1793099736959,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Key Program of the National Natural Science Foundation of China","award":["82330055"],"award-info":[{"award-number":["82330055"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s10067-025-07336-9","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T03:29:47Z","timestamp":1737602987000},"page":"1103-1111","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cardiovascular autonomic neuropathy is associated with SLEDAI in patients with systemic lupus erythematosus"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8665-007X","authenticated-orcid":false,"given":"Simin","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"7336_CR1","doi-asserted-by":"publisher","unstructured":"Mohammed A, Oboseh J, Ogedegbe et al (2023) Systemic Lupus Erythematosus and Cardiovascular Diseases: A Systematic Review. Cureus 15(5):e39284. https:\/\/doi.org\/10.7759\/cureus.39284","DOI":"10.7759\/cureus.39284"},{"issue":"1","key":"7336_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4093\/dmj.2018.0259","volume":"43","author":"S Vincenza","year":"2019","unstructured":"Vincenza S (2019) Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: What Is Defined, What Is New, and What Is Unmet. Diabetes Metab J 43(1):3\u201330. https:\/\/doi.org\/10.4093\/dmj.2018.0259","journal-title":"Diabetes Metab J"},{"issue":"8","key":"7336_CR3","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.2337\/diacare.27.8.1954","volume":"27","author":"FJ Th","year":"2004","unstructured":"Th FJ, Lawrence H, Silvio E et al (2004) Detection of silent myocardial ischemia in asymptomatic diabetic subjects: the DIAD study. Diabetes Care 27(8):1954\u20131961. https:\/\/doi.org\/10.2337\/diacare.27.8.1954","journal-title":"Diabetes Care"},{"issue":"8","key":"7336_CR4","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1177\/0961203318771502","volume":"27","author":"PS Matusik","year":"2018","unstructured":"Matusik PS, Matusik PT, Stein PK (2018) Heart rate variability in patients with systemic lupus erythematosus: a systematic review and methodological considerations. Lupus 27(8):1225\u20131239. https:\/\/doi.org\/10.1177\/0961203318771502","journal-title":"Lupus"},{"issue":"11","key":"7336_CR5","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1177\/0961203318783052","volume":"27","author":"PS Matusik","year":"2018","unstructured":"Matusik PS, Matusik PT, Stein PK (2018) Cardiovascular reflex tests in patients with systemic lupus erythematosus: clinical performance and utility. Lupus 27(11):1759\u20131768. https:\/\/doi.org\/10.1177\/0961203318783052","journal-title":"Lupus"},{"issue":"6","key":"7336_CR6","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/s11892-006-0074-z","volume":"6","author":"I Aaron","year":"2006","unstructured":"Aaron I, Vinik TE (2006) Cardiovascular autonomic neuropathy: diagnosis and management. Curr Diab Rep 6(6):424\u2013430. https:\/\/doi.org\/10.1007\/s11892-006-0074-z","journal-title":"Curr Diab Rep"},{"issue":"1","key":"7336_CR7","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12933-018-0752-6","volume":"17","author":"Y Jae-Seung","year":"2018","unstructured":"Jae-Seung Y, Yong-Moon P, Seon-Ah C et al (2018) Progression of cardiovascular autonomic neuropathy and cardiovascular disease in type 2 diabetes. Cardiovasc Diabetol 17(1):109. https:\/\/doi.org\/10.1186\/s12933-018-0752-6","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"7336_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12264-019-00337-0","volume":"35","author":"C Zixi Jack","year":"2019","unstructured":"Zixi Jack C, Renjun W, QingHui C (2019) Autonomic Regulation of the Cardiovascular System: Diseases, Treatments, and Novel Approaches. Neurosci Bull 35(1):1\u20133. https:\/\/doi.org\/10.1007\/s12264-019-00337-0","journal-title":"Neurosci Bull"},{"key":"7336_CR9","doi-asserted-by":"publisher","unstructured":"Zinglersen AH, Iversen KK, Leffers HCB et al (2021) Characteristics of cardiovascular autonomic dysfunction and association with quality of life in patients with systemic lupus erythematosus. Lupus Sci Med 8(1). https:\/\/doi.org\/10.1136\/lupus-2021-000507","DOI":"10.1136\/lupus-2021-000507"},{"issue":"5","key":"7336_CR10","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","volume":"93","author":"Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology","year":"1996","unstructured":"Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996) Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation 93(5):1043\u20131065","journal-title":"Circulation"},{"issue":"10","key":"7336_CR11","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.2337\/dc10-1303","volume":"33","author":"S Tesfaye","year":"2010","unstructured":"Tesfaye S, Boulton AJ, Dyck PJ et al (2010) Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care 33(10):2285\u20132293","journal-title":"Diabetes Care"},{"issue":"1","key":"7336_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.2337\/dc10-1303","volume":"18","author":"A Thanou","year":"2016","unstructured":"Thanou A, Stavrakis S, Dyer JW et al (2016) Impact of heart rate variability, a marker for cardiac health, on lupus disease activity. Arthritis Res Ther 18(1):197. https:\/\/doi.org\/10.2337\/dc10-1303","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"7336_CR13","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1093\/rheumatology\/kep134","volume":"48","author":"ZA El-Sayed","year":"2009","unstructured":"El-Sayed ZA, Mostafa GA, Aly GS et al (2009) Cardiovascular autonomic function assessed by autonomic function tests and serum autonomic neuropeptides in Egyptian children and adolescents with rheumatic diseases. Rheumatology (Oxford) 48(7):843\u2013848. https:\/\/doi.org\/10.1093\/rheumatology\/kep134","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"7336_CR14","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1046\/j.1365-2249.1997.4501466.x","volume":"110","author":"S Maule","year":"1997","unstructured":"Maule S, Quadri R, Mirante D et al (1997) Autonomic nervous dysfunction in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA): possible pathogenic role of autoantibodies to autonomic nervous structures. Clin Exp Immunol 110(3):423\u2013427. https:\/\/doi.org\/10.1046\/j.1365-2249.1997.4501466.x","journal-title":"Clin Exp Immunol"},{"issue":"5","key":"7336_CR15","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.berh.2005.03.010","volume":"19","author":"B Griffiths","year":"2005","unstructured":"Griffiths B, Mosca M, Gordon C (2005) Assessment of patients with systemic lupus erythematosus and the use of lupus disease activity indices. Best Pract Res Clin Rheumatol 19(5):685\u2013708. https:\/\/doi.org\/10.1016\/j.berh.2005.03.010","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"7336_CR16","doi-asserted-by":"publisher","unstructured":"Bombardier C, Gladman DD, Urowitz MB et al (1992) Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 35(6): 630\u201340. https:\/\/doi.org\/10.1002\/art.1780350606","DOI":"10.1002\/art.1780350606"},{"issue":"9","key":"7336_CR17","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1002\/art.1780400928","volume":"40","author":"MC Hochberg","year":"1997","unstructured":"Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40(9):1725. https:\/\/doi.org\/10.1002\/art.1780400928","journal-title":"Arthritis Rheum"},{"issue":"5","key":"7336_CR18","doi-asserted-by":"publisher","first-page":"491","DOI":"10.2337\/diacare.8.5.491","volume":"8","author":"DJ Ewing","year":"1985","unstructured":"Ewing DJ, Martyn CN, Young RJ et al (1985) The value of cardiovascular autonomic function tests: 10 years experience in diabetes. Diabetes Care 8(5):491\u2013498. https:\/\/doi.org\/10.2337\/diacare.8.5.491","journal-title":"Diabetes Care"},{"key":"7336_CR19","doi-asserted-by":"publisher","unstructured":"Bombardier C, Gladman DD, Urowitz MB et al (1992) Derivation of the SLEDAI: a disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 35:630\u201340. https:\/\/doi.org\/10.1002\/art.1780350606","DOI":"10.1002\/art.1780350606"},{"issue":"1","key":"7336_CR20","doi-asserted-by":"publisher","first-page":"136","DOI":"10.2337\/dc16-2042","volume":"40","author":"R Pop-Busui","year":"2017","unstructured":"Pop-Busui R, Boulton AJ, Feldman EL et al (2017) Diabetic neuropathy: a position statement by the American diabetes association. Diabetes Care 40(1):136\u2013154. https:\/\/doi.org\/10.2337\/dc16-2042","journal-title":"Diabetes Care"},{"key":"7336_CR21","doi-asserted-by":"publisher","first-page":"808839","DOI":"10.3389\/fimmu.2021.808839","volume":"12","author":"G Tan","year":"2022","unstructured":"Tan G, Baby B, Zhou Y et al (2022) Emerging Molecular Markers Towards Potential Diagnostic Panels for Lupus. Front Immunol 12:808839. https:\/\/doi.org\/10.3389\/fimmu.2021.808839","journal-title":"Front Immunol"},{"issue":"1","key":"7336_CR22","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/jdi.13635","volume":"13","author":"R Pop-Busui","year":"2022","unstructured":"Pop-Busui R, Backlund JC, Bebu I et al (2022) Utility of using electrocardiogram measures of heart rate variability as a measure of cardiovascular autonomic neuropathy in type 1 diabetes patients. J Diabetes Investig 13(1):125\u2013133. https:\/\/doi.org\/10.1111\/jdi.13635","journal-title":"J Diabetes Investig"},{"issue":"2","key":"7336_CR23","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.diabres.2008.08.012","volume":"82","author":"HT Chen","year":"2008","unstructured":"Chen HT, Lin HD, Won JG et al (2008) Cardiovascular autonomic neuropathy, autonomic symptoms and diabetic complications in 674 type 2 diabetes. Diabetes Res Clin Pract 82(2):282\u2013290. https:\/\/doi.org\/10.1016\/j.diabres.2008.08.012","journal-title":"Diabetes Res Clin Pract"},{"issue":"6","key":"7336_CR24","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1111\/j.1464-5491.2011.03278.x","volume":"28","author":"T Laitinen","year":"2011","unstructured":"Laitinen T, Lindstr\u00f6m J, Eriksson J et al (2011) Cardiovascular autonomic dysfunction is associated with central obesity in persons with impaired glucose tolerance. Diabet Med 28(6):699\u2013704. https:\/\/doi.org\/10.1111\/j.1464-5491.2011.03278.x","journal-title":"Diabet Med"},{"issue":"17","key":"7336_CR25","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1001\/archinte.166.17.1884","volume":"166","author":"IP Nisha","year":"2006","unstructured":"Nisha IP, Shih-Jen H, Martin G et al (2006) Cardiovascular disease risk factors in chronic kidney disease: overall burden and rates of treatment and control. Arch Intern Med 166(17):1884\u20131891. https:\/\/doi.org\/10.1001\/archinte.166.17.1884","journal-title":"Arch Intern Med"},{"issue":"1","key":"7336_CR26","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s40618-022-01886-4","volume":"46","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Bai J, Li L et al (2023) Research for correlation between heart rate variability parameters and bone mineral density in patients of type 2 diabetes mellitus. J Endocrinol Invest 46(1):79\u201388. https:\/\/doi.org\/10.1007\/s40618-022-01886-4","journal-title":"J Endocrinol Invest"},{"key":"7336_CR27","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1007\/s00592-021-01744-4","volume":"58","author":"G Simin","year":"2021","unstructured":"Simin G, Weimin W, Hong H et al (2021) Quantitative sensory testing can effectively predict cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus. Acta Diabetol 58:1541\u20131549. https:\/\/doi.org\/10.1007\/s00592-021-01744-4","journal-title":"Acta Diabetol"},{"issue":"3","key":"7336_CR28","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1177\/0961203306076223","volume":"16","author":"L Stojanovich","year":"2007","unstructured":"Stojanovich L, Milovanovich B, de Luka SR et al (2007) Cardiovascular autonomic dysfunction in systemic lupus, rheumatoid arthritis, primary Sj\u00f6gren syndrome and other autoimmune diseases. Lupus 16(3):181\u2013185. https:\/\/doi.org\/10.1177\/0961203306076223","journal-title":"Lupus"},{"issue":"8","key":"7336_CR29","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1177\/0961203318771502","volume":"27","author":"PS Matusik","year":"2018","unstructured":"Matusik PS, Matusik PT, Stein PK (2018) Heart rate variability in patients with systemic lupus erythematosus: a systematic review and methodological considerations. Lupus 27(8):1225\u20131239. https:\/\/doi.org\/10.1177\/0961203318771502","journal-title":"Lupus"},{"key":"7336_CR30","doi-asserted-by":"publisher","unstructured":"Jiaxu Li, Carolyn L, Cummins (2022) Fresh insights into glucocorticoid-induced diabetes mellitus and new therapeutic directions. Nat Rev Endocrinol 18(9):540-447. https:\/\/doi.org\/10.1038\/s41574-022-00683-6","DOI":"10.1038\/s41574-022-00683-6"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-025-07336-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-025-07336-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-025-07336-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T08:18:46Z","timestamp":1740557926000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-025-07336-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,23]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["7336"],"URL":"https:\/\/doi.org\/10.1007\/s10067-025-07336-9","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,23]]},"assertion":[{"value":"24 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standard"}},{"value":"The study data collections were approved by the Institutional Review Board of Nanjing Drum Tower Hospital and written informed consent was obtained from all patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"None.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}