{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:26:33Z","timestamp":1777109193747,"version":"3.51.4"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Jiangsu Provincial Health Commission elderly health research project","award":["LKM2022071"],"award-info":[{"award-number":["LKM2022071"]}]},{"name":"Jiangsu Province Chinese medicine science and technology development fund project","award":["MS2022106"],"award-info":[{"award-number":["MS2022106"]}]},{"name":"The Development Fund of Affiliated Hospital of Xuzhou Medical University","award":["XYFM202232"],"award-info":[{"award-number":["XYFM202232"]}]},{"DOI":"10.13039\/501100011441","name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases","doi-asserted-by":"publisher","award":["HAP202302"],"award-info":[{"award-number":["HAP202302"]}],"id":[{"id":"10.13039\/501100011441","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Rheumatol"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1007\/s10067-025-07532-7","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T22:33:44Z","timestamp":1749594824000},"page":"3013-3024","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Causal effects of lipidomics and osteoporosis-related traits: a Mendelian randomization study"],"prefix":"10.1007","volume":"44","author":[{"given":"Ping","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deqian","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5643-8043","authenticated-orcid":false,"given":"Shaohua","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"issue":"3","key":"7532_CR1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.semarthrit.2016.07.013","volume":"46","author":"E Yelin","year":"2016","unstructured":"Yelin E, Weinstein S, King T (2016) The burden of musculoskeletal diseases in the United States. Semin Arthritis Rheum 46(3):259\u2013260","journal-title":"Semin Arthritis Rheum"},{"issue":"1","key":"7532_CR2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2105\/AJPH.2018.304747","volume":"109","author":"FM Blyth","year":"2019","unstructured":"Blyth FM, Briggs AM, Schneider CH, Hoy DG, March LM (2019) The global burden of musculoskeletal pain-where to from here? Am J Public Health 109(1):35\u201340","journal-title":"Am J Public Health"},{"issue":"3","key":"7532_CR3","doi-asserted-by":"crossref","first-page":"105135","DOI":"10.1016\/j.jbspin.2021.105135","volume":"88","author":"B Bouvard","year":"2021","unstructured":"Bouvard B, Annweiler C, Legrand E (2021) Osteoporosis in older adults. Joint Bone Spine 88(3):105135","journal-title":"Joint Bone Spine"},{"issue":"7","key":"7532_CR4","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00198-019-04892-0","volume":"30","author":"J Wang","year":"2019","unstructured":"Wang J, Yan D, Zhao A, Hou X, Zheng X, Chen P et al (2019) Discovery of potential biomarkers for osteoporosis using LC-MS\/MS metabolomic methods. Osteoporos Int 30(7):1491\u20131499","journal-title":"Osteoporos Int"},{"issue":"1","key":"7532_CR5","doi-asserted-by":"crossref","first-page":"e23016","DOI":"10.1002\/jcla.23016","volume":"34","author":"H Fang","year":"2020","unstructured":"Fang H, Zhang H, Wang Z, Zhou Z, Li Y, Lu L (2020) Systemic immune-inflammation index acts as a novel diagnostic biomarker for postmenopausal osteoporosis and could predict the risk of osteoporotic fracture. J Clin Lab Anal 34(1):e23016","journal-title":"J Clin Lab Anal"},{"issue":"5","key":"7532_CR6","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.mcna.2020.06.004","volume":"104","author":"CB Johnston","year":"2020","unstructured":"Johnston CB, Dagar M (2020) Osteoporosis in older adults. Med Clin North Am 104(5):873\u2013884","journal-title":"Med Clin North Am"},{"issue":"1","key":"7532_CR7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11657-013-0137-0","volume":"8","author":"A Svedbom","year":"2013","unstructured":"Svedbom A, Hernlund E, Iverg\u00e5rd M, Compston J, Cooper C, Stenmark J et al (2013) Osteoporosis in the European Union: a compendium of country-specific reports. Arch Osteoporos 8(1):137","journal-title":"Arch Osteoporos"},{"key":"7532_CR8","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.2147\/TCRM.S138000","volume":"14","author":"F Pouresmaeili","year":"2018","unstructured":"Pouresmaeili F, Kamalidehghan B, Kamarehei M, Goh YM (2018) A comprehensive overview on osteoporosis and its risk factors. Ther Clin Risk Manag 14:2029\u20132049","journal-title":"Ther Clin Risk Manag"},{"issue":"1","key":"7532_CR9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1359\/jbmr.2001.16.1.182","volume":"16","author":"F Parhami","year":"2001","unstructured":"Parhami F, Tintut Y, Beamer WG, Gharavi N, Goodman W, Demer LL (2001) Atherogenic high-fat diet reduces bone mineralization in mice. J Bone Miner Res: Off J Am Soc Bone Min Res 16(1):182\u2013188","journal-title":"J Bone Miner Res: Off J Am Soc Bone Min Res"},{"issue":"2","key":"7532_CR10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1507\/endocrj.49.211","volume":"49","author":"T Yamaguchi","year":"2002","unstructured":"Yamaguchi T, Sugimoto T, Yano S, Yamauchi M, Sowa H, Chen Q et al (2002) Plasma lipids and osteoporosis in postmenopausal women. Endocr J 49(2):211\u2013217","journal-title":"Endocr J"},{"issue":"12","key":"7532_CR11","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s10654-004-1706-8","volume":"19","author":"P Orozco","year":"2004","unstructured":"Orozco P (2004) Atherogenic lipid profile and elevated lipoprotein (a) are associated with lower bone mineral density in early postmenopausal overweight women. Eur J Epidemiol 19(12):1105\u20131112","journal-title":"Eur J Epidemiol"},{"issue":"3","key":"7532_CR12","first-page":"237","volume":"4","author":"GS Ersoy","year":"2017","unstructured":"Ersoy GS, Simsek EE, Vatansever D, Kasikci HO, Keser B, Sakin O (2017) Lipid profile and plasma atherogenic index in postmenopausal osteoporosis. North Clin Istanbul 4(3):237\u2013241","journal-title":"North Clin Istanbul"},{"issue":"3","key":"7532_CR13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.bone.2003.11.024","volume":"34","author":"EJ Samelson","year":"2004","unstructured":"Samelson EJ, Cupples LA, Hannan MT, Wilson PW, Williams SA, Vaccarino V et al (2004) Long-term effects of serum cholesterol on bone mineral density in women and men: the Framingham Osteoporosis Study. Bone 34(3):557\u2013561","journal-title":"Bone"},{"issue":"1","key":"7532_CR14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S8756-3282(02)00918-3","volume":"32","author":"LB Tank\u00f3","year":"2003","unstructured":"Tank\u00f3 LB, Bagger YZ, Nielsen SB, Christiansen C (2003) Does serum cholesterol contribute to vertebral bone loss in postmenopausal women? Bone 32(1):8\u201314","journal-title":"Bone"},{"issue":"19","key":"7532_CR15","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","volume":"318","author":"CA Emdin","year":"2017","unstructured":"Emdin CA, Khera AV, Kathiresan S (2017) Mendelian randomization. JAMA 318(19):1925\u20131926","journal-title":"JAMA"},{"issue":"13","key":"7532_CR16","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1111\/1471-0528.15199","volume":"125","author":"E Hariton","year":"2018","unstructured":"Hariton E, Locascio JJ (2018) Randomised controlled trials - the gold standard for effectiveness research: study design: randomised controlled trials. BJOG\u202f: Int J Obstet Gynaecol 125(13):1716","journal-title":"BJOG : Int J Obstet Gynaecol"},{"issue":"1","key":"7532_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/dyg070","volume":"32","author":"GD Smith","year":"2003","unstructured":"Smith GD, Ebrahim S (2003) \u2018Mendelian randomization\u2019: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 32(1):1\u201322","journal-title":"Int J Epidemiol"},{"issue":"4","key":"7532_CR18","first-page":"a041302","volume":"12","author":"E Birney","year":"2022","unstructured":"Birney E (2022) Mendelian randomization. Cold Spring Harbor Perspect Med 12(4):a041302","journal-title":"Cold Spring Harbor Perspect Med"},{"key":"7532_CR19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bone.2019.05.037","volume":"127","author":"XL Yang","year":"2019","unstructured":"Yang XL, Cui ZZ, Zhang H, Wei XT, Feng GJ, Liu L et al (2019) Causal link between lipid profile and bone mineral density: a Mendelian randomization study. Bone 127:37\u201343","journal-title":"Bone"},{"issue":"2","key":"7532_CR20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00223-023-01160-6","volume":"114","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Duan Y, Huo J (2024) Lipid metabolism, methylation aberrant, and osteoporosis: a multi-omics study based on Mendelian randomization. Calcif Tissue Int 114(2):147\u2013156","journal-title":"Calcif Tissue Int"},{"issue":"1","key":"7532_CR21","doi-asserted-by":"crossref","first-page":"6934","DOI":"10.1038\/s41467-023-42532-8","volume":"14","author":"L Ottensmann","year":"2023","unstructured":"Ottensmann L, Tabassum R, Ruotsalainen SE, Gerl MJ, Klose C, Wid\u00e9n E et al (2023) Genome-wide association analysis of plasma lipidome identifies 495 genetic associations. Nat Commun 14(1):6934","journal-title":"Nat Commun"},{"issue":"1","key":"7532_CR22","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1038\/s41467-021-21952-4","volume":"12","author":"M Guindo-Mart\u00ednez","year":"2021","unstructured":"Guindo-Mart\u00ednez M, Amela R, Bon\u00e0s-Guarch S, Puiggr\u00f2s M, Salvoro C, Miguel-Escalada I et al (2021) The impact of non-additive genetic associations on age-related complex diseases. Nat Commun 12(1):2436","journal-title":"Nat Commun"},{"issue":"2","key":"7532_CR23","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41588-018-0302-x","volume":"51","author":"JA Morris","year":"2019","unstructured":"Morris JA, Kemp JP, Youlten SE, Laurent L, Logan JG, Chai RC et al (2019) An atlas of genetic influences on osteoporosis in humans and mice. Nat Genet 51(2):258\u2013266","journal-title":"Nat Genet"},{"issue":"1","key":"7532_CR24","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ajhg.2017.12.005","volume":"102","author":"C Medina-Gomez","year":"2018","unstructured":"Medina-Gomez C, Kemp JP, Trajanoska K, Luan J, Chesi A, Ahluwalia TS et al (2018) Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects. Am J Hum Genet 102(1):88\u2013102","journal-title":"Am J Hum Genet"},{"issue":"7571","key":"7532_CR25","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature14878","volume":"526","author":"HF Zheng","year":"2015","unstructured":"Zheng HF, Forgetta V, Hsu YH, Estrada K, Rosello-Diez A, Leo PJ et al (2015) Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture. Nature 526(7571):112\u2013117","journal-title":"Nature"},{"issue":"11","key":"7532_CR26","doi-asserted-by":"crossref","first-page":"e1007081","DOI":"10.1371\/journal.pgen.1007081","volume":"13","author":"G Hemani","year":"2017","unstructured":"Hemani G, Tilling K, Davey SG (2017) Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet 13(11):e1007081","journal-title":"PLoS Genet"},{"key":"7532_CR27","doi-asserted-by":"crossref","first-page":"578194","DOI":"10.3389\/fendo.2020.578194","volume":"11","author":"NS Alekos","year":"2020","unstructured":"Alekos NS, Moorer MC, Riddle RC (2020) Dual effects of lipid metabolism on osteoblast function. Front Endocrinol 11:578194","journal-title":"Front Endocrinol"},{"issue":"8","key":"7532_CR28","doi-asserted-by":"crossref","first-page":"e0273025","DOI":"10.1371\/journal.pone.0273025","volume":"17","author":"YH Tompkins","year":"2022","unstructured":"Tompkins YH, Chen C, Sweeney KM, Kim M, Voy BH, Wilson JL et al (2022) The effects of maternal fish oil supplementation rich in n-3 PUFA on offspring-broiler growth performance, body composition and bone microstructure. PLoS ONE 17(8):e0273025","journal-title":"PLoS ONE"},{"key":"7532_CR29","doi-asserted-by":"crossref","first-page":"1202688","DOI":"10.3389\/fnut.2023.1202688","volume":"10","author":"AR Ahmadi","year":"2023","unstructured":"Ahmadi AR, Shirani F, Abiri B, Siavash M, Haghighi S, Akbari M (2023) Impact of omega-3 fatty acids supplementation on the gene expression of peroxisome proliferator activated receptors-\u03b3, \u03b1 and fibroblast growth factor-21 serum levels in patients with various presentation of metabolic conditions: a GRADE assessed systematic review and dose-response meta-analysis of clinical trials. Front Nutr 10:1202688","journal-title":"Front Nutr"},{"key":"7532_CR30","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.2147\/DMSO.S231735","volume":"13","author":"H Huang","year":"2020","unstructured":"Huang H, Luo L, Liu Z, Li Y, Tong Z, Liu Z (2020) Role of TNF-\u03b1 and FGF-2 in the fracture healing disorder of type 2 diabetes model induced by high fat diet followed by streptozotocin. Diabetes Metab Syndr Obes: Targets Ther 13:2279\u20132288","journal-title":"Diabetes Metab Syndr Obes: Targets Ther"},{"issue":"1","key":"7532_CR31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3892\/ijmm.2024.5385","volume":"54","author":"X Wang","year":"2024","unstructured":"Wang X, Zhang C, Zhao G, Yang K, Tao L (2024) Obesity and lipid metabolism in the development of osteoporosis. Int J Mol Med 54(1):61","journal-title":"Int J Mol Med"},{"issue":"7","key":"7532_CR32","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1007\/s00198-011-1835-3","volume":"23","author":"WJ Xiao","year":"2012","unstructured":"Xiao WJ, Ke YH, He JW, Zhang H, Yu JB, Hu WW et al (2012) Polymorphisms in the human ALOX12 and ALOX15 genes are associated with peak bone mineral density in Chinese nuclear families. Osteoporos Int 23(7):1889\u20131897","journal-title":"Osteoporos Int"},{"issue":"3","key":"7532_CR33","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/bbb\/zbaa097","volume":"85","author":"Y Wu","year":"2021","unstructured":"Wu Y, Zhang M, Chen X, Zhou Y, Chen Z (2021) Metabolomic analysis to elucidate the change of the n-3 polyunsaturated fatty acids in senescent osteoblasts. Biosci Biotechnol Biochem 85(3):611\u2013620","journal-title":"Biosci Biotechnol Biochem"},{"key":"7532_CR34","doi-asserted-by":"crossref","first-page":"117443","DOI":"10.1016\/j.lfs.2020.117443","volume":"247","author":"P Liu","year":"2020","unstructured":"Liu P, Zhu W, Chen C, Yan B, Zhu L, Chen X et al (2020) The mechanisms of lysophosphatidylcholine in the development of diseases. Life Sci 247:117443","journal-title":"Life Sci"},{"issue":"5","key":"7532_CR35","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cmet.2011.02.016","volume":"13","author":"Z Zhou","year":"2011","unstructured":"Zhou Z, Subramanian P, Sevilmis G, Globke B, Soehnlein O, Karshovska E et al (2011) Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium. Cell Metab 13(5):592\u2013600","journal-title":"Cell Metab"},{"key":"7532_CR36","doi-asserted-by":"crossref","first-page":"778078","DOI":"10.3389\/fimmu.2021.778078","volume":"12","author":"Y Sun","year":"2021","unstructured":"Sun Y, Li J, Xie X, Gu F, Sui Z, Zhang K et al (2021) Macrophage-osteoclast associations: origin, polarization, and subgroups. Front Immunol 12:778078","journal-title":"Front Immunol"},{"issue":"10","key":"7532_CR37","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.3390\/nu12102999","volume":"12","author":"J Mu\u00f1oz","year":"2020","unstructured":"Mu\u00f1oz J, Akhavan NS, Mullins AP, Arjmandi BH (2020) Macrophage polarization and osteoporosis: a review. Nutrients 12(10):2999","journal-title":"Nutrients"},{"issue":"5","key":"7532_CR38","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00281-019-00754-3","volume":"41","author":"D Yang","year":"2019","unstructured":"Yang D, Wan Y (2019) Molecular determinants for the polarization of macrophage and osteoclast. Semin Immunopathol 41(5):551\u2013563","journal-title":"Semin Immunopathol"},{"issue":"6","key":"7532_CR39","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3390\/metabo14060317","volume":"14","author":"Q Zhou","year":"2024","unstructured":"Zhou Q, Chen Y, Liang Y, Sun Y (2024) The role of lysophospholipid metabolites lpc and LPA in the pathogenesis of chronic obstructive pulmonary disease. Metabolites 14(6):317","journal-title":"Metabolites"},{"issue":"21","key":"7532_CR40","doi-asserted-by":"crossref","first-page":"7905","DOI":"10.3390\/ijms21217905","volume":"21","author":"M Tsubaki","year":"2020","unstructured":"Tsubaki M, Seki S, Takeda T, Chihara A, Arai Y, Morii Y et al (2020) The HGF\/Met\/NF-\u03baB pathway regulates RANKL expression in osteoblasts and bone marrow stromal cells. Int J Mol Sci 21(21):7905","journal-title":"Int J Mol Sci"},{"issue":"3","key":"7532_CR41","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3803\/EnM.2018.33.3.318","volume":"33","author":"MC Moorer","year":"2018","unstructured":"Moorer MC, Riddle RC (2018) Regulation of osteoblast metabolism by Wnt signaling. Endocrinol Metab (Seoul, Korea) 33(3):318\u2013330","journal-title":"Endocrinol Metab (Seoul, Korea)"},{"key":"7532_CR42","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41413-018-0023-x","volume":"6","author":"L Wang","year":"2018","unstructured":"Wang L, Chai Y, Li C, Liu H, Su W, Liu X et al (2018) Oxidized phospholipids are ligands for LRP6. Bone Res 6:22","journal-title":"Bone Res"},{"key":"7532_CR43","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.freeradbiomed.2023.08.031","volume":"208","author":"T Hao","year":"2023","unstructured":"Hao T, Fang W, Xu D, Chen Q, Liu Q, Cui K et al (2023) Phosphatidylethanolamine alleviates OX-LDL-induced macrophage inflammation by upregulating autophagy and inhibiting NLRP1 inflammasome activation. Free Radical Biol Med 208:402\u2013417","journal-title":"Free Radical Biol Med"},{"key":"7532_CR44","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.nu.06.070186.003023","volume":"6","author":"BJ Holub","year":"1986","unstructured":"Holub BJ (1986) Metabolism and function of myo-inositol and inositol phospholipids. Annu Rev Nutr 6:563\u2013597","journal-title":"Annu Rev Nutr"},{"issue":"12","key":"7532_CR45","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1002\/jbmr.1703","volume":"27","author":"M Shinohara","year":"2012","unstructured":"Shinohara M, Nakamura M, Masuda H, Hirose J, Kadono Y, Iwasawa M et al (2012) Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through protein kinase B-mediated vesicle transport. J Bone Miner Res: Off J Am Soc Bone Miner Res 27(12):2464\u20132475","journal-title":"J Bone Miner Res: Off J Am Soc Bone Miner Res"},{"issue":"1","key":"7532_CR46","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/10799893.2019.1625061","volume":"39","author":"JM Pan","year":"2019","unstructured":"Pan JM, Wu LG, Cai JW, Wu LT, Liang M (2019) Dexamethasone suppresses osteogenesis of osteoblast via the PI3K\/Akt signaling pathway in vitro and in vivo. J Recept Signal Transduct Res 39(1):80\u201386","journal-title":"J Recept Signal Transduct Res"},{"issue":"1","key":"7532_CR47","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41392-023-01467-8","volume":"8","author":"H Xu","year":"2023","unstructured":"Xu H, Wang W, Liu X, Huang W, Zhu C, Xu Y et al (2023) Targeting strategies for bone diseases: signaling pathways and clinical studies. Signal Transduct Target Ther 8(1):202","journal-title":"Signal Transduct Target Ther"},{"key":"7532_CR48","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s13287-015-0225-8","volume":"6","author":"N Baker","year":"2015","unstructured":"Baker N, Sohn J, Tuan RS (2015) Promotion of human mesenchymal stem cell osteogenesis by PI3-kinase\/Akt signaling, and the influence of caveolin-1\/cholesterol homeostasis. Stem Cell Res Ther 6:238","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"7532_CR49","first-page":"1542","volume":"18","author":"J Chai","year":"2022","unstructured":"Chai J, Xu L, Liu N (2022) miR-23b-3p regulates differentiation of osteoclasts by targeting PTEN via the PI3k\/AKT pathway. Arch Med Sci: AMS 18(6):1542\u20131557","journal-title":"Arch Med Sci: AMS"},{"issue":"2","key":"7532_CR50","doi-asserted-by":"crossref","first-page":"e12735","DOI":"10.1111\/cpr.12735","volume":"53","author":"M Bao","year":"2020","unstructured":"Bao M, Zhang K, Wei Y, Hua W, Gao Y, Li X et al (2020) Therapeutic potentials and modulatory mechanisms of fatty acids in bone. Cell Prolif 53(2):e12735","journal-title":"Cell Prolif"},{"issue":"7","key":"7532_CR51","first-page":"18","volume":"28","author":"T Wang","year":"2022","unstructured":"Wang T, Li S, Yi C, Wang X, Han X (2022) Protective role of \u03b2-sitosterol in glucocorticoid-induced osteoporosis in rats via the RANKL\/OPG pathway. Altern Ther Health Med 28(7):18\u201325","journal-title":"Altern Ther Health Med"},{"key":"7532_CR52","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ijcard.2021.01.073","volume":"331","author":"JS Tan","year":"2021","unstructured":"Tan JS, Yan XX, Wu Y, Gao X, Xu XQ, Jiang X et al (2021) Rare variants in MTHFR predispose to occurrence and recurrence of pulmonary embolism. Int J Cardiol 331:236\u2013242","journal-title":"Int J Cardiol"}],"container-title":["Clinical Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-025-07532-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10067-025-07532-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10067-025-07532-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T07:46:52Z","timestamp":1751874412000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10067-025-07532-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,11]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["7532"],"URL":"https:\/\/doi.org\/10.1007\/s10067-025-07532-7","relation":{},"ISSN":["0770-3198","1434-9949"],"issn-type":[{"value":"0770-3198","type":"print"},{"value":"1434-9949","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,11]]},"assertion":[{"value":"20 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"None.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}